Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats

Toxicological Sciences

Volumn 124, Issue 1, 2011, Pages 202-214

  Lai, Ian K ^a   Chai, Yingtao ^b,e   Simmons, Donald ^b   Watson, Walter H ^c   Tan, Rommel ^d   Haschek, Wanda M ^d   Wang, Kai ^a   Wang, Bingxuan ^a   Ludewig, Gabriele ^a   Robertson, Larry W ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c University of Louisville School of Medicine   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e BD Biosciences Advanced Bioprocessing   (United States)

Author keywords

Copper; Glutathione; Glutathione peroxidase; Hepatotoxicity; Polychlorinated biphenyls; Redox status; Selenium; Superoxide dismutase; Thioredoxin; Zinc

Indexed keywords

3,3',4,4',5 PENTACHLOROBIPHENYL; ANTIOXIDANT; AROMATIC HYDROCARBON RECEPTOR; COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME P450 1A1; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; IRON; MANGANESE; POLYCHLORINATED BIPHENYL DERIVATIVE; SELENIUM; THIOREDOXIN; THIOREDOXIN REDUCTASE; ZINC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; HOMEOSTASIS; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; OXIDATION; RAT; RECEPTOR UPREGULATION; SPRAGUE DAWLEY RAT; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG-INDUCED LIVER INJURY; LIVER; MALE; ORGAN SIZE; ORGAN SPECIFICITY; OXIDATION-REDUCTION; POLYCHLORINATED BIPHENYLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; SELENIUM COMPOUNDS;

EID: 84155196845     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr215     Document Type: Article

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