Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 472, Issue 1-2, 2000, Pages 129-138

  Yamazaki, Hiroshi ^a   Hatanaka, Naoya ^a   Kizu, Ryoichi ^a   Hayakawa, Kazuichi ^a   Shimada, Noriaki ^b   Guengerich, F Peter ^c   Nakajima, Miki ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diesel exhaust particles extracts; Dinitropyrene; Human P450 1B1; Nitropyrene; S. typhimurium; umu gene expression

Indexed keywords

1 NITROPYRENE; 1,3 DINITROPYRENE; 1,6 DINITROPYRENE; 1,8 DINITROPYRENE; 2 NITROFLUORANTHENE; 3 NITROFLUORANTHENE; 6 NITROBENZO[A]PYRENE; 6 NITROCHRYSENE; 7 NITROBENZ[A]ANTHRACENE; AROMATIC NITRO COMPOUND; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; POLYCYCLIC AROMATIC HYDROCARBON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG;

AMES TEST; ARTICLE; BACTERIAL MEMBRANE; CONTROLLED STUDY; ESCHERICHIA COLI; EXHAUST GAS; GENE INDUCTION; GENOTOXICITY; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; HUMANS; MUTAGENICITY TESTS; MUTAGENS; NADPH-FERRIHEMOPROTEIN REDUCTASE; PYRENES; RECOMBINANT FUSION PROTEINS; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP; VEHICLE EMISSIONS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0034695040     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00138-8     Document Type: Article

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