Factors influencing polycation/siRNA colloidal stability toward aerosol lung delivery

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 80, Issue 1, 2012, Pages 14-24

  Steele, Terry W J ^a   Zhao, Xiaobin ^b,d   Tarcha, Peter ^b   Kissel, Thomas ^c  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b ABBOTT LABORATORIES   (United States)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Aerosol; Gene therapy; Lung; Oligoethylenimine; Surfactant; Transfection

Indexed keywords

BERACTANT; NONIONIC CONTRAST MEDIUM; NONIONIC SURFACTANT; POLYCATION; SMALL INTERFERING RNA;

AEROSOL; ARTICLE; CLINICAL EFFECTIVENESS; COLLOID; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FREEZE DRYING; MOLECULAR STABILITY; NEBULIZATION; PARTICLE SIZE; ROOM TEMPERATURE; ZETA POTENTIAL;

ACRYLATES; ADMINISTRATION, INHALATION; AEROSOLS; BUFFERS; CHEMISTRY, PHARMACEUTICAL; COLLOIDS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; FREEZE DRYING; FREEZING; ISOTONIC SOLUTIONS; LUNG; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; POLYAMINES; POLYETHYLENEIMINE; POLYMERS; RNA, SMALL INTERFERING; SURFACE-ACTIVE AGENTS; TRANSFECTION;

EID: 83955164249     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.08.008     Document Type: Article

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