Biochemical mechanism of modulation of human p-glycoprotein by stemofoline

Planta Medica

Volumn 77, Issue 18, 2011, Pages 1990-1995

  Chanmahasathien, Wisinee ^a,b   Ohnuma, Shinobu ^c   Ambudkar, Suresh V ^c   Limtrakul, Pornngarm ^a  

^a Faculty of Medicine Chiang Mai University   (Thailand)

^b CHIANG MAI UNIVERSITY   (Thailand)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

KB V1; multidrug resistance; P glycoprotein; stemofoline; Stemona burkillii; Stemonaceae

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALKALOID; CYCLOSPORIN A; GLYCOPROTEIN P; IODOARYLAZIDOPRAZOSIN I 125; RADIOPHARMACEUTICAL AGENT; STEMOFOLINE; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG RETENTION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; ISOTOPE LABELING; MULTIDRUG RESISTANCE; PHOTOAFFINITY LABELING; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; ANTINEOPLASTIC AGENTS; AZIDES; BINDING SITES; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; FLUORESCEINS; FLUORESCENT DYES; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INSECTS; MEMBRANES; P-GLYCOPROTEIN; PHOTOAFFINITY LABELS; PLANT ROOTS; PRAZOSIN; PROTEIN BINDING; RHODAMINE 123; STEMONACEAE; VINBLASTINE;

STEMONA BURKILLII; STEMONACEAE;

EID: 84155172846     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1280054     Document Type: Article

References (21)

1. Ramachandra M, Ambudkar S V., Chen D, Hrycyna C A., Dey S, Gottesman M M., Pastan I. Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state. Biochemistry 1998 37 5010-5019 (Pubitemid 28175983)
2. Sharom F J. The P-glycoprotein efflux pump: how does it transport drugs? J Membr Biol 1997 160 161-175 (Pubitemid 28026729)
3. Bosch I, Croop J. P-glycoprotein multidrug resistance and cancer. Biochim Biophys Acta 1996 1288 F37-F54 (Pubitemid 26335491)
4. Sharom F J., Liu R, Romsicki Y, Lu P. Insights into the structure and substrate interactions of the P-glycoprotein multidrug transport from spectroscopic studies. Biochim Biophys Acta 1999 1461 327-345
5. Ambudkar S V., Kim I, Sauna Z E. The power of the pump: mechanisms of action of P-glycoprotein (ABCB1). Eur J Pharm Sci 2006 27 392-400 (Pubitemid 43363335)
6. Sauna Z E., Ambudkar S V. Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. J Biol Chem 2001 276 11653-11661
7. Hrycyna C A., Ramachandra M, Germann U A., Cheng P W., Pastan I, Gottesman M M. Both ATP sites of human P-glycoprotein are essential but not symmetric. Biochemistry 1999 38 13887-13899 (Pubitemid 29504219)
8. Litman T, Druley T E., Stein W D., Bates S E. From MDR to MXR: new understanding of multidrug resistance system, their properties and clinical significance. Cell Mol Life Sci 2001 58 931-959 (Pubitemid 32652819)
9. Chanmahasathien W, Ampasavate C, Greger H, Limtrakul P. Stemona alkaloids, from traditional Thai medicine, increase chemosensitivity via P-glycoprotein-mediated multidrug resistance. Phytomedicine 2011 18 199-204
10. Greger H. Structure relationships, distribution and biological activities of Stemona alkaloids. Planta Med 2006 72 99-113 (Pubitemid 43293863)
11. Plouzek C A., Ciolino H P., Clarke R, Yeh G C. Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract. Eur J Cancer 1999 35 1541-1545 (Pubitemid 29454653)
12. Jodoin J, Demeule M, Beliveau R. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim Biophys Acta 2002 1542 149-159
13. Bradford M M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976 72 248-254
14. Sauna Z E., Muller M, Peng X, Ambudkar S V. Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1). Biochemistry 2002 41 13989-14000 (Pubitemid 35364871)
15. Shukla S, Robey R W., Bates S E., Ambudkar S V. Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosone kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Dispos 2009 37 359-365
16. Ambudkar S V. Drug stimulatable ATPase activity in crude membranes of human MDR1 transfected mammalian cells. Methods Enzymol 1998 292 504-514 (Pubitemid 29343911)
17. Maki N, Hafkemeyer P, Dey S. Allosteric modulation of human P-gp. J Biol Chem 2003 278 18132-18139
18. Ozben T. Mechanisms and strategies to overcome multiple drug resistance in cancer. FEBS Lett 2006 580 2903-2909 (Pubitemid 43729172)
19. Limtrakul P, Khantamat O, Pintha K. Inhibition of P-glycoprotein function and expression by kaempferol and quercetin. J Chemother 2005 17 86-95 (Pubitemid 40463763)
20. Chearwae W, Anuchapreeda S, Nandigama K, Ambudkar S V., Limtrakul P. Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. Biochem Pharmacol 2004 68 2043-2052 (Pubitemid 39346194)
21. Anuchapreeda S, Ambudkar S V., Leechanachai P, Limtrakul P. Modulation of P-glycoprotein expression and function by curcumin in multidrug resistant human KB Cells. Biochem Pharmacol 2002 64 573-582