Regulation of taurine transport systems by protein kinase CK2 in mammalian cells

Cellular Physiology and Biochemistry

Volumn 28, Issue 6, 2011, Pages 1099-1110

  Lambert, Ian Henry ^a   Hansen, Daniel Bloch ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

CK2; GSK3 ; PI3K; PTEN; Reactive oxygen species; Volume regulation

Indexed keywords

CASEIN KINASE II; LEUKOTRIENE A4; LYSOPHOSPHATIDYLCHOLINE; PHOSPHOLIPASE A2; PROTEIN SERINE THREONINE KINASE; TAURINE; TAURINE TRANSPORTER;

APOPTOSIS; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; CELL SWELLING; CELL VOLUME; HUMAN; INTRACELLULAR SIGNALING; MAMMAL CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TRANSPORT; REVIEW;

EID: 83755186689     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000335846     Document Type: Review

References (125)

1. Habela CW, Ernest NJ, Swindall AF, Sontheimer H: Chloride accumulation drives volume dynamics underlying cell proliferation and migration. J Neurophysiol 2009;101:750-757.
2. Habela CW, Sontheimer H: Cytoplasmic volume condensation is an integral part of mitosis. Cell Cycle 2007;6:1613-1620. (Pubitemid 47327948)
3. Poulsen KA, Andersen EC, Hansen CF, Klausen TK, Hougaard C, Lambert IH, Hoffmann EK: Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels. Am J Physiol Cell Physiol 2010;298:C14-C25.
4. Ernest NJ, Habela CW, Sontheimer H: Cytoplasmic condensation is both necessary and sufficient to induce apoptotic cell death. J Cell Sci 2008;121:290-297. (Pubitemid 351356700)
5. Lang F, Foller M, Lang K, Lang P, Ritter M, Vereninov A, Szabo I, Huber SM, Gulbins E: Cell volume regulatory ion channels in cell proliferation and cell death. Methods Enzymol 2007;428:209-225.
6. Lang F, Ritter M, Gamper N, Huber S, Fillon S, Tanneur V, Lepple-Wienhues A, Szabo I, Gulbins E: Cell volume in the regulation of cell proliferation and apoptotic cell death. Cell Physiol Biochem 2000;10:417-428. (Pubitemid 32008925)
7. Hoffmann EK, Lambert IH, Pedersen SF: Physiology of cell volume regulation in vertebrates. Physiol Rev 2009;89:193-277.
8. Lambert IH, Hoffmann EK, Pedersen SF: Cell volume regulation: physiology and pathophysiology. Acta Physiol (Oxf) 2008;194:255-282.
9. Huxtable RJ: Taurine in the Central Nervous-System and the Mammalian Actions of Taurine. Prog Neurobiol 1989;32:471-533.
10. Huxtable RJ: Physiological actions of taurine. Physiol Rev 1992;72:101-163.
11. Jacobsen JG, Smith LH: Biochemistry and physiology of taurine and taurine derivatives. Physiol Rev 1968;48:424-511.
12. Lourenço R, Camilo ME: Taurine: A conditionally essential amino acid in humans An overview in health and disease. Nutr Hosp 2002;17:262-270. (Pubitemid 44616128)
13. Aerts L, Van Assche FA: Taurine and taurine-deficiency in the perinatal period. J Perinat Med 2002;30:281-286. (Pubitemid 34976464)
14. Warskulat U, Heller-Stilb B, Oermann E, Zilles K, Haas H, Lang F, Haussinger D: Phenotype of the taurine transporter knockout mouse. Methods Enzymol 2007;428:439-58.
15. Kearns S, Dawson R Jr: Cytoprotective effect of taurine against hypochlorous acid toxicity to PC12 cells. Taurine 4: Taurine and Excitable Tissues Adv Exp Med Biol 2000;483:563-570.
16. Atmaca G: Antioxidant effects of sulfurcontaining amino acids. Yonsei Med J 2004;45:776-788. (Pubitemid 39545364)
17. Schaffer SW, Azuma J, Mozaffari M: Role of antioxidant activity of taurine in diabetes. Can J Physiol Pharmacol 2009;87:91-99.
18. Hansen DB, Guerra B, Jacobsen JH, Lambert IH: Regulation of taurine homeostasis by protein kinase CK2 in mouse fibroblasts. Amino Acids 2011;40:1091-1106.
19. Jacobsen JH, Clement CA, Friis MB, Lambert IH: Casein kinase 2 regulates the active uptake of the organic osmolyte taurine in NIH3T3 mouse fibroblasts. Pflugers Arch 2008;457:327-337.
20. Sarno S, Pinna LA: Protein kinase CK2 as a druggable target. Mol Biosyst 2008;4:889-894.
21. Guerra B, Issinger OG: Protein kinase CK2 in human diseases. Curr Med Chem 2008;15:1870-1886.
22. Zhu D, Hensel J, Hilgraf R, Abbasian M, Pornillos O, Deyanat-Yazdi G, Hua XH, Cox S: Inhibition of protein kinase CK2 expression and activity blocks tumor cell growth. Mol Cell Biochem 2010;333:159-167.
23. Schneider CC, Hessenauer A, Montenarh M, Gotz C: p53 is dispensable for the induction of apoptosis after inhibition of protein kinase CK2. Prostate 2010;70:126-134.
24. St-Denis NA, Litchfield DW: Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival. Cell Mol Life Sci 2009;66:1817-1829.
25. Trembley JH, Wang G, Unger G, Slaton J, Ahmed K: Protein kinase CK2 in health and disease: CK2: A key player in cancer biology. Cell Mol Life Sci 2009;66:1858-1867.
26. Niefind K, Raaf J, Issinger OG: Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights. Cell Mol Life Sci 2009;66:1800-1816.
27. Cozza G, Bortolato A, Moro S: How druggable is protein kinase CK2 Med Res Rev 2010;30:419-462.
28. Canton DA, Litchfield DW: The shape of things to come: An emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton. Cell Signal 2006;18:267-275. (Pubitemid 41661342)
29. Montenarh M: Cellular regulators of protein kinase CK2. Cell Tissue Res 2010;342:139-146.
30. Olsten MEK, Weber JE, Litchfield DW: CK2 interacting proteins: Emerging paradigms for CK2 regulation Mol Cell Biochem 2005;274:115-124. (Pubitemid 41001507)
31. Faust M, Montenarh M: Subcellular localization of protein kinase CK2. A key to its function Cell Tissue Res 2000;301:329-340. (Pubitemid 30663550)
32. Theis-Febvre N, Martel V, Laudet B, Souchier C, Grunwald D, Cochet C, Filhol O: Highlighting protein kinase CK2 movement in living cells. Mol Cell Biochem 2005;274:15-22. (Pubitemid 41001495)
33. Olsen BB, Guerra B, Niefind K, Issinger OG: Structural basis of the constitutive activity of protein kinase CK2. Methods Enzymol 2010;484:515-529.
34. Litchfield DW: Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochem J 2003;369:1-15. (Pubitemid 36174119)
35. Di MG, Brustolon F, Tosoni K, Belli S, Kramer SD, Pinna LA, Ruzzene M: Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis. Mol Cell Biochem 2008;316:155-161.
36. Chen NH, Reith MEA, Quick MW: Synaptic uptake and beyond: the sodiumand chloride-dependent neurotransmitter transporter family SLC6. Pflugers Arch 2004;447:519-531. (Pubitemid 38241438)
37. Liu QR, Lopez-Corcuera B, Nelson H, Mandiyan S, Nelson N: Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain. Proc Natl Acad Sci USA 1992;89:12145-12149. (Pubitemid 23004802)
38. Smith KE, Borden LA, Wang CH, Hartig PR, Branchek TA, Weinshank RL: Cloning and expression of a high affinity taurine transporter from rat brain. Mol Pharmacol 1992;42:563-569. (Pubitemid 23027616)
39. Uchida S, Kwon HM, Yamauchi A, Preston AS, Marumo F, Handler JS: Molecular cloning of the cDNA for an MDCK cell Na+-and Cl-dependent taurine transporter that is regulated by hypertonicity. Proc Natl Acad Sci USA 1992;89:8230-8234.
40. Ramamoorthy S, Del Monte MA, Leibach FH, Ganapathy V: Molecular identity and calmodulin-mediated regulation of the taurine transporter in a human retinal pigment epithelial cell line. Curr Eye Res 1994;13:523-529. (Pubitemid 24215989)
41. Pinto W, Ronnestad I, Jordal AE, Gomes AS, Dinis MT, Aragao C: Cloning, tissue and ontogenetic expression of the taurine transporter in the flatfish Senegalese sole (Solea senegalensis). Amino Acids 2011, in press.
42. Poulsen KA, Litman T, Eriksen J, Mollerup J, Lambert IH: Downregulation of taurine uptake in multidrug resistant Ehrlich ascites tumor cells. Amino Acids 2002;22:333-350. (Pubitemid 34639592)
43. Voss JW, Pedersen SF, Christensen ST, Lambert IH: Regulation of the expression and subcellular localisation of the taurine transporter TauT in mouse NIH3T3 fibroblasts. Eur J Biochem 2004;271:4646-4658. (Pubitemid 40065568)
44. Yamashita A, Singh SK, Kawate T, Jin Y, Gouaux E: Crystal structure of a bacterial homologue of Na+/Cl-dependent neurotransmitter transporters. Nature 2005;437:215-223. (Pubitemid 41294479)
45. Gether U, Andersen PH, Larsson OM, Schousboe A: Neurotransmitter transporters: molecular function of important drug targets. Trends Pharmacol Sci 2006;27:375-383. (Pubitemid 43977787)
46. Lambert IH: Regulation of the cellular content of the organic osmolyte taurine in mammalian cells. Neurochem Res 2004;29:27-63. (Pubitemid 38185786)
47. Voss JW, Pedersen SF, Christensen ST, Lambert IH: Regulation of the expression and subcellular localization of the taurine transporter TauT in mouse NIH3T3 fibroblasts. Eur J Biochem 2004;271:4646-4658. (Pubitemid 40065568)
48. Heller-Stilb B, van Roeyen C, Rascher K, Hartwig HG, Huth A, Seeliger MW, Warskulat U, Haussinger D: Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. Faseb J 2002;16:231-3.
49. Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Roth C, Witt M, Haussinger D: Taurine deficiency and apoptosis: findings from the taurine transporter knockout mouse. Arch Biochem Biophys 2007;462:202-209. (Pubitemid 46856324)
50. Warskulat U, Flogel U, Jacoby C, Hartwig HG, Thewissen M, Merx MW, Molojavyi A, Heller-Stilb B, Schrader J, Haussinger D: Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised. Faseb J 2004;18:577-579.
51. Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Monnighoff I, Buchczyk D, Donner M, Flogel U, Kappert G, Soboll S, Beer S, Pfeffer K, Marschall HU, Gabrielsen M, Amiry-Moghaddam M, Ottersen OP, Dienes HP, Haussinger DH: Chronic liver disease is triggered by taurine transporter knockout in the mouse. Faseb J 2006;20:574-6. (Pubitemid 46671254)
52. Han X, Yue J, Chesney RW: Functional TauT protects against acute kidney injury. J Am Soc Nephrol 2009;20:1323-1332.
53. Tastesen HS, Holm JB, Moller J, Poulsen KA, Moller C, Sturup S, Hoffmann EK, Lambert IH: Pinpointing differences in cisplatin-induced apoptosis in adherent and non-adherent cancer cells. Cell Physiol Biochem 2010;26:809-820.
54. Anderson CM, Howard A, Walters JR, Ganapathy V, Thwaites DT: Taurine uptake across the human intestinal brushborder membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+-and Cl-dependent TauT (SLC6A6). J Physiol 2009;587:731-744.
55. Han X, Budreau AM, Chesney RW: Identification of promoter elements involved in adaptive regulation of the taurine transporter gene: role of cytosolic Ca2+ signaling. Adv Exp Med Biol 2000;483:535-544.
56. Han X, Patters AB, Jones DP, Zelikovic I, Chesney RW: The taurine transporter: mechanisms of regulation. Acta Physiol 2006;187:61-73. (Pubitemid 43828764)
57. Meggio F, Pinna LA: One-thousand-andone substrates of protein kinase CK2 Faseb J 2003;17:349-368.
58. Ferraris JD, Williams CK, Persaud P, Zhang Z, Chen Y, Burg MB: Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration. Proc Natl Acad Sci USA 2002;99:739-744. (Pubitemid 34106580)
59. Hoffmann EK, Lambert IH: Amino acid transport and cell volume regulation in Ehrlich ascites tumour cells. J Physiol 1983;338:613-625. (Pubitemid 13099508)
60. Mollerup J, Lambert IH: Phosphorylation is involved in the regulation of the taurine influx via the beta-system in Ehrlich ascites tumor cells. J Membr Biol 1996;150:73-82. (Pubitemid 26102444)
61. Mollerup J, Lambert IH: Calyculin A modulates the kinetic constants for the Na+-coupled taurine transport in Ehrlich ascites tumour cells. Biochim Biophys Acta 1998;1371:335-344. (Pubitemid 28269271)
62. Han X, Budreau AM, Chesney RW: Ser is a critical site for PKC regulation of the MDCK cell taurine transporter (pNCT). J Am Soc Nephrol 1999;10:1874-1879. (Pubitemid 29402507)
63. Han X, Budreau AM, Chesney RW: Role of conserved peptide in taurine transporter inactivation modulated by protein kinase C. J Am Soc Nephrol 1996;7:2088-2096. (Pubitemid 27468237)
64. Qian X, Vinnakota S, Edwards C, Sarkar HK: Molecular characterization of taurine transport in bovine aortic endothelial cells. Biochim Biophys Acta 2000;1509:324-334.
65. Loo DD, Hirsch JR, Sarkar HK, Wright EM: Regulation of the mouse retinal taurine transporter (TAUT) by protein kinases in Xenopus oocytes. FEBS Lett 1996;392:250-254. (Pubitemid 26289124)
66. Shennan DB: Swelling-induced taurine transport: Relationship with chloride channels, anion-exchangers and other swelling-activated transport pathways. Cell Physiol Biochem 2008;21:15-28.
67. Shen MR, Chou CY, Ellory JC: Swellingactivated taurine and K+ transport in human cervical cancer cells: association with cell cycle progression. Pflugers Arch 2001;441:787-795. (Pubitemid 32186545)
68. Lambert IH, Hoffmann EK: Cell swelling activates separate taurine and chloride channels in Ehrlich mouse ascites tumor cells. J Membr Biol 1994;142:289-298.
69. Shennan DB, Thomson J, Gow IF: Osmoregulation of taurine efflux from cultured human breast cancer cells: Comparison with volume activated Clefflux and regulation by extracellular ATP. Cell Physiol Biochem 2006;18:113-122.
70. Lukacs GL, Nanda A, Rotstein OD, Grinstein S: The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells. FEBS Lett 1991;288:17-20.
71. Lu J, Boron WF: Reversible and irreversible interactions of DIDS with the human electrogenic Na/HCO3 cotransporter NBCe1-A: role of lysines in the KKMIK motif of TM5. Am J Physiol Cell Physiol 2007;292:C1787-C1798. (Pubitemid 47080540)
72. Wilson MC, Meredith D, Bunnun C, Sessions RB, Halestrap AP: Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle. J Biol Chem 2009;284:20011-20021.
73. Stutzin A, Torres R, Oporto M, Pacheco P, Eguiguren AL, Cid LP, Sepulveda FV: Separate taurine and chloride efflux pathways activated during regulatory volume decrease. Am J Physiol 1999;277:C392-C402. (Pubitemid 29458174)
74. Hall JA, Kirk J, Potts JR, Rae C, Kirk K: Anion channel blockers inhibit swellingactivated anion, cation, and nonelectrolyte transport in HeLa cells. Am J Physiol 1996;271:C579-C588.
75. Lambert IH, Falktoft B: Lysophosphatidylcholine induces taurine release from HeLa cells. J Membr Biol 2000;176:175-185. (Pubitemid 30611642)
76. Lambert IH, Falktoft B: Lysophosphatidylcholine-induced taurine release in HeLa cells involves protein kinase activity. Comp Biochem Physiol A Mol Integr Physiol 2001;130:577-584. (Pubitemid 32972007)
77. Lambert IH, Nielsen JH, Andersen HJ, Ortenblad N: Cellular model for induction of drip loss in meat. J Agric Food Chem 2001;49:4876-4883. (Pubitemid 32988734)
78. Villumsen KR, Duelund L, Lambert IH: Acute cholesterol depletion leads to net loss of the organic osmolyte Taurine in Ehrlich Lettré tumor cells. Amino Acids 2010;39:1521-36.
79. Moran J, Hernandez-Pech X, Merchant-Larios H, Pasantes-Morales H: Release of taurine in apoptotic cerebellar granule neurons in culture. Pflugers Arch 2000;439:271-277. (Pubitemid 30056903)
80. Thoroed SM, Lauritzen L, Lambert IH, Hansen HS, Hoffmann EK: Cell swelling activates phospholipase A2 in Ehrlich ascites tumor cells. J Membr Biol 1997;160:47-58. (Pubitemid 27491721)
81. Kinnaird AA, Choy PC, Man RY: Lysophosphatidylcholine accumulation in the ischemic canine heart. Lipids 1988;23:32-35.
82. Lundbaek JA, Andersen OS: Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers. J Gen Physiol 1994;104:645-673. (Pubitemid 24328596)
83. Lambert IH: Activation and inactivation of the volume-sensitive taurine leak pathway in NIH3T3 fibroblasts and Ehrlich Lettre ascites cells. Am J Physiol Cell Physiol 2007;293:C390-C400. (Pubitemid 47105013)
84. Pedersen S, Lambert IH, Thoroed SM, Hoffmann EK: Hypotonic cell swelling induces translocation of the alpha isoform of cytosolic phospholipase A2 but not the gamma isoform in Ehrlich ascites tumor cells. Eur J Biochem 2000;267:5531-5539.
85. Pedersen SF, Poulsen KA, Lambert IH: Roles of phospholipase A(2) isoforms in swelling-and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts. Am J Physiol Cell Physiol 2006;291:C1286-C1296. (Pubitemid 44878600)
86. Rådmark OP: The molecular biology and regulation of 5-lipoxygenase. Am J Respir Crit Care Med 2000;161:S11-S15. (Pubitemid 30129408)
87. Radmark O, Samuelsson B: 5-Lipoxygenase: mechanisms of regulation. J Lipid Res 2009;50:S40-S45.
88. Radmark O, Samuelsson B: 5-lipoxygenase: regulation and possible involvement in atherosclerosis. Prostaglandins Other Lipid Mediat 2007;83:162-174. (Pubitemid 46661256)
89. Newcomer ME, Gilbert NC: Location, location, location: compartmentalization of early events in leukotriene biosynthesis. J Biol Chem 2010;285:25109-25114.
90. Lambert IH: Reactive oxygen species regulate swelling-induced taurine efflux in NIH3T3 mouse fibroblasts. J Membr Biol 2003;192:19-32. (Pubitemid 37011471)
91. Wolf MJ, Wang J, Turk J, Gross RW: Depletion of intracellular calcium stores activates smooth muscle cell calciumindependent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization. J Biol Chem 1997;272:1522-1526. (Pubitemid 27043230)
92. Jenkins CM, Wolf MJ, Mancuso DJ, Gross RW: Identification of the calmodulinbinding domain of recombinant calciumindependent phospholipase A2β, implications for structure and function. J Biol Chem 2001;276:7129-7135.
93. Lambert IH, Hoffmann EK: Regulation of taurine transport in Ehrlich ascites tumor cells. J Membr Biol 1993;131:67-79. (Pubitemid 23029248)
94. Cruz-Rangel S, Hernandez-Benitez R, Vazquez-Juarez E, Lopez-Dominguez A, Pasantes-Morales H: Potentiation by thrombin of hyposmotic glutamate and taurine efflux from cultured astrocytes: signalling chains. Neurochem Res 2008;33:1518-1524.
95. Arrigoni G, Marin O, Pagano MA, Settimo L, Paolin B, Meggio F, Pinna LA: Phosphorylation of calmodulin fragments by protein kinase CK2. Mechanistic aspects and structural consequences. Biochemistry 2004;43:12788-12798. (Pubitemid 39331798)
96. Greif DM, Sacks DB, Michel T: Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis. Proc Natl Acad Sci USA 2004;101:1165-1170. (Pubitemid 38182660)
97. Shimoyama Y, Sakamoto R, Akaboshi T, Tanaka M, Ohtsuki K: Characterization of secretory type IIA phospholipase A2 (sPLA2-IIA) as a glycyrrhizin (GL)-binding protein and the GL-induced inhibition of the CK-II-mediated stimulation of sPLA2-IIA activity in vitro. Biol Pharm Bull 2001;24:1004-1008. (Pubitemid 32894118)
98. Piomelli D, Greengard P: Bidirectional control of phospholipase A2 activity by Ca2+/calmodulin-dependent protein kinase II, cAMP-dependent protein kinase, and casein kinase II. Proc Natl Acad Sci USA 1991;88:6770-6774. (Pubitemid 21915031)
99. Friis MB, Vorum KG, Lambert IH: Volume-sensitive NADPH oxidase activity and taurine efflux in NIH3T3 mouse fibroblasts. Am J Physiol Cell Physiol 2008;294:C1552-C1565.
100. Varela D, Simon F, Riveros A, Jorgensen F, Stutzin A: NAD(P)H oxidase-derived H2O2 signals chloride channel activation in cell volume regulation and cell proliferation. J Biol Chem 2004;279:13301-13304. (Pubitemid 38468851)
101. Ørtenblad N, Young JF, Oksbjerg N, Nielsen JH, Lambert IH: Reactive oxygen species are important mediators of taurine release from skeletal muscle cells. Am J Physiol; 2003: 284: C1362-C1373 (Pubitemid 36583377)
102. Katsuyama M: NOX/NADPH oxidase, the superoxide-generating enzyme: its transcriptional regulation and physiological roles. J Pharmacol Sci 2010;114:134-146.
103. Barford D, Das AK, Egloff MP: The structure and mechanism of protein phosphatases: insights into catalysis and regulation. Annu Rev Biophys Biomol Struct 1998;27:133-164. (Pubitemid 28286012)
104. Lee SR, Kwon KS, Kim SR, Rhee SG: Reversible inactivation of proteintyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor. J Biol Chem 1998;273:15366-15372. (Pubitemid 28298140)
105. Meinhard M, Grill E: Hydrogen peroxide is a regulator of ABI1, a protein phosphatase 2C from Arabidopsis. Febs Letters 2001;508:443-446. (Pubitemid 33135488)
106. Lambert IH, Klausen TK, Bergdahl A, Hougaard C, Hoffmann EK: ROS activate KCl cotransport in nonadherent Ehrlich ascites cells but K+ and Cl-channels in adherent Ehrlich Lettre and NIH3T3 cells. Am J Physiol Cell Physiol 2009;297:C198-C206.
107. Pasantes-Morales H, Lezama RA, Ramos-Mandujano G: Tyrosine kinases and osmolyte fluxes during hyposmotic swelling. Acta Physiol (Oxf) 2006;187:93-102. (Pubitemid 43828767)
108. Park HS, Lee SM, Lee JH, Kim YS, Bae YS, Park JW: Phosphorylation of the leucocyte NADPH oxidase subunit p47(phox) by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activity. Biochem J 2001;358:783-790. (Pubitemid 32896966)
109. Shiose A, Sumimoto H: Arachidonic acid and phosphorylation synergistically induce a conformational change of p47(phox) to activate the phagocyte NADPH oxidase. J Biol Chem 2000;275:13793-13801. (Pubitemid 30257452)
110. Park HS, Lee SM, Lee JH, Kim YS, Bae YS, Park JW: Phosphorylation of the leucocyte NADPH oxidase subunit p47(phox) by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activity. Biochem J 2001;358:783-790. (Pubitemid 32896966)
111. Ahmad KA, Wang GX, Ahmed K: Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells. Mol Cancer Res 2006;4:331-338. (Pubitemid 43837334)
112. Hanif IM, Ahmad KA, Ahmed K, Pervaiz S: Involvement of Reactive Oxygen Species in Apoptosis Induced by Pharmacological Inhibition of Protein Kinase CK2. Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways. Ann NY Acad Sci 2009;1171:591-599.
113. Pergola C, Werz O: 5-Lipoxygenase inhibitors: A review of recent developments and patents. Expert Opin Ther Pat 2010;20:355-375.
114. Wang GX, McCrudden C, Dai YP, Horowitz B, Hume JR, Yamboliev IA: Hypotonic activation of volumesensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK. Am J Physiol Heart Circ Physiol 2004;287:H533-H544. (Pubitemid 38955281)
115. Franco R, Lezama R, Ordaz B, Pasantes-Morales H: Epidermal growth factor receptor is activated by hyposmolarity and is an early signal modulating osmolyte efflux pathways in Swiss 3T3 fibroblasts. Pflugers Arch 2004;447:830-839. (Pubitemid 38372917)
116. Oudit GY, Penninger JM: Cardiac regulation by phosphoinositide 3-kinases and PTEN. Cardiovasc Res 2009;82:250-260.
117. Bayascas JR: PDK1: the major transducer of PI 3-kinase actions. Curr Top Microbiol Immunol 2010;346:9-29.
118. Silva A, Yunes JA, Cardoso BA, Martins LR, Jotta PY, Abecasis M, Nowill AE, Leslie NR, Cardoso AA, Barata JT: PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest 2008;118:3762-3774.
119. Lee SR, Yang KS, Kwon J, Lee C, Jeong W, Rhee SG: Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem 2002;277:20336-20342. (Pubitemid 34967328)
120. Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A, Downes CP: Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J 2003;22:5501-5510. (Pubitemid 37279959)
121. Cao J, Schulte J, Knight A, Leslie NR, Zagozdzon A, Bronson R, Manevich Y, Beeson C, Neumann CA: Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity. EMBO J 2009;28:1505-1517.
122. Wu D, Pan W: GSK3: A multifaceted kinase in Wnt signaling. Trends Biochem Sci 2010;35:161-168.
123. Frame S, Cohen P: GSK3 takes centre stage more than 20 years after its discovery. Biochem J 2001;359:1-16. (Pubitemid 32939202)
124. Sun T, Rodriguez M, Kim L: Glycogen synthase kinase 3 in the world of cell migration. Dev Growth Differ 2009;51:735-742.
125. Fiol CJ, Mahrenholz AM, Wang Y, Roeske RW, Roach PJ: Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3. J Biol Chem 1987;262:14042-14048.