The effect of 2'-2' difluorodeoxycytidine (dFdC, gemcitabine) on radiation-induced cell lethality in two human head and neck squamous carcinoma cell lines differing in intrinsic radiosensitivity

International Journal of Radiation Biology

Volumn 75, Issue 2, 1999, Pages 245-251

  Rosier, J F ^a   Beauduin, M ^b   Bruniaux, M ^b   De Bast, M ^a   De Coster, B ^a   Octave Prignot, M ^a   Scalliet, P ^a   Gregoire V ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b Hospital de Jolimont   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GEMCITABINE;

ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; HEAD CANCER; HUMAN; HUMAN CELL; INCUBATION TIME; MULTIMODALITY CANCER THERAPY; NECK CANCER; PRIORITY JOURNAL; RADIATION RESPONSE; RADIOSENSITIVITY; RADIOSENSITIZATION; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL DEATH; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; HEAD AND NECK NEOPLASMS; HUMANS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED;

EID: 0033028180     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530099140708     Document Type: Article

References (32)

1. ELSHAIKH, M., HUNTER, N., MILAS, L., HITTELMAN, W. N., ANG, K. K. and MASON, K., 1997, Time dependent modulation of jejunal radioresponse with Gemcitabine. Proceedings of the 45th Annual Meeting of the Radiation Research Society, Chicago, USA, A528.
2. FERTIL, B. and MALAISE, E. P., 1981, Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 7, 621-629.
3. FUJII, T., HUNTER, N., ELSHAIKH, M., HITTELMAN, W. N., PLUNKETT, W., ANG, K. K. and MILAS L., 1997, Gemcitabine improves the therapeutic ratio of radiotherapy in mouse tumours after single dose irradiation. Proceedings of the 45th Annual Meeting of the Radiation Research Society, Chicago, USA, A529.
4. GREGOIRE, V., BEAUDUIN, M., BRUNIAUX, M., DECOSTER, B., OCTAVE, M. and SCALLIET, P., 1998a, Radiosensitization of mouse sarcoma cells by fludarabine (F-ara-A) or gemcitabine (dFdC), two nucleoside analogues, is not mediated by an increased induction or a repair inhibition of DNA double-strand breaks as measured by pulsed-field gel electrophoresis. International Journal of Radiation Biology, 73, 511-520.
5. GREGOIRE, V., BEAUDUIN, M., ROSIER, J.-F., BRUNIAUX, M., DECOSTER, B., OCTAVE, M. and SCALLIET, P., 1997, Kinetics of mouse jejunum radiosensitization by 2′-2′ difluorodeoxycytidine (gemcitabine) and its relationship with pharmacodynamics of DNA synthesis inhibition and cell cycle redistribution in crypt cells. British Journal of Cancer, 76, 1315-1321.
6. GREGOIRE, V., DEBAST, M., ROSIER, J.-F., BEAUDUIN, M., BRUNIAUX, M., DECOSTER, B. and SCALLIET, P., 1998b, Relationship between deoxycytidine kinase (dck) activity and dck over deoxycytidine deaminase activity ratio, and radiosensitization by fludarabine and gemcitabine. Proceedings of American Association for Cancer Research, 39, A2597.
7. GREGOIRE, V. and HITTELMAN, W. N., 1997, Nucleoside analogs as radiosensitizing agents. In Nucleoside Analogs in Cancer Therapy, edited by B. D. Cheson, M. J. Keating and W. Plunkett (New York: Marcel Dekker), pp. 315-358.
8. GRUNEWALD, R., KANTARIJAN, H., MIN, D., FAUCHER, K., TARASSOFF, P. and PLUNKETT, W., 1992, Gemcitabine in leukemia: a phase I clinical, plasma and pharmacology study. Journal of Clinical Oncology, 10, 406-413.
9. HALL E. J., 1994, Radiosensitivity and cell age in the mitotic cycle. In Radiobiology for the Radiologist, edited by E. J. Hall (Philadelphia: JB Lippincott), pp. 97-98.
10. HEINEMANN, V., XU, Y. Z., CHUBB, S., SEN, A., HERTEL, L. W., GRINDEY, G. B. and PLUNKETT, W., 1992, Cellular elimination of 2′-2′ difluorodeoxycitidine 5′ triphosphate: a mechanism of self-potentiation. Cancer Research, 52, 533-539.
11. HENGSTSCHLAGER, M., DENK, C. and WAWRA, E., 1993, Cell cycle regulation of deoxycytidine kinase. Evidence for post-transcriptional control. FEB's Letter, 321, 237-240.
12. HERTEL, L. W., BODER, G. B., KROIN, J. S., RINZEL, S. M., POORE, G. A., TODD, G. C. and GRINDEY, G. B., 1990, Evaluation of the antitumor activity of Gemcitabine (2′-2′ difluorodeoxycitidine). Cancer Research, 50, 4417-4422.
13. HUANG, P., CHUBB, S., HERTEL, L. W., GRINDEY, G. B. and PLUNKETT, W., 1991, Action of 2′-2′ difluorodeoxycitidine on DNA synthesis. Cancer Research, 51, 6110-6117.
14. JOSCHKO, M. A., WEBSTER, L. K., GROVES, J., YUEN, K., PALATSIDES, M., BALL, D. L. and MILLWARD, M. J., 1997, Enhancement of radiation-induced regrowth delay by Gemcitabine in a Human Tumor Xenograft Model. Radiation Oncology Investigations, 5, 62-71.
15. LATZ, D., FLECKENSTEIN, K., EBLE, M., BLATTER, J., WANNENMACHER, M. and WEBER, K. J., 1998, Radiosensitizing potential of gemcitabine within the cell cycle in vitro. International Journal of Radiation Oncology, Biology, Physics, 41, 875-882.
16. LAWRENCE, T. S., CHANG, E., HAHN, T. M., HERTEL, L. W. and SHEWACH, D. S., 1996, Radiosensitization of pancreatic cancer cells by 2′-2′ difluoro-2′ deoxycytidine. International Journal of Radiation Oncology, Biology, Physics, 41, 867-872.
17. LAWRENCE, T. S., CHANG, E., HAHN, T. M. and SHEWACH, D. S., 1997, Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2′-2′ difluoro-2′ deoxycytidine (Gemcitabine). Clinical Cancer Research, 3, 777-782.
18. McLARTY, J. W. and THAMES, H. D., 1977, A parametric method for estimation of dose-modifying factors: low-dose extrapolation limit. Radiation Research, 69, 1-15.
19. MULLEN, J., Xu, Y. Z., LEPEK, K., PLUNKETT, W. and RICH, T., 1994, Cytotoxicity and radiosensitization by Gemcitabine in exponential human colon adenocarcinoma cells. Proceedings of the 42nd Annual Meeting of the Radiation Research Society, Nashville, TE, USA, A206.
20. PETERS, G. J. and ACKLAND, S. P., 1996, New antimetabolites in preclinical and clinical development. Experimental Opinion Investigation Drugs, 5, 637-679.
21. PLUNKETT, W., HUANG, P., XU, Y. Z., HEINEMAN, V., GRUNEWALD, R. and GANDHI, V., 1995, Gemcitabine: metabolism, mechanisms of action, and self-potentiation. Seminars in Oncology, 22, 3-10.
22. ROCKWELL, S. and GRINDEY, G. B., 1992, Effect of 2′-2′ difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro. Oncology Research, 4, 151-155.
23. ROSIER, J.-F., BEAUDUIN, M., BRUNIAUX, M., DECOSTER, B., DEBAST, M., SCALLIET, P. and GREGOIRE, V., 1997, The role of gemcitabine-induced cell cycle synchronization in radiosensitization of a radioresistant and a radiosensitive human head and neck squamous cell carcinoma cell lines. European Journal of Cancer, 33, S23-S24.
24. RUIZ VAN HAPPEREN, V. W. T., 1994, Schedule-dependence of sensitivity to 2′-2′ difluoro-deoxycytidine (gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours. Biochemical Pharmacology, 48, 1327-1339.
25. SCHWARTZ, J. L., ROTMENSCH, J., GIOVANAZZI, S. M., COHEN, M. B. and WEICHSELBAUM, R. R., 1988, Faster repair of DNA double strand breaks in radioresistant human tumor cells. International Journal of Radiation Oncology, Biology, Physics, 15, 907-912.
26. SHEWACH, D. S., HAHN, T. M., CHANG, E., HERTEL., H. W. and LAWRENCE, T. S., 1994, Metabolism of 2′-2′ difluoro-2′ deoxycytidine and radiation sensitization of human colon carcinoma cells. Cancer Research, 54, 3218-3223.
27. SHEWACH, D. S. and LAWRENCE, T. S., 1995, Radiosensitization of human tumor cells by gemcitabine in vitro. Seminars in Oncology, 22, 68-71.
28. SMEETS, M. F., MOOREN, E. H., ABDEL-WAHAB, A. H. A., BARTELINK, H. and BEGG, A. C., 1994, Differential repair of radiation induced DNA damage in human squamous carcinoma cells and the effect of caffeine and cysteamine on DNA double strand break induction and repair. Radiation Research, 140, 153-160.
29. SONDAK, V. K., KORN, E. L. and KERN, D. H., 1988, In vitro testing of chemotherapeutic combinations in a rapid thymidine incorporation assay. International Journal of Cell Cloning, 6, 378-391.
30. STEEL, G. G., 1988, The search for therapeutic gain in the combination of radiotherapy and chemotherapy. Radiotherapy and Oncology, 11, 31-53.
31. STEEL, G. G., 1993, Glossary of terms in radiation biology. In Basic Clinical Radiobiology, edited by G. G. Steel (London: Edward Arnold), pp. 225-229.
32. VALERIOTE, F. and HSIU-SAN, L., 1975, Synergistic interaction of anticancer agents: a cellular perspective. Cancer Chemotherapy Reports, 59, 895-900.