Is dietary fat, vitamin D, or folate associated with pancreatic cancer?

Molecular Carcinogenesis

Volumn 51, Issue 1, 2012, Pages 119-127

  Sanchez, G V ^a,b   Weinstein, S J ^a   Stolzenberg Solomon, R Z ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Dietary fat; Folate; Nutritional risk factors; Pancreatic cancer; Vitamin D

Indexed keywords

FOLIC ACID; VITAMIN D;

ALCOHOL CONSUMPTION; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INCIDENCE; CANCER RISK; CELL ADHESION; CELL DIFFERENTIATION; CIGARETTE SMOKING; CONFIDENCE INTERVAL; DIABETES MELLITUS; DNA REPLICATION; FAT INTAKE; FOLIC ACID BLOOD LEVEL; GENE EXPRESSION; HAZARD RATIO; HUMAN; OBESITY; PANCREAS CANCER; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK; RISK FACTOR; SMOKING;

DIET; DIETARY FATS; FOLIC ACID; HUMANS; PANCREATIC NEOPLASMS; RISK FACTORS; VITAMIN D;

EID: 83455198184     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20833     Document Type: Article

References (63)

1. American Institute for Cancer Research. WCRF/AICR food, nutrition, physical activity, and the prevention of cancer: A global perspective. Washington, DC: American Institute for Cancer Research; 2007.
2. Ghadirian P, Lynch HT, Krewski D. Epidemiology of pancreatic cancer: An overview. Cancer Detect Prev 2003; 27: 87-93.
3. Woutersen RA, Appel MJ, van Garderen-Hoetmer A, Wijnands MV. Dietary fat and carcinogenesis. Mutat Res 1999; 443: 111-127.
4. Tucker ON, Dannenberg AJ, Yang EK, Fahey TJ. Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines. Carcinogenesis 2004; 25: 419-423.
5. Vessby B. Dietary fat and insulin action in humans. Br J Nutr 2000; 83: S91-S96.
6. López S, Bermúdez B, Pacheco YM, et al. Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: Monounsaturated compared with saturated fatty acids. Am J Clin Nutr 2008; 88: 638-644.
7. Vessby B, Uusitupa M, Hermansen K, et al. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia 2001; 44: 312-319.
8. Huxley R, Ansary-Moghaddam A, Berrington deGonzalez A, Barzi F, Woodward M. Type-II diabetes and pancreatic cancer: A meta-analysis of 36 studies. Br J Cancer 2005; 92: 2076-2083.
9. Ben Q, Xu M, Ning X, et al. Diabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies. Eur J Cancer 2011; DOI: 10.1016/j.ejca.2011.03.003.
10. Zhang J, Zhao Z, Berkel HJ. Animal fat consumption and pancreatic cancer incidence: Evidence of interaction with cigarette smoking. Ann Epidemiol 2005; 15: 500-508.
11. Ghadirian P, Thouez JP, PetitClerc C. International comparisons of nutrition and mortality from pancreatic cancer. Cancer Detect Prev 1991; 15: 357-362.
12. Chan JM, Wang F, Holly EA. Pancreatic cancer, animal protein and dietary fat in a population-based study, San Francisco Bay Area, California. Cancer Causes Control 2007; 18: 1153-1167.
13. Zhang J, Dhakal IB, Gross MD, et al. Physical activity, diet, and pancreatic cancer: A population-based, case-control study in Minnesota. Nutr Cancer 2009; 61: 457-465.
14. Gong Z, Holly EA, Wang F, Chan JM, Bracci PM. Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area. Int J Cancer 2010; 127: 1893-1904.
15. Nkondjock A, Krewski D, Johnson KC, Ghadirian P. Specific fatty acid intake and the risk of pancreatic cancer in Canada. Br J Cancer 2005; 92: 971-977.
16. Nöthlings U, Wilkens LR, Murphy SP, et al. Meat and fat intake as risk factors for pancreatic cancer: The multiethnic cohort study. J Natl Cancer Inst 2005; 97: 1458-1465.
17. Stolzenberg-Solomon RZ, Pietinen P, Taylor PR, Virtamo J, Albanes D. Prospective study of diet and pancreatic cancer in male smokers. Am J Epidemiol 2002; 155: 783-792.
18. Thiébaut ACM, Jiao L, Silverman DT, et al. Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study. J Natl Cancer Inst 2009; 101: 1001-1011.
19. Michaud DS, Giovannucci E, Willett WC, Colditz GA, Fuchs CS. Dietary meat, dairy products, fat, and cholesterol and pancreatic cancer risk in a prospective study. Am J Epidemiol 2003; 157: 1115-1125.
20. Heinen MM, Verhage BAJ, Goldbohm RA, van den Brandt PA. Meat and fat intake and pancreatic cancer risk in the Netherlands Cohort Study. Int J Cancer 2009; 125: 1118-1126.
21. Howe GR, Ghadirian P, Bueno deMesquita HB, et al. A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme. Int J Cancer 1992; 51: 365-372.
22. Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know. J Clin Endocrinol Metab 2011; 96: 53-58.
23. Bulathsinghala P, Syrigos KN, Saif MW. Role of vitamin d in the prevention of pancreatic cancer. J Nutr Metab 2010; 2010: 721365.
24. Schwartz GG, Eads D, Rao A, et al. Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3. Carcinogenesis 2004; 25: 1015-1026.
25. Persons KS, Eddy VJ, Chadid S, et al. Anti-growth effect of 1, 25-dihydroxyvitamin D3-3-bromoacetate alone or in combination with 5-amino-imidazole-4-carboxamide-1-beta-4-ribofuranoside in pancreatic cancer cells. Anticancer Res 2010; 30: 1875-1880.
26. Schwartz GG, Eads D, Naczki C, et al. 19-nor-1 alpha, 25-dihydroxyvitamin D2 (paricalcitol) inhibits the proliferation of human pancreatic cancer cells in vitro and in vivo. Cancer Biol Ther 2008; 7: 430-436.
27. Yu W, Ma Y, Flynn G, et al. Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system. Cell Cycle 2010; 9: 3022-3029.
28. Maestro B, Dávila N, Carranza MC, Calle C. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol 2003; 84: 223-230.
29. Stolzenberg-Solomon RZ, Graubard BI, Chari S, et al. Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers. JAMA 2005; 294: 2872-2878.
30. Boscoe FP, Schymura MJ. Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993-2002. BMC Cancer 2006; 6: 264.
31. Kinoshita S, Wagatsuma Y, Okada M. Geographical distribution for malignant neoplasm of the pancreas in relation to selected climatic factors in Japan. Int J Health Geogr 2007; 6: 34.
32. Grant WB. An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer 2002; 94: 1867-1875.
33. NCI: Cancer Mortality Maps and Graphs. Available at: [Accessed March 25, 2011].
34. Mohr SB, Garland CF, Gorham ED, Grant WB, Garland FC. Ultraviolet B irradiance and vitamin D status are inversely associated with incidence rates of pancreatic cancer worldwide. Pancreas 2010; 39: 669-674.
35. Neale RE, Youlden DR, Krnjacki L, Kimlin MG, van der Pols JC. Latitude variation in pancreatic cancer mortality in Australia. Pancreas 2009; 38: 387-390.
36. Zablotska LB, Gong Z, Wang F, Holly EA, Bracci PM. Vitamin D, calcium, and retinol intake, and pancreatic cancer in a population-based case-control study in the San Francisco Bay area. Cancer Causes Control 2011; 22: 91-100.
37. Skinner HG, Michaud DS, Giovannucci E, et al. Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomarkers Prev 2006; 15: 1688-1695.
38. Giovannucci E, Liu Y, Rimm EB, et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006; 98: 451-459.
39. Bao Y, Ng K, Wolpin BM, et al. Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies. Br J Cancer 2010; 102: 1422-1427.
40. Stolzenberg-Solomon RZ, Vieth R, Azad A, et al. A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers. Cancer Res 2006; 66: 10213-10219.
41. Stolzenberg-Solomon RZ, Hayes RB, Horst RL, et al. Serum vitamin D and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian screening trial. Cancer Res 2009; 69: 1439-1447.
42. Stolzenberg-Solomon RZ, Jacobs EJ, Arslan AA, et al. Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol 2010; 172: 81-93.
43. Hofmann JN, Yu K, Horst RL, Hayes RB, Purdue MP. Long-term variation in serum 25-hydroxyvitamin D concentration among participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cancer Epidemiol Biomarkers Prev 2010; 19: 927-931.
44. Jorde R, Sneve M, Hutchinson M, et al. Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study. Am J Epidemiol 2010; 171: 903-908.
45. Holick MF. Vitamin D status: Measurement, interpretation, and clinical application. Ann Epidemiol 2009; 19: 73-78.
46. Zhou C, Verma S, Blumberg B. The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. Nucl Recept Signal 2009; 7: e001.
47. Dietrich M, Brown CJP, Block G. The effect of folate fortification of cereal-grain products on blood folate status, dietary folate intake, and dietary folate sources among adult non-supplement users in the United States. J Am Coll Nutr 2005; 24: 266-274.
48. Kim Y. Folic acid fortification and supplementation-Good for some but not so good for others. Nutr Rev 2007; 65: 504-511.
49. Kim Y. Role of folate in colon cancer development and progression. J Nutr 2003; 133: 3731S-3739S.
50. Larsson SC, Giovannucci E, Wolk A. Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: A meta-analysis. Gastroenterology 2006; 131: 1271-1283.
51. Song J, Medline A, Mason JB, Gallinger S, Kim YI. Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse. Cancer Res 2000; 60: 5434-5440.
52. Mason JB, Dickstein A, Jacques PF, et al. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: A hypothesis. Cancer Epidemiol Biomarkers Prev 2007; 16: 1325-1329.
53. Cole BF, Baron JA, Sandler RS, et al. Folic acid for the prevention of colorectal adenomas: A randomized clinical trial. JAMA 2007; 297: 2351-2359.
54. Jaszewski R, Misra S, Tobi M, et al. Folic acid supplementation inhibits recurrence of colorectal adenomas: A randomized chemoprevention trial. World J Gastroenterol 2008; 14: 4492-4498.
55. Wu K, Platz EA, Willett WC, et al. A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma. Am J Clin Nutr 2009; 90: 1623-1631.
56. Stolzenberg-Solomon RZ, Pietinen P, Barrett MJ, et al. Dietary and other methyl-group availability factors and pancreatic cancer risk in a cohort of male smokers. Am J Epidemiol 2001; 153: 680-687.
57. Larsson SC, Håkansson N, Giovannucci E, Wolk A. Folate intake and pancreatic cancer incidence: A prospective study of Swedish women and men. J Natl Cancer Inst 2006; 98: 407-413.
58. Oaks BM, Dodd KW, Meinhold CL, et al. Folate intake, post-folic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr 2010; 91: 449-455.
59. Skinner HG, Michaud DS, Giovannucci EL, et al. A prospective study of folate intake and the risk of pancreatic cancer in men and women. Am J Epidemiol 2004; 160: 248-258.
60. Keszei AP, Verhage BAJ, Heinen MM, Goldbohm RA, van den Brandt PA. Dietary folate and folate vitamers and the risk of pancreatic cancer in the Netherlands cohort study. Cancer Epidemiol Biomarkers Prev 2009; 18: 1785-1791.
61. Stolzenberg-Solomon RZ, Albanes D, Nieto FJ, et al. Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers. J Natl Cancer Inst 1999; 91: 535-541.
62. Schernhammer E, Wolpin B, Rifai N, et al. Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts. Cancer Res 2007; 67: 5553-5560.
63. Chuang S, Stolzenberg-Solomon R, Ueland PM, et al. A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. Eur J Cancer 2011; DOI: 10.1016/j.ejca.2011.02.007.