-
1
-
-
0035152487
-
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death
-
Bonny C., Oberson A., Negri S., Sauser C., Schorderet D.F. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 2001, 50:77-82.
-
(2001)
Diabetes
, vol.50
, pp. 77-82
-
-
Bonny, C.1
Oberson, A.2
Negri, S.3
Sauser, C.4
Schorderet, D.F.5
-
2
-
-
0033369685
-
Potent beta-cell protection in vitro by an isoquinolinone-derived PARP inhibitor
-
Burkart V., Blaeser K., Kolb H. Potent beta-cell protection in vitro by an isoquinolinone-derived PARP inhibitor. Horm. Metab. Res. 1999, 31:641-644.
-
(1999)
Horm. Metab. Res.
, vol.31
, pp. 641-644
-
-
Burkart, V.1
Blaeser, K.2
Kolb, H.3
-
3
-
-
0033011114
-
Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin
-
Burkart V., Wang Z.Q., Radons J., Heller B., Herceg Z., Stingl L., Wagner E.F., Kolb H. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozotocin. Nat. Med. 1999, 5:314-319.
-
(1999)
Nat. Med.
, vol.5
, pp. 314-319
-
-
Burkart, V.1
Wang, Z.Q.2
Radons, J.3
Heller, B.4
Herceg, Z.5
Stingl, L.6
Wagner, E.F.7
Kolb, H.8
-
4
-
-
0036499892
-
Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide' hypothesis revisited
-
Chiarugi A. Poly(ADP-ribose) polymerase: killer or conspirator? The 'suicide' hypothesis revisited. Trends Pharmacol. Sci. 2002, 23:122-129.
-
(2002)
Trends Pharmacol. Sci.
, vol.23
, pp. 122-129
-
-
Chiarugi, A.1
-
5
-
-
0040984333
-
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
-
de Murcia J.M., Niedergang C., Trucco C., Ricoul M., Dutrillaux B., Mark M., Oliver F.J., Masson M., Dierich A., LeMeur M., Walztinger C., Chambon P., de Murcia G. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:7303-7307.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 7303-7307
-
-
de Murcia, J.M.1
Niedergang, C.2
Trucco, C.3
Ricoul, M.4
Dutrillaux, B.5
Mark, M.6
Oliver, F.J.7
Masson, M.8
Dierich, A.9
LeMeur, M.10
Walztinger, C.11
Chambon, P.12
de Murcia, G.13
-
6
-
-
37549042844
-
C-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury
-
Fukuda K., Tesch G.H., Nikolic-Paterson D.J. c-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury. Biochem. Biophys. Res. Com. 2008, 366:710-716.
-
(2008)
Biochem. Biophys. Res. Com.
, vol.366
, pp. 710-716
-
-
Fukuda, K.1
Tesch, G.H.2
Nikolic-Paterson, D.J.3
-
7
-
-
0036018538
-
Generation of hydroxyl radicals mediated by streptozotocin in pancreatic islets of mice in vitro
-
Gille L., Schott-Ohly P., Friesen N., Shulte im Walde S., Udilova N., Nohl H., Gleichmann H. Generation of hydroxyl radicals mediated by streptozotocin in pancreatic islets of mice in vitro. Pharmacol. Toxicol. 2002, 90:317-326.
-
(2002)
Pharmacol. Toxicol.
, vol.90
, pp. 317-326
-
-
Gille, L.1
Schott-Ohly, P.2
Friesen, N.3
Shulte im Walde, S.4
Udilova, N.5
Nohl, H.6
Gleichmann, H.7
-
8
-
-
1842687173
-
Defective transcription factor activation for proinflammatory gene expression in poly(ADP-ribose) polymerase 1-deficient glia
-
Ha H.C. Defective transcription factor activation for proinflammatory gene expression in poly(ADP-ribose) polymerase 1-deficient glia. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:5087-5092.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 5087-5092
-
-
Ha, H.C.1
-
9
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J., Tuncman G., Chang L., Gorgun C.Z., Uysal K.T., Maeda K., Karin M., Hotamisligil G.S. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
10
-
-
0032964810
-
Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis
-
Hoorens A., Pipeleers D. Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis. Diabetologia 1999, 42:52-59.
-
(1999)
Diabetologia
, vol.42
, pp. 52-59
-
-
Hoorens, A.1
Pipeleers, D.2
-
11
-
-
21044453408
-
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type 1 diabetes
-
Jaeschke A., Rincon M., Doran B., Reilly J., Neuberg D., Greiner D.L., Shultz L.D., Rossini A.A., Flavell R.A., Davis R.J. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type 1 diabetes. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:6931-6935.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 6931-6935
-
-
Jaeschke, A.1
Rincon, M.2
Doran, B.3
Reilly, J.4
Neuberg, D.5
Greiner, D.L.6
Shultz, L.D.7
Rossini, A.A.8
Flavell, R.A.9
Davis, R.J.10
-
12
-
-
14844327760
-
Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatase
-
Kamata H., Honda S., Maeda S., Chang L., Hirata H., Karin M. Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatase. Cell 2005, 120:649-661.
-
(2005)
Cell
, vol.120
, pp. 649-661
-
-
Kamata, H.1
Honda, S.2
Maeda, S.3
Chang, L.4
Hirata, H.5
Karin, M.6
-
13
-
-
0037119417
-
Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
-
Kaneto H., Xu G., Fujii N., Kim S., Bonner-Weir S., Weir G.C. Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J. Biol. Chem. 2002, 277:30010-30018.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30010-30018
-
-
Kaneto, H.1
Xu, G.2
Fujii, N.3
Kim, S.4
Bonner-Weir, S.5
Weir, G.C.6
-
14
-
-
22544482621
-
Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen activated protein kinase/STAT1/reactive oxygen species pathway
-
Kim H.S., Lee M.-S. Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen activated protein kinase/STAT1/reactive oxygen species pathway. Mol. Cell. Biol. 2005, 25:6821-6833.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 6821-6833
-
-
Kim, H.S.1
Lee, M.-S.2
-
15
-
-
0024240517
-
Mechanisms of nicotinamide and thymidine protection from alloxan and streptozocin toxicity
-
LeDoux S.P., Hall C.R., Forbes P.M., Patton N.J., Wilson G.L. Mechanisms of nicotinamide and thymidine protection from alloxan and streptozocin toxicity. Diabetes 1988, 37:1015-1019.
-
(1988)
Diabetes
, vol.37
, pp. 1015-1019
-
-
LeDoux, S.P.1
Hall, C.R.2
Forbes, P.M.3
Patton, N.J.4
Wilson, G.L.5
-
16
-
-
33745288540
-
Inhibition of poly(ADP-Ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis
-
Martin-Oliva D., Aguilar-Quesada R., O'Valle F., Muñoz-Gámez J.A., Martínez-Romero R., García del Moral R., Ruiz de Almodóvar J.M., Villuendas R., Piris M.A., Oliver F.J. Inhibition of poly(ADP-Ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis. Cancer Res. 2006, 66:5744-5756.
-
(2006)
Cancer Res.
, vol.66
, pp. 5744-5756
-
-
Martin-Oliva, D.1
Aguilar-Quesada, R.2
O'Valle, F.3
Muñoz-Gámez, J.A.4
Martínez-Romero, R.5
García del Moral, R.6
Ruiz de Almodóvar, J.M.7
Villuendas, R.8
Piris, M.A.9
Oliver, F.J.10
-
17
-
-
42449126643
-
Inhibition of Foxo1 protects pancreatic islet b-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis
-
Martinez S.C., Tanabe K., Cras-Meneur C., Abumrad N.A., Bernal-Mizrachi E., Permutt M.A. Inhibition of Foxo1 protects pancreatic islet b-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes 2008, 57:846-859.
-
(2008)
Diabetes
, vol.57
, pp. 846-859
-
-
Martinez, S.C.1
Tanabe, K.2
Cras-Meneur, C.3
Abumrad, N.A.4
Bernal-Mizrachi, E.5
Permutt, M.A.6
-
18
-
-
44249094869
-
The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death
-
Mokhtari D., Myers J.W., Welsh N. The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death. Endocrinology 2008, 149:3046-3053.
-
(2008)
Endocrinology
, vol.149
, pp. 3046-3053
-
-
Mokhtari, D.1
Myers, J.W.2
Welsh, N.3
-
19
-
-
0036897224
-
Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in beta-cells
-
S
-
Okamoto H., Takasawa S. Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in beta-cells. Diabetes 2002, 51(S3):462-473.
-
(2002)
Diabetes
, vol.51
, Issue.3
, pp. 462-473
-
-
Okamoto, H.1
Takasawa, S.2
-
20
-
-
34248595035
-
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
-
Owens D.M., Keyse S.M. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 2007, 26:3203-3213.
-
(2007)
Oncogene
, vol.26
, pp. 3203-3213
-
-
Owens, D.M.1
Keyse, S.M.2
-
21
-
-
1542350182
-
Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase
-
Park S.Y., Chang I., Kim J.-Y., Kang S.W., Park S.-H., Singh K., Lee M.-S. Resistance of mitochondrial DNA-depleted cells against cell death: role of mitochondrial superoxide dismutase. J. Biol. Chem. 2004, 279:7512-7520.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7512-7520
-
-
Park, S.Y.1
Chang, I.2
Kim, J.-Y.3
Kang, S.W.4
Park, S.-H.5
Singh, K.6
Lee, M.-S.7
-
22
-
-
0032981559
-
Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes
-
Pieper A.A., Brat D.J., Krug D.K., Watkins C.C., Gupta A., Blackshaw S., Verma A., Wang Z.-Q., Snyder S.H. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:3059-3064.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 3059-3064
-
-
Pieper, A.A.1
Brat, D.J.2
Krug, D.K.3
Watkins, C.C.4
Gupta, A.5
Blackshaw, S.6
Verma, A.7
Wang, Z.-Q.8
Snyder, S.H.9
-
23
-
-
0042525938
-
NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
-
Sakon S., Xue X., Takekawa M., Sasazuki T., Okazaki T., Kojima Y., Piao J.-H., Yagita H., Okumura K., Doi T., Nakano H. NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 2003, 15:3898-3909.
-
(2003)
EMBO J.
, vol.15
, pp. 3898-3909
-
-
Sakon, S.1
Xue, X.2
Takekawa, M.3
Sasazuki, T.4
Okazaki, T.5
Kojima, Y.6
Piao, J.-H.7
Yagita, H.8
Okumura, K.9
Doi, T.10
Nakano, H.11
-
24
-
-
0028604486
-
STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells
-
Schnedl W.J., Ferber S., Johnson J.H., Newgard C.B. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes 1994, 43:1326-1333.
-
(1994)
Diabetes
, vol.43
, pp. 1326-1333
-
-
Schnedl, W.J.1
Ferber, S.2
Johnson, J.H.3
Newgard, C.B.4
-
25
-
-
33750823407
-
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates
-
Solinas G., Naugler W., Galimi F., Lee M.-S., Karin M. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:16454-16459.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 16454-16459
-
-
Solinas, G.1
Naugler, W.2
Galimi, F.3
Lee, M.-S.4
Karin, M.5
-
26
-
-
0035918171
-
IFNγ/TNFα synergism in ME-180 cervical cancer cell apoptosis and necrosis: IFNγ inhibits cytoprotective NF-κB through STAT1/IRF-1 pathways
-
Suk K., Chang I., Kim Y.H., Kim S., Kim J.Y., Kim H., Lee M.S. IFNγ/TNFα synergism in ME-180 cervical cancer cell apoptosis and necrosis: IFNγ inhibits cytoprotective NF-κB through STAT1/IRF-1 pathways. J. Biol. Chem. 2001, 276:13153-13159.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 13153-13159
-
-
Suk, K.1
Chang, I.2
Kim, Y.H.3
Kim, S.4
Kim, J.Y.5
Kim, H.6
Lee, M.S.7
-
27
-
-
0035313059
-
IFNγ/TNFα synergism as the final effector in autoimmune diabetes: a key role for STAT1/IRF-1 in pancreatic β-cell death
-
Suk K., Kim S., Kim Y.-H., Kim K.-A., Chang I., Yagita H., Shong M., Lee M.-S. IFNγ/TNFα synergism as the final effector in autoimmune diabetes: a key role for STAT1/IRF-1 in pancreatic β-cell death. J. Immunol. 2001, 166:4481-4489.
-
(2001)
J. Immunol.
, vol.166
, pp. 4481-4489
-
-
Suk, K.1
Kim, S.2
Kim, Y.-H.3
Kim, K.-A.4
Chang, I.5
Yagita, H.6
Shong, M.7
Lee, M.-S.8
-
28
-
-
0035891320
-
Inhibition of JNK activation through NF-κB target genes
-
Tang G., Minemoto Y., Dibling B., Purcell N.H., Li Z., Karin M., Lin A. Inhibition of JNK activation through NF-κB target genes. Nature 2001, 414:313-317.
-
(2001)
Nature
, vol.414
, pp. 313-317
-
-
Tang, G.1
Minemoto, Y.2
Dibling, B.3
Purcell, N.H.4
Li, Z.5
Karin, M.6
Lin, A.7
-
29
-
-
0034607702
-
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
-
Tournier C., Hess P., Yang D.D., Xu J., Turner T.K., Nimnual A., Bar-Sagi D., Jones S.N., Flavell R.A., Davis R.J. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000, 288:870-874.
-
(2000)
Science
, vol.288
, pp. 870-874
-
-
Tournier, C.1
Hess, P.2
Yang, D.D.3
Xu, J.4
Turner, T.K.5
Nimnual, A.6
Bar-Sagi, D.7
Jones, S.N.8
Flavell, R.A.9
Davis, R.J.10
-
30
-
-
0032193692
-
Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death
-
Virag L., Salzman A.L., Szabo C. Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J. Immunol. 1998, 161:3753-3759.
-
(1998)
J. Immunol.
, vol.161
, pp. 3753-3759
-
-
Virag, L.1
Salzman, A.L.2
Szabo, C.3
-
31
-
-
0030984490
-
PARP is important for genomic stability but dispensable in apoptosis
-
Wang Z.-Q., Stingl L., Morrison C., Jantsch M., Los M., Schultze-Osthoff K., Wanger E.F. PARP is important for genomic stability but dispensable in apoptosis. Genes Dev. 1997, 11:2347-2358.
-
(1997)
Genes Dev.
, vol.11
, pp. 2347-2358
-
-
Wang, Z.-Q.1
Stingl, L.2
Morrison, C.3
Jantsch, M.4
Los, M.5
Schultze-Osthoff, K.6
Wanger, E.F.7
-
32
-
-
18144384775
-
Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling
-
Wu J.J., Bennett A.M. Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling. J. Biol. Chem. 2005, 280:16461-16466.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 16461-16466
-
-
Wu, J.J.1
Bennett, A.M.2
-
33
-
-
33646827842
-
Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation
-
Xu Y., Huang S., Liu Z.-G., Han J. Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J. Biol. Chem. 2006, 281:8788-8795.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 8788-8795
-
-
Xu, Y.1
Huang, S.2
Liu, Z.-G.3
Han, J.4
-
34
-
-
33845317242
-
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
-
Yu S.-W., Andrabi S.A., Wang H., Kim N.S., Poirier G.G., Dawson T.M., Dawson V.L. Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:18314-18319.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 18314-18319
-
-
Yu, S.-W.1
Andrabi, S.A.2
Wang, H.3
Kim, N.S.4
Poirier, G.G.5
Dawson, T.M.6
Dawson, V.L.7
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