-
1
-
-
73149104190
-
Chemical modification of oligonucleotides for therapeutic, bioanalytical and other applications
-
Bell, N.M. and Micklefield, J. (2009) Chemical modification of oligonucleotides for therapeutic, bioanalytical and other applications. ChemBioChem, 10, 2691-2703.
-
(2009)
ChemBioChem
, vol.10
, pp. 2691-2703
-
-
Bell, N.M.1
Micklefield, J.2
-
2
-
-
77952043572
-
RNAi-based therapeutics - Current status, challenges and prospects
-
Tiemann, K. and Rossi, J.J. (2009) RNAi-based therapeutics - current status, challenges and prospects. EMBO Mol. Med., 1, 142-151.
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 142-151
-
-
Tiemann, K.1
Rossi, J.J.2
-
3
-
-
77649275761
-
Novel RNA-based strategies for therapeutic gene silencing
-
Sibley, C.R., Seow, Y. and Wood, M.J.A. (2010) Novel RNA-based strategies for therapeutic gene silencing. Mol. Ther., 18, 466-476.
-
(2010)
Mol. Ther.
, vol.18
, pp. 466-476
-
-
Sibley, C.R.1
Seow, Y.2
Wood, M.J.A.3
-
4
-
-
77949512140
-
RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform
-
Bennett, C.F. and Swayze, E.E. (2010) RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu. Rev. Pharmacol. Toxicol., 50, 259-293.
-
(2010)
Annu. Rev. Pharmacol. Toxicol.
, vol.50
, pp. 259-293
-
-
Bennett, C.F.1
Swayze, E.E.2
-
5
-
-
4043059428
-
Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides
-
Kang, H., Fisher, M.H., Xu, D., Miyamoto, Y.J., Marchand, A., Van Aerschot, A., Herdewijn, P. and Juliano, R.L. (2004) Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides. Nucleic Acids Res., 32, 4411-4419.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 4411-4419
-
-
Kang, H.1
Fisher, M.H.2
Xu, D.3
Miyamoto, Y.J.4
Marchand, A.5
Van Aerschot, A.6
Herdewijn, P.7
Juliano, R.L.8
-
6
-
-
77949676231
-
Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications
-
Veedu, R.N. and Wengel, J. (2010) Locked nucleic acids: promising nucleic acid analogs for therapeutic applications. Chem. Biodivers., 7, 536-542.
-
(2010)
Chem. Biodivers.
, vol.7
, pp. 536-542
-
-
Veedu, R.N.1
Wengel, J.2
-
7
-
-
0036061380
-
BNAs: Novel nucleic acid analogs with a bridged sugar moiety
-
Imanishi, T. and Obika, S. (2002) BNAs: novel nucleic acid analogs with a bridged sugar moiety. Chem. Commun., 1653-1659.
-
(2002)
Chem. Commun.
, pp. 1653-1659
-
-
Imanishi, T.1
Obika, S.2
-
8
-
-
42949121053
-
Comparing in vitro and in vivo activity of 20-O-[2- (methylamino)-2- oxoethyl]- and 20-O-methoxyethyl-modified antisense oligonucleotides
-
Prakash, T.P., Kawasaki, A.M., Wancewicz, E.V., Shen, L., Monia, B.P., Ross, B.S., Bhat, B. and Manoharan, M. (2008) Comparing in vitro and in vivo activity of 20-O-[2- (methylamino)-2-oxoethyl]- and 20-O-methoxyethyl-modified antisense oligonucleotides. J. Med. Chem., 51, 2766-2776.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 2766-2776
-
-
Prakash, T.P.1
Kawasaki, A.M.2
Wancewicz, E.V.3
Shen, L.4
Monia, B.P.5
Ross, B.S.6
Bhat, B.7
Manoharan, M.8
-
9
-
-
77951198765
-
Peptide nucleic acids (PNA) in chemical biology and drug discovery
-
Nielsen, P.E. (2010) Peptide nucleic acids (PNA) in chemical biology and drug discovery. Chem. Biodivers., 7, 786-804.
-
(2010)
Chem. Biodivers.
, vol.7
, pp. 786-804
-
-
Nielsen, P.E.1
-
10
-
-
63449133262
-
Gene knockdowns in adult animals: PPMOs and vivo-morpholinos
-
Moulton, J.D. and Jiang, S. (2009) Gene knockdowns in adult animals: PPMOs and vivo-morpholinos. Molecules, 14, 1304-1323.
-
(2009)
Molecules
, vol.14
, pp. 1304-1323
-
-
Moulton, J.D.1
Jiang, S.2
-
11
-
-
1242297789
-
Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: A comparison of tricyclo-DNA with LNA
-
Ittig, D., Liu, S., Renneberg, D., Schümperli, D. and Leumann, C.J. (2004) Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA. Nucleic Acids Res., 32, 346-353.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 346-353
-
-
Ittig, D.1
Liu, S.2
Renneberg, D.3
Schümperli, D.4
Leumann, C.J.5
-
12
-
-
0036640332
-
Biological and antisense properties of tricyclo-DNA
-
Renneberg, D., Schümperli, D. and Leumann, C.J. (2002) Biological and antisense properties of tricyclo-DNA. Nucleic Acids Res., 30, 2751-2757.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 2751-2757
-
-
Renneberg, D.1
Schümperli, D.2
Leumann, C.J.3
-
13
-
-
0142165224
-
Functional siRNAs and miRNAs Exhibit Strand Bias
-
Khvorova, A., Reynolds, A. and Jayasena, S.D. (2003) Functional siRNAs and miRNAs Exhibit Strand Bias. Cell, 115, 209-216.
-
(2003)
Cell
, vol.115
, pp. 209-216
-
-
Khvorova, A.1
Reynolds, A.2
Jayasena, S.D.3
-
14
-
-
10744225153
-
Asymmetry in the assembly of the RNAi enzyme complex
-
Schwarz, D.S., Hutvagner, G., Du, T., Xu, Z., Aronin, N. and Zamore, P.D. (2003) Asymmetry in the assembly of the RNAi enzyme complex. Cell, 115, 199-208.
-
(2003)
Cell
, vol.115
, pp. 199-208
-
-
Schwarz, D.S.1
Hutvagner, G.2
Du, T.3
Xu, Z.4
Aronin, N.5
Zamore, P.D.6
-
15
-
-
13744250159
-
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
-
Elmen, J., Thonberg, H., Ljungberg, K., Frieden, M., Westergaard, M., Xu, Y., Wahren, B., Liang, Z., Orum, H., Koch, T. et al. (2005) Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res., 33, 439-447.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 439-447
-
-
Elmen, J.1
Thonberg, H.2
Ljungberg, K.3
Frieden, M.4
Westergaard, M.5
Xu, Y.6
Wahren, B.7
Liang, Z.8
Orum, H.9
Koch, T.10
-
16
-
-
34848926634
-
Improved silencing properties using small internally segmented interfering RNAs
-
Bramsen, J.B., Laursen, M.B., Damgaard, C.K., Lena, S.W., Ravindra Babu, B., Wengel, J. and Kjems, J. (2007) Improved silencing properties using small internally segmented interfering RNAs. Nucleic Acids Res., 35, 5886-5897.
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 5886-5897
-
-
Bramsen, J.B.1
Laursen, M.B.2
Damgaard, C.K.3
Lena, S.W.4
Ravindra Babu, B.5
Wengel, J.6
Kjems, J.7
-
17
-
-
52049090811
-
Chemically modified siRNA: Tools and applications
-
Watts, J.K., Deleavey, G.F. and Damha, M.J. (2008) Chemically modified siRNA: tools and applications. Drug Discov. Today, 13, 842-855.
-
(2008)
Drug Discov. Today
, vol.13
, pp. 842-855
-
-
Watts, J.K.1
Deleavey, G.F.2
Damha, M.J.3
-
18
-
-
66349108231
-
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
-
Bramsen, J.B., Laursen, M.B., Nielsen, A.F., Hansen, T.B., Bus, C., Langkjaer, N., Babu, B.R., Hojland, T., Abramov, M., Van Aerschot, A. et al. (2009) A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity. Nucleic Acids Res., 37, 2867-2881.
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 2867-2881
-
-
Bramsen, J.B.1
Laursen, M.B.2
Nielsen, A.F.3
Hansen, T.B.4
Bus, C.5
Langkjaer, N.6
Babu, B.R.7
Hojland, T.8
Abramov, M.9
Van Aerschot, A.10
-
19
-
-
78651298572
-
Improving gene silencing of siRNAs via tricyclo-DNA modification
-
Ittig, D., Luisier, S., Weiler, J., Schümperli, D. and Leumann, C. (2010) Improving gene silencing of siRNAs via tricyclo-DNA modification. Artif. DNA PNA XNA, 1, 9-16.
-
(2010)
Artif. DNA PNA XNA
, vol.1
, pp. 9-16
-
-
Ittig, D.1
Luisier, S.2
Weiler, J.3
Schümperli, D.4
Leumann, C.5
-
20
-
-
0033848429
-
Synthesis of 20- deoxyribonucleoside 50-phosphoramidites: New building blocks for the inverse (50- 30)-oligonucleotide approach
-
Wagner, T. and Pfleiderer, W. (2000) Synthesis of 20- deoxyribonucleoside 50-phosphoramidites: new building blocks for the inverse (50-30)- oligonucleotide approach. Helv. Chim. Acta, 83, 2023-2035.
-
(2000)
Helv. Chim. Acta
, vol.83
, pp. 2023-2035
-
-
Wagner, T.1
Pfleiderer, W.2
-
21
-
-
0023406843
-
Calculating thermodynamic data for transitions of any molecularity from equilibrium melting curves
-
Marky, L.A. and Breslauer, K.J. (1987) Calculating thermodynamic data for transitions of any molecularity from equilibrium melting curves. Biopolymers, 26, 1601-1620.
-
(1987)
Biopolymers
, vol.26
, pp. 1601-1620
-
-
Marky, L.A.1
Breslauer, K.J.2
-
22
-
-
0020579962
-
Salt-dependent conformational transitions in the self-complementary deoxydodecanucleotide d(CGCGAATTC GCG): Evidence for hairpin formation
-
Marky, L.A., Blumenfeld, K.S., Kozlowski, S. and Breslauer, K.J. (1983) Salt-dependent conformational transitions in the self-complementary deoxydodecanucleotide d(CGCGAATTC GCG): Evidence for hairpin formation. Biopolymers, 22, 1247-1257.
-
(1983)
Biopolymers
, vol.22
, pp. 1247-1257
-
-
Marky, L.A.1
Blumenfeld, K.S.2
Kozlowski, S.3
Breslauer, K.J.4
-
23
-
-
0020674698
-
Base-stacking and base-pairing contributions to helix stability: Thermodynamics of double helix formation with CCGG, CCGGp, CCGGAp, ACCGGp, CCGGUp and ACCGGUp
-
Petersheim, M. and Turner, D.H. (1983) Base-stacking and base-pairing contributions to helix stability: thermodynamics of double helix formation with CCGG, CCGGp, CCGGAp, ACCGGp, CCGGUp and ACCGGUp. Biochemistry, 22, 256-263.
-
(1983)
Biochemistry
, vol.22
, pp. 256-263
-
-
Petersheim, M.1
Turner, D.H.2
-
24
-
-
0032054719
-
Bicyclo[3.2.1] -DNA, a new DNA analog with a rigid backbone and flexibly linked bases: Pairing properties with complementary DNA
-
Epple, C. and Leumann, C. (1998) Bicyclo[3.2.1]-DNA, a new DNA analog with a rigid backbone and flexibly linked bases: pairing properties with complementary DNA. Chem. Biol., 5, 209-216.
-
(1998)
Chem. Biol.
, vol.5
, pp. 209-216
-
-
Epple, C.1
Leumann, C.2
-
25
-
-
0037140735
-
Watson-Crick base-pairing properties of tricyclo-DNA
-
Renneberg, D. and Leumann, C.J. (2002) Watson-Crick base-pairing properties of tricyclo-DNA. J. Am. Chem. Soc., 124, 5993-6002.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 5993-6002
-
-
Renneberg, D.1
Leumann, C.J.2
-
26
-
-
0029395478
-
Win some, lose some: Enthalpy-entropy compensation in weak intermolecular interactions
-
Dunitz, J.D. (1995) Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions. Chem. Biol., 2, 709-712.
-
(1995)
Chem. Biol.
, vol.2
, pp. 709-712
-
-
Dunitz, J.D.1
-
27
-
-
0034581545
-
Enthalpy-entropy compensations in nucleic acids: Contribution of electrostriction and structural hydration
-
Johnson, M.L. and Ackers, G.K. (eds Academic Press, San Diego
-
Marky, L.A., Kupke, D.W., Michael, L. and Johnson, G.K.A. (2000) Enthalpy-entropy compensations in nucleic acids: contribution of electrostriction and structural hydration. In Johnson, M.L. and Ackers, G.K. (eds), Methods Enzymol., Vol. 323. Academic Press, San Diego, pp. 419-441.
-
(2000)
Methods Enzymol
, vol.323
, pp. 419-441
-
-
Marky, L.A.1
Kupke, D.W.2
Michael, L.3
Johnson, G.K.A.4
-
28
-
-
38849157057
-
Crystal structure of tricyclo-DNA: An unusual compensatory change of two adjacent backbone torsion angles
-
Pallan, P.S., Ittig, D., Heroux, A., Wawrzak, Z., Leumann, C.J. and Egli, M. (2008) Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles. Chem. Commun., 883-885.
-
(2008)
Chem. Commun.
, pp. 883-885
-
-
Pallan, P.S.1
Ittig, D.2
Heroux, A.3
Wawrzak, Z.4
Leumann, C.J.5
Egli, M.6
-
29
-
-
0033613846
-
Chemical etiology of nucleic acid structure: Comparing pentopyranosyl-(20-> 4') oligonucleotides with RNA
-
Beier, M., Reck, F., Wagner, T., Krishnamurthy, R. and Eschenmoser, A. (1999) Chemical etiology of nucleic acid structure: Comparing pentopyranosyl-(20->4') oligonucleotides with RNA. Science, 283, 699-703.
-
(1999)
Science
, vol.283
, pp. 699-703
-
-
Beier, M.1
Reck, F.2
Wagner, T.3
Krishnamurthy, R.4
Eschenmoser, A.5
-
30
-
-
0028557559
-
Chemistry of potentially prebiological natural-products
-
Eschenmoser, A. (1994) Chemistry of potentially prebiological natural-products. Orig. Life Evol. Biosph., 24, 389-423.
-
(1994)
Orig. Life Evol. Biosph.
, vol.24
, pp. 389-423
-
-
Eschenmoser, A.1
-
31
-
-
0032713003
-
The solution structure of a locked nucleic acid (LNA) hybridized to DNA
-
Nielsen, C.B., Singh, S.K., Wengel, J. and Jacobsen, J.P. (1999) The solution structure of a locked nucleic acid (LNA) hybridized to DNA. J. Biomol. Struct. Dyn., 17, 175-191.
-
(1999)
J. Biomol. Struct. Dyn.
, vol.17
, pp. 175-191
-
-
Nielsen, C.B.1
Singh, S.K.2
Wengel, J.3
Jacobsen, J.P.4
-
32
-
-
0037140761
-
Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA: Hybrids
-
Petersen, M., Bondensgaard, K., Wengel, J. and Jacobsen, J.P. (2002) Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA : RNA hybrids. J. Am. Chem. Soc., 124, 5974-5982.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 5974-5982
-
-
Petersen, M.1
Bondensgaard, K.2
Wengel, J.3
Jacobsen, J.P.4
-
33
-
-
0034604510
-
Structural studies of LNA:RNA duplexes by NMR: Conformation and implications for RNase H activity
-
Bondensgaard, K., Petersen, M., Singh, S.K., Rajwanshi, V.K., Kumar, R., Wengel, J. and Jacobsen, J.P. (2000) Structural studies of LNA:RNA duplexes by NMR: conformation and implications for RNase H activity. Chem. Eur. J., 6, 2687-2695.
-
(2000)
Chem. Eur. J.
, vol.6
, pp. 2687-2695
-
-
Bondensgaard, K.1
Petersen, M.2
Singh, S.K.3
Rajwanshi, V.K.4
Kumar, R.5
Wengel, J.6
Jacobsen, J.P.7
-
34
-
-
33745012353
-
Thermodynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes
-
Kaur, H., Arora, A., Wengel, J. and Maiti, S. (2006) Thermodynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes. Biochemistry, 45, 7347-7355.
-
(2006)
Biochemistry
, vol.45
, pp. 7347-7355
-
-
Kaur, H.1
Arora, A.2
Wengel, J.3
Maiti, S.4
-
35
-
-
34247540352
-
Tricyclo-DNA containing oligonucleotides as steric block inhibitors of HIV-1 Tat-dependent trans activation and HIV-1 infectivity
-
Ivanova, G., Reigadas, S., Ittig, D., Arzumanov, A., Andreola, M.L., Leumann, C., Toulmé, J.J. and Gait, M.J. (2007) Tricyclo-DNA containing oligonucleotides as steric block inhibitors of HIV-1 Tat-dependent trans activation and HIV-1 infectivity. Oligonucleotides, 17, 54-65.
-
(2007)
Oligonucleotides
, vol.17
, pp. 54-65
-
-
Ivanova, G.1
Reigadas, S.2
Ittig, D.3
Arzumanov, A.4
Andreola, M.L.5
Leumann, C.6
Toulmé, J.J.7
Gait, M.J.8
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