Citrate treatment reduces endothelial death and inflammation under hyperglycaemic conditions

Diabetes and Vascular Disease Research

Volumn 9, Issue 1, 2012, Pages 42-51

  Bryland, Anna ^a   Wieslander, Anders ^b   Carlsson, Ola ^a   Hellmark, Thomas ^a   Godaly, Gabriela ^a  

^a LUND UNIVERSITY   (Sweden)

^b Gambro AB   (Sweden)

Author keywords

Apoptosis; diabetes; endothelium; hyperglycaemia; inflammation

Indexed keywords

CITRIC ACID; GLUCONIC ACID; GLUCOSE; GLUCOSE DEGRADATION PRODUCT; INTERCELLULAR ADHESION MOLECULE 1; LIPOCORTIN 5; PROPIDIUM IODIDE; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA 11; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL FUNCTION; CELL MIGRATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE RELEASE; DIAPEDESIS; DRUG ACTIVITY; ENDOTHELIUM CELL; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INFLAMMATION; NECROSIS; NEUTROPHIL; PROTEIN EXPRESSION; STAINING; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CITRIC ACID; COCULTURE TECHNIQUES; ENZYME ACTIVATION; FLOW CYTOMETRY; GLUCONATES; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPERGLYCEMIA; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; MICROSCOPY, CONFOCAL; NECROSIS; NEUTROPHILS; PROTEIN KINASE C; PYRONES; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION;

EID: 83455258057     PISSN: 14791641     EISSN: 17528984     Source Type: Journal    
DOI: 10.1177/1479164111424297     Document Type: Article

References (43)

1. Shrishrimal K, Hart P, Michota F. Managing diabetes in hemodialysis patients: observations and recommendations. Cleve Clin J Med. 2009 ; 76: 649-655
2. Stratton IM, Adler AI, Neil HA, Matthews DR, Manley SE, Cull CA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000 ; 321: 405-412 (Pubitemid 30609442)
3. Pearce LR, Komander D, Alessi DR. The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol. 2010 ; 11: 9-22
4. Idris I, Gray S, Donnelly R. Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia. 2001 ; 44: 659-673 (Pubitemid 32846021)
5. Tomo T. Peritoneal dialysis solutions low in glucose degradation products-evidence for clinical benefits. Perit Dial Int. 2008 ; 28: S123 - S127
6. Zeier M, Schwenger V, Deppisch R, Haug U, Weigel K, Bahner U, et al. Glucose degradation products in PD fluids: do they disappear from the peritoneal cavity and enter the systemic circulation?. Kidney Int. 2003 ; 63: 298-305 (Pubitemid 35463934)
7. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001 ; 414: 813-820 (Pubitemid 34000785)
8. Bryland A, Broman M, Erixon M, Klarin B, Lindén T, Friberg H, et al. Infusion fluids contain harmful glucose degradation products. Intensive Care Med. 2010 ; 36: 1213-1220
9. Turina M, Fry DE, Polk HC. Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects. Crit Care Med. 2005 ; 33: 1624-1633 (Pubitemid 40980623)
10. Ata A, Lee J, Bestle SL, Desemone J, Stain SC. Postoperative hyperglycemia and surgical site infection in general surgery patients. Arch Surg. 2010 ; 145: 858-864
11. Erixon M, Wieslander A, Lindén T, Carlsson O, Jönsson JA, Simonsen O, et al. 3,4-DGE in peritoneal dialysis fluids cannot be found in plasma after infusion into the peritoneal cavity. Perit Dial Int. 2008 ; 28: 277-282 (Pubitemid 352003043)
12. Kusunoki H, Miyata S, Ohara T, Liu BF, Uriuhara A, Kojima H, et al. Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. Diabetes Care. 2003 ; 26: 1889-1894 (Pubitemid 36929139)
13. Erixon M, Wieslander A, Lindén T, Carlsson O, Forsbäck G, Svensson E, et al. Take care in how you store your PD fluids: actual temperature determines the balance between reactive and non-reactive GDPs. Perit Dial Int. 2005 ; 25: 583-590 (Pubitemid 43109262)
14. Catalan M, Santamaría B, Reyero A, Ortiz A, Egido J, Ortiz A. 3,4-di-deoxyglucosone-3-ene promotes leukocyte apoptosis. Kidney Int. 2005 ; 68: 1303-1311 (Pubitemid 43246451)
15. Tsuneki H, Sekizaki N, Suzuki T, Kobayashi S, Wada T, Okamoto T, et al. Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells. Eur J Pharmacol. 2007 ; 566: 1-10 (Pubitemid 46782791)
16. Rashid G, Benchetrit S, Fishman D, Bernheim J. Effect of advanced glycation end-products on gene expression and synthesis of TNF-alpha and endothelial nitric oxide synthase by endothelial cells. Kidney Int. 2004 ; 66: 1099-1106 (Pubitemid 39121015)
17. Schuett H, Luchtefeld M, Grothusen C, Grote K, Schieffer B. How much is too much? Interleukin-6 and its signalling in atherosclerosis. Thromb Haemost. 2009 ; 102: 215-222
18. Manduteanu I, Voinea M, Serban G, Simionescu M. High glucose induces enhanced monocyte adhesion to valvular endothelial cells via a mechanism involving ICAM-1, VCAM-1 and CD18. Endothelium. 1999 ; 6: 315-324 (Pubitemid 29364177)
19. Lawson C, Wolf S. ICAM-1 signaling in endothelial cells. Pharmacol Rep. 2009 ; 61: 22-32
20. Hamada Y, Nakashima E, Naruse K, Nakae M, Naiki M, Fujisawa H, et al. A copper chelating agent suppresses carbonyl stress in diabetic rat lenses. J Diabetes Complications. 2005 ; 19: 328-334 (Pubitemid 41563015)
21. Zheng Y, Li XK, Wang Y, Cai L. The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: therapeutic effects by chelators. Hemoglobin. 2008 ; 32: 135-145 (Pubitemid 351264519)
22. Baynes JW, Murray DB. The metal chelators, trientine and citrate, inhibit the development of cardiac pathology in the Zucker diabetic rat. Exp Diabetes Res. 2009 ; 2009: 696378
23. Gabutti L, Ferrari L, Mombelli G, Keller F, Marone C. The favorable effect of regional citrate anticoagulation on interleukin-1beta release is dissociated from both coagulation and complement activation. J Nephrol. 2004 ; 17: 819-825 (Pubitemid 41158302)
24. Bauer E, Derfler K, Joukhadar C, Druml W. Citrate kinetics in patients receiving long-term hemodialysis therapy. Am J Kidney Dis. 2005 ; 46: 903-907 (Pubitemid 41505465)
25. Gabutti L, Lucchini B, Marone C, Alberio L, Burnier M., Citrate- vs. acetate-based dialysate in bicarbonate haemodialysis: consequences on haemodynamics, coagulation, acid-base status, and electrolytes. BMC Nephrol. 2009 ; 10: 7
26. Mak IT, Komarov AM, Kramer JH, Weglicki WB. Protective mechanisms of Mg-gluconate against oxidative endothelial cytotoxicity. Cell Mol Biol (Noisy-le-grand). 2000 ; 46: 1337-1344
27. Repetto G, del Peso A, Zurita JL. Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat Protoc. 2008 ; 3: 1125-1131
28. Linden T, Cohen A, Deppisch R, Kjellstrand P, Wieslander A. 3,4-Dideoxyglucosone-3-ene (3,4-DGE): a cytotoxic glucose degradation product in fluids for peritoneal dialysis. Kidney Int. 2002 ; 62: 697-703 (Pubitemid 34779784)
29. Godaly G, Proudfoot AE, Offord RE, Svanborg C, Agace WW. Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration. Infect Immun. 1997 ; 65: 3451-3456 (Pubitemid 27342435)
30. Das Evcimen N, King GL. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res. 2007 ; 55: 498-510 (Pubitemid 46962309)
31. Edwards AS, Faux MC, Scott JD, Newton AC. Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII. J Biol Chem. 1999 ; 274: 6461-6468 (Pubitemid 29111061)
32. Quagliaro L, Piconi L, Assaloni R, Martinelli L, Motz E, Ceriello A. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes. 2003 ; 52: 2795-2804 (Pubitemid 37339710)
33. Casellini CM, Barlow PM, Rice AL, Casey M, Simmons K, Pittenger G, et al. A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy. Diabetes Care. 2007 ; 30: 896-902 (Pubitemid 46556584)
34. Mehta NN, Sheetz M, Price K, Comiskey L, Amrutia S, Iqbal N, et al. Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus. Cardiovasc Drugs Ther. 2009 ; 23: 17-24
35. Beckman JA, Goldfine AB, Goldin A, Prsic A, Kim S, Creager MA. Inhibition of protein kinase Cbeta does not improve endothelial function in type 2 diabetes. J Clin Endocrinol Metab. 2010 ; 95: 3783-3787
36. Venugopal SK, Devaraj S, Yang T, Jialal I. Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha. Diabetes. 2002 ; 51: 3049-3054
37. Dang L, Seale JP, Qu X. High glucose-induced human umbilical vein endothelial cell hyperpermeability is dependent on protein kinase C activation and independent of the Ca2+-nitric oxide signalling pathway. Clin Exp Pharmacol Physiol. 2005 ; 32: 771-776 (Pubitemid 41603157)
38. Mallet RT, Sun J. Antioxidant properties of myocardial fuels. Mol Cell Biochem. 2003 ; 253: 103-111 (Pubitemid 37321716)
39. Andreasen AS, Pedersen-Skovsgaard T, Berg RM, Svendsen KD, Feldt-Rasmussen B, Pedersen BK, et al. Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia. Intensive Care Med. 2010 ; 36: 1548-1555
40. Delamaire M, Maugendre D, Moreno M, Le Goff MC, Allannic H, Genetet B. Impaired leucocyte functions in diabetic patients. Diabet Med. 1997 ; 14: 29-34 (Pubitemid 27019919)
41. Delvecchio C, Brizuela R, Khan S, Byer K, Li Z, Zhong P, et al. Citrate and vitamin E blunt the shock wave-induced free radical surge in an in vitro cell culture model. Urol Res. 2005 ; 33: 448-452 (Pubitemid 41778786)
42. Bernstein EF, Brown DB, Schwartz MD, Kaidbey K, Ksenzenko SM. The polyhydroxy acid gluconolactone protects against ultraviolet radiation in an in vitro model of cutaneous photoaging. Dermatol Surg. 2004 ; 30: 189-195
43. Murthi SB, Wise RM, Weglicki WB, Komarov AM, Kramer JH. Mg-gluconate provides superior protection against postischemic dysfunction and oxidative injury compared to Mg-sulfate. Mol Cell Biochem. 2003 ; 245: 141-148 (Pubitemid 36416830)