-
1
-
-
74549144266
-
Challenges predicting ligand-receptor interactions of promiscuous proteins: The nuclear receptor PXR
-
J
-
Ekins S, Kortagere S, Iyer M, et al. Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR [J]. PLoS Comput Biol, 2009, 5: 1-12.
-
(2009)
PLoS Comput Biol
, vol.5
, pp. 1-12
-
-
Ekins, S.1
Kortagere, S.2
Iyer, M.3
-
2
-
-
0035933511
-
The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity
-
DOI 10.1126/science.1060762
-
Watkins RE, Wisely GB, Moore LB, et al. The human nuclear xenobiotic receptor PXR: structural determinant of directed promiscuity [J]. Science, 2001, 292: 2329-2333. (Pubitemid 32568055)
-
(2001)
Science
, vol.292
, Issue.5525
, pp. 2329-2333
-
-
Watkins, R.E.1
Wisely, G.B.2
Moore, L.B.3
Collins, J.L.4
Lambert, M.H.5
Williams, S.P.6
Willson, T.M.7
Kliewer, S.A.8
Redinbo, M.R.9
-
3
-
-
0035224757
-
Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes
-
J
-
Maglich J, Sluder A, Guan X, et al. Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes [J]. Genome Biol, 2001: 21-27.
-
(2001)
Genome Biol
, pp. 21-27
-
-
Maglich, J.1
Sluder, A.2
Guan, X.3
-
4
-
-
78650175257
-
Regulation of drug metabolizing enzymes by xenobiotic receptors: PXR and CAR
-
J
-
Tolson AH, Wang H. Regulation of drug metabolizing enzymes by xenobiotic receptors: PXR and CAR [J]. Adv Drug Deliv Rev, 2010, 62: 1238-1249.
-
(2010)
Adv Drug Deliv Rev
, vol.62
, pp. 1238-1249
-
-
Tolson, A.H.1
Wang, H.2
-
5
-
-
34247349605
-
Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: Implications for interindividual variability in response to drugs
-
DOI 10.1177/0091270007299930
-
Urquhart BL, Tirona RG, Kim RB. Nuclear receptors and the regulation of drug metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs [J]. Clin Pharmacol, 2007, 47: 566-578. (Pubitemid 46632158)
-
(2007)
Journal of Clinical Pharmacology
, vol.47
, Issue.5
, pp. 566-578
-
-
Urquhart, B.L.1
Tirona, R.G.2
Kim, R.B.3
-
6
-
-
0035851148
-
Orphan nuclear receptors: The exotics of xenobiotics
-
J
-
Xie W, Evans RM. Orphan nuclear receptors: the exotics of xenobiotics [J]. Biol Chem, 2001, 276: 37739-37742.
-
(2001)
Biol Chem
, vol.276
, pp. 37739-37742
-
-
Xie, W.1
Evans, R.M.2
-
7
-
-
23144456286
-
Regulation of hepatic transporters by xenobiotic receptors
-
DOI 10.2174/1389200054633826
-
Klaassen CD, Slitt AL. Regulation of hepatic transporters by xenobiotic receptors [J]. Curr Drug Metab, 2005, 6: 309-328. (Pubitemid 41086765)
-
(2005)
Current Drug Metabolism
, vol.6
, Issue.4
, pp. 309-328
-
-
Klaassen, C.D.1
Slitt, A.L.2
-
9
-
-
0344740559
-
Induction of Drug Metabolism: The Role of Nuclear Receptors
-
DOI 10.1124/pr.55.4.2
-
Handschini C, Meyer UA. Induction of drug metabolism: the role of nuclear receptors [J]. Pharmacol Rev, 2003, 55: 649-673. (Pubitemid 37504978)
-
(2003)
Pharmacological Reviews
, vol.55
, Issue.4
, pp. 649-673
-
-
Handschin, C.1
Meyer, U.A.2
-
10
-
-
0034691064
-
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
-
DOI 10.1073/pnas.130155097
-
Moore LB, Goodwin B, Jones SA, et al. St. John'swort induces hepatic drug metabolism through activation of the pregnane X receptor [J]. Proc Natl Acad Sci U S A, 2000, 97: 7500-7502. (Pubitemid 30431492)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.13
, pp. 7500-7502
-
-
Moore, L.B.1
Goodwin, B.2
Jones, S.A.3
Wisely, G.B.4
Serabjit-Singh, C.J.5
Willson, T.M.6
Collins, J.L.7
Kliewer, S.A.8
-
11
-
-
1642498178
-
Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor
-
DOI 10.1124/jpet.103.058818
-
Chen Y, Ferguson SS, Negishi M, et al. Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor [J]. Pharmacol Exp Ther, 2004, 308: 495-501. (Pubitemid 38134210)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.308
, Issue.2
, pp. 495-501
-
-
Chen, Y.1
Ferguson, S.S.2
Negishi, M.3
Goldstein, J.A.4
-
12
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
DOI 10.1073/pnas.051551698
-
Staudinger JL, Goodwin B, Jones SA, et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity [J]. Proc Natl Acad Sci USA, 2001, 98: 3369-3374. (Pubitemid 32220852)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.6
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
Hawkins-Brown, D.4
MacKenzie, K.I.5
LaTour, A.6
Liu, Y.7
Klaassen, C.D.8
Brown, K.K.9
Reinhard, J.10
Willson, T.M.11
Koller, B.H.12
Kliewer, S.A.13
-
13
-
-
0038650987
-
Nuclear receptor, pregnane X receptor, is required for induction of UDP-glucuronosyltransferases in mouse liver by 16aalpha-carbonitrile
-
DOI 10.1124/dmd.31.7.908
-
Chen C, Staudinger JL, Klaassen CD. Nuclear receptor, pregnane X receptor, is required for induction of UDP - glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile [J]. Drug Metab Dispos, 2003, 31: 908-915. (Pubitemid 36759061)
-
(2003)
Drug Metabolism and Disposition
, vol.31
, Issue.7
, pp. 908-915
-
-
Chen, C.1
Staudinger, J.L.2
Klaassen, C.D.3
-
14
-
-
0037108916
-
Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)
-
DOI 10.1073/pnas.212494599
-
Sonoda J, Xie W, Rosenfeld JM, et al. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR) [J]. Proc Natl Acad Sci USA, 2002, 99: 13801-13806. (Pubitemid 35215461)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.21
, pp. 13801-13806
-
-
Sonoda, J.1
Xie, W.2
Rosenfeld, J.M.3
Barwick, J.L.4
Guzelian, P.S.5
Evans, R.M.6
-
15
-
-
33746053520
-
Cancer chemotherapy and drug metabolism enzyme
-
J
-
Xu F, Zhen YS, Shao RG. Cancer chemotherapy and drug metabolism enzyme [J]. Prog Physiol Sci, 2005, 36: 295-298.
-
(2005)
Prog Physiol Sci
, vol.36
, pp. 295-298
-
-
Xu, F.1
Zhen, Y.S.2
Shao, R.G.3
-
16
-
-
0032754284
-
The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
-
J
-
Greiner B, Eichelbaum M, Fritz P, et al. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin [J]. Clin Invest, 1999, 104: 147-153.
-
(1999)
Clin Invest
, vol.104
, pp. 147-153
-
-
Greiner, B.1
Eichelbaum, M.2
Fritz, P.3
-
17
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
J
-
Geick A, Eichelbaum M, Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin [J]. Biol Chem, 2001, 276: 14581-14587.
-
(2001)
Biol Chem
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
-
18
-
-
0142150021
-
Induction of ABCC3 (MRP3) by pregnane X receptor activators
-
DOI 10.1124/dmd.31.11.1296
-
Teng S, Jekerle V, Piquette-Miller M. Induction of ABCC3 (MRP3) by pregnane X receptor activators [J]. Drug Metab Dispos, 2003, 31: 1296-1299. (Pubitemid 37310315)
-
(2003)
Drug Metabolism and Disposition
, vol.31
, Issue.11
, pp. 1296-1299
-
-
Teng, S.1
Jekerle, V.2
Piquette-Miller, M.3
-
19
-
-
0036205380
-
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile Is via interaction with pregnane X receptor
-
DOI 10.1124/mol.61.4.832
-
Guo GL, Staudinger J, Ogura K, et al. Induction of rat organic anion transporting polypeptide 2 by pregnenolone - 16alpha - carbonitrile is via interaction with pregnane X receptor [J]. Mol Pharmacol, 2002, 61: 832-839. (Pubitemid 34273163)
-
(2002)
Molecular Pharmacology
, vol.61
, Issue.4
, pp. 832-839
-
-
Guo, G.L.1
Staudinger, J.2
Ogura, K.3
Klaassen, C.D.4
-
20
-
-
34848828243
-
Broad but distinct role of pregnane X receptor on the expression of individual cytochrome p450s in human hepatocytes
-
J
-
Kojima K, Nagata K, Matsubara T, et al. Broad but distinct role of pregnane X receptor on the expression of individual cytochrome p450s in human hepatocytes [J]. Drug Metab Pharmacokinet, 2007, 22: 276-286.
-
(2007)
Drug Metab Pharmacokinet
, vol.22
, pp. 276-286
-
-
Kojima, K.1
Nagata, K.2
Matsubara, T.3
-
22
-
-
0034782509
-
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor
-
Staudinger J, Liu Y, Madan A, et al. Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor [J]. Drug Metab Dispos, 2001, 29: 1467-1472. (Pubitemid 33000694)
-
(2001)
Drug Metabolism and Disposition
, vol.29
, Issue.11
, pp. 1467-1472
-
-
Staudinger, J.1
Liu, Y.2
Madan, A.3
Habeebu, S.4
Klaassen, C.D.5
-
23
-
-
7444253800
-
Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: Insights into PXR-mediated gene regulation
-
DOI 10.1074/jbc.M408395200
-
Vyhlidal CA, Rogan PK, Leeder JS. Development and refinement of pregnane X receptor (PXR) DNA binding site model using information theory: insights into PXR-mediated gene regulation [J]. Biol Chem, 2004, 279: 46779-46786. (Pubitemid 39518327)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.45
, pp. 46779-46786
-
-
Vyhlidal, C.A.1
Rogan, P.K.2
Leeder, J.S.3
-
24
-
-
33646497418
-
Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines
-
J
-
Huang R, Murry DJ, Kolwankar D, et al. Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines [J]. Biochem Pharmacol, 2006, 71: 1695-1704.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1695-1704
-
-
Huang, R.1
Murry, D.J.2
Kolwankar, D.3
-
25
-
-
0035185021
-
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
-
DOI 10.1172/JCI200112876
-
Nakae J, Kitamura T, Silver DL, et al. The forkhead transcription factor FoxO1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression [J]. Clin Investig, 2001, 108: 1359-1367. (Pubitemid 33107764)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.9
, pp. 1359-1367
-
-
Nakae, J.1
Kitamura, T.2
Silver, D.L.3
Accili, D.4
-
26
-
-
0021850197
-
Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects
-
Lahtela JT, Arranto AJ, Sotanaient EA. Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects [J]. Diabetes, 1985, 34: 911-916. (Pubitemid 15016555)
-
(1985)
Diabetes
, vol.34
, Issue.9
, pp. 911-916
-
-
Lahtela, J.T.1
Arranto, A.J.2
Sotaniemi, E.A.3
-
27
-
-
35748972683
-
Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene
-
DOI 10.1042/BJ20070481
-
Kodama S, Moore R, Yamamoto Y, et al. Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene [J]. Biochemistry, 2007, 407: 373-381. (Pubitemid 350058471)
-
(2007)
Biochemical Journal
, vol.407
, Issue.3
, pp. 373-381
-
-
Kodama, S.1
Moore, R.2
Yamamoto, Y.3
Negishi, M.4
-
28
-
-
4444246000
-
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes
-
DOI 10.1128/MCB.24.18.7931-7940.2004
-
Kodama S, Koike C, Negishi M, et al. Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes [J]. Mol Cell Biol, 2004, 24: 7931-7940. (Pubitemid 39167443)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.18
, pp. 7931-7940
-
-
Kodama, S.1
Koike, C.2
Negishi, M.3
Yamamoto, Y.4
-
29
-
-
33744962967
-
Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha
-
DOI 10.1074/jbc.M510713200
-
Miao J, Fang S, Bae Y, et al. Functional inhibitory crosstalk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1α [J]. Biol Chem, 2006, 281: 14537-14546. (Pubitemid 43855156)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.21
, pp. 14537-14546
-
-
Miao, J.1
Fang, S.2
Bae, Y.3
Kemper, J.K.4
-
30
-
-
0032621095
-
Insulin-mediated modulation of cytochrome P450 gene induction profiles in primary rat hepatocyte cultures
-
Sidhu JS, Omiecinski CJ. Insulin-mediated modulation of cytochrome P450 gene induction profiles on primary rat hepatocytes cultures [J]. Biochem Mol Toxicol, 1999, 13: 1-9. (Pubitemid 129709398)
-
(1999)
Journal of Biochemical and Molecular Toxicology
, vol.13
, Issue.1
, pp. 1-9
-
-
Sidhu, J.S.1
Omiecinski, C.J.2
-
31
-
-
34248202757
-
Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver
-
DOI 10.1074/jbc.M610072200
-
Nakamura K, Moore R, Negishi M, et al. Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver [J]. Biol Chem, 2007, 282: 9768-9776. (Pubitemid 47104600)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.13
, pp. 9768-9776
-
-
Nakamura, K.1
Moore, R.2
Negishi, M.3
Sueyoshi, T.4
-
32
-
-
33744948052
-
A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
-
DOI 10.1074/jbc.M511116200
-
Zhou J, Zhai Y, Mu Y, et al. A novel pregnane X receptor mediated and sterol regulatory element-binding protein-independent lipogenic pathway [J]. Biol Chem, 2006, 281: 15013-15020. (Pubitemid 43855205)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.21
, pp. 15013-15020
-
-
Zhou, J.1
Zhai, Y.2
Mu, Y.3
Gong, H.4
Uppal, H.5
Toma, D.6
Ren, S.7
Evans, R.M.8
Xie, W.9
-
33
-
-
13244258414
-
The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice
-
DOI 10.1124/jpet.104.076141
-
Teng S, Piquette-Miller M. The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice [J]. Pharmacol Exp Ther, 2005, 312: 841-848. (Pubitemid 40189587)
-
(2005)
Journal of Pharmacology and Experimental Therapeutics
, vol.312
, Issue.2
, pp. 841-848
-
-
Teng, S.1
Piquette-Miller, M.2
-
34
-
-
33746675685
-
Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation
-
DOI 10.1172/JCI26283
-
Zhou C. Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation [J]. Clin Invest, 2006, 116: 2280-2289. (Pubitemid 44162338)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.8
, pp. 2280-2289
-
-
Zhou, C.1
Tabb, M.M.2
Nelson, E.L.3
Grun, F.4
Verma, S.5
Sadatrafiei, A.6
Lin, M.7
Mallick, S.8
Forman, B.M.9
Thummel, K.E.10
Blumberg, B.11
-
35
-
-
33645057202
-
SUMOylation and PPARgamma: Wrestling with inflammatory signaling
-
J
-
Zelcer N, Tontonoz P. SUMOylation and PPARgamma: wrestling with inflammatory signaling [J]. Cell Metab, 2005, 2: 273-275.
-
(2005)
Cell Metab
, vol.2
, pp. 273-275
-
-
Zelcer, N.1
Tontonoz, P.2
|