5-Lipoxygenase: Mechanisms of regulation

Journal of Lipid Research

Volumn 50, Issue SUPPL., 2009, Pages

  Rad̊mark, Olof ^a   Samuelsson, Bengt ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Arachidonic acid; Inflammation; Leukotriene

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CALCITRIOL; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NEUTROPHIL;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CALCITRIOL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; NEUTROPHILS; TRANSFORMING GROWTH FACTOR BETA;

EID: 66349101349     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R800062-JLR200     Document Type: Review

References (51)

1. Samuelsson, B., S-E. Dahlén, J-Å. Lindgren, C. A. Rouzer, and C. N. Serhan. 1987. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science. 237: 1171-1176. (Pubitemid 17131222)
2. Dahlen, S. E. 2006. Treatment of asthma with antileukotrienes: first line or last resort therapy? Eur. J. Pharmacol. 533: 40-56.
3. Peters-Golden, M., and W. R. Henderson, Jr. 2007. Leukotrienes. N. Engl. J. Med. 357: 1841-1854.
4. Radmark, O., and B. Samuelsson. 2005. Regulation of 5-lipoxygenase enzyme activity. Biochem. Biophys. Res. Commun. 338: 102-110. (Pubitemid 41540543)
5. Werz, O., and D. Steinhilber. 2006. Therapeutic options for 5- lipoxygenase inhibitors. Pharmacol. Ther. 112: 701-718.
6. Rådmark, O., O. Werz, D. Steinhilber, and B. Samuelsson. 2007. 5- Lipoxygenase: regulation of expression and enzyme activity. Trends Biochem. Sci. 32: 332-341. (Pubitemid 47021417)
7. Funk, C. D., S. Hoshiko, T. Matsumoto, O. Rådmark, and B. Samuelsson. 1989. Characterization of the human 5-lipoxygenase gene. Proc. Natl. Acad. Sci. USA. 86: 2587-2591. (Pubitemid 19112592)
8. Uhl, J., N. Klan, M. Rose, K. D. Entian, O. Werz, and D. Steinhilber. 2002. The 5-lipoxygenase promoter is regulated by DNA methylation. J. Biol. Chem. 277: 4374-4379. (Pubitemid 34975655)
9. Furstenberger, G., P. Krieg, K. Muller-Decker, and A. J. Habenicht. 2006. What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis? Int. J. Cancer. 119: 2247-2254. (Pubitemid 44546942)
10. Dishart, D., N. Schnur, N. Klan, O. Werz, D. Steinhilber, B. Samuelsson, and O. Rådmark. 2005. GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site. Biochim. Biophys. Acta. 1738:37-47. (Pubitemid 43124108)
11. Schnur, N., S. Seuter, C. Katryniok, O. Radmark, and D. Steinhilber. 2007. The histone deacetylase inhibitor trichostatin A mediates up-regulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes. Biochim. Biophys. Acta. 1771: 1271-1282. (Pubitemid 47499235)
12. In, K. H., E. S. Silverman, K. Asano, D. Beier, A. R. Fischer, T. P. Keith, K. Serino, C. Yandava, G. T. De Sanctis, and J. M. Drazen. 1999. Mutations in the human 5-lipoxygenase gene. [Review] Clin. Rev. Allergy Immunol. 17: 59-69. (Pubitemid 29349934)
13. Drazen, J. M., C. N. Yandava, L. Dube, N. Szczerback, R. Hippensteel, A. Pillari, E. Israel, N. Schork, E. S. Silverman, D. A. Katz, et al. 1999. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat. Genet. 22: 168-170. (Pubitemid 29264811)
14. Kalayci, O., E. Birben, C. Sackesen, O. Keskin, F. Tahan, M. E. Wechsler, E. Civelek, O. U. Soyer, G. Adalioglu, A. Tuncer, et al. 2006. ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. Allergy. 61: 97-103. (Pubitemid 43381198)
15. Herb, F., T. Thye, S. Niemann, E. N. Browne, M. A. Chinbuah, J. Gyapong, I. Osei, E. Owusu-Dabo, O. Werz, S. Rusch-Gerdes, et al. 2008. ALOX5 variants associated with susceptibility to human pulmonary tuberculosis. Hum. Mol. Genet. 17: 1052-1060. (Pubitemid 351426039)
16. Dwyer, J. H., H. Allayee, K. M. Dwyer, J. Fan, H. Wu, R. Mar, A. J. Lusis, and M. Mehrabian. 2004. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N. Engl. J. Med. 350: 29-37. (Pubitemid 38032181)
17. Silverman, E. S., L. Le, R. M. Baron, A. Hallock, J. Hjoberg, T. Shikanai, K. S. V. Gravesande, P. E. Auron, and W. N. Lu. 2002. Cloning and functional analysis of the mouse 5-lipoxygenase promoter. Am. J. Respir. Cell Mol. Biol. 26: 475-483. (Pubitemid 34253932)
18. Seuter, S., B. L. Sorg, and D. Steinhilber. 2006. The coding sequence mediates induction of 5-lipoxygenase expression by Smads3/4. Biochem. Biophys. Res. Commun. 348: 1403-1410. (Pubitemid 44291354)
19. Seuter, S., S. Väisänen, O. Rådmark, C. Carlberg, and D. Steinhilber. 2007. Functional characterization of vitamin D responding regions in the human 5-lipoxygenase gene. Biochim. Biophys. Acta. 1771: 864-872. (Pubitemid 46900904)
20. Sorg, B. L., N. Klan, S. Seuter, D. Dishart, O. Rådmark, A. Habenicht, C. Carlberg, O. Werz, and D. Steinhilber. 2006. Analysis of the 5- lipoxygenase promoter and characterization of a vitamin D receptor binding site. Biochim. Biophys. Acta. 1761: 686-697. (Pubitemid 44164374)
21. Gillmor, S. A., A. Villasenor, R. Fletterick, E. Sigal, and M. F. Browner. 1997. The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity. [published erratum appears in Nat Struct Biol 1998 Mar;5(3):242] Nat. Struct. Biol. 4: 1003-1009. (Pubitemid 27525804)
22. Hegg, E. L., and L. Que, Jr. 1997. The 2-His-1-carboxylate facial triad-an emerging structural motif in mononuclear non-heme iron(II) enzymes. [Review] [35 refs] Eur. J. Biochem. 250: 625-629. (Pubitemid 28022477)
23. Hammarberg, T., S. Kuprin, O. Rådmark, and A. Holmgren. 2001. EPR investigation of the active site of recombinant human 5-lipoxygenase: inhibition by selenide. Biochemistry. 40: 6371-6378. (Pubitemid 32472726)
24. Hammarberg, T., P. Provost, B. Persson, and O. Radmark. 2000. The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity. J. Biol. Chem. 275: 38787-38793. (Pubitemid 32009215)
25. Rouzer, C. A., and B. Samuelsson. 1985. On the nature of the 5- lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors. Proc. Natl. Acad. Sci. USA. 82: 6040-6044. (Pubitemid 16223894)
26. Kulkarni, S., S. Das, C. D. Funk, D. Murray, and W. Cho. 2002. Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase. J. Biol. Chem. 277: 13167-13174. (Pubitemid 34952687)
27. Chen, X. S., and C. D. Funk. 2001. The N-terminal "beta-barrel" domain of 5-lipoxygenase is essential for nuclear membrane translocation. J. Biol. Chem. 276: 811-818.
28. Pande, A. H., D. Moe, K. N. Nemec, S. Qin, S. Tan, and S. A. Tatulian. 2004. Modulation of human 5-lipoxygenase activity by membrane lipids. Biochemistry. 43: 14653-14666. (Pubitemid 39524940)
29. Provost, P., B. Samuelsson, and O. Rådmark. 1999. Interaction of 5-lipoxygenase with cellular proteins. Proc. Natl. Acad. Sci. USA. 96:1881-1885. (Pubitemid 29117836)
30. Provost, P., J. Doucet, T. Hanmmarberg, G. Gerisch, B. Samuelsson, and O. Rådmark. 2001. 5-Lipoxygenase interacts with coactosin-like protein. J. Biol. Chem. 276: 16520-16527.
31. Rakonjac, M., L. Fischer, P. Provost, O. Werz, D. Steinhilber, B. Samuelsson, and O. Radmark. 2006. Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. Proc. Natl. Acad. Sci. USA. 103: 13150-13155. (Pubitemid 44338931)
32. Brock, T. G. 2008. Capturing proteins that bind polyunsaturated fatty acids: demonstration using arachidonic acid and eicosanoids. Lipids. 43: 161-169.
33. Peters-Golden, M., and T. G. Brock. 2003. 5-lipoxygenase and FLAP. Prostaglandins Leukot. Essent. Fatty Acids. 69: 99-109. (Pubitemid 36976166)
34. Ferguson, A. D., B. M. McKeever, S. Xu, D. Wisniewski, D. K. Miller, T. T. Yamin, R. H. Spencer, L. Chu, F. Ujjainwalla, B. R. Cunningham, et al. 2007. Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. Science. 317: 510-512. (Pubitemid 47196114)
35. Mandal, A. K., J. Skoch, B. J. Bacskai, B. T. Hyman, P. Christmas, D. Miller, T. T. Yamin, S. Xu, D. Wisniewski, J. F. Evans, et al. 2004. The membrane organization of leukotriene synthesis. Proc. Natl. Acad. Sci. USA. 101: 6587-6592. (Pubitemid 38586018)
36. Luo, M., C. W. Pang, A. E. Gerken, and T. G. Brock. 2004. Multiple nuclear localization sequences allow modulation of 5-lipoxygenase nuclear import. Traffic. 5: 847-854.
37. Brock, T. G. 2005. Regulating leukotriene synthesis: the role of nuclear 5-lipoxygenase. J. Cell. Biochem. 96: 1203-1211. (Pubitemid 41681863)
38. Hanaka, H., T. Shimizu, and T. Izumi. 2002. Nuclear-localization- dependent and nuclear-export-signal-dependent mechanisms determine the localization of 5-lipoxygenase. Biochem. J. 361: 505-514. (Pubitemid 34177820)
39. Werz, O., J. Klemm, B. Samuelsson, and O. Radmark. 2000. 5-Lipoxygenase is phosphorylated by p38 kinase dependent MAPKAP kinases. Proc. Natl. Acad. Sci. USA. 97: 5261-5266. (Pubitemid 30313706)
40. Werz, O., E. Burkert, L. Fischer, D. Szellas, D. Dishart, B. Samuelsson, O. Radmark, and D. Steinhilber. 2002. Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes. FASEB J. 16: 1441-1443.
41. Luo, M., S. M. Jones, S. M. Phare, M. J. Coffey, M. Peters-Golden, and T. G. Brock. 2004. Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. J. Biol. Chem. 279: 41512-41520 Epub 2004 Jul 26.
42. Werz, O., E. Bürkert, B. Samuelsson, O. Radmark, and D. Steinhilber. 2002. Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes. Blood. 99: 1044-1052. (Pubitemid 34527142)
43. Luo, M., S. M. Jones, N. Flamand, D. M. Aronoff, M. Peters-Golden, and T. G. Brock. 2005. Phosphorylation by protein kinase a inhibits nuclear import of 5-lipoxygenase. J. Biol. Chem. 280: 40609-40616. (Pubitemid 41780551)
44. Flamand, N., M. E. Surette, S. Picard, S. Bourgoin, and P. Borgeat. 2002. Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils. Mol. Pharmacol. 62: 250-256. (Pubitemid 34804103)
45. Flamand, N., J. Lefebvre, M. E. Surette, S. Picard, and P. Borgeat. 2006. Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils. J. Biol. Chem. 281:129-136. (Pubitemid 43671171)
46. Pergola, C., G. Dodt, A. Rossi, E. Neunhoeffer, B. Lawrenz, H. Northoff, B. Samuelsson, O. Rådmark, L. Sautebin, and O. Werz. 2008. ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma. Proc. Natl. Acad. Sci. USA. 105: 19881-19886.
47. Brock, T. G., R. W. McNish, and G. M. Peters. 1998. Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages. Biochem. J. 329: 519-525. (Pubitemid 28055173)
48. Hill, E., J. Maclouf, R. C. Murphy, and P. M. Henson. 1992. Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity. J. Biol. Chem. 267: 22048-22053.
49. Johnston, N. W., P. J. Mandhane, J. Dai, J. M. Duncan, J. M. Greene, K. Lambert, and M. R. Sears. 2007. Attenuation of the September epidemic of asthma exacerbations in children: a randomized, controlled trial of montelukast added to usual therapy. Pediatrics. 120:e702-e712.
50. ENFUMOSA Study Group. 2003. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma. Eur. Respir. J. 22: 470-477.
51. Liepinsh, E., M. Rakonjac, V. Boissonneault, P. Provost, B. Samuelsson, O. Radmark, and G. Otting. 2004. NMR structure of human coactosin-like protein. J. Biomol. NMR. 30: 353-356.