2,3,7,8-tetrachlorodibenzo-p-dioxin's suppression of 1-nitropyrene-induced p53 expression is mediated by cytochrome P450 1A1

Chemical Research in Toxicology

Volumn 24, Issue 12, 2011, Pages 2167-2175

  Su, Jyan Gwo Joseph ^a   Huang, Min Cong ^a   Chen, Fei Yun ^a  

^a NATIONAL CHIAYI UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 1A1; NUTLIN 3; PROTEIN P53; SHORT HAIRPIN RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME REPRESSION; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; HYPOXIA; INTRODUCED SPECIES; MUTAGENESIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; XENOBIOTIC METABOLISM; XENOBIOTIC STRESS;

ANIMALS; AZO COMPOUNDS; BENZO(A)PYRENE; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION; HUMANS; MICE; PROTO-ONCOGENE PROTEINS C-MDM2; PYRAZOLES; PYRENES; RECEPTORS, ARYL HYDROCARBON; RNA INTERFERENCE; TETRACHLORODIBENZODIOXIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84055223063     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200309p     Document Type: Article

References (49)

1. Singh, S. and Prakash, V. (2007) Toxic environmental releases from medical waste incineration: a review Environ. Monit. Assess. 132, 67-81
2. Schecter, A., Birnbaum, L., Ryan, J. J., and Constable, J. D. (2006) Dioxins: an overview Environ. Res. 101, 419-428 (Pubitemid 43782675)
3. Van den Berg, M., Birnbaum, L., Bosveld, A. T., Brunstrom, B., Cook, P., Feeley, M., Giesy, J. P., Hanberg, A., Hasegawa, R., Kennedy, S. W., Kubiak, T., Larsen, J. C., van Leeuwen, F. X., iem, A. K., Nolt, C., Peterson, R. E., Poellinger, L., Safe, S., Schrenk, D., Tillitt, D., Tysklind, M., Younes, M., Waern, F., and Zacharewski, T. (1998) Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife Environ. Health Perspect. 106, 775-792 (Pubitemid 29073822)
4. Cole, P., Trichopoulos, D., Pastides, H., Starr, T., and Mandel, J. S. (2003) Dioxin and cancer: a critical review Regul. Toxicol. Pharmacol. 38, 378-388 (Pubitemid 37414825)
5. Bock, K. W. and Kohle, C. (2006) Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions Biochem. Pharmacol. 72, 393-404 (Pubitemid 44061741)
6. Connor, K. T. and Aylward, L. L. (2006) Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR J. Toxicol. Environ. Health, Part B 9, 147-171
7. Guengerich, F. P. (2008) Cytochrome p450 and chemical toxicology Chem. Res. Toxicol. 21, 70-83 (Pubitemid 351219709)
8. Nakata, K., Tanaka, Y., Nakano, T., Adachi, T., Tanaka, H., Kaminuma, T., and Ishikawa, T. (2006) Nuclear receptor-mediated transcriptional regulation in Phase I, II, and III xenobiotic metabolizing systems Drug Metab. Pharmacokinet. 21, 437-457
9. Shimada, T. (2006) Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons Drug Metab. Pharmacokinet. 21, 257-276
10. Solhaug, A., Refsnes, M., Lag, M., Schwarze, P. E., Husoy, T., and Holme, J. A. (2004) Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells Carcinogenesis 25, 809-819 (Pubitemid 38618535)
11. Aoki, Y., Hashimoto, A. H., Amanuma, K., Matsumoto, M., Hiyoshi, K., Takano, H., Masumura, K., Itoh, K., Nohmi, T., and Yamamoto, M. (2007) Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice Cancer Res. 67, 5643-5648 (Pubitemid 46984995)
12. NIST (2000) Certificate of Analysis, Standard Reference Material (SRM) 2975, Diesel Particulate Matter (Industrial Forklift), pp 1-8, National Institute of Standards and Technology (NIST), Gaithersburg, MD.
13. NIST (2008) Certificate of Analysis, Standard Reference Material (SRM) 1975, Diesel Particulate Extract, pp 1-9, National Institute of Standards and Technology (NIST), Gaithersburg, MD.
14. Schuetzle, D., Lee, F. S., and Prater, T. J. (1981) The identification of polynuclear aromatic hydrocarbon (PAH) derivatives in mutagenic fractions of diesel particulate extracts Int. J. Environ. Anal. Chem. 9, 93-144 (Pubitemid 11004171)
15. Andersson, H., Piras, E., Demma, J., Hellman, B., and Brittebo, E. (2009) Low levels of the air pollutant 1-nitropyrene induce DNA damage, increased levels of reactive oxygen species and endoplasmic reticulum stress in human endothelial cells Toxicology 262, 57-64
16. Su, J. G., Liao, P. J., Huang, M. C., Chu, W. C., Lin, S. C., and Chang, Y. J. (2008) Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis Toxicology 244, 257-270
17. Feki, A. and Irminger-Finger, I. (2004) Mutational spectrum of p53 mutations in primary breast and ovarian tumors Crit. Rev. Oncol. Hematol. 52, 103-116 (Pubitemid 39419493)
18. Guimaraes, D. P. and Hainaut, P. (2002) TP53: a key gene in human cancer Biochimie 84, 83-93 (Pubitemid 34477096)
19. Jegga, A. G., Inga, A., Menendez, D., Aronow, B. J., and Resnick, M. A. (2008) Functional evolution of the p53 regulatory network through its target response elements Proc. Natl. Acad. Sci. U.S.A. 105, 944-949 (Pubitemid 351282061)
20. Olivier, M., Petitjean, A., Marcel, V., Petre, A., Mounawar, M., Plymoth, A., de Fromentel, C. C., and Hainaut, P. (2009) Recent advances in p53 research: an interdisciplinary perspective Cancer Gene Ther. 16, 1-12
21. Honda, R., Tanaka, H., and Yasuda, H. (1997) Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 FEBS Lett. 420, 25-27 (Pubitemid 28037193)
22. Shangary, S. and Wang, S. (2008) Targeting the MDM2-p53 interaction for cancer therapy Clin. Cancer Res. 14, 5318-5324
23. Komarov, P. G., Komarova, E. A., Kondratov, R. V., Christov-Tselkov, K., Coon, J. S., Chernov, M. V., and Gudkov, A. V. (1999) A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy Science 285, 1733-1737 (Pubitemid 29428873)
24. Hoagland, M. S., Hoagland, E. M., and Swanson, H. I. (2005) The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor J. Pharmacol. Exp. Ther. 314, 603-610 (Pubitemid 41043840)
25. Paajarvi, G., Viluksela, M., Pohjanvirta, R., Stenius, U., and Hogberg, J. (2005) TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents Carcinogenesis 26, 201-208 (Pubitemid 40214336)
26. Seifert, A., Taubert, H., Hombach-Klonisch, S., Fischer, B., and Navarrete Santos, A. (2009) TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions Int. J. Oncol. 35, 417-424
27. Klein, C. B., Broday, L., and Costa, M. (1999) Mutagenesis Assays in Mammalian Cells, John Wiley and Sons, Inc., Hoboken, NJ.
28. Seifert, A., Taubert, H., Hombach-Klonisch, S., Fischer, B., and Navarrete Santos, A. (2009) TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions Int. J. Oncol. 35, 417-424
29. Mayo, L. D. and Donner, D. B. (2002) The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network Trends Biochem. Sci. 27, 462-467 (Pubitemid 35246255)
30. Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., and Hung, M. C. (2001) HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation Nat. Cell Biol. 3, 973-982 (Pubitemid 34428742)
31. Whitlock, J. P., Jr. (1999) Induction of cytochrome P4501A1 Annu. Rev. Pharmacol. Toxicol. 39, 103-125 (Pubitemid 29222553)
32. Iwanari, M., Nakajima, M., Kizu, R., Hayakawa, K., and Yokoi, T. (2002) Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences Arch. Toxicol. 76, 287-298 (Pubitemid 34639524)
33. Yamazaki, H., Hatanaka, N., Kizu, R., Hayakawa, K., Shimada, N., Guengerich, F. P., Nakajima, M., and Yokoi, T. (2000) Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1 Mutat. Res. 472, 129-138
34. Chu, W. C., Hong, W. F., Huang, M. C., Chen, F. Y., Lin, S. C., Liao, P. J., and Su, J. G. (2009) 1-Nitropyrene stabilizes the mRNA of cytochrome P450 1a1, a carcinogen-metabolizing enzyme, via the Akt pathway Chem. Res. Toxicol. 22, 1938-1947
35. Weiss, R. H. (2003) p21Waf1/Cip1 as a therapeutic target in breast and other cancers Cancer Cell 4, 425-429 (Pubitemid 38050039)
36. Carvan, M. J., III, Flood, L. P., Campbell, B. D., and Busbee, D. L. (1995) Effects of benzo(a)pyrene and tetrachlorodibenzo(p)dioxin on fetal dolphin kidney cells: inhibition of proliferation and initiation of DNA damage Chemosphere 30, 187-198
37. de Waard, P. W., de Kok, T. M., Maas, L. M., Peijnenburg, A. A., Hoogenboom, R. L., Aarts, J. M., and van Schooten, F. J. (2008) Influence of TCDD and natural Ah receptor agonists on benzo[a]pyrene-DNA adduct formation in the Caco-2 human colon cell line Mutagenesis 23, 67-73 (Pubitemid 351161355)
38. Thornton, A. S., Oda, Y., Stuart, G. R., Glickman, B. W., and de Boer, J. G. (2001) Mutagenicity of TCDD in Big Blue transgenic rats Mutat. Res. 478, 45-50 (Pubitemid 32530849)
39. Thornton, A. S., Oda, Y., Stuart, G. R., Holcroft, J., and de Boer, J. G. (2004) The dioxin TCDD protects against aflatoxin-induced mutation in female rats, but not in male rats Mutat. Res. 561, 147-152 (Pubitemid 38845062)
40. Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M., and Gehring, P. J. (1979) Long-term toxicologic studies of 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) in laboratory animals Ann. N.Y. Acad. Sci. 320, 397-404
41. Silvers, K. J., Couch, L. H., Rorke, E. A., and Howard, P. C. (1997) Role of nitroreductases but not cytochromes P450 in the metabolic activation of 1-nitropyrene in the HepG2 human hepatoblastoma cell line Biochem. Pharmacol. 54, 927-936 (Pubitemid 27404599)
42. Iwanari, M., Nakajima, M., Kizu, R., Hayakawa, K., and Yokoi, T. (2002) Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences Arch. Toxicol. 76, 287-298 (Pubitemid 34639524)
43. Kang, Z. C., Tsai, S. J., and Lee, H. (1999) Quercetin inhibits benzo[a]pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 1A1 gene expression Nutr. Cancer 35, 175-179 (Pubitemid 30115129)
44. Harrigan, J. A., Vezina, C. M., McGarrigle, B. P., Ersing, N., Box, H. C., Maccubbin, A. E., and Olson, J. R. (2004) DNA adduct formation in precision-cut rat liver and lung slices exposed to benzo[a]pyrene Toxicol. Sci. 77, 307-314 (Pubitemid 38262604)
45. Jin, Y. and Penning, T. M. (2007) Aldo-keto reductases and bioactivation/detoxication Annu. Rev. Pharmacol. Toxicol. 47, 263-292
46. Baird, W. M., Hooven, L. A., and Mahadevan, B. (2005) Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action Environ. Mol. Mutagen. 45, 106-114
47. Proskuryakov, S. Y., Konoplyannikov, A. G., Konoplyannikova, O. A., Shevchenko, L. I., Verkhovskii, Y. G., and Tsyb, A. F. (2009) Possible involvement of NO in the stimulating effect of pifithrins on survival of hemopoietic clonogenic cells Biochemistry (Moscow) 74, 130-136
48. Solhaug, A., Ovrebo, S., Mollerup, S., Lag, M., Schwarze, P. E., Nesnow, S., and Holme, J. A. (2005) Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites Chem.-Biol. Interact. 151, 101-119 (Pubitemid 40208562)
49. Sparfel, L., Van Grevenynghe, J., Le Vee, M., Aninat, C., and Fardel, O. (2006) Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha Carcinogenesis 27, 656-663 (Pubitemid 43372894)