Immune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients

Journal of Neuroimmunology

Volumn 240-241, Issue , 2011, Pages 109-113

  Kalinowska Łyszczarz, Alicja ^a   Pawlak, Mikołaj A ^a   Michalak, Sławomir ^a,b   Paprzycki, Włodzimierz ^a   Losy, Jacek ^a,b  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

Brain atrophy; Multiple sclerosis; Neurotrophic factors; Neurotrophin 3 (NT 3)

Indexed keywords

NERVE GROWTH FACTOR BETA SUBUNIT; NEUROTROPHIN 3; NEUROTROPHIN 4;

ADULT; ARTICLE; BRAIN ATROPHY; BRAIN PARENCHYMAL FRACTION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CALLOSUM; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INTERMETHOD COMPARISON; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PARENCHYMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; ATROPHY; CORPUS CALLOSUM; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENTS; NEUROTROPHIN 3; RECEPTORS, NERVE GROWTH FACTOR; YOUNG ADULT;

EID: 83555177283     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.10.002     Document Type: Article

References (36)

1. Altman L. Programmed cell death: the paths to suicide. Trends Neurosci. 1992, 15:278-280.
2. Azoulay D., Vachapova V., Shihman B., Miler A., Karni A. Lower brain-derived neurotrophic factor in serum of relapsing-remitting MS: reversal by glatiramer acetate. J. Neuroimmunol. 2005, 167:215-218.
3. Azoulay D., Urshansky A., Karni A. Low and dysregulated BDNF secretion from immune cells of MS patients is related to reduced neuroprotection. J. Neuroimmunol. 2008, 195:186-193.
4. Bjartmar C., Kidd G., Mörk S., Rudick R., Trapp B.D. Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Ann. Neurol. 2000, 48:893-901.
5. Caggiula M., Batocchi A.P., Frisullo G., Angelucci F., Patanella A.K., Sancricca C., Nociti V., Tonali P.A., Mirabella M. Neurotrophic factors and clinical recovery in relapsing-remitting multiple sclerosis. Scand. J. Immunol. 2005, 62:176-182.
6. Chao M.V. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 2003, 4:299-309.
7. Connor B., Dragunow M. The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res. Rev. 2009, 27:1-39.
8. Hohlfeld R. Neurotrophic cross-talk between the nervous and immune systems: relevance for repair strategies in multiple sclerosis?. J. Neurol. Sci. 2008, 265:93-96.
9. Johnson E.M., Chang J.Y., Koike T., Martin D.P. Why do neurons die when deprived of trophic factors?. Neurobiol. Aging 1989, 10:549-552.
10. Jones J.L., Anderson J.M., Phuah C.L., Fox E.J., Selmaj K., Margolin D., Lake S.L., Palmer J., Thompson S.J., Wilkins A., Webber D.J., Compston D.A., Coles A.J. Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity. Brain 2010, 133:2232-2247.
11. Kerschensteiner M., Stadelmann C., Dechant G., Wekerle H., Hohlfeld R. Neurotrophic cross-talk between the nervous and immune systems: implications for neurological diseases. Ann. Neurol. 2003, 53:292-304.
12. Lalive P.H., Kantengwa S., Benkhoucha M., Juillard C., Chofflon M. Interferon-β induces brain-derived neurotrophic factor in peripheral blood mononuclear cells of multiple sclerosis patients. J. Neuroimmunol. 2008, 197:147-151.
13. Lilliefors H. On the Kolmogorov-Smirnov test for normality with mean and variance unknown. J. Am. Stat. Assoc. 1967, 62:399-402.
14. Linker R., Lee D.-H., Siglienti I., Gold R. Is there a role for neurotrophins in the pathology of multiple sclerosis?. J. Neurol. 2007, 254(suppl 1):I/33-I/40.
15. Linker R.A., Gold R., Lühder F. Function of neurotrophic factors beyond the nervous system: inflammation and autoimmune demyelination. Crit. Rev. Immunol. 2009, 29:43-68.
16. Linker R.A., Lee D.H., Demir S., Wiese S., Kruse N., Siglienti I., Gerhardt E., Neumann H., Sendtner M., Lühder F., Gold R. Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis. Brain 2010, 133:2248-2263.
17. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
18. Peterson L.K., Fujinami R.S. Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis. J. Neuroimmunol. 2007, 184:37-44.
19. Pirko I., Johnson A.J., Chen Y., Lindquist D.M., Lohrey A.K., Ying J., Dunn R.S. Brain atrophy correlates with functional outcome in a murine model of multiple sclerosis. Neuroimage 2011, 54:802-806.
20. Polman C.H., Reingold S.C., Edan G., Filippi M., Hartung H.P., Kappos L., Lublin F.D., Metz L.M., McFarland H.F., O'Connor P.W., Sandberg-Wollheim M., Thompson A.J., Weinshenker B.G., Wolinsky J.S. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann. Neurol. 2005, 58:840-846.
21. Pradat P.F., Kennel P., Naimi-Sadaoui S., Finiels F., Orsini C., Revah F., Delaere P., Mallet J. Continuous delivery of neurotrophin 3 by gene therapy has a neuroprotective effect in experimental models of diabetic and acrylamide neuropathies. Hum. Gene Ther. 2001, 12:2237-2249.
22. Pradat P.F., Kennel P., Naimi-Sadaoui S., Finiels F., Scherman D., Orsini C., Delaere P., Mallet J., Revah F. Viral and non-viral gene therapy partially prevents experimental cisplatin-induced neuropathy. Gene Ther. 2002, 19:1333-1337.
23. R Development Core Team, R Foundation for Statistical Computing R: A Language and Environment for Statistical Computing 2010, (Vienna, Austria).
24. Raff M.C., Whitmore A.V., Finn J.T. Axonal self-destruction and neurodegeneration. Science 2002, 296:868-871.
25. Rasouly D., Rahamim E., Lester D., Matsuda Y., Lazarovici P. Staurosporine-induced neurite outgrowth in PC12 cells is independent of protein kinase C inhibition. Mol. Pharmacol. 1992, 42:35-43.
26. Reichardt L.F. Neurotrophin-regulated signalling pathways. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2006, 361:1545-1564.
27. Rorden C., Karnath H.O., Bonilha L. Improving lesion-symptom mapping. J. Cogn. Neurosci. 2007, 19:1081-1088.
28. Roux P.P., Dorval G., Boudreau M., Angers-Loustau A., Morris S.J., Makkerh J., Barker P.A. K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. J. Biol. Chem. 2002, 277:49473-49480.
29. Merritt's Neurology 2005, Lippincott Williams & Wilkins, Philadelphia, USA. 11th edition. L.P. Rowland (Ed.).
30. Sahenk Z., Galloway G., Edwards C., Malik V., Kaspar B.K., Eagle A., Yetter B., Forgie A., Tsao D., Lin J.C. TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice. Exp. Neurol. 2010, 224:495-506.
31. Tabakman R., Lecht S., Sephanova S., Arien-Zakay H., Lazarovici P. Interactions between the cells of the immune and nervous system: neurotrophins as neuroprotection mediators in CNS injury. Prog. Brain Res. 2004, 146:387-401.
32. Thoenen H. Neurotrophins and activity-dependent plasticity. Prog. Brain Res. 2000, 128:183-191.
33. Urshansky N., Mausner-Fainberg K., Auriel E., Regev K., Farhum F., Karni A. Dysregulated neurotrophin mRNA production by immune cells of patients with relapsing remitting multiple sclerosis. J. Neurol. Sci. 2010, 295:31-37.
34. Vega J.A., Garcia-Suarez O., Hannestad J., Pérez-Pérez M., Germanà A. Neurotrophins and the immune system. J. Anat. 2003, 203:1-19.
35. Weinstock-Guttman B., Zivadinov R., Tamano-Blanco M., Abdelrahman N., Badgett D., Durfee J., Hussein S., Feichter J., Patrick K., Benedict R., Ramanathan M. Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis. J. Neuroimmunol. 2007, 188:167-174.
36. Zhang Y., Brady M., Smith S. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans. Med. Imaging 2001, 20:45-57.