The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling

Molecular Endocrinology

Volumn 15, Issue 6, 2001, Pages 936-945

  Visser, Jenny A ^a   Olaso, Robert ^a   Verhoef Post, Miriam ^b   Kramer, Piet ^b   Themmen, Axel P N ^b   Ingraham, Holly A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MUELLERIAN INHIBITING FACTOR; RECEPTOR; SERINE; SMAD PROTEIN; THREONINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASSAY; CONTROLLED STUDY; EMBRYO; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MESENCHYME; MOUSE; MUELLERIAN DUCT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TARGET ORGAN;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL LINE; DNA-BINDING PROTEINS; EMBRYO; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; GLYCOPROTEINS; GROWTH INHIBITORS; MALE; MICE; MULLERIAN DUCTS; OLIGONUCLEOTIDES, ANTISENSE; ORGAN CULTURE TECHNIQUES; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTORS, GROWTH FACTOR; RECEPTORS, PEPTIDE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD5 PROTEIN; TESTICULAR HORMONES; TRANS-ACTIVATORS; TRANSFECTION;

ANIMALIA;

EID: 0034982133     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.15.6.936     Document Type: Article

References (49)

1. TGF-β signal transduction
2. Müllerian inhibiting substance: A gonadal hormone with multiple functions
3. Anti-Müllerian hormone: The Jost factor
4. Paracrine-mediated apoptosis in reproductive tract development
5. Cloning, expression, and alternative splicing of the receptor for anti-Müllerian hormone
6. A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the Müllerian duct
7. Abnormal sexual development in transgenic mice chronically expressing Müllerian inhibiting substance
8. Müllerian-inhibiting substance function during mammalian sexual development
9. Control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary
10. Ontogeny of reproductive abnormalities induced by deregulation of anti-Müllerian hormone expression in transgenic mice
11. Insensitivity to anti-Müllerian hormone due to a mutation in the human anti-Müllerian hormone receptor
12. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryo-genesis
13. TGF-β signalling from cell membrane to nucleus through SMAD proteins
14. The Smad pathway
15. Smad1 and Smad5 act down-stream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts
16. TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4
17. Engagement of bone morphogenetic protein type IB receptor and Smad1 signaling by anti-Müllerian hormone and its type II receptor
18. Combinatorial signaling through BMP receptor IB and GDF5: Shaping of the distal mouse limb and the genetics of distal limb diversity
19. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
20. Müllerian inhibiting substance signaling uses a BMP-like pathway mediated by ALK2 and induces Smad6 expression
21. The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse
22. The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo
23. Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis
24. The TIx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development
25. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
26. Bioactivation of Müllerian inhibiting substance during gonadal development by a kex2/subtilisin-like endoprotease
27. MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling
28. TβRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
29. Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling
30. Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-β type II receptor family
31. Anti-Müllerian hormone and anti-Müllerian hormone type II receptor messenger ribonucleic acid expression in rat ovaries during postnatal development, the estrous cycle, and gonadotropin-induced follicle growth
32. Anti-Müllerian hormone and anti-Müllerian hormone type II receptor messenger ribonucleic acid expression during postnatal testis development and in the adult testis of the rat
33. Developmental expression of a candidate Müllerian inhibiting substance type II receptor
34. Morpholino antisense oligomers: The case for an RNase H-independent structural type
35. The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
36. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
37. Müllerian-inhibiting substance regulates androgen synthesis at the transcriptional level
38. Receptors for anti-Müllerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation
39. Cloning of a TGF β type I receptor that forms a heteromeric complex with the TGF β type II receptor
40. Activin receptor-like kinases: A novel subclass of cell-surface receptors with predicted serine/threonine kinase activity
41. Characterization of type I receptors for transforming growth factor-β and activin
42. MADR1, a MAD-related protein that functions in BMP2 signaling pathways
43. Mammalian dwarfins are phosphorylated in response to transforming growth factor β and are implicated in control of cell growth
44. Intracellular signaling of osteogenic protein-1 through Smad5 activation
45. Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-β receptor
46. Activation of signalling by the activin receptor complex
47. Transforming growth factor-β (TGF-beta)-induced down-regulation of cyclin A expression requires a functional TGF-β receptor complex. Characterization of chimeric and truncated type I and type II receptors
48. Morpholino antisense oligomers: Design, preparation, and properties
49. Effect of prenatal exposure to diethylstilbestrol on Müllerian duct development in fetal male mice