Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas: An Eastern Cooperative Oncology Group Study

Journal of Clinical Oncology

Volumn 16, Issue 1, 1998, Pages 317-323

  Hoffman, John P ^a   Lipsitz, Stuart ^b   Pisansky, Thomas ^b   Weese, James L ^b   Solin, Lawrence ^b   Benson III, Al B ^b  

^a FOX CHASE CANCER CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; MITOMYCIN;

ADULT; ADVANCED CANCER; AGED; ANGINA PECTORIS; ARTICLE; BILE DUCT OBSTRUCTION; BLOOD TOXICITY; CANCER LOCALIZATION; CANCER SURVIVAL; CHOLANGITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GASTROINTESTINAL SYMPTOM; HEART ATRIUM FIBRILLATION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LUNG FIBROSIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTICENTER STUDY; PANCREAS ADENOCARCINOMA; PANCREAS RESECTION; PANCREATICODUODENECTOMY; PHASE 2 CLINICAL TRIAL; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; STENT;

EID: 0031972708     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1998.16.1.317     Document Type: Article

References (21)

1. Weese JL, Nussbaum ML, Paul AR, et al: Increased resectability of locally advanced pancreatic and periampullary carcinoma with neoadjuvant chemoradiotherapy. Int J Pancreatol 7:177-185, 1990
2. Hoffman JP, Weese JL, Solin LJ, et al: A pilot study of preoperative chemoradiation for patients with localized adenocarcinoma of the pancreas. Am J Surg 169:71-78, 1995
3. Evans DB, Byrd DR, Mansfield PF: Preoperative chemoradiotherapy for adenocarcinoma of the pancreas: Rationale and techniques. Am J Clin Oncol 14:359-364, 1991
4. Beahrs OH, Henson DE, Hutter RVP, et al: Manual for Staging of Cancer (ed 3). American Joint Committee on Cancer. Philadelphia, PA, Lippincott, 1988
5. Cox DR: Analysis of Binary Data. London, England, Chapman and Hall, 1970
6. Mehta CR, Patel NR, Tsatis AA: Exact significance testing to establish treatment equivalence with ordered categorical data. Biometrics 40:819-825, 1984
7. Kaplan EL, Meier P: Nonparametric estimation of incomplete observations. J Am Stat Assoc 53:457-481, 1958
8. Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Reports 50:163-170, 1966
9. Freeny PC, Traverso LW, Ryan JA: Diagnosis and staging of pancreatic adenocarcinoma with dynamic computed tomography. Am J Surg 165:600-606, 1993
10. Warshaw AL, Gu Z, Wittenberg J, et al: Preoperative staging and assessment of resectability of pancreatic cancer. Arch Surg 125:230-233, 1990
11. Fernandez-del Castillo C, Rattner DW, Warshaw AL: Further experience with laparoscopy and peritoneal cytology in the staging of pancreatic cancer. B J Surg 82:1127-1129, 1995
12. Fuhrman GM, Charnsangavej C, Abbruzzese JL, et al: Thin-section contrast-enhanced computed tomography accurately predicts the resectability of malignant pancreatic neoplasms. Am J Surg 167:104-113, 1994
13. Ichikawa T, Haradome H, Hachiya J, et al: Pancreatic ductal adenocarcinoma: Preoperative assessment with helical CT versus dynamic MR imaging. Radiology 202:655-662, 1997
14. Nitecki SS, Sarr MG, Colby TV, et al: Long-term survival after resection for ductal adenocarcinoma of the pancreas. Is it really improving? Ann Surg 221:59-66, 1995
15. Carducci MA, Abrams RA, Yeo CJ, et al: Early evaluation of abdominal/hepatic irradiation and 5-fluorouracil infusion after pancreati-coduodenectomy. Int J Radiat Oncol Biol Phys 35:143-150, 1996
16. Conlon KC, Klimstra DS, Brennan MF: Long-term survival after curative resection for pancreatic ductal adenocarcinoma. Clinicopathologic analysis of 5-year survivors. Ann Surg 223:273-279, 1996
17. Whittington R, Bryer MP, Haller DG, et al: Adjuvant therapy of resected adenocarcinoma of the pancreas. Int J Radiat Oncol Biol Phys 21:1137-1143, 1991
18. Staley CA, Lee JE, Cleary KR, et al: Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head. Am J Surg 171:118-125, 1996
19. Klempmauer J, Ridder GJ, Bektas H, et al: Extended resections of ductal pancreatic cancer - impact on operative risk and prognosis. Oncology 53:47-53, 1996
20. Yeo CJ, Cameron JL, Lillimoe KD, et al: Pancreaticoduodenectomy for cancer of the head of the pancreas. Ann Surg 221:721-733, 1995
21. Geer RJ, Brennan MF: Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg 165:68-73, 1993