Local control of experimental malignant pancreatic tumors by treatment with a combination of chemotherapy and intratumoral 224Radium-loaded wires releasing alpha-emitting atoms

Translational Research

Volumn 159, Issue 1, 2012, Pages 32-41

  Horev Drori, Galit ^a   Cooks, Tomer ^a   Bittan, Hadas ^a   Lazarov, Elinor ^a   Schmidt, Michael ^a   Arazi, Lior ^a,b   Efrati, Margalit ^a   Kelson, Itzhak ^a,b   Keisari, Yona ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b Althera Medical   (Israel)

Author keywords

5 fluorouracil; 5 FU; DaRT; diffusing alpha emitters radiation therapy; DMEM; double strand breaks; DSB; Dulbecco's modified eagle medium; LET; linear energy transfer; OD; optical density; PBS; phosphate buffered saline; SCC; single stranded break; squamous cell carcinoma; SSB

Indexed keywords

EBEWE; FLUOROURACIL; GEMCITABINE; RADIUM 224; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOM; AUTORADIOGRAPHY; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DOSIMETRY; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS TUMOR; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VOLUME;

EID: 83455163747     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2011.08.009     Document Type: Article

References (53)

1. D.A. Mulford, D.A. Scheinberg, and J.C. Jurcic The promise of targeted alpha-particle therapy J Nucl Med 46 2005 199S 204S
2. K.M. Prise, G. Schettino, M. Folkard, and K.D. Held New insights on cell death from radiation exposure Lancet Oncol 6 2005 520 528 (Pubitemid 40903633)
3. J.C. Roeske, and T.G. Stinchcomb The average number of alpha-particle hits to the cell nucleus required to eradicate a tumour cell population Phys Med Biol 51 2006 N179 N186
4. S. Nilsson, R.H. Larsen, and S.D. Fossa First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases Clin Cancer Res 11 2005 4451 4459 (Pubitemid 40834252)
5. L. Arazi, T. Cooks, M. Schmidt, Y. Keisari, and I. Kelson Treatment of solid tumours by interstitial release of recoiling short-lived alpha emitters Phys Med Biol 52 2007 5025 5042 (Pubitemid 47232303)
6. T. Cooks, L. Arazi, and M. Schmidt Growth retardation and destruction of experimental Squamous cell carcinoma by interstitial radioactive wires releasing diffusing alpha-emitting atoms Int J Cancer 122 2008 1657 1664 (Pubitemid 351294977)
7. T. Cooks, L. Arazi, and M. Efrati Interstitial wires releasing diffusing alpha-emitters combined with chemotherapy improved local tumor control and survival in squamous cell carcinoma bearing mice Cancer 115 2009 1791 1801
8. T. Cooks, M. Schmidt, and H. Bittan Local control of lung derived tumors by diffusing alpha-emitting atoms released from intratumoral wires loaded with Radium-224 Int J Radiat Oncol Biol Phys 74 2009 966 973
9. A. Jemal, R. Siegel, and E. Ward Cancer statistics, 2006 CA Cancer J Clin 56 2006 106 130
10. Pancreatic Cancer, Cancer research, UK. Available at: http://www.cancerhelp.org.uk.
11. R. Freelove, and A.D. Walling Pancreatic cancer: diagnosis and management Am Fam Physician 73 2006 485 492 (Pubitemid 43211735)
12. H.R. Cardenes, E.G. Chiorean, J. DeWitt, M. Schmidt, and P. Loehrer Locally advance pancreatic cancer: current therapeutic approach Oncologist 11 2006 612 623 (Pubitemid 43967616)
13. R. Willkowski, M. Thoma, C. Bruns, A. Wagner, and V. Heinemann Chemotherapy with gemcitabine and continuous 5-FU in patients with primary inoperable pancreatic cancer JOP 7 2006 349 360 (Pubitemid 44083106)
14. D.P. Eisenberg, P.S. Adusmilli, and K.J. Hendershott 5-fluorouracil and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer J Gastrointest Surg 9 2005 1068 1079 (Pubitemid 41564102)
15. C.H. Crane, J.L. Abbruzzese, and D.B. Evans Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer? Int J Radiat Oncol Biol Phys 52 2002 1293 1302 (Pubitemid 34302881)
16. T.M. Cardillo, R. Blumenthal, Z. Ying, and D.V. Gold Combined gencitabine and radioimmunotherapy for the treatment of pancreatic cancer Int J Cancer 97 2002 386 392 (Pubitemid 34049033)
17. J.P. Hoffman, S. Lipsitz, and T. Pisansky Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas: an Eastern Cooperative Oncology Group Study J Clin Oncol 16 1998 317 323 (Pubitemid 28041615)
18. C.J.A. van Moorsel, H.M. Pinedo, and G. Veerman Scheduling of gemcitabine and cisplatin in lewis lung tumour bearing mice Eur J Cancer 35 1999 808 814 (Pubitemid 29258152)
19. Y. Keisari A colorimetric microtiter assay for the quantitation of cytokine activity on adherent cells in tissue culture J Immunol Meth 146 1992 155 161
20. P. Ghaneh, R. Smith, C. Tudor-Smith, M. Raraty, and J.P. Neoptolemos Neoadjuvant and adjuvant strategies for pancreatic cancer Eur J Surg Oncol 34 2008 297 305 (Pubitemid 351312868)
21. W.M. Saif Pancreatic cancer: highlights from the 42nd annual meeting of the American society of clinical oncology, 2006 JOP 7 2006 337 348
22. L.M. Passeto, A. Jirillo, M. Stefani, and S. Monfardini Old and new drugs in systemic therapy of pancreatic cancer Crit Rev Oncol Hematol 49 2004 135 151 (Pubitemid 38175440)
23. H.A. Burris III, M.J. Moore, and J. Andersen Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial J Clin Oncol 15 1997 2403 2413 (Pubitemid 27251144)
24. T.C. Chua, and A. Saxena Preoperative chemoradiation followed by surgical resection for resectable pancreatic cancer: a review of current results Surg Oncol 2011 Jun 23 [Epub ahead of print]
25. G. Boz, A. De Paoli, R. Innocente, and C. Rossi Radiotherapy and continuous infusion 5-fluorouracil in patients with nonresectable pancreatic carcinoma Int J Radiat Oncol Biol Phys 51 2001 736 740
26. C.C. Pan, and J.A. Hayman Recent advances in radiation oncology J Neuro-Ophthalmol 24 2004 251 257 (Pubitemid 39181033)
27. J.F. Williamson Brachytherapy technology and physics practice since 1950: a half-century of progress Phys Med Biol 51 2006 R303 R325
28. W.U. Shipley, G.L. Nardi, A.M. Cohen, and C.C. Ling Iodine-125 implant and external beam irradiation in patients with localized pancreatic carcinoma: a comparative study to surgical resection Cancer 45 1980 709 714 (Pubitemid 10174613)
29. M. Morrow, B. Hilaris, and M.F. Brennan Comparison of conventional surgical resection, radioactive implantation, and bypass procedures for exocrine carcinoma of the pancreas, 1975-1980 Ann Surg 199 1984 1 5 (Pubitemid 14218866)
30. T. Peretz, D. Nori, and B. Hilaris Treatment of primary unresectable carcinoma of the pancreas with I-125 implantation Int J Radiat Oncol Biol Phys 17 1989 931 935 (Pubitemid 19279494)
31. D. Nori, O. Merimsky, and A.D. Osian Palladium-103: a new radioactive source in the treatment of unresectable carcinoma of the pancreas: a phase I-II study J Surg Oncol 61 1996 300 305 (Pubitemid 26117640)
32. A. Raben, B. Mychalczak, and M.F. Brennan Feasibility study of the treatment of primary unresectable carcinoma of the pancreas with PD-103 brachytherapy Int J Radiat Oncol Biol Phys 35 1996 351 356
33. R.R. Dobelbower, and P. Montemaggi Brachytherapy for pancreatic cancer: a review Hepatogastroenterology 43 1996 333 337 (Pubitemid 26111953)
34. Z. Takácsi-Nagy, J. Varga, and I. Poller Successful treatment of a T1 cancer of the pancreatic head with high dose rate brachytherapy and external radiotherapy Hepatogastroenterology 49 2002 844 846 (Pubitemid 34615362)
35. J. King, R. Quinn, and D.M. Glenn Radioembolization with selective internal radiation microspheres for neuroendocrine liver metastases Cancer 113 2008 921 929
36. W. Hofmann, H. Fakir, I. Aubineau-Laniece, and P. Pihet Interaction of alpha particles at the cellular level-implications for the radiation weighting factor Radiat Prot Dosimetry 112 2004 493 500 (Pubitemid 40185867)
37. E.C. Halperin Particle therapy and treatment of cancer, Historical Review Lancet Oncol 7 2006 676 685 (Pubitemid 44143779)
38. M. Chérel, F. Davodeau, F. Kraeber-Bodéré, and J.F. Chatal Current status and perspectives in alpha radioimmunotherapy Q J Nucl Med Mol Imaging 50 2006 322 329 (Pubitemid 46157613)
39. T.C. Karagiannis Comparison of different classes of radionuclides for potential use in radioimmunotherapy Hell J Nucl Med 10 2007 82 88 (Pubitemid 47342270)
40. M.W. Brechbiel Targeted alpha-therapy: past, present, future? Dalton Trans 43 2007 4918 4928
41. 223Ra: adjuvant or alternative to conventional modalities? Clin Cancer Res 12 2006 6250s 6257s (Pubitemid 44703798)
42. C.J. McGinn, D.S. Shewach, and T.S. Lawrence Radiosensitizing nucleosides-Review J Natl Cancer Inst 88 1996 1193 1203
43. B. Pauwels, A.E.C. Korst, F. Lardon, and J.B. Vermorken Combined modality therapy of gemcitabine and radiation Oncologist 10 2005 34 51 (Pubitemid 40171250)
44. D.S. Shewach, and T.S. Lawrence Antimetabolite radiosensitizers J Clin Oncol 25 2007 4043 4050 (Pubitemid 47492948)
45. T.S. Lawrence, E.Y. Chang, T.M. Hahn, L.W. Hertel, and D.S. Shewach Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro- 2′-deoxycytidine Int J Radiat Oncol Biol Phys 34 1996 867 872
46. J.W.G. van Putten, H.J.M. Groen, K. Smid, G.J. Peters, and H.H. Kampinga End- joining deficiency and radiosensitization induced by gemcitabine Cancer Res 61 2001 1585 1591 (Pubitemid 34292591)
47. D.S. Shewach, and T.S. Lawrence Gemcitabine and radiosensitization in human tumor cells Invest New Drugs 14 1996 257 263 (Pubitemid 26383939)
48. J.F. Rosier, M. Beauduin, and M. Bruniaux The effect of 2′-2′ difluorodeoxycytidine (dFdC, gemcitabine) on radiation-induced cell lethality in two human head and neck squamous carcinoma cell lines differing in intrinsic radiosensitivity Int J Radiat Biol 75 1999 245 251 (Pubitemid 29089164)
49. V.K. Sangar, R. Cowan, G.P. Margison, J.H. Hendry, and N.W. Clarke An evaluation of gemcitabines differential radiosensitising effect in related bladder cancer cell lines Br J Cancer 26 90 2004 542 548 (Pubitemid 38250656)
50. T.S. Lawrence, A. Eisbruch, and C.J. McGinn Radiosensitization by gemcitabine Oncology 13 1999 55 60
51. T.H. Doyle, F. Mornex, and W.G. McKenna The clinical implications of gemcitabine radiosensitization Clin Cancer Res 7 2001 226 228 (Pubitemid 32183022)
52. S. Supiot, F. Thillays, and E. Rio Gemcitabine radiosensitizes multiple myeloma cells to low LET, but not high LET, irradiation Radiother Oncol 83 2007 97 101 (Pubitemid 46527946)
53. 224Ra-loaded sources - internal dosimetry analysis Phys Med Biol 55 2010 1203 1218