Synthesis and properties of a bridged nucleic acid with a perhydro-1,2-oxazin-3-one ring

Journal of Organic Chemistry

Volumn 76, Issue 24, 2011, Pages 9891-9899

  Shrestha, Ajaya R ^a   Hari, Yoshiyuki ^a   Yahara, Aiko ^a   Osawa, Takashi ^a   Obika, Satoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE TECHNOLOGY; BRIDGED STRUCTURES; CARBONYL FUNCTION; EXONUCLEASE; HIGH AFFINITY; IN-SITU; MODIFIED OLIGONUCLEOTIDES; PLANARITY; POTENTIAL APPLICATIONS; RING OPENING; STRUCTURAL FEATURE; SUGAR MOIETY;

BIOMOLECULES; RNA; SUGARS;

OLIGONUCLEOTIDES;

BRIDGED COMPOUND; CARBONYL DERIVATIVE; HYDROXAMATE BRIDGED NUCLEIC ACID; MONOMER; NUCLEASE; NUCLEIC ACID; OLIGONUCLEOTIDE; PERHYDRO 1,2 OXAZIN 3 ONE; SPLEEN EXONUCLEASE; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; CYCLIZATION; DEBENZYLATION; DESILYLATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGENOLYSIS; OXIDATION; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; RING OPENING; RNA BINDING; THERMOSTABILITY;

BASE SEQUENCE; BRIDGED COMPOUNDS; CHROMATOGRAPHY, REVERSE-PHASE; DNA; EXONUCLEASES; HUMANS; HYDROXAMIC ACIDS; MOLECULAR SEQUENCE ANNOTATION; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES, ANTISENSE; OXAZINES; RNA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY;

EID: 84055200166     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo201597e     Document Type: Article

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