Rapid conversion of API hydrates to anhydrous forms in aqueous media

Journal of Pharmaceutical Sciences

Volumn 98, Issue 11, 2009, Pages 4111-4118

  Petrova, Rositza I ^a   Peresypkin, Andrey ^a,b   Mortko, Christopher J ^a   Mckeown, Arlene E ^a   Lee, Jaemoon ^a   Williams, J Michael ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

Author keywords

Crystal structure; Eutectic melting; Hot stage optical microscopy; Metastable hydrate; Physical characterization; Physical stability; Polymorphism; Thermal analysis

Indexed keywords

ACETAMIDE DERIVATIVE; N [[(5)3(4(6[(1,5)6 CYANO 3 OXABICYCLO [3.1.0] HEX 6 YL]PYRIDIN 3 YL)PHENYL) 2 OXO 1,3 OXAZOLIDIN 5 YL]METHYL]ACETAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; DRUG STABILITY; HUMIDITY; HYDRATION; THERMAL ANALYSIS; THERMODYNAMICS; THERMOGRAVIMETRY; X RAY POWDER DIFFRACTION;

EID: 70349636200     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21703     Document Type: Article

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