Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat

Toxicological Sciences

Volumn 90, Issue 1, 2006, Pages 87-95

  Fisher, Jeffrey W ^a   Campbell, Jerry ^a   Muralidhara, Srinivasa ^a   Bruckner, James V ^a   Ferguson, Duncan ^a   Mumtaz, Moiz ^b   Harmon, Barry ^a   Hedge, Joan M ^c   Crofton, Kevin M ^d   Kim, Hekap ^e   Almekinder, Tara L ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^e National University   (South Korea)

Author keywords

P450, EROD; PCB 126; Rat; Thyroid hormones; TSH; UDPGT

Indexed keywords

3,3',4,4',5 PENTACHLOROBIPHENYL; AROMATIC HYDROCARBON RECEPTOR; ETHOXYRESORUFIN DEETHYLASE; GLUCURONOSYLTRANSFERASE; LIVER ENZYME; THYROTROPIN; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DETERMINATION; ENZYME ACTIVITY; ENZYME ANALYSIS; HORMONE DETERMINATION; HORMONE METABOLISM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LIVER METABOLISM; MALE; NONHUMAN; NONLINEAR SYSTEM; RAT; SINGLE DRUG DOSE; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; AREA UNDER CURVE; BODY WEIGHT; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; ESTROGEN ANTAGONISTS; GLUCURONOSYLTRANSFERASE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LIVER; MALE; POLYCHLORINATED BIPHENYLS; RATS; RATS, SPRAGUE-DAWLEY; THYROID GLAND; THYROTROPIN; THYROXINE;

ANIMALIA; ZEA MAYS;

EID: 33144478166     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfj069     Document Type: Article

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