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Volumn 14, Issue 3, 1996, Pages 257-263

Gemcitabine and radiosensitization in human tumor cells

Author keywords

Chemotherapy; Gemcitabine; Human tumor cells; Radiation; Radiosensitization

Indexed keywords

ANTINEOPLASTIC AGENT; GEMCITABINE; RIBONUCLEOTIDE REDUCTASE;

EID: 0029805849     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00194528     Document Type: Review
Times cited : (77)

References (52)
  • 1
    • 0025978216 scopus 로고
    • A phase I clinical, plasma and cellular pharmacology study of gemcitabine
    • Abbruzzese JL, Grunewald R, Weeks EA et al.: A phase I clinical, plasma and cellular pharmacology study of gemcitabine. J Clin Oncol 9:491-498, 1991
    • (1991) J Clin Oncol , vol.9 , pp. 491-498
    • Abbruzzese, J.L.1    Grunewald, R.2    Weeks, E.A.3
  • 2
    • 0026441565 scopus 로고
    • Difluorodeoxycytidine (dFdC)-gemcitabine. A phase I study
    • Poplin EA, Corbett T, Flaherty L et al.: Difluorodeoxycytidine (dFdC)-gemcitabine. A phase I study. Invest New Drugs 10:165-170, 1992
    • (1992) Invest New Drugs , vol.10 , pp. 165-170
    • Poplin, E.A.1    Corbett, T.2    Flaherty, L.3
  • 3
    • 0027399764 scopus 로고
    • Clinical and preclinical activity of 2′,2′difluorodeoxycytidine (gemcitabine)
    • Lund B, Kristjansen PEG, Hansen HH: Clinical and preclinical activity of 2′,2′difluorodeoxycytidine (gemcitabine). Cancer Treat Rev 19:45-55, 1993
    • (1993) Cancer Treat Rev , vol.19 , pp. 45-55
    • Lund, B.1    Kristjansen, P.E.G.2    Hansen, H.H.3
  • 4
    • 0023935362 scopus 로고
    • Synthesis of 2-deoxy-2,2-difluoro-D-ribose and 2-deoxy-2,2-difluoro-D-ribofuranosyl nucleosides
    • Hertel LW, Kroin JS, Misner JW, Tustin JM: Synthesis of 2-deoxy-2,2-difluoro-D-ribose and 2-deoxy-2,2-difluoro-D-ribofuranosyl nucleosides. J Org Chem 53:2406-2409, 1988
    • (1988) J Org Chem , vol.53 , pp. 2406-2409
    • Hertel, L.W.1    Kroin, J.S.2    Misner, J.W.3    Tustin, J.M.4
  • 5
    • 0025325071 scopus 로고
    • Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′deoxycytidine)
    • Hertel LW, Boder GB, Kroin JS et al.: Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′deoxycytidine). Cancer Res 50:4417-4422, 1990
    • (1990) Cancer Res , vol.50 , pp. 4417-4422
    • Hertel, L.W.1    Boder, G.B.2    Kroin, J.S.3
  • 6
    • 0023783698 scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 2′2′-difluorodeoxycytidine and 1-Darabinofuranosylcytosine
    • Heinemann B, Hertel LW, Grindey GB, Plunkett W: Comparison of the cellular pharmacokinetics and toxicity of 2′2′-difluorodeoxycytidine and 1-Darabinofuranosylcytosine. Cancer Res 48:4024-4031, 1988
    • (1988) Cancer Res , vol.48 , pp. 4024-4031
    • Heinemann, B.1    Hertel, L.W.2    Grindey, G.B.3    Plunkett, W.4
  • 7
    • 8944226829 scopus 로고
    • Evaluation of the antitumor activity of gemcitabine against human carcinoma xenografts
    • Merriman RL, Schultz RM, Hertel LW et al.: Evaluation of the antitumor activity of gemcitabine against human carcinoma xenografts. Proc Am Assoc Cancer Res 35:448, 1994
    • (1994) Proc Am Assoc Cancer Res , vol.35 , pp. 448
    • Merriman, R.L.1    Schultz, R.M.2    Hertel, L.W.3
  • 8
    • 0010436605 scopus 로고
    • Improved antitumor effect of 2′,2′-difluorodeoxycytidine (Gemcitabine) in murine colon carcinomas, when administered as continuous infusions
    • Ruiz van Haperen VWT, Veerman G, Vermorken JB, Peters GJ: Improved antitumor effect of 2′,2′-difluorodeoxycytidine (Gemcitabine) in murine colon carcinomas, when administered as continuous infusions. Proc Am Assoc Cancer Res 35:447, 1994
    • (1994) Proc Am Assoc Cancer Res , vol.35 , pp. 447
    • Ruiz Van Haperen, V.W.T.1    Veerman, G.2    Vermorken, J.B.3    Peters, G.J.4
  • 9
    • 0025977171 scopus 로고
    • Preclinical in vivo activity of 2′,2′-difluorodeoxycytidine (gemcitabine) against human head and neck cancer
    • Braakhuis BJM, Dongen GAMS, Vermorken JB, Snow GB: Preclinical in vivo activity of 2′,2′-difluorodeoxycytidine (gemcitabine) against human head and neck cancer. Cancer Res 51:211-214, 1994
    • (1994) Cancer Res , vol.51 , pp. 211-214
    • Braakhuis, B.J.M.1    Dongen, G.A.M.S.2    Vermorken, J.B.3    Snow, G.B.4
  • 10
    • 0026550270 scopus 로고
    • Gemcitabine in leukemia: A phase I clinical, plasma, and cellular pharmacology study
    • Grunewald R, Kantarjian H, Du M et al.: Gemcitabine in leukemia: a phase I clinical, plasma, and cellular pharmacology study. J Clin Oncol 10:406-413, 1992
    • (1992) J Clin Oncol , vol.10 , pp. 406-413
    • Grunewald, R.1    Kantarjian, H.2    Du, M.3
  • 12
    • 0028022127 scopus 로고
    • Gemcitabine: Current status of phase I and II trials
    • Kaye SB: Gemcitabine: current status of phase I and II trials. J Clin Oncol 12:1527-1531, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 1527-1531
    • Kaye, S.B.1
  • 13
    • 0006564732 scopus 로고
    • Phase I/II study of gemcitabine, an active agent for advanced non-small cell lung cancer(NSCLC)
    • abstr1144
    • Fossella FV, Lippman SM, Tarassoff P: Phase I/II study of gemcitabine, an active agent for advanced non-small cell lung cancer(NSCLC). Proc Am Soc Clin Oncol 14:371 (abstr1144), 1995
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 371
    • Fossella, F.V.1    Lippman, S.M.2    Tarassoff, P.3
  • 14
    • 0028799915 scopus 로고    scopus 로고
    • Advanced breast cancer: A phase II trial with gemcitabine
    • in press
    • Carmichael J, Possinger K, Phillip P et al.: Advanced breast cancer: a phase II trial with gemcitabine. J Clin Oncol (in press)
    • J Clin Oncol
    • Carmichael, J.1    Possinger, K.2    Phillip, P.3
  • 15
    • 0028020890 scopus 로고
    • Phase II study of gemcitabine (2′ ,2′-difluorodeoxycytidine) in previously treated ovarian cancer
    • Lund B, Hansen OP, Theilade K et al.: Phase II study of gemcitabine (2′ ,2′-difluorodeoxycytidine) in previously treated ovarian cancer. J Nat Cancer Inst 86:1530-1533, 1994
    • (1994) J Nat Cancer Inst , vol.86 , pp. 1530-1533
    • Lund, B.1    Hansen, O.P.2    Theilade, K.3
  • 16
    • 0000635437 scopus 로고
    • A randomized trial of gemcitabine (GEM) versus 5FU as first-line therapy in advanced pancreatic cancer
    • abstr 473
    • Moore M, Andersen J, Burris H et al.: A randomized trial of gemcitabine (GEM) versus 5FU as first-line therapy in advanced pancreatic cancer. Proc Am Soc Clin Oncol 14:199(abstr 473), 1995
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 199
    • Moore, M.1    Andersen, J.2    Burris, H.3
  • 17
    • 0028033227 scopus 로고
    • Single-agent activity of weekly gemcitabine in advanced non-small cell lung cancer. A phase II study
    • Anderson H, Lund B, Bach F et al.: Single-agent activity of weekly gemcitabine in advanced non-small cell lung cancer. A phase II study. J Clin Oncol 12:1821-1826, 1994
    • (1994) J Clin Oncol , vol.12 , pp. 1821-1826
    • Anderson, H.1    Lund, B.2    Bach, F.3
  • 18
    • 0016184503 scopus 로고
    • X-ray sensitization by halopyrimidines
    • Szybalski W: X-ray sensitization by halopyrimidines. Cancer Chemother Reports 58:539-557, 1974
    • (1974) Cancer Chemother Reports , vol.58 , pp. 539-557
    • Szybalski, W.1
  • 19
    • 0022498513 scopus 로고
    • The potentiation of radiation response on murine tumor by fludarabine phosphate
    • Kim JH, Alfieri AA, Kim SH, Fuks Z: The potentiation of radiation response on murine tumor by fludarabine phosphate. Cancer Lett 31:69-76, 1986
    • (1986) Cancer Lett , vol.31 , pp. 69-76
    • Kim, J.H.1    Alfieri, A.A.2    Kim, S.H.3    Fuks, Z.4
  • 20
    • 0023749583 scopus 로고
    • Differences in inhibition by betaarabinofuranosyladenine (araA) of radiation induced DNA damage repair in exponentially growing and plateau-phase CHO cells
    • Iliakis G, Seaner P: Differences in inhibition by betaarabinofuranosyladenine (araA) of radiation induced DNA damage repair in exponentially growing and plateau-phase CHO cells. Radiat Environ Biol Phys 27:295-305, 1988
    • (1988) Radiat Environ Biol Phys , vol.27 , pp. 295-305
    • Iliakis, G.1    Seaner, P.2
  • 21
    • 0025651424 scopus 로고
    • Fluorodeoxyuridine-induced radiosensitization and inhibition of NA double strand break repair in human colon cancer cells
    • Bruso CE, Shewac DS, Lawrence TS: Fluorodeoxyuridine-induced radiosensitization and inhibition of NA double strand break repair in human colon cancer cells. Int J Radiat Oncol Biol Phys 19:1411-1417, 1990
    • (1990) Int J Radiat Oncol Biol Phys , vol.19 , pp. 1411-1417
    • Bruso, C.E.1    Shewac, D.S.2    Lawrence, T.S.3
  • 22
    • 0027976379 scopus 로고
    • Potentiation of radiation-induced regrowth delay in murine tumors by fludarabine
    • Gregoire V, Hunter N, Milas L et al.: Potentiation of radiation-induced regrowth delay in murine tumors by fludarabine. Cancer Res 54:468-474, 1994
    • (1994) Cancer Res , vol.54 , pp. 468-474
    • Gregoire, V.1    Hunter, N.2    Milas, L.3
  • 23
    • 0026984625 scopus 로고
    • Effect of 2′,2′-difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro
    • Rockwell S, Grindey GB: Effect of 2′,2′-difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro. Oncol Res 4:151-155, 1992
    • (1992) Oncol Res , vol.4 , pp. 151-155
    • Rockwell, S.1    Grindey, G.B.2
  • 24
    • 0028240063 scopus 로고
    • Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells
    • Shewach DS, Hahn TM, Chang E et al.: Metabolism of 2′,2′-difluoro-2′-deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Res 54:3218-3223, 1994
    • (1994) Cancer Res , vol.54 , pp. 3218-3223
    • Shewach, D.S.1    Hahn, T.M.2    Chang, E.3
  • 25
    • 0028105119 scopus 로고
    • Schedule dependence of sensitivity to 2′,2′-difluorodeoxycytidine (gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumor cell lines and solid tumors
    • Ruiz van Haperen VWT, Veerman G, Boven E et al.: Schedule dependence of sensitivity to 2′,2′-difluorodeoxycytidine (gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumor cell lines and solid tumors. Biochem Pharmacol 48:1327-1339, 1994
    • (1994) Biochem Pharmacol , vol.48 , pp. 1327-1339
    • Ruiz Van Haperen, V.W.T.1    Veerman, G.2    Boven, E.3
  • 26
    • 0028067217 scopus 로고
    • Development and molecular characterization of a 2′,2′-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780
    • Ruiz van Haperen VWT, Veerman G, Eriksson S et al.: Development and molecular characterization of a 2′,2′-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780. Cancer Res 54:4138-4143, 1994
    • (1994) Cancer Res , vol.54 , pp. 4138-4143
    • Ruiz Van Haperen, V.W.T.1    Veerman, G.2    Eriksson, S.3
  • 28
    • 0025089191 scopus 로고
    • Pharmacologically directed design of the dose rate and schedule of 2′,2′-difluorodeoxycytidine (gemcitabine) administration in leukemia
    • Grunewald R, Kanatarjian H, Keating MJ et al.: Pharmacologically directed design of the dose rate and schedule of 2′,2′-difluorodeoxycytidine (gemcitabine) administration in leukemia. Cancer Res 50:6823-6826, 1990
    • (1990) Cancer Res , vol.50 , pp. 6823-6826
    • Grunewald, R.1    Kanatarjian, H.2    Keating, M.J.3
  • 29
    • 0026101039 scopus 로고
    • Saturation of 2′,2′-difluorodeoxycytidine 5′-triphosphate accumulation by mononuclear cells during aphase I trial of gemcitabine
    • Grunewald R, Abbruzzese JL, Tarassoff P, Plunkett W: Saturation of 2′,2′-difluorodeoxycytidine 5′-triphosphate accumulation by mononuclear cells during aphase I trial of gemcitabine. Cancer Chemother Pharmacol 27:285-292, 1991
    • (1991) Cancer Chemother Pharmacol , vol.27 , pp. 285-292
    • Grunewald, R.1    Abbruzzese, J.L.2    Tarassoff, P.3    Plunkett, W.4
  • 30
    • 0026571795 scopus 로고
    • Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: A mechanism of self-potentiation
    • Heinemann V, Xu Y-Z, Chubb S et al.: Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: a mechanism of self-potentiation. Cancer Res 52:53-539, 1991
    • (1991) Cancer Res , vol.52 , pp. 53-539
    • Heinemann, V.1    Xu, Y.-Z.2    Chubb, S.3
  • 31
    • 0026440509 scopus 로고
    • Modulation of deoxycytidylate deaminase in intact human leukemia cells. Action of 2′,2′-difluorodeoxycytidine
    • Xu Y-Z, Plunkett W: Modulation of deoxycytidylate deaminase in intact human leukemia cells. Action of 2′,2′-difluorodeoxycytidine. Biochem Pharmacol 44:1819-1827, 1992
    • (1992) Biochem Pharmacol , vol.44 , pp. 1819-1827
    • Xu, Y.-Z.1    Plunkett, W.2
  • 32
    • 0027180521 scopus 로고
    • ′,2′-difluorodeoxycytidine (gemcitabine) incorporation into RNA and DNA of tumor cell lines
    • Ruiz van Haperen VWT, Veerman G, Vermorken JB, Peters GJ: ′,2′-difluorodeoxycytidine (gemcitabine) incorporation into RNA and DNA of tumor cell lines. Biochem Pharmacol 46:762-766, 1993
    • (1993) Biochem Pharmacol , vol.46 , pp. 762-766
    • Ruiz Van Haperen, V.W.T.1    Veerman, G.2    Vermorken, J.B.3    Peters, G.J.4
  • 33
    • 0026324313 scopus 로고
    • Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
    • Huang P, Chubb S, Hertel LW et al.: Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res 51:6110-6117, 1991
    • (1991) Cancer Res , vol.51 , pp. 6110-6117
    • Huang, P.1    Chubb, S.2    Hertel, L.W.3
  • 34
    • 0028062981 scopus 로고
    • Molecular effects of 2′,2′-difluorodeoxycytidine (gemcitabine) on DNA replication in intact HL-60 cells
    • Ross DD, Cuddy DP: Molecular effects of 2′,2′-difluorodeoxycytidine (gemcitabine) on DNA replication in intact HL-60 cells. Biochem Pharmacol 48:1619-1630, 1994
    • (1994) Biochem Pharmacol , vol.48 , pp. 1619-1630
    • Ross, D.D.1    Cuddy, D.P.2
  • 35
    • 0027429568 scopus 로고
    • Effect of a template-located 2′,2′-difluorodeoxycytidine on the kinetics and fidelity of base insertion by Klenow (3′-5′exonuclease) fragment
    • Schy WE, Hertel LW, Kroin JS et al.: Effect of a template-located 2′,2′-difluorodeoxycytidine on the kinetics and fidelity of base insertion by Klenow (3′-5′exonuclease) fragment. Cancer Res 53:4582-4587, 1993
    • (1993) Cancer Res , vol.53 , pp. 4582-4587
    • Schy, W.E.1    Hertel, L.W.2    Kroin, J.S.3
  • 36
    • 0025049372 scopus 로고
    • Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine
    • Heinemann V, Xu Y-Z, Chubb S, Sen A et al.: Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine. Mol Pharmacol 38:567-572, 1990
    • (1990) Mol Pharmacol , vol.38 , pp. 567-572
    • Heinemann, V.1    Xu, Y.-Z.2    Chubb, S.3    Sen, A.4
  • 37
    • 0025737572 scopus 로고
    • 2′-Deoxy-2′-methylenecytidine and 2′-deoxy-2′,2′difluorocytidine 5′-diphosphates: Potent mechanism-based inhibitors of ribonucleotide reductase
    • Baker CH, Banzon J, Bollinger JM: 2′-Deoxy-2′-methylenecytidine and 2′-deoxy-2′,2′difluorocytidine 5′-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase. J Med Chem 34:1879-1884. 1991
    • (1991) J Med Chem , vol.34 , pp. 1879-1884
    • Baker, C.H.1    Banzon, J.2    Bollinger, J.M.3
  • 38
    • 0024987021 scopus 로고
    • Ribonucleotide reductases
    • Stubbe J: Ribonucleotide reductases. Adv Enzymol 63:349-419, 1990
    • (1990) Adv Enzymol , vol.63 , pp. 349-419
    • Stubbe, J.1
  • 39
    • 0017728872 scopus 로고
    • The effects of incorporation of 5-halogenated deoxyuridines into the DNA of eukaryotic cells
    • Goz B: The effects of incorporation of 5-halogenated deoxyuridines into the DNA of eukaryotic cells. Pharmacol Rev 29:249-272, 1978
    • (1978) Pharmacol Rev , vol.29 , pp. 249-272
    • Goz, B.1
  • 41
    • 0025128324 scopus 로고
    • The effect of single versus double-strand substitution on halogenated pyrimidine-induced radiosensitization and DNA strand breakage in human tumor cells
    • Lawrence TS, Davis MA, Stetson PL, Ensminger WD: The effect of single versus double-strand substitution on halogenated pyrimidine-induced radiosensitization and DNA strand breakage in human tumor cells. Radiat Res 123:192-198, 1990
    • (1990) Radiat Res , vol.123 , pp. 192-198
    • Lawrence, T.S.1    Davis, M.A.2    Stetson, P.L.3    Ensminger, W.D.4
  • 42
    • 0026593802 scopus 로고
    • Decrease in TTP pools mediated by 5-bromo-2′-deoxyuridine exposure in a human glioblastoma cell line
    • Shewach DS, Ellero J, Mancini WR, Ensminger WD: Decrease in TTP pools mediated by 5-bromo-2′-deoxyuridine exposure in a human glioblastoma cell line. Biochem Pharmacol 43:1579-1585, 1992
    • (1992) Biochem Pharmacol , vol.43 , pp. 1579-1585
    • Shewach, D.S.1    Ellero, J.2    Mancini, W.R.3    Ensminger, W.D.4
  • 43
    • 34447489921 scopus 로고
    • The combined effect of hydroxyurea and X-rays on Chinese hamster cells in vitro
    • Sinclair WK: The combined effect of hydroxyurea and X-rays on Chinese hamster cells in vitro. Cancer Res 28:190-196, 1992
    • (1992) Cancer Res , vol.28 , pp. 190-196
    • Sinclair, W.K.1
  • 44
    • 34447490379 scopus 로고
    • Depletion of dNTP pools and radiosensitization by difluorodeoxycytidine in HT-29 colon carcinoma cells
    • Shewach DS, Hahn T, Chang EY et al.: Depletion of dNTP pools and radiosensitization by difluorodeoxycytidine in HT-29 colon carcinoma cells. Proc Am Assoc Cancer Res 34:418, 1993
    • (1993) Proc Am Assoc Cancer Res , vol.34 , pp. 418
    • Shewach, D.S.1    Hahn, T.2    Chang, E.Y.3
  • 45
    • 34447489554 scopus 로고    scopus 로고
    • Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′deoxycytidine
    • in press
    • Lawrence TS, Chang EY, Hahn TM et al.: Radiosensitization of pancreatic cancer cells by 2′,2′-difluoro-2′deoxycytidine. Radiat Res (in press)
    • Radiat Res
    • Lawrence, T.S.1    Chang, E.Y.2    Hahn, T.M.3
  • 46
    • 0002309215 scopus 로고
    • Variations in several responses of HeLa cells to X-irradiation during the division cycle
    • Terasima T, Tolmach LJ: Variations in several responses of HeLa cells to X-irradiation during the division cycle. Biophys J 3:11-33, 1963
    • (1963) Biophys J , vol.3 , pp. 11-33
    • Terasima, T.1    Tolmach, L.J.2
  • 47
    • 0015429015 scopus 로고
    • Changes in radiosensitivity and dispersion of chromatin during the cell cycle of synchronous Chinese hamster cells
    • Dewey WC, Noel JS, Dettor CM: Changes in radiosensitivity and dispersion of chromatin during the cell cycle of synchronous Chinese hamster cells. Radiat Res 52:373-394, 1972
    • (1972) Radiat Res , vol.52 , pp. 373-394
    • Dewey, W.C.1    Noel, J.S.2    Dettor, C.M.3
  • 48
    • 0023947934 scopus 로고
    • Variation through the cell cycle in the dose-response of DNA neutral filter elution in X-irradiated synchronous CHO-cells
    • Okayasu R, Bloecher D, Iliakis G: Variation through the cell cycle in the dose-response of DNA neutral filter elution in X-irradiated synchronous CHO-cells. Int J Radial Biol 53:729-747, 1988
    • (1988) Int J Radial Biol , vol.53 , pp. 729-747
    • Okayasu, R.1    Bloecher, D.2    Iliakis, G.3
  • 49
    • 0013635636 scopus 로고
    • Sensitivity to mitotic delay and stage in the cycle
    • Sinclair WK: Sensitivity to mitotic delay and stage in the cycle. Curr Topics Radiat Res 7:323-327, 1972
    • (1972) Curr Topics Radiat Res , vol.7 , pp. 323-327
    • Sinclair, W.K.1
  • 50
    • 34447489637 scopus 로고
    • Radiosensitization of HT-29 human colon carcinoma cells after 2 hours exposure to difluorodeoxycytidine
    • Shewach DS, Hahn TM, Chang E et al.: Radiosensitization of HT-29 human colon carcinoma cells after 2 hours exposure to difluorodeoxycytidine. Proc Am Assoc Cancer Res 36:405, 1995
    • (1995) Proc Am Assoc Cancer Res , vol.36 , pp. 405
    • Shewach, D.S.1    Hahn, T.M.2    Chang, E.3
  • 51
    • 0001107308 scopus 로고
    • Cisplatin-gemcitabine combination in non-small cell lung cancer (NSCLC). A phase II study
    • abstr 1066
    • Crino L, Scagliotti G, Marangolo M et al.: Cisplatin-gemcitabine combination in non-small cell lung cancer (NSCLC). A phase II study. Proc Am Soc Clin Oncol 14:352 (abstr 1066), 1995
    • (1995) Proc Am Soc Clin Oncol , vol.14 , pp. 352
    • Crino, L.1    Scagliotti, G.2    Marangolo, M.3
  • 52
    • 0021985620 scopus 로고
    • A pilot study of protracted venous infusion of 5-fluorouracil and concomitant radiation therapy
    • Rich TA, Lokich JJ, Chaffey JT: A pilot study of protracted venous infusion of 5-fluorouracil and concomitant radiation therapy. J Clin Oncol 3:402-406, 1985
    • (1985) J Clin Oncol , vol.3 , pp. 402-406
    • Rich, T.A.1    Lokich, J.J.2    Chaffey, J.T.3


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