Simultaneous blockade of the CD40/CD40L and NF-κB pathways prolonged islet allograft survival

Transplant International

Volumn 25, Issue 1, 2012, Pages 118-126

  Wang, Xiao Hong ^a   Ding, Xiao Ming ^a   Li, Yang ^a   Liu, Hong Bao ^a   Xue, Wu Jun ^a   Tian, Xiao Hui ^a   Feng, Xin Shun ^a   Jiao, Feng Mei ^a   Zheng, Jin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

I B ; immune tolerance; inflammation; islet transplantation; sCD40L

Indexed keywords

ADENOVIRUS VECTOR; CD40 ANTIGEN; CD40 LIGAND; CYTOKINE; GAMMA INTERFERON; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; DOWN REGULATION; GRAFT SURVIVAL; MALE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURIFICATION; RAT; SEPARATION TECHNIQUE; SPLEEN CELL; STREPTOZOCIN DIABETES;

ANIMALS; ANTIGENS, CD40; CD40 LIGAND; CELL LINE; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; GRAFT SURVIVAL; HUMANS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SPLEEN; STREPTOZOCIN; TIME FACTORS;

EID: 83955161683     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2011.01374.x     Document Type: Article

References (37)

1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid free immunosuppressive regimen. N Engl J Med 2000; 343: 230.
2. Noguchi H, Iwanaga Y, Okitsu T, et al. Evaluation of islet transplantation from non-heart beating donors. Am J Transplant 2006; 6: 2476.
3. Matsumoto S, Okitsu T, Iwanaga Y, et al. Insulin independence after living-donor distal pancreatectomy and islet allotransplantation. Lancet 2005; 365: 1642.
4. Park SG, Kim JH, Oh JH, et al. Polymyxin B, scavenger of endotoxin, enhances isolation yield and in vivo function of islets. Transpl Int 2010; 23: 325.
5. Kakabadze Z, Gupta S, Brandhorst D, et al. Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine. Transpl Int 2011; 24: 175.
6. Bennet W, Sundberg B, Groth CG, et al. Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation. Diabetes 1999; 48: 1907.
7. Badet L, Titus T, Metzen E, et al. The interaction between primate blood and mouse islets induces accelerated clotting with islet destruction. Xenotransplantation 2002; 9: 91.
8. Dobson T, Fraga D, Saba C, et al. Human pancreatic islets transfected to produce an inhibitor of TNF are protected against destruction by human leukocytes. Cell Transplant 2000; 9: 857.
9. Matsuda T, Omori K, Vuong T, et al. Inhibition of P38 pathway suppresses human islet production of pro-inflammatory cytokines and improve islet graft function. Am J Transplant 2005; 5: 484.
10. Yang Z, Chen M, Ellett JD, et al. The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation. Transplantation 2004; 77: 55.
11. Noguchi H, Nakai Y,. Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft lossby intraportal injection of JNK inhibitor. Diabetologia 2007; 50: 612.
12. Xenos ES, Stevens RB, Sutherland DE, et al. The role of nitric oxide in IL-1 beta-mediated dysfunction of rodent islets of Langerhans: implications for the function of intrahepatic islet grafts. Transplantation 1994; 57: 1208.
13. Schwartz RH,. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992; 71: 1065.
14. Poirier N, Blancho G, Vanhove B,. A more selective costimulatory blockade of the CD28-B7 pathway. Transpl Int 2011; 24: 2.
15. +B cell line. J Immunol 1998; 160: 2145.
16. Damaris Molano R, Berney T, Li H, et al. Prolonged Islet Graft Survival in NOD Mice by Blockade of the CD40-CD154 Pathway of T-Cell Costimulation. Diabetes 2001; 50: 270.
17. Jung DY, Kim EY, Joo SY, et al. Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody. Exp Mol Med 2008; 40: 1.
18. Cardozo AK, Heimberg H, Heremans Y, et al. A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells. J Biol Chem 2001; 276: 48879.
19. Saccania S, Pantanoa S, Natoli G,. Two Waves of Nuclear Factor κb Recruitment to Target Promoters. JEM 2001; 193: 1351.
20. Giarratana N, Penna G, Amuchastegui S, et al. A Vitamin D Analog Down-Regulates Proinflammatory Chemokine Production by Pancreatic Islets Inhibiting T Cell Recruitment and Type 1 Diabetes Development. J Immunol 2004; 173: 2280.
21. Hoffmannl A, Levchenko A, Scott ML, et al. The IκB-NF-κB signaling module: temporal control and selective gene activation. Science 2002; 298: 1241.
22. Danese XX, Sans M, Fiocchi C,. The CD40/CD40L costimulatory pathway in inflammatory bowel disease. Gut 2004; 53: 1035.
23. Sakai T, Li S, Tanioka Y, et al. Intraperitoneal Injection of Oxygenated Perfluorochemical Improves the Outcome of Intraportal Islet Transplantation in a Rat Model. Transplant Proc 2006; 38: 3289.
24. Ding XM, Niu XL, Xue WJ, et al. Construction and identification of recombinant adenovirus vector expressing IκBα-IRES2-shCD40L [J] Chinese. J Cell Mol Immunol 2010; 26: 416.
25. Boutonnat J, Barbier M, Muirhead K, et al. Response of chemosensitive and chemoresistant leukemic cell lines to drug therapy: simultaneous assessment of proliferation, apoptosis, and necrosis. Cytometry 2000; 42: 50.
26. van der Windt DJ, Bottino R,. Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets. Am J Transplant 2009; 9: 2716.
27. Delle H, Noronha IL,. Induction of Indoleamine 2,3-Dioxygenase by Gene Delivery in Allogeneic Islets ProlongsAllograft Survival. Am J Transplant 2010; 10: 1918.
28. Li ZL, Xue WJ, Tian PX, et al. Prolongation of Islet Allograft Survival by Coexpression of CTLA4Ig and CD40LIg in Mice. Transplant Proc 2007; 39: 3436.
29. Lee BW, Lee M, Chae HY, et al. Effect of hypoxia-inducible VEGF gene expression on revascularization and graft function in mouse islet transplantation. Transpl Int 2011; 24: 307.
30. Kobayashi T, Harb G, Rayat GR,. Prolonged survival of microencapsulated neonatal porcine islets in mice treated with a combination of anti-CD154 and anti-LFA-1 monoclonal antibodies. Transplantation 2005; 80: 821.
31. Baker MS, Marshall S,. Expression of a Dominant Negative Inhibitor of NF-κB Protects MIN6 β-Cells from Cytokine-Induced Apoptosis. J Surg Res 2001; 97: 117.
32. Contreras JL, Eckstein C, Smyth CA,. Activated Protein C Preserves Functional Islet Mass After Intraportal Transplantation. Diabetes 2004; 53: 2804.
33. Covarrubias M, Ware LB, Kawut SM,. Plasma Intercellular Adhesion Molecule-1 and von Willebrand Factor in Primary Graft Dysfunction After Lung Transplantation. Am J Transplant 2007; 7: 2573.
34. Liu SF, Malik AB,. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 2006; 290: L622.
35. Lin R, Liu J, Peng N, Yang G,. Lovastatin Reduces Nuclear Factor k B Activation Induced by C-Reactive Protein in Human Vascular Endothelial Cells. Biol Pharm Bull 2005; 28: 1630.
36. Daisy F,. Lazarous Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: effect on myocardial angiogenesis. Cardiovasc Res 1999; 44: 294.
37. Xia H, Mao Q, Davidson BL,. The HIV Tat protein transduction domain improves the biodistribution of β-glucuronidase expressed from recombinant viral vectors. Nat Biotechnol 2001; 19: 640.