Müllerian inhibiting substance signaling uses a bone morphogenetic protein (BMP)-like pathway mediated by ALK2 and induces Smad6 expression

Molecular Endocrinology

Volumn 15, Issue 6, 2001, Pages 946-959

  Clarke, Trent R ^a   Hoshiya, Yasunori ^a   Yi, Soyun E ^b   Liu, Xiaohong ^a   Lyons, Karen M ^b   Donahoe, Patricia K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE; BONE MORPHOGENETIC PROTEIN; MUELLERIAN INHIBITING FACTOR; PROTEIN KINASE; SMAD PROTEIN; SMAD6 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; ENZYME INDUCTION; MOUSE; MUELLERIAN DUCT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; BLOTTING, NORTHERN; BONE MORPHOGENETIC PROTEINS; CELL LINE; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; GLYCOPROTEINS; GROWTH INHIBITORS; IN SITU HYBRIDIZATION; LEYDIG CELLS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MULLERIAN DUCTS; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD1 PROTEIN; SMAD6 PROTEIN; TESTICULAR HORMONES; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034994419     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.15.6.946     Document Type: Article

References (71)

1. Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells
2. Cloning and expression of cDNA for anti-Müllerian hormone
3. The in vivo roles of Müllerian-inhibiting substance
4. The role of anti-Müllerian hormone in gonadal development
5. New insights into Müllerian inhibiting substance and its mechanism of action
6. Müllerian-inhibiting substance function during mammalian sexual development
7. Control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary
8. TGF-β signal transduction
9. Regulation of Smad activity
10. Transcriptional control by the TGF-β/Smad signaling system
11. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-β signalling
12. Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members
13. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
14. Regulation of Smad7 promoter by direct association with Smad3 and Smad4
15. Smad6 is a Smad1/5-induced Smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter
16. Smad1 and Smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo
17. The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
18. Induction of Smad6 mRNA by bone morphogenetic proteins
19. A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the Müllerian duct
20. Cloning, expression, and alternative splicing of the receptor for anti-Müllerian hormone
21. Developmental expression of a candidate Müllerian inhibiting substance type II receptor
22. Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation
23. Engagement of bone morphogenetic protein type IB receptor and Smad1 signaling by anti-Müllerian hormone and its type II receptor
24. Ontogeny of reproductive abnormalities induced by deregulation of anti-Müllerian hormone expression in transgenic mice
25. Receptors for anti-Müllerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation
26. Effect of anti-Müllerian hormone on Sertoli and Leydig cell functions in fetal and immature rats
27. Müllerian-inhibiting substance type II receptor expression and function in purified rat Leydig cells
28. Müllerian-inhibiting substance regulates androgen synthesis at the transcriptional level
29. Autocrine and paracrine Müllerian inhibiting substance hormone signaling in reproduction
30. TGF-β signal through a heteromeric protein kinase receptor complex
31. Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
32. Cellular interpretation of multiple TGF-β signals: Intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads
33. The TIx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development
34. The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling dorsoventral patterning of Xenopus mesoderm
35. A human Mad protein acting as a BMP-regulated transcriptional activator
36. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
37. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
38. Smad8 mediates the signaling of the ALK2 receptor serine kinase
39. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
40. Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors
41. Effect of human recombinant Müllerian inhibiting substance on isolated epithelial and mesenchymal cells during Müllerian duct regression in the rat
42. Paracrine-mediated apoptosis in reproductive tract development
43. Molecular mechanisms of hormone-mediated Müllerian duct regression: Involvement of β-catenin
44. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
45. Female development in mammals is regulated by Wnt-4 signalling
46. A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo
47. Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-β type II receptor family
48. Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis
49. The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo
50. Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis
51. Programmed cell death in the Mullerian duct induced by Müllerian inhibiting substance
52. The epithelial-mesenchymal interface of the male rate Müllerian duct: Loss of basement membrane integrity and ductal regression
53. The TGF-β-related DVR gene family in mammalian development
54. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
55. Müllerian inhibiting substance inhibits branching morphogenesis and induces apoptosis in fetal rat lung
56. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
57. Müllerian inhibiting substance inhibits ovarian cell growth through an Rb-independent mechanism
58. The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse
59. Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis
60. Growth differentiation factor-9 is required during early ovarian folliculogenesis
61. The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes
62. Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner
63. Sertori cell signaling by Desert hedgehog regulates the mare germline
64. Twin peaks: Spitz and Argos star in patterning of the Drosophila egg
65. Expression of sprouty2 during early development of the chick embryo is coincident with known sites of FGF signalling
66. Naked cuticle encodes an inducible antagonist of Wnt signalling
67. Human Müllerian inhibiting substance: Enhanced purification imparts biochemical stability and restores antiproliferative effects
68. Cloning, structure, and expression of the mitochondrial cytochrome P450 sterol 26-hydroxylase, a bite acid biosynthetic enzyme
69. Endogenous expression of Müllrerian inhibiting substance in early postnatal rat Sertoli cells requires multiple steroidogenic factor-1 and GATA-4-binding sites
70. Roles of BMP signaling and Nkx2.5 in patterning at the chick midgut-foregut boundary
71. The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling