Citrate- vs. acetate-based dialysate in bicarbonate haemodialysis: Consequences on haemodynamics, coagulation, acid-base status, and electrolytes

BMC Nephrology

Volumn 10, Issue 1, 2009, Pages

  Gabutti, Luca ^a   Lucchini, Barbara ^a   Marone, Claudio ^b   Alberio, Lorenzo ^c   Burnier, Michel ^d  

^a Ospedale La Carita   (Switzerland)

^b OSPEDALE SAN GIOVANNI   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; BICARBONATE; CALCIUM; CITRIC ACID; ELECTROLYTE; ACETIC ACID DERIVATIVE; HEMODIALYSIS FLUID; PHOSPHATE;

ACID BASE BALANCE; ADULT; AGED; ARTICLE; BLOOD CLOTTING; CALCIUM BALANCE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIALYSATE; FEMALE; HEART STROKE VOLUME; HEMODIALYSIS; HEMODIALYSIS PATIENT; HEMODYNAMICS; HUMAN; HYPERTENSION; MALE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SYSTOLIC BLOOD PRESSURE; VASCULAR RESISTANCE; BLOOD; DRUG EFFECT; METHODOLOGY; MIDDLE AGED; RENAL REPLACEMENT THERAPY; UREA NITROGEN BLOOD LEVEL;

ACETATES; ACID-BASE EQUILIBRIUM; AGED; AGED, 80 AND OVER; BICARBONATES; BLOOD COAGULATION; BLOOD UREA NITROGEN; CALCIUM; CITRIC ACID; CROSS-OVER STUDIES; ELECTROLYTES; FEMALE; HEMODIALYSIS SOLUTIONS; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; PHOSPHATES; RENAL DIALYSIS; SINGLE-BLIND METHOD;

EID: 62749144504     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/1471-2369-10-7     Document Type: Article

References (27)

1. Dialysate made from dry chemicals using citric acid increases dialysis dose. S Ahmad R Callan JJ Cole CR Blagg, Am J Kidney Dis 2000 35 493 499 10.1016/S0272-6386(00)70203-4 10692276
2. Heparin-free hemodialysis with citrate-containing dialysate in intensive care patients. A Tu S Ahmad, Neph Dial Transplant 2000 29 620 626
3. Increased dialyzer reuse with citrate dialysate. S Ahmad R Callan J Cole C Blagg, Hemodial Int 2005 9 264 267 10.1111/j.1492-7535.2005.01140.x 16191076
4. Citrate for long-term hemodialysis: prospective study of 1,009 consecutive high-flux treatments in 59 patients. R Apsner H Buchmayer D Gruber G Sunder-Plassmann, Am J Kidney Dis 2005 45 557 564 10.1053/j.ajkd.2004.12.002 15754278
5. Regional citrate anticoagulation for hemodialysis in the patient at high risk for bleeding. RV Pinnick TB Wiegmann DA Diederich, N Engl J Med 1983 308 258 61 6848936
6. Citrate kinetics in patients long-term hemodialysis therapy. E Bauer K Derfler C Joukhdar W Druml, Am J Kidney Dis 2005 46 903 907 10.1053/j.ajkd.2005. 07.041 16253731
7. Citrate anticoagulation in continuous venovenous hemodiafiltration: a metabolic challenge. L Gabutti C Marone G Colucci F Duchini C Schönholzer, Intensive Care Med 2002 28 1419 1425 10.1007/s00134-002-1443-y 12373466
8. Does monitoring of pre-/post-dialyzer pressure difference improve efficiency in intermittent hemodialysis? L Gabutti G Colucci A Martella C Schönholzer C Marone, Blood Purif 2003 21 294 300 10.1159/000072548 12944729
9. The favorable effect of regional citrate anticoagulation on interleukin-1beta release is dissociated from both coagulation and complement activation. L Gabutti N Ferrari G Mombelli F Keller C Marone, J Nephrol 2004 17 819 825 15593057
10. Heparin and its biocompatibility. JC Stiekema, Clin Nephrol 1986 26 S3 8 2435441
11. Effect of thrombosis on complement activation and neutrophil degranulation during in vitro hemodialysis. AK Cheung B Faezi-Jenkin JK Leypoldt, J Am Soc Nephrol 1994 5 110 115 10.1159/000106705 7948777
12. Reduction of granulocyte activation during hemodialysis with regional citrate anticoagulation: dissociation of complement activation and neutropenia from neutrophil degranulation. J Böhler P Schollmeyer B Dressel G Dobos W Hörl, J Am Soc Nephrol 1996 7 234 241 8785392
13. Effect of anticoagulation on blood membrane interactions during hemodialysis. R Hofbauer D Moser M Frass R Oberbauer AD Kaye O Wagner S Kapiotis W Druml, Kidney Int 1999 56 1578 1583 10.1046/j.1523-1755.1999.00671.x 10504511
14. Low polymorphonuclear cell degranulation during citrate anticoagulation: a comparison between citrate and heparin dialysis. JC Bos MP Grooteman AJ Van Houte M Schoorl J Van Limbeek MJ Nube, Nephrol Dial Transplant 1997 12 1387 1393 10.1093/ndt/12.7.1387 9249774
15. Effect of regional citrate anticoagulation on leukopenia, complement activation and expression of leukocyte surface molecules during hemodialysis with unmodified cellulose membranes. A Dhondt R Vanholder C Tielemans G Glorieux MA Waterloos R De Smet N Lameire, Nephron 2000 85 334 342 10.1159/000045683 10940744
16. Activation of coagulation during treatment with hemodialysis. PC Bartels M Schoorl JG Wiering MJ Nube, Scand J Clin Lab Invest 2000 60 283 290 10.1080/003655100750046440 10943598
17. Dialysis leukopenia, hypoxemia and anaphylatoxin formation: effect of membrane, bath and citrate anticoagulation. TB Wiegmann ML McDougall DA Diederich, Am J Kidney Dis 1988 11 418 424 3259402
18. Essentials of anticoagulation in hemodialysis. KG Fischer, Hemodial Int 2007 11 178 189 10.1111/j.1542-4758.2007.00166.x 17403168
19. The effect on blood pressure of an acute fall in ionized calcium during hemodialysis. A randomized study in two patients. M Kaye M Vasilevsky M Ketis, Clin Nephrol 1998 50 361 366 9877109
20. Effect of dialysate calcium concentrations on intradialytic blood pressure course in cardiac-compromised patients. FM Van der Sande EC Cheriex WHM Van Kuijk KML Leunissen, Am J Kidney Dis 1998 32 125 131 10.1053/ajkd.1998.v32. pm9669433 9669433
21. Ionized calcium plays a pivotal role in controlling blood pressure during haemodialysis. KML Leunissen BW Van den Berg JP van Hooff, Blood Purif 1989 7 233 239 10.1159/000169600 2803704
22. The effect of dialysate calcium levels on blood pressure during hemodialysis. RA Sherman GB Bialy B Gazinski AS Bernholc RP Eisinger, Am J Kidney Dis 1986 8 244 247 3532771
23. Blood pressure response to changes in serum ionized calcium during hemodialysis. JC Maynard C Cruz M Kleerekoper NW Levin, Ann Intern Med 1986 104 358 361 3946979
24. Does Bicarbonate transfer have relevant hemodynamic consequences in standard hemodialysis? L Gabutti V Ross F Duchini G Mombelli C Marone, Blood Purif 2005 23 365 372 10.1159/000087193 16088104
25. Unexpected haemodynamic instability associated with standard bicarbonate haemodialysis. L Gabutti N Ferrari G Giudici G Mombelli C Marone, Nephrol Dial Transplant 2003 18 2369 2376 10.1093/ndt/gfg383 14551368
26. Measurement of fibrinopeptide A in human blood. HL Nossel I Yudelman RE Canfield VP Butler K Spanondis GD Wilner GD Qureshi, J Clin Invest 1974 54 43 53 4600045 10.1172/JCI107749
27. The effect of correction of metabolic acidosis on nitrogen and potassium balance of patients with chronic renal failure. NJ Papadoyannakis CJ Stefanidis M McGeown, Am J Clin Nutr 1984 40 623 627 6089541