Pinpointing differences in cisplatin-induced apoptosis in adherent and non-adherent cancer cells

Cellular Physiology and Biochemistry

Volumn 26, Issue 6, 2010, Pages 809-820

  Tastesen, Hanne Sørup ^a   Holm, Jacob B ^a   Møller, Jacob ^a   Poulsen, Kristian A ^a   Møller, Charlotte ^b   Stürup, Stefan ^b   Hoffmann, Else K ^a   Lambert, Ian H ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cell volume regulation; Cisplatin accumulation; DNA damage; Glutathione; Programmed cell death; TauT activity

Indexed keywords

CASPASE 3; CISPLATIN; GLUTATHIONE; POTASSIUM CHLORIDE; POTASSIUM ION; SODIUM ION; TAURINE; TAURINE TRANSPORTER;

ADHERENT CELL; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL DEATH; CELL NUCLEUS; CELL VOLUME; CONTROLLED STUDY; CYTOSOL; DRUG ACCUMULATION; DRUG DNA BINDING; DRUG EXPOSURE; DRUG UPTAKE; EHRLICH ASCITES TUMOR; ENZYME ACTIVITY; GENE SILENCING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SODIUM TRANSPORT; WATER LOSS;

EID: 78651234820     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000323990     Document Type: Article

References (40)

1. Todd RC, Lippard SJ: Inhibition of transcription by platinum antitumor compounds. Metallomics 2009;1:280-291.
2. Ciarimboli G, Ludwig T, Lang D, Pavenstadt H, Koepsell H, Piechota HJ, Haier J, Jaehde U, Zisowsky J, Schlatter E: Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol 2005;167:1477-1484.
3. Ishida S, Lee J, Thiele DJ, Herskowitz I: Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proc Natl Acad Sci USA 2002;99:14298-14302.
4. Lin X, Okuda T, Holzer A, Howell SB: The copper transporter CTR1 regulates cisplatin uptake in Saccharomyces cerevisiae. Mol Pharmacol 2002;62:1154-1159.
5. Stavrovskaya AA: Cellular mechanisms of multidrug resistance of tumor cells. Biochemistry (Mosc) 2000;65:95-106.
6. Kasherman Y, Sturup S, Gibson D: Is glutathione the major cellular target of cisplatin? A study of the interactions of cisplatin with cancer cell extracts. J Med Chem 2009;52:4319-4328.
7. Godwin AK, Meister A, O'Dwyer PJ, Huang CS, Hamilton TC, Anderson ME: High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci USA 1992;89:3070-3074.
8. Mestdagh N, Pommery N, Saucier JM, Hecquet B, Fournier C, Slomianny C, Teissier E, Henichart JP: Chemoresistance to doxorubicin and cisplatin in a murine cell line. Analysis of P-glycoprotein, topoisomerase II activity, glutathione and related enzymes. Anticancer Res 1994;14:869-874.
9. Gottesman MM, Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 1993;62:385-427.
10. Ren L, Xiao L, Hu J: MDR1 and MDR3 genes and drug resistance to cisplatin of ovarian cancer cells. J Huazhong Univ Sci Technolog Med Sci 2007;27:721-724.
11. Kuo MT, Chen HH, Song IS, Savaraj N, Ishikawa T: The roles of copper transporters in cisplatin resistance. Cancer Metastasis Rev 2007;26:71-83.
12. Krishna R, Mayer LD: Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur J Pharm Sci 2000;11:265-283.
13. Lothstein L, Israel M, Sweatman TW: Anthracycline drug targeting: cytoplasmic versus nuclear-a fork in the road. Drug Resist Updat 2001;4:169-177.
14. Hoffmann EK, Lambert IH, Pedersen SF: Physiology of cell volume regulation in vertebrates. Physiol Rev 2009;89:193-277.
15. Lambert IH, Hoffmann EK, Pedersen SF: Cell volume regulation: Physiology and Pathophysiology. Acta Physiol Scand 2008;194:255-282.
16. Okada Y, Maeno E: Apoptosis, cell volume regulation and volume-regulatory chloride channels. Comp Biochem Physiol A Mol Integr Physiol 2001;130:377-383.
17. Yang J, Xu ZP, Huang Y, Hamrick HE, Duerksen-Hughes PJ, Yu YN: ATM and ATR: sensing DNA damage. World J Gastroenterol 2004;10:155-160.
18. Poulsen KA, Andersen EC, Hansen CF, Klausen TK, Hougaard C, Lambert IH, Hoffmann EK: Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels. Am J Physiol Cell Physiol 2010;298:C14-C25.
19. Lambert IH: Regulation of the Cellular Content of the Organic Osmolyte Taurine in Mammalian Cells. Neurochem Res 2004;29:27-63.
20. Takatani T, Takahashi K, Uozumi Y, Shikata E, Yamamoto Y, Ito T, Matsuda T, Schaffer SW, Fujio Y, Azuma J: Taurine inhibits apoptosis by preventing formation of the Apaf-1/caspase-9 apoptosome. Am J Physiol Cell Physiol 2004;287:C949-C953.
21. Takatani T, Takahashi K, Uozumi Y, Matsuda T, Ito T, Schaffer SW, Fujio Y, Azuma J: Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway. Biochem Biophys Res Commun 2004;316:484-489. (Pubitemid 38338617)
22. Taranukhin AG, Taranukhina EY, Saransaari P, Djatchkova IM, Pelto-Huikko M, Oja SS: Taurine reduces caspase-8 and caspase-9 expression induced by ischemia in the mouse hypothalamic nuclei. Amino Acids 2008;34:169-174.
23. Das J, Ghosh J, Manna P, Sinha M, Sil PC: Taurine protects rat testes against NaAsO(2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett 2009;187:201-210.
24. Saad SY, Al-Rikabi AC: Protection effects of Taurine supplementation against cisplatin-induced nephrotoxicity in rats. Chemotherapy 2002;48:42-48.
25. Lang F, Madlung J, Siemen D, Ellory C, Lepple-Wienhues A, Gulbins E: The involvement of caspases in the CD95(Fas/Apo-1) but not swelling-induced cellular taurine release from Jurkat T-lymphocytes. Pflugers Arch 2000;440:93-99.
26. Poulsen KA, Litman T, Eriksen J, Mollerup J, Lambert IH: Downregulation of taurine uptake in multidrug resistant Ehrlich ascites tumor cells. Amino Acids 2002;22:333-350.
27. Kim HJ, Lee JH, Kim SJ, Oh GS, Moon HD, Kwon KB, Park C, Park BH, Lee HK, Chung S Y, Park R, So HS: Roles of NADPH oxidases in cisplatin-induced reactive oxygen species generation and ototoxicity. J Neurosci 2010;30:3933-3946.
28. Lambert IH, Klausen TK, Bergdahl A, Hougaard C, Hoffmann EK: Reactive oxygen species activate KCl co-transport in non-adherent Ehrlich ascites cells but K+ and Cl- channels in adherent Ehrlich Lettre and NIH3T3 cells. Am J Physiol Cell Physiol 2009;297:C198-C206.
29. Han X, Yue J, Chesney RW: Functional TauT protects against acute kidney injury. J Am Soc Nephrol 2009;20:1323-1332.
30. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein Measurement with the Folin Phenol Reagent. J Biol Chem 1951;193:265-275.
31. Gonzalez VM, Fuertes MA, Alonso C, Perez JM: Is cisplatin-induced cell death always produced by apoptosis? Mol Pharmacol 2001;59:657-663.
32. Wang D, Lippard SJ: Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 2005;4:307-320.
33. Brozovic A, Ambriovic-Ristov A, Osmak M: The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatin. Crit Rev Toxicol 2010;40:347-359.
34. Kelland L: The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer 2007;7:573-584.
35. Stewart JH, Tran TL, Levi N, Tsai WS, Schrump DS, Nguyen DM: The essential role of the mitochondria and reactive oxygen species in Cisplatin-mediated enhancement of fas ligand-induced apoptosis in malignant pleural mesothelioma. J Surg Res 2007;141:120-131.
36. Das J, Ghosh J, Manna P, Sinha M, Sil PC: Taurine protects rat testes against NaAsO(2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett 2009;187:201-210.
37. Montiel M, Urso L, de la Blanca EP, Marsigliante S, Jimenez E: Cisplatin reduces endothelial cell migration via regulation of type 2-matrix metalloproteinase activity. Cell Physiol Biochem 2009;23:441-448.
38. Friis MB, Friborg C, Schneider L, Nielsen MB, Lambert IH, Christensen ST, Hoffmann EK: Cell shrinkage as a signal to apoptosis in NIH3T3 fibroblasts. J Physiol 2005;567:427-443.
39. Janson V, Andersson B, Behnam-Motlagh P, Engstrom KG, Henriksson R, Grankvist K: Acquisition of cisplatin-resistance in malignant mesothelioma cells abrogates Na+,K+,2Cl(-)-cotransport activity and cisplatin-induced early membrane blebbing. Cell Physiol Biochem 2008;22:45-56.
40. Villumsen KR, Duelund L, Lambert IH: Acute cholesterol depletion leads to net loss of the organic osmolyte Taurine in Ehrlich Lettré tumor cells. Amino Acids 2010;39:1521-1536.