메뉴 건너뛰기




Volumn 49, Issue 2, 2004, Pages 135-151

Old and new drugs in systemic therapy of pancreatic cancer

Author keywords

Chemotherapy; Pancreatic cancer; Review

Indexed keywords

2,3,5 TRIMETHYL 6 (3 PYRIDYLMETHYL) 1,4 BENZOQUINONE; AMONAFIDE; ANTINEOPLASTIC AGENT; BATIMASTAT; BORTEZOMIB; CAPECITABINE; CETUXIMAB; CISPLATIN; CYCLOOXYGENASE 2 INHIBITOR; DEOXYCYTIDINE; DIAZIQUONE; DOCETAXEL; DOXORUBICIN; EDATREXATE; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EPIRUBICIN; ERLOTINIB; FLUOROURACIL; FOLIC ACID ANTAGONIST; FOLINIC ACID; GEFITINIB; GEMCITABINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IPROPLATIN; IRINOTECAN; LONAFARNIB; METALLOPROTEINASE INHIBITOR; MITOMYCIN C; PROCARBAZINE; RALTITREXED; RAS PROTEIN; STREPTOZOCIN; TIPIFARNIB; TRIMETREXATE; UFT; UNINDEXED DRUG;

EID: 0842285403     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1040-8428(03)00170-7     Document Type: Review
Times cited : (22)

References (137)
  • 1
    • 0029868667 scopus 로고    scopus 로고
    • National pattern of care for pancreatic cancer: Results of a survey by the commission on cancer
    • Janes R.H., Niederhuber J.E., Chmiel J.S.et al. National pattern of care for pancreatic cancer: results of a survey by the commission on cancer. Ann. Surg. 223:1996;261-272.
    • (1996) Ann. Surg. , vol.223 , pp. 261-272
    • Janes, R.H.1    Niederhuber, J.E.2    Chmiel, J.S.3
  • 2
    • 0026738325 scopus 로고
    • A phase II trial of 5-fluorouracil, leucovorin, and recombinant alpha-2-interferon in advanced adenocarcinoma of pancreas
    • Scheithauer W., Pfeffel F., Kornek G., Marczell A., Wiltschke C., Funovics J. A phase II trial of 5-fluorouracil, leucovorin, and recombinant alpha-2-interferon in advanced adenocarcinoma of pancreas. Cancer. 70:1992;1864-1866.
    • (1992) Cancer , vol.70 , pp. 1864-1866
    • Scheithauer, W.1    Pfeffel, F.2    Kornek, G.3    Marczell, A.4    Wiltschke, C.5    Funovics, J.6
  • 3
    • 0026609861 scopus 로고
    • Phase II trial of PALA in combination with 5-fluorouracil in advanced pancreatic cancer
    • Rosvold E., Schider R., Walczak J.et al. Phase II trial of PALA in combination with 5-fluorouracil in advanced pancreatic cancer. Cancer Chem. Pharm. 29:1992;305-308.
    • (1992) Cancer Chem. Pharm. , vol.29 , pp. 305-308
    • Rosvold, E.1    Schider, R.2    Walczak, J.3
  • 4
    • 0025815267 scopus 로고
    • Lack of efficacy of high dose leucovorin and fluorouracil in patients with advanced pancreatic adenocarcinoma
    • Crown J., Casper E.S., Botet J., Murray P., Kelsen D.P. Lack of efficacy of high dose leucovorin and fluorouracil in patients with advanced pancreatic adenocarcinoma. J. Clin. Oncol. 9:1991;1682-1684.
    • (1991) J. Clin. Oncol. , vol.9 , pp. 1682-1684
    • Crown, J.1    Casper, E.S.2    Botet, J.3    Murray, P.4    Kelsen, D.P.5
  • 5
    • 0027461223 scopus 로고
    • Adjuvant combination chemotherapy (AMF) following radical resection of carcinoma of the pancreas and papilla of Vater: Results of a controlled, prospective randomized multicenter study
    • Bakkevold K.E., Arnesjo B., Dahl O., Kambestad B. Adjuvant combination chemotherapy (AMF) following radical resection of carcinoma of the pancreas and papilla of Vater: results of a controlled, prospective randomized multicenter study. Eur. J. Cancer. 29A:1993;698-703.
    • (1993) Eur. J. Cancer , vol.29 , pp. 698-703
    • Bakkevold, K.E.1    Arnesjo, B.2    Dahl, O.3    Kambestad, B.4
  • 6
    • 84944367593 scopus 로고
    • A comparison of three chemotherapeutic regimens in the treatment of advanced pancreatic and gastric carcinoma. Fluorouracil vs fluorouracil and doxorubicin vs fluorouracil, doxorubicin, and mitomycin
    • Cullinan S.A., Moertel C.G., Fleming T.R.et al. A comparison of three chemotherapeutic regimens in the treatment of advanced pancreatic and gastric carcinoma. Fluorouracil vs fluorouracil and doxorubicin vs fluorouracil, doxorubicin, and mitomycin. JAMA. 253(14):1985;2061-2067.
    • (1985) JAMA , vol.253 , Issue.14 , pp. 2061-2067
    • Cullinan, S.A.1    Moertel, C.G.2    Fleming, T.R.3
  • 7
    • 0000659563 scopus 로고    scopus 로고
    • Five year results of a randomized study of postoperative adjuvant chemotherapy for resected pancreatic biliary carcinomas
    • [abstract 1049]
    • Amano H., Takada T., Kato H.et al. Five year results of a randomized study of postoperative adjuvant chemotherapy for resected pancreatic biliary carcinomas. Proc. Am. Soc. Clin. Oncol. 18:1999;273. [abstract 1049].
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18 , pp. 273
    • Amano, H.1    Takada, T.2    Kato, H.3
  • 8
    • 0021867923 scopus 로고
    • Pancreatic cancer: Adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer
    • Kalser M.H., Ellenberg S.S. Pancreatic cancer: adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Arch. Surg. 120:1985;899.
    • (1985) Arch. Surg. , vol.120 , pp. 899
    • Kalser, M.H.1    Ellenberg, S.S.2
  • 9
    • 0023262033 scopus 로고    scopus 로고
    • Gastrointestinal Tumor Study Group. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection for pancreatic cancer. Cancer 1987;59:2006-10.
    • Gastrointestinal Tumor Study Group. Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection for pancreatic cancer. Cancer 1987;59:2006-10.
  • 10
    • 0023873752 scopus 로고
    • An organized multi-institutional interdisciplinary evaluation of the role of radiation therapy alone or combined with chemotherapy in treatment of adenocarcinoma of the gastrointestinal tract
    • Douglass H.O., Stablein D.M., Thomas P.R.M. An organized multi-institutional interdisciplinary evaluation of the role of radiation therapy alone or combined with chemotherapy in treatment of adenocarcinoma of the gastrointestinal tract. NCI Monogr. 6:1988;253-257.
    • (1988) NCI Monogr. , vol.6 , pp. 253-257
    • Douglass, H.O.1    Stablein, D.M.2    Thomas, P.R.M.3
  • 11
    • 0000867332 scopus 로고    scopus 로고
    • Radiotherapy and 5FU after curative resection for cancer of the pancreas and periampullar region: A phase III trial of the EORTC and GITCCG
    • Klinkenbijl J.H.G., Sahmoud T., Van Pel R. Radiotherapy and 5FU after curative resection for cancer of the pancreas and periampullar region: a phase III trial of the EORTC and GITCCG. Eur. J. Cancer. 33:1997;1239.
    • (1997) Eur. J. Cancer , vol.33 , pp. 1239
    • Klinkenbijl, J.H.G.1    Sahmoud, T.2    Van Pel, R.3
  • 12
    • 0033497862 scopus 로고    scopus 로고
    • Adjuvant radiotherapy and 5FU after curative resection for cancer of the pancreas and periampullar region: Phase III trial of the EORTC Gastrointestinal Tract Cancer Cooperative Group
    • Klinkenbijl J.H.G., Jeekel J., Sahmoud T.et al. Adjuvant radiotherapy and 5FU after curative resection for cancer of the pancreas and periampullar region: phase III trial of the EORTC Gastrointestinal Tract Cancer Cooperative Group. Ann. Surg. 230:1999;776-784.
    • (1999) Ann. Surg. , vol.230 , pp. 776-784
    • Klinkenbijl, J.H.G.1    Jeekel, J.2    Sahmoud, T.3
  • 13
    • 0034333248 scopus 로고    scopus 로고
    • Intensified adjuvant combined modality therapy for resected periampullary adenocarcinoma: Acceptable toxicity and suggestion of improved 1-year disease-free survival
    • Chakravarthy A., Abrams R.A., Yeo C.J.et al. Intensified adjuvant combined modality therapy for resected periampullary adenocarcinoma: acceptable toxicity and suggestion of improved 1-year disease-free survival. Int. J. Radiat. Oncol. Biol. Phys. 48(5):2000;1089-1096.
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.48 , Issue.5 , pp. 1089-1096
    • Chakravarthy, A.1    Abrams, R.A.2    Yeo, C.J.3
  • 14
    • 0042489265 scopus 로고    scopus 로고
    • ESPAC-1: A European, randomized study to assess the roles of adjuvant chemotherapy and chemoradiation in resectable pancreatic cancer
    • [abstract 940]
    • Neoptolemos J.P., Moffitt D.D., Dunn J.A.et al. ESPAC-1: a European, randomized study to assess the roles of adjuvant chemotherapy and chemoradiation in resectable pancreatic cancer. Eur. J. Cancer. 37(suppl 6):2001;253. [abstract 940].
    • (2001) Eur. J. Cancer , vol.37 , Issue.SUPPL. 6 , pp. 253
    • Neoptolemos, J.P.1    Moffitt, D.D.2    Dunn, J.A.3
  • 15
    • 0035841631 scopus 로고    scopus 로고
    • Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: A randomised controlled trial
    • Neoptolemos J.P., Dunn J.A., Stocken D.D.et al. Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial. Lancet. 358(9293):2001;1576-1585.
    • (2001) Lancet , vol.358 , Issue.9293 , pp. 1576-1585
    • Neoptolemos, J.P.1    Dunn, J.A.2    Stocken, D.D.3
  • 16
    • 0034566044 scopus 로고    scopus 로고
    • Adjuvant radiotherapy and concomitant 5 fluorouracil by protracted venous infusion for resected pancreatic cancer
    • Mehta V.K., Fisher G.A., Ford J.M.et al. Adjuvant radiotherapy and concomitant 5 fluorouracil by protracted venous infusion for resected pancreatic cancer. Int. J. Radiat. Oncol. Biol. Phys. 48(5):2000;1483-1487.
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.48 , Issue.5 , pp. 1483-1487
    • Mehta, V.K.1    Fisher, G.A.2    Ford, J.M.3
  • 17
    • 0032791920 scopus 로고    scopus 로고
    • Chemoradiation for pancreatic and biliary cancer: Current status of RTOG studies
    • Rich T.A. Chemoradiation for pancreatic and biliary cancer: current status of RTOG studies. Ann. Oncol. 10(4):1999;231-233.
    • (1999) Ann. Oncol. , vol.10 , Issue.4 , pp. 231-233
    • Rich, T.A.1
  • 18
    • 0034656872 scopus 로고    scopus 로고
    • Interferon-based adjuvant chemoradiation therapy improves survival after pancreaticoduodenectomy for pancreatic adenocarcinoma
    • Nukui Y., Picozzi V.J., Traverso L.W. Interferon-based adjuvant chemoradiation therapy improves survival after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am. J. Surg. 179:2000;367-371.
    • (2000) Am. J. Surg. , vol.179 , pp. 367-371
    • Nukui, Y.1    Picozzi, V.J.2    Traverso, L.W.3
  • 19
    • 0000197226 scopus 로고    scopus 로고
    • Phase II trial of twice-weekly gemcitabine and concurrent radiation for the treatment of resected pancreatic cancer
    • [abstract 2334]
    • Kachnic L.A., Mornex F., Partensky C.et al. Phase II trial of twice-weekly gemcitabine and concurrent radiation for the treatment of resected pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 20:2001;146b. [abstract 2334].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Kachnic, L.A.1    Mornex, F.2    Partensky, C.3
  • 20
    • 0010572842 scopus 로고    scopus 로고
    • A phase I trial of radiation (RT) dose escalation with concurrent full dose gemcitabine following resection of pancreatic cancer
    • [abstract 549]
    • Allen A.M., Zalupski M.M., Eckhauser F.E.et al. A phase I trial of radiation (RT) dose escalation with concurrent full dose gemcitabine following resection of pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 21:2002;138a. [abstract 549].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Allen, A.M.1    Zalupski, M.M.2    Eckhauser, F.E.3
  • 21
    • 0035212974 scopus 로고    scopus 로고
    • Influence of resection margins on survival for patients with pancreatic cancer treated by adjuvant chemoradiation and/or chemotherapy in the ESPAC-1 randomised controlled trial
    • Neoptolemos J.P., Stocken D.D., Dunn J.A.et al. Influence of resection margins on survival for patients with pancreatic cancer treated by adjuvant chemoradiation and/or chemotherapy in the ESPAC-1 randomised controlled trial. Ann. Surg. 234:2001;758-768.
    • (2001) Ann. Surg. , vol.234 , pp. 758-768
    • Neoptolemos, J.P.1    Stocken, D.D.2    Dunn, J.A.3
  • 22
    • 0037606120 scopus 로고    scopus 로고
    • Adjuvant and additive therapy for cancer of the pancreas
    • Neoptolemos J.P., Raraty M.G., Ghaneh P.et al. Adjuvant and additive therapy for cancer of the pancreas. Chirurg. 74(3):2003;191-201.
    • (2003) Chirurg , vol.74 , Issue.3 , pp. 191-201
    • Neoptolemos, J.P.1    Raraty, M.G.2    Ghaneh, P.3
  • 23
    • 0035841605 scopus 로고    scopus 로고
    • Continuing controversy over adjuvant therapy of pancreatic cancer
    • Abrams R.A., Lillemoe K.D., Plantadosi S. Continuing controversy over adjuvant therapy of pancreatic cancer. Lancet. 358:2001;1565-1566.
    • (2001) Lancet , vol.358 , pp. 1565-1566
    • Abrams, R.A.1    Lillemoe, K.D.2    Plantadosi, S.3
  • 24
    • 0032784821 scopus 로고    scopus 로고
    • Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: Survival results and observations regarding patterns of failure, radiotherapy dose and Ca 19-9 levels
    • Abrams R.A., Grochow L.B., Chakravarthly A.et al. Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy dose and Ca 19-9 levels. Int. J. Rad. Oncol. Biol. Phys. 44:1999;1039-1046.
    • (1999) Int. J. Rad. Oncol. Biol. Phys. , vol.44 , pp. 1039-1046
    • Abrams, R.A.1    Grochow, L.B.2    Chakravarthly, A.3
  • 25
    • 0038444003 scopus 로고    scopus 로고
    • Adjuvant therapy in pancreatic cancer: Historical and current perspective
    • Neoptolemos J.P., Cunningham D., Friess H.et al. Adjuvant therapy in pancreatic cancer: historical and current perspective. Ann. Oncol. 14(5):2003;675-692.
    • (2003) Ann. Oncol. , vol.14 , Issue.5 , pp. 675-692
    • Neoptolemos, J.P.1    Cunningham, D.2    Friess, H.3
  • 26
    • 0028120291 scopus 로고
    • Preoperative chemoradiation for adenocarcinoma of the pancreas and duodenum
    • Coia L., Hoffman J., Scher R.et al. Preoperative chemoradiation for adenocarcinoma of the pancreas and duodenum. Int. J. Radiat. Oncol. Biol. Phys. 30:1994;161-167.
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.30 , pp. 161-167
    • Coia, L.1    Hoffman, J.2    Scher, R.3
  • 27
    • 0031886329 scopus 로고    scopus 로고
    • Neoadjuvant chemoradiation for adenocarcinoma of the pancreas
    • Miller A.R., Robinson E.K., Lee J.E.et al. Neoadjuvant chemoradiation for adenocarcinoma of the pancreas. Surg. Oncol. Clin. N. Am. 7:1998;183-197.
    • (1998) Surg. Oncol. Clin. N. Am. , vol.7 , pp. 183-197
    • Miller, A.R.1    Robinson, E.K.2    Lee, J.E.3
  • 28
    • 0030070277 scopus 로고    scopus 로고
    • Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head
    • Staley C.A., Lee J.E., Cleary K.R.et al. Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head. Am. J. Surg. 171:1996;118-125.
    • (1996) Am. J. Surg. , vol.171 , pp. 118-125
    • Staley, C.A.1    Lee, J.E.2    Cleary, K.R.3
  • 29
    • 0031056942 scopus 로고    scopus 로고
    • Preoperative and postoperative chemoradiation strategies in patients with pancreaticoduodenectomy for adenocarcinoma of the pancreas
    • Spitz F.R., Abbruzzese J.L., Lee J.E.et al. Preoperative and postoperative chemoradiation strategies in patients with pancreaticoduodenectomy for adenocarcinoma of the pancreas. J. Clin. Oncol. 15:1997;928-937.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 928-937
    • Spitz, F.R.1    Abbruzzese, J.L.2    Lee, J.E.3
  • 30
    • 0032421150 scopus 로고    scopus 로고
    • Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma
    • Pisters P.W.T., Abbruzzese J.L., Janjan N.A.et al. Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma. J. Clin. Oncol. 16:1998;3843-3850.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 3843-3850
    • Pisters, P.W.T.1    Abbruzzese, J.L.2    Janjan, N.A.3
  • 31
    • 0026454511 scopus 로고
    • Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas
    • Evans D.B., Rich T.A., Byrd D.R.et al. Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. Arch. Surg. 127(11):1992;1335-1339.
    • (1992) Arch. Surg. , vol.127 , Issue.11 , pp. 1335-1339
    • Evans, D.B.1    Rich, T.A.2    Byrd, D.R.3
  • 32
    • 0002994880 scopus 로고
    • Chemoradiation or accelerated fractioned: Basic considerations
    • Rich T.A. Chemoradiation or accelerated fractioned: basic considerations. J. Infusional Chemother. 1:1992;2-8.
    • (1992) J. Infusional Chemother. , vol.1 , pp. 2-8
    • Rich, T.A.1
  • 33
    • 0041988417 scopus 로고    scopus 로고
    • Neoadjuvant radiotherapy: Drugs or rays? Hypo- or hyper-?
    • [abstract 942]
    • Haustermans K. Neoadjuvant radiotherapy: drugs or rays? Hypo- or hyper-? Eur. J. Cancer. 37(suppl 6):2001;254. [abstract 942].
    • (2001) Eur. J. Cancer , vol.37 , Issue.SUPPL. 6 , pp. 254
    • Haustermans, K.1
  • 34
    • 0037092960 scopus 로고    scopus 로고
    • Preoperative paclitaxel and concurrent rapid fractioned radiation for resectable pancreatic adenocarcinoma: Toxicities, histologic response rate, and event-free outcome
    • Pisters P.W., Wolff R.A., Janjan N.A.et al. Preoperative paclitaxel and concurrent rapid fractioned radiation for resectable pancreatic adenocarcinoma: toxicities, histologic response rate, and event-free outcome. J. Clin. Oncol. 20(10):2002;2537-2544.
    • (2002) J. Clin. Oncol. , vol.20 , Issue.10 , pp. 2537-2544
    • Pisters, P.W.1    Wolff, R.A.2    Janjan, N.A.3
  • 35
    • 0035093234 scopus 로고    scopus 로고
    • Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: Treatment variables and survival duration
    • Breslin T.M., Hess K.R., Harbison D.B.et al. Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: treatment variables and survival duration. Ann. Surg. Oncol. 8:2001;123-132.
    • (2001) Ann. Surg. Oncol. , vol.8 , pp. 123-132
    • Breslin, T.M.1    Hess, K.R.2    Harbison, D.B.3
  • 36
    • 0009262434 scopus 로고    scopus 로고
    • Outcomes trial demonstrating a survival advantage of initial chemoradiotherapy for regional pancreatic adenocarcinoma (PCa)
    • [abstract 941]
    • Snady H., Bruckner H., Cooperman A., Paradiso H., Kiefer L. Outcomes trial demonstrating a survival advantage of initial chemoradiotherapy for regional pancreatic adenocarcinoma (PCa). Eur. J. Cancer. 37(suppl 6):2001;253. [abstract 941].
    • (2001) Eur. J. Cancer , vol.37 , Issue.SUPPL. 6 , pp. 253
    • Snady, H.1    Bruckner, H.2    Cooperman, A.3    Paradiso, H.4    Kiefer, L.5
  • 37
    • 0031972708 scopus 로고    scopus 로고
    • Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas: An Eastern Cooperative Oncology Group
    • Hoffman J.P., Lispitz S., Pisansky T., Weese J.L., Solin L., Benson A.B. Phase II trial of preoperative radiation therapy and chemotherapy for patients with localized, resectable adenocarcinoma of the pancreas: an Eastern Cooperative Oncology Group. J. Clin. Oncol. 16(1):1998;317-323.
    • (1998) J. Clin. Oncol. , vol.16 , Issue.1 , pp. 317-323
    • Hoffman, J.P.1    Lispitz, S.2    Pisansky, T.3    Weese, J.L.4    Solin, L.5    Benson, A.B.6
  • 38
    • 0010607413 scopus 로고    scopus 로고
    • Initial results of preoperative gemcitabine (GEM)-based chemoradiation for resectable pancreatic adenocarcinoma
    • [abstract 516]
    • Wolff R.A., Evans D.B., Crane C.H.et al. Initial results of preoperative gemcitabine (GEM)-based chemoradiation for resectable pancreatic adenocarcinoma. Proc. Am. Soc. Clin. Oncol. 21:2002;130. [abstract 516].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 130
    • Wolff, R.A.1    Evans, D.B.2    Crane, C.H.3
  • 39
    • 0009011281 scopus 로고    scopus 로고
    • Neoadjuvant therapy for adenocarcinoma of the pancreas: Histopathologic effect and analysis of outcome
    • [abstract 621]
    • Sasson A.R., Wetherington R.W., Hoffman J.P.et al. Neoadjuvant therapy for adenocarcinoma of the pancreas: histopathologic effect and analysis of outcome. Proc. Am. Soc. Clin. Oncol. 20:2001;156a. [abstract 621].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Sasson, A.R.1    Wetherington, R.W.2    Hoffman, J.P.3
  • 40
    • 0025360261 scopus 로고
    • A phase III trial on the therapy of advanced pancreatic carcinoma. Evaluations of the Mallinson regimen and combined 5-fluorouracil, doxorubicin, and cisplatin
    • Cullinan S., Moertel C.G., Wieand H.S.et al. A phase III trial on the therapy of advanced pancreatic carcinoma. Evaluations of the Mallinson regimen and combined 5-fluorouracil, doxorubicin, and cisplatin. Cancer. 65:1990;220-224.
    • (1990) Cancer , vol.65 , pp. 220-224
    • Cullinan, S.1    Moertel, C.G.2    Wieand, H.S.3
  • 41
    • 0023722682 scopus 로고    scopus 로고
    • Gastrointestinal Tumor Study Group. Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst 1988;80:751-5.
    • Gastrointestinal Tumor Study Group. Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst 1988;80:751-5.
  • 42
    • 0032009833 scopus 로고    scopus 로고
    • Resection of locally advanced pancreatic cancer. After downstaging with continuous infusion 5FU, mitomycin and dipyridamole
    • Todd K.E., Gloor B., Lane J.S., Isacoff W.H., Reber H.A. Resection of locally advanced pancreatic cancer. after downstaging with continuous infusion 5FU, mitomycin and dipyridamole. J. Gastrointest. Surg. 2:1998;159-166.
    • (1998) J. Gastrointest. Surg. , vol.2 , pp. 159-166
    • Todd, K.E.1    Gloor, B.2    Lane, J.S.3    Isacoff, W.H.4    Reber, H.A.5
  • 43
    • 13344286320 scopus 로고    scopus 로고
    • Phase II trial of 5-fluorouracil, leucovorin and cisplatin for treatment of advanced pancreatic adenocarcinoma
    • Andre T., Lotz J., Bouleuc C.et al. Phase II trial of 5-fluorouracil, leucovorin and cisplatin for treatment of advanced pancreatic adenocarcinoma. Ann. Oncol. 7:1996;173-178.
    • (1996) Ann. Oncol. , vol.7 , pp. 173-178
    • Andre, T.1    Lotz, J.2    Bouleuc, C.3
  • 44
    • 0001588594 scopus 로고    scopus 로고
    • Efficacy of 5FU + cisplatin compared to bolus 5FU in advanced pancreatic carcinoma: A randomized trial from the French Anticancer Digestive Group
    • [abstract 1114]
    • Rougier P., Ducreux M., Douillard J.et al. Efficacy of 5FU + cisplatin compared to bolus 5FU in advanced pancreatic carcinoma: a randomized trial from the French Anticancer Digestive Group. Proc. Am. Soc. Clin. Oncol. 18:1999;274a. [abstract 1114].
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18
    • Rougier, P.1    Ducreux, M.2    Douillard, J.3
  • 45
    • 0003288198 scopus 로고    scopus 로고
    • Randomized phase II study of oxaliplatin alone (OXA), 5fluorouracil (5FU) alone and the two drugs combined (OXA-FU) in advanced or metastatic pancreatic adenocarcinoma (APC)
    • [abstract 1018]
    • Rougier P., Ducreux M., Ould Kaci M.et al. Randomized phase II study of oxaliplatin alone (OXA), 5fluorouracil (5FU) alone and the two drugs combined (OXA-FU) in advanced or metastatic pancreatic adenocarcinoma (APC). Proc. Am. Soc. Clin. Oncol. 9:2000;262a. [abstract 1018].
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.9
    • Rougier, P.1    Ducreux, M.2    Ould Kaci, M.3
  • 46
    • 0026102652 scopus 로고
    • Chemotherapy in pancreatic cancer: A rational pursuit?
    • Wils J.A. Chemotherapy in pancreatic cancer: a rational pursuit? Anticancer Drugs. 2(1):1991;3-10.
    • (1991) Anticancer Drugs , vol.2 , Issue.1 , pp. 3-10
    • Wils, J.A.1
  • 47
    • 0019410935 scopus 로고
    • Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5FU), and high dose radiation + 5FU: The Gastrointestinal Tumor Study Group
    • Moertel C.G., Frytak S., Hahn R.G.et al. Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5FU), and high dose radiation + 5FU: the Gastrointestinal Tumor Study Group. Cancer. 48(8):1981;1705-1710.
    • (1981) Cancer , vol.48 , Issue.8 , pp. 1705-1710
    • Moertel, C.G.1    Frytak, S.2    Hahn, R.G.3
  • 48
  • 49
    • 0024216472 scopus 로고
    • Ifosfamide and mesna: Marginally active in patients with advanced carcinoma of the pancreas
    • Ajani J.A., Abbruzzese J.L., Goudeau P.et al. Ifosfamide and mesna: marginally active in patients with advanced carcinoma of the pancreas. J. Clin. Oncol. 6:1988;1703-1709.
    • (1988) J. Clin. Oncol. , vol.6 , pp. 1703-1709
    • Ajani, J.A.1    Abbruzzese, J.L.2    Goudeau, P.3
  • 50
    • 0026483768 scopus 로고
    • Phase II evaluation of iproplatin in patients with advanced gastric and pancreatic cancer
    • Hubbard K.P., Pazdur R., Ajani J.A.et al. Phase II evaluation of iproplatin in patients with advanced gastric and pancreatic cancer. Am. J. Clin. Oncol. 15:1992;524.
    • (1992) Am. J. Clin. Oncol. , vol.15 , pp. 524
    • Hubbard, K.P.1    Pazdur, R.2    Ajani, J.A.3
  • 51
    • 0008896559 scopus 로고
    • Phase II study of trimetrexate glucoronate in the treatment of advanced cancer of the pancreas
    • Shimoto G.M., Kuo S., Wade J.et al. Phase II study of trimetrexate glucoronate in the treatment of advanced cancer of the pancreas. Proc. Am. Soc. Clin. Oncol. 11:1992;184.
    • (1992) Proc. Am. Soc. Clin. Oncol. , vol.11 , pp. 184
    • Shimoto, G.M.1    Kuo, S.2    Wade, J.3
  • 52
    • 0027056402 scopus 로고
    • Phase II trial of edatrexate in patients with advanced pancreatic cancer
    • Casper E.S., Schwartz G.K., Johnson B., Kelsen D.P. Phase II trial of edatrexate in patients with advanced pancreatic cancer. Invest New Drugs. 10:1992;313-316.
    • (1992) Invest New Drugs , vol.10 , pp. 313-316
    • Casper, E.S.1    Schwartz, G.K.2    Johnson, B.3    Kelsen, D.P.4
  • 53
    • 0027511139 scopus 로고
    • Evaluation of combination chemotherapy and phase II agents in pancreatic adenocarcinoma: A Southwest Oncology Group Study
    • Bukowski R.M., Wolf M., Kulander B.G., Montie J., Crawford E.D., Blumenstein B. Evaluation of combination chemotherapy and phase II agents in pancreatic adenocarcinoma: a Southwest Oncology Group Study. Cancer. 71:1993;322-326.
    • (1993) Cancer , vol.71 , pp. 322-326
    • Bukowski, R.M.1    Wolf, M.2    Kulander, B.G.3    Montie, J.4    Crawford, E.D.5    Blumenstein, B.6
  • 54
    • 0026355178 scopus 로고
    • Phase II trial of amonafide in advanced pancreatic adenocarcinoma
    • Linke K., Pazdur R., Abbruzzese J.et al. Phase II trial of amonafide in advanced pancreatic adenocarcinoma. Invest New Drugs. 9:1991;353-358.
    • (1991) Invest New Drugs , vol.9 , pp. 353-358
    • Linke, K.1    Pazdur, R.2    Abbruzzese, J.3
  • 56
    • 0019208060 scopus 로고
    • Chemotherapy in pancreatic cancer: Results from a controlled, prospective, randomized, multicenter trial
    • Mallinson C.N., Rake M.O., Cocking J.B.et al. Chemotherapy in pancreatic cancer: results from a controlled, prospective, randomized, multicenter trial. Br. Med. J. 281:1980;1589-1591.
    • (1980) Br. Med. J. , vol.281 , pp. 1589-1591
    • Mallinson, C.N.1    Rake, M.O.2    Cocking, J.B.3
  • 58
    • 0000025839 scopus 로고    scopus 로고
    • Randomized phase II trial of dose intense gemcitabine by standard infusion versus fixed dose rate in metastatic pancreatic adenocarcinoma
    • [abstract 1048]
    • Tempero M., Plumkett W., Ruiz Van Haperen V.et al. Randomized phase II trial of dose intense gemcitabine by standard infusion versus fixed dose rate in metastatic pancreatic adenocarcinoma. Proc. Am. Soc. Clin. Oncol. 18:1999;273a. [abstract 1048].
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18
    • Tempero, M.1    Plumkett, W.2    Ruiz Van Haperen, V.3
  • 59
    • 0028292341 scopus 로고
    • Phase II trial of gemcitabine (2,2-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas
    • Casper E., Green M., Kelsen D. Phase II trial of gemcitabine (2,2-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas. Invest New Drugs. 12:1994;29-34.
    • (1994) Invest New Drugs , vol.12 , pp. 29-34
    • Casper, E.1    Green, M.2    Kelsen, D.3
  • 60
    • 0030049697 scopus 로고    scopus 로고
    • Phase II study of gemcitabine in patients with advanced pancreatic cancer
    • Carmichael J., Fink U., Russel R.C.G.et al. Phase II study of gemcitabine in patients with advanced pancreatic cancer. Br. J. Cancer. 73:1996;101-1205.
    • (1996) Br. J. Cancer , vol.73 , pp. 101-1205
    • Carmichael, J.1    Fink, U.2    Russel, R.C.G.3
  • 61
    • 18744420709 scopus 로고    scopus 로고
    • A phase II trial of biweekly high dose gemcitabine for patients with metastatic pancreatic adenocarcinoma
    • Ulrich-Pur H., Kornek G.V., Raderer M.et al. A phase II trial of biweekly high dose gemcitabine for patients with metastatic pancreatic adenocarcinoma. Cancer. 88:2000;2505-2511.
    • (2000) Cancer , vol.88 , pp. 2505-2511
    • Ulrich-Pur, H.1    Kornek, G.V.2    Raderer, M.3
  • 62
    • 0003265267 scopus 로고    scopus 로고
    • Cancer and Leukemia Group B (CALGB) 89805: Phase II chemoradiation trial using gemcitabine in patients with locoregional adenocarcinoma of the pancreas
    • [abstract 627]
    • Blackstock A.W., Tempero M.A., Niedwiecki D., Hollis D.R., Mayer R.J., Tepper J.E. Cancer and Leukemia Group B (CALGB) 89805: phase II chemoradiation trial using gemcitabine in patients with locoregional adenocarcinoma of the pancreas. Proc. Am. Soc. Clin. Oncol. 20:2001;158a. [abstract 627].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Blackstock, A.W.1    Tempero, M.A.2    Niedwiecki, D.3    Hollis, D.R.4    Mayer, R.J.5    Tepper, J.E.6
  • 63
    • 0008965607 scopus 로고    scopus 로고
    • Gemcitabine and concomitant radiation for locally advanced relapsed pancreatic cancer
    • [abstract 2288]
    • Mustacchi G., Beorchia A., Milani S.et al. Gemcitabine and concomitant radiation for locally advanced relapsed pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 20:2001;134b. [abstract 2288].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Mustacchi, G.1    Beorchia, A.2    Milani, S.3
  • 64
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris H.A. 3rd, Moore M., Anderson J.et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J. Clin. Oncol. 15:1997;2403-2413.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.2    Anderson, J.3
  • 65
    • 0036534672 scopus 로고    scopus 로고
    • Is the therapeutic index better with gemcitabine-based chemoradiation than with 5FU-based chemoradiation in locally advanced pancreatic cancer?
    • Crane C.H., Abbruzzese J.L., Evans D.B.et al. Is the therapeutic index better with gemcitabine-based chemoradiation than with 5FU-based chemoradiation in locally advanced pancreatic cancer? Int. J. Radiat. Oncol. Biol. Phys. 52(5):2002;1293-1302.
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.52 , Issue.5 , pp. 1293-1302
    • Crane, C.H.1    Abbruzzese, J.L.2    Evans, D.B.3
  • 66
    • 0000505259 scopus 로고    scopus 로고
    • A phase III study of gemcitabine in combination with 5FU versus gemcitabine alone in patients with advanced pancreatic carcinoma: An Eastern Cooperative Oncology Group (ECOG) trial
    • [abstract 505]
    • Berlin J., Catalano P., Thomas J., Kluger J., Haller D.G., Nenson A.B. A phase III study of gemcitabine in combination with 5FU versus gemcitabine alone in patients with advanced pancreatic carcinoma: an Eastern Cooperative Oncology Group (ECOG) trial. Proc. Am. Soc. Clin. Oncol. 20:2001;127a. [abstract 505].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Berlin, J.1    Catalano, P.2    Thomas, J.3    Kluger, J.4    Haller, D.G.5    Nenson, A.B.6
  • 67
    • 0033029525 scopus 로고    scopus 로고
    • A combination of gemcitabine and 5FU in advanced pancreatic cancer, a report from the Italian Group of Digestive Tract Cancer (GISCAD)
    • Cascinu S., Silva R., Barni S.et al. A combination of gemcitabine and 5FU in advanced pancreatic cancer, a report from the Italian Group of Digestive Tract Cancer (GISCAD). Br. J. Cancer. 80(10):1999;1595-1598.
    • (1999) Br. J. Cancer , vol.80 , Issue.10 , pp. 1595-1598
    • Cascinu, S.1    Silva, R.2    Barni, S.3
  • 68
    • 0000327536 scopus 로고    scopus 로고
    • Phase II trial of the use of gemcitabine and 5FU in the treatment of advanced pancreatic cancer and biliary tract adenocarcinoma
    • [abstract 1116]
    • De Gusmao C.B.R.A., Murad A.M., Scalabrini-Neto A.O.et al. Phase II trial of the use of gemcitabine and 5FU in the treatment of advanced pancreatic cancer and biliary tract adenocarcinoma. Proc. Am. Soc. Clin. Oncol. 17:1998;290a. [abstract 1116].
    • (1998) Proc. Am. Soc. Clin. Oncol. , vol.17
    • De Gusmao, C.B.R.A.1    Murad, A.M.2    Scalabrini-Neto, A.O.3
  • 69
    • 0033402664 scopus 로고    scopus 로고
    • Phase I trial of gemcitabine in combination with 5FU (24 h) and folinic acid in patients with inoperable pancreatic cancer
    • Oettle H., Pelzer U., Hochmuth K.et al. Phase I trial of gemcitabine in combination with 5FU (24 h) and folinic acid in patients with inoperable pancreatic cancer. Anticancer Drugs. 10:1999;699-704.
    • (1999) Anticancer Drugs , vol.10 , pp. 699-704
    • Oettle, H.1    Pelzer, U.2    Hochmuth, K.3
  • 70
    • 0033768608 scopus 로고    scopus 로고
    • A phase II trial of gemcitabine in combination with 5FU (24 h) and folinic acid in patients with chemonaive advanced pancreatic cancer
    • Oettle H., Arning M., Pelzer U.et al. A phase II trial of gemcitabine in combination with 5FU (24 h) and folinic acid in patients with chemonaive advanced pancreatic cancer. Ann. Oncol. 11(10):2000;1267-1272.
    • (2000) Ann. Oncol. , vol.11 , Issue.10 , pp. 1267-1272
    • Oettle, H.1    Arning, M.2    Pelzer, U.3
  • 71
    • 0000666724 scopus 로고    scopus 로고
    • A phase II study of gemcitabine plus 5FU modulated by leucovorin (LV) for advanced pancreatic cancer
    • [abstract 1229]
    • Polyzos A., Tsavaris N., Kosmas C.et al. A phase II study of gemcitabine plus 5FU modulated by leucovorin (LV) for advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 19:2000;311a. [abstract 1229].
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Polyzos, A.1    Tsavaris, N.2    Kosmas, C.3
  • 72
    • 0000128087 scopus 로고    scopus 로고
    • Multicenter phase II study in advanced pancreatic adenocarcinoma patients treated with a combination of leucovorin, 5FU bolus and infusion, and gemcitabine (FOLFUGEM regimen)
    • [abstract 1054]
    • Louvet C., Hammel P., Andrè T.et al. Multicenter phase II study in advanced pancreatic adenocarcinoma patients treated with a combination of leucovorin, 5FU bolus and infusion, and gemcitabine (FOLFUGEM regimen). Proc. Am. Soc. Clin. Oncol. 18:1999;280a. [abstract 1054].
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18
    • Louvet, C.1    Hammel, P.2    Andrè, T.3
  • 73
    • 0001671405 scopus 로고    scopus 로고
    • A phase I study of gemcitabine (GEM) in combination with 5 days 5-Fluorouracil (5FU) and folinic acid (FA) in patients with advanced adenocarcinoma of pancreas and bile duct
    • [abstract 1097]
    • Gutzler F., Moehler M., Hosch W.P.et al. A phase I study of gemcitabine (GEM) in combination with 5 days 5-Fluorouracil (5FU) and folinic acid (FA) in patients with advanced adenocarcinoma of pancreas and bile duct. Proc. Am. Soc. Clin. Oncol. 18:1999;286a. [abstract 1097].
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18
    • Gutzler, F.1    Moehler, M.2    Hosch, W.P.3
  • 74
    • 0000215529 scopus 로고    scopus 로고
    • A phase I/II clinical and pharmacological study of dose-escalating and dose-sequencing of administration of gemcitabine and folinic acid (FA)/fluorouracil (FU) and leucovorin (LV) in patients with advanced pancreatic cancer
    • [abstract 1133]
    • Castellano D., Paz-Ares L., Pronk L.et al. A phase I/II clinical and pharmacological study of dose-escalating and dose-sequencing of administration of gemcitabine and folinic acid (FA)/fluorouracil (FU) and leucovorin (LV) in patients with advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 19:2000;290a. [abstract 1133].
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Castellano, D.1    Paz-Ares, L.2    Pronk, L.3
  • 75
    • 0002498605 scopus 로고    scopus 로고
    • Gemcitabine and continuous infusion fluorouracil: A phase II study in advanced pancreatic cancer
    • [abstract 241P]
    • Borner M.M., Maurer C.A., Friess H.et al. Gemcitabine and continuous infusion fluorouracil: a phase II study in advanced pancreatic cancer. Ann. Oncol. 9(suppl 4):1998;51. [abstract 241P].
    • (1998) Ann. Oncol. , vol.9 , Issue.SUPPL. 4 , pp. 51
    • Borner, M.M.1    Maurer, C.A.2    Friess, H.3
  • 76
    • 0033012340 scopus 로고    scopus 로고
    • Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer
    • Hidalgo M., Castellano D., Paz-Ares L.et al. Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer. J. Clin. Oncol. 17:1999;585-592.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 585-592
    • Hidalgo, M.1    Castellano, D.2    Paz-Ares, L.3
  • 77
    • 0000667914 scopus 로고    scopus 로고
    • Gemcitabine and continuous infusion 5FU is active and well tolerated in advanced or metastatic pancreatic cancer
    • [abstract 1280]
    • Anchisi S., Delaloye B., Petite G.et al. Gemcitabine and continuous infusion 5FU is active and well tolerated in advanced or metastatic pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 19:2000;326a. [abstract 1280].
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Anchisi, S.1    Delaloye, B.2    Petite, G.3
  • 78
    • 0003200037 scopus 로고    scopus 로고
    • Phase I-II study of gemcitabine (GEM) and weekly 48 h continuous intravenous infusion (CIV) 5-fluorouracil (5FU) in advanced pancreatic cancer (PC). A University of Chicago Phase II Consortium Study
    • [abstract 1145]
    • Rodriquez-Lescure A., Carrato A., Massuti B.et al. Phase I-II study of gemcitabine (GEM) and weekly 48 h continuous intravenous infusion (CIV) 5-fluorouracil (5FU) in advanced pancreatic cancer (PC). A University of Chicago Phase II Consortium Study. Proc. Am. Soc. Clin. Oncol. 19:2000;288a. [abstract 1145].
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Rodriquez-Lescure, A.1    Carrato, A.2    Massuti, B.3
  • 79
    • 0001130402 scopus 로고    scopus 로고
    • Phase II trial of gemcitabine, epirubicin, and G-CSF in patients with metastatic pancreatic cancer
    • [abstract 648]
    • Raderer M., Kornek G.V., Valencak J.et al. Phase II trial of gemcitabine, epirubicin, and G-CSF in patients with metastatic pancreatic cancer. Ann. Oncol. 9(suppl 2):1998;169. [abstract 648].
    • (1998) Ann. Oncol. , vol.9 , Issue.SUPPL. 2 , pp. 169
    • Raderer, M.1    Kornek, G.V.2    Valencak, J.3
  • 80
    • 0001461012 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin in the treatment of advanced and metastatic pancreatic cancer. Final results of a phase II study
    • [abstract 1052]
    • Heinemann V., Wilke H., Possinger K.et al. Gemcitabine and cisplatin in the treatment of advanced and metastatic pancreatic cancer. Final results of a phase II study. Proc. Am. Soc. Clin. Oncol. 18:1999;330. [abstract 1052].
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18 , pp. 330
    • Heinemann, V.1    Wilke, H.2    Possinger, K.3
  • 81
    • 0000575676 scopus 로고    scopus 로고
    • Randomized trial of Gemcitabine (GEM) alone or with cisplatin (CDDP) in the treatment of advanced pancreatic cancer (APC): A phase II multicenter study of the Southern Italy Oncology Group
    • [abstract 961]
    • Colucci G., Riccardi F., Giuliani F.et al. Randomized trial of Gemcitabine (GEM) alone or with cisplatin (CDDP) in the treatment of advanced pancreatic cancer (APC): a phase II multicenter study of the Southern Italy Oncology Group. Proc. Am. Soc. Clin. Oncol. 18:1999;252. [abstract 961].
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18 , pp. 252
    • Colucci, G.1    Riccardi, F.2    Giuliani, F.3
  • 82
    • 0000024284 scopus 로고    scopus 로고
    • Gemcitabine plus cisplatin versus gemcitabine in advanced pancreatic cancer: Preliminary results of a randomized phase III trial
    • [abstract 625]
    • Heinemann V., Quietzsch D., Gieseler F.et al. Gemcitabine plus cisplatin versus gemcitabine in advanced pancreatic cancer: preliminary results of a randomized phase III trial. Proc. Am. Soc. Clin. Oncol. 20:2001;157a. [abstract 625].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Heinemann, V.1    Quietzsch, D.2    Gieseler, F.3
  • 83
    • 0000510072 scopus 로고    scopus 로고
    • Gemcitabine, cisplatin and 5-Fluorourcil in advanced pancreatic cancer
    • [abstract 2341]
    • Philip P.A., Shields A., Zalupski M.et al. Gemcitabine, cisplatin and 5-Fluorourcil in advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 20:2001;148b. [abstract 2341].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Philip, P.A.1    Shields, A.2    Zalupski, M.3
  • 84
    • 0010540477 scopus 로고    scopus 로고
    • Biweekly sequential gemcitabine, 5FU (5-Fluorourcil), LV (Leucovorin), and cisplatin (GFP): A highly active novel combination for metastatic adenocarcinoma of the exocrine pancreas (MPAC)
    • [abstract 617]
    • Kozuch P., Areneo M., Homel P.et al. Biweekly sequential gemcitabine, 5FU (5-Fluorourcil), LV (Leucovorin), and cisplatin (GFP): a highly active novel combination for metastatic adenocarcinoma of the exocrine pancreas (MPAC). Proc. Am. Soc. Clin. Oncol. 20:2001;155a. [abstract 617].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Kozuch, P.1    Areneo, M.2    Homel, P.3
  • 85
    • 0035873947 scopus 로고    scopus 로고
    • Definitive results of a phase II trial of Cisplatin, Epirubicin, continuous infusion 5-Fluorouracil, and Gemcitabine in stage IV pancreatic adenocarcinoma
    • Reni M., Passoni P., Panucci M.G.et al. Definitive results of a phase II trial of Cisplatin, Epirubicin, continuous infusion 5-Fluorouracil, and Gemcitabine in stage IV pancreatic adenocarcinoma. J. Clin. Oncol. 19:2001;2679-2686.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2679-2686
    • Reni, M.1    Passoni, P.2    Panucci, M.G.3
  • 86
    • 0003239576 scopus 로고    scopus 로고
    • Phase II study of combination with leucovorin (LV), 5FU bolus and infusion (FU), Gemcitabine (GEM) and Oxaliplatin (LOHP) (FOLFU GEMOX regimen) in locally advanced (LA) and metastatic (M) pancreatic carcinoma (APC)
    • [abstract 620]
    • Garnier C., Rebischung C., Chirpaz E.et al. Phase II study of combination with leucovorin (LV), 5FU bolus and infusion (FU), Gemcitabine (GEM) and Oxaliplatin (LOHP) (FOLFU GEMOX regimen) in locally advanced (LA) and metastatic (M) pancreatic carcinoma (APC). Proc. Am. Soc. Clin. Oncol. 20:2001;156a. [abstract 620].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Garnier, C.1    Rebischung, C.2    Chirpaz, E.3
  • 87
    • 0003302728 scopus 로고    scopus 로고
    • Gemcitabine-Oxaliplatin (GEMOX regimen) in advanced pancreatic carcinoma (APC). A Gercor multicenter phase II study
    • abstract 506
    • Louvet C., Andrè T., Lledo G.et al. Gemcitabine-Oxaliplatin (GEMOX regimen) in advanced pancreatic carcinoma (APC). A Gercor multicenter phase II study. Proc. Am. Soc. Clin. Oncol. 20:2001;127a. [abstract 506].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Louvet, C.1    Andrè, T.2    Lledo, G.3
  • 88
    • 0001046862 scopus 로고    scopus 로고
    • Multicenter phase II study of weekly docetaxel and gemcitabine for the treatment of patients with advanced or recurrent pancreatic cancer
    • [abstract 624]
    • Ridwelski K., Kettner E., Greiner L.et al. Multicenter phase II study of weekly docetaxel and gemcitabine for the treatment of patients with advanced or recurrent pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 20:2001;157a. [abstract 624].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Ridwelski, K.1    Kettner, E.2    Greiner, L.3
  • 89
    • 0000432215 scopus 로고    scopus 로고
    • Pancreatic cancer: Biweekly gemcitabine/docetaxel chemotherapy
    • [abstract 614]
    • Shepard R.C., Levy D., Stuart K.et al. Pancreatic cancer: biweekly gemcitabine/docetaxel chemotherapy. Proc. Am. Soc. Clin. Oncol. 20:2001;154a. [abstract 614].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Shepard, R.C.1    Levy, D.2    Stuart, K.3
  • 90
    • 0000539778 scopus 로고    scopus 로고
    • Docetaxel/gemcitabine or docetaxel/cisplatin in advanced pancreatic carcinoma: A randomized phase II study of the EORTC-GI group
    • [abstract 498]
    • Lutz M.P., Ducreux M., Wagener T.et al. Docetaxel/gemcitabine or docetaxel/cisplatin in advanced pancreatic carcinoma: a randomized phase II study of the EORTC-GI group. Proc. Am. Soc. Clin. Oncol. 21:2002;125a. [abstract 498].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Lutz, M.P.1    Ducreux, M.2    Wagener, T.3
  • 91
    • 0010610263 scopus 로고    scopus 로고
    • Irinotecan combined with gemcitabine, 5FU (5-Fluorouracil), LV (Leucovorin), and Cisplatin (G-FLIP) is an effective and non-cross resistant regimen for refractory metastatic adenocarcinoma of the exocrine pancreas (MPAC)
    • [abstract 615]
    • Bruckner H., Barzdins A., Homel P.et al. Irinotecan combined with gemcitabine, 5FU (5-Fluorouracil), LV (Leucovorin), and Cisplatin (G-FLIP) is an effective and non-cross resistant regimen for refractory metastatic adenocarcinoma of the exocrine pancreas (MPAC). Proc. Am. Soc. Clin. Oncol. 20:2001;155a. [abstract 615].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Bruckner, H.1    Barzdins, A.2    Homel, P.3
  • 92
    • 4243592614 scopus 로고    scopus 로고
    • A phase II study of weekly irinotecan (CPT11) and gemcitabine (GEM) as a first line treatment in locally advanced and metastatic pancreatic cancer
    • [abstract 2328]
    • Alfonso P.G., Sancho J., Mendez M.et al. A phase II study of weekly irinotecan (CPT11) and gemcitabine (GEM) as a first line treatment in locally advanced and metastatic pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 20:2001;144b. [abstract 2328].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Alfonso, P.G.1    Sancho, J.2    Mendez, M.3
  • 93
    • 0000421614 scopus 로고    scopus 로고
    • Front line treatment with gemcitabine in combination with irinotecan: Preliminary results of a multicenter phase II study
    • [abstract 1260]
    • Stapthopoulos G., Rigatos G., Kouroussis C.H.et al. Front line treatment with gemcitabine in combination with irinotecan: preliminary results of a multicenter phase II study. Proc. Am. Soc. Clin. Oncol. 19:2000;319a. [abstract 1260].
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Stapthopoulos, G.1    Rigatos, G.2    Kouroussis, C.H.3
  • 94
    • 0036498787 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine induces both radiographic and Ca19 9 tumor marker responses in patients with previously untreated advanced pancreatic cancer
    • Rocha Lima C.M.S., Savarese D., Bruckner H.et al. Irinotecan plus gemcitabine induces both radiographic and Ca19 9 tumor marker responses in patients with previously untreated advanced pancreatic cancer. J. Clin. Oncol. 20:2002;1182-1191.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1182-1191
    • Rocha Lima, C.M.S.1    Savarese, D.2    Bruckner, H.3
  • 95
    • 0001528559 scopus 로고    scopus 로고
    • Gemcitabine (GEM) and Capecitabine (CPC) in advanced pancreatic cancer and solid tumors. A single institution experience
    • [abstract 2315]
    • Campos L.T., Alvarez R., Sanford D.et al. Gemcitabine (GEM) and Capecitabine (CPC) in advanced pancreatic cancer and solid tumors. A single institution experience. Proc. Am. Soc. Clin. Oncol. 20:2001;141b. [abstract 2315].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Campos, L.T.1    Alvarez, R.2    Sanford, D.3
  • 96
    • 0036137690 scopus 로고    scopus 로고
    • Phase II study of oral capecitabine in patients with advanced or metastatic pancreatic cancer
    • Cartwright T.H., Cohn A., Varkey J.A.et al. Phase II study of oral capecitabine in patients with advanced or metastatic pancreatic cancer. J. Clin. Oncol. 20(1):2002;160-164.
    • (2002) J. Clin. Oncol. , vol.20 , Issue.1 , pp. 160-164
    • Cartwright, T.H.1    Cohn, A.2    Varkey, J.A.3
  • 97
    • 0003317155 scopus 로고    scopus 로고
    • Combining gemcitabine and capecitabine in advanced pancreatic cancer. Results of a phase I trial
    • [abstract 1038]
    • Herrmann R., Borner M., Morant R., Roth A.D., Ludwig C., Bedoucha V. Combining gemcitabine and capecitabine in advanced pancreatic cancer. Results of a phase I trial. Proc. Am. Soc. Clin. Oncol. 19:2000;267a. [abstract 1038].
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Herrmann, R.1    Borner, M.2    Morant, R.3    Roth, A.D.4    Ludwig, C.5    Bedoucha, V.6
  • 98
    • 0001234219 scopus 로고    scopus 로고
    • Gemcitabine alone or in combination with capecitabine in patients with advanced pancreatic adenocarcinoma
    • [abstract 500]
    • Scheithauer W., Schull B., Ulrich-Pur H.et al. Gemcitabine alone or in combination with capecitabine in patients with advanced pancreatic adenocarcinoma. Proc. Am. Soc. Clin. Oncol. 21:2002;126a. [abstract 500].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Scheithauer, W.1    Schull, B.2    Ulrich-Pur, H.3
  • 99
    • 0036284919 scopus 로고    scopus 로고
    • Phase II study of uracil-tegafur in patients with metastatic pancreatic cancer
    • Ueno H., Okada S., Okusaka T., Ikeda M., Kuriyama H. Phase II study of uracil-tegafur in patients with metastatic pancreatic cancer. Oncology. 62(3):2002;223-227.
    • (2002) Oncology , vol.62 , Issue.3 , pp. 223-227
    • Ueno, H.1    Okada, S.2    Okusaka, T.3    Ikeda, M.4    Kuriyama, H.5
  • 100
    • 0036860329 scopus 로고    scopus 로고
    • Phase II study of a fixed dose-rate infusion of gemcitabine associated with uracil/tegafur in advanced carcinoma of the pancreas
    • Feliu J., Mel R., Borrega P.et al. Phase II study of a fixed dose-rate infusion of gemcitabine associated with uracil/tegafur in advanced carcinoma of the pancreas. Ann. Oncol. 13(11):2002;1756-1762.
    • (2002) Ann. Oncol. , vol.13 , Issue.11 , pp. 1756-1762
    • Feliu, J.1    Mel, R.2    Borrega, P.3
  • 101
    • 0011748497 scopus 로고    scopus 로고
    • Combination of oral tegafur (TF) and levofolinic acid (LA) with gemcitabine (gem) in locally advanced or metastatic pancreatic carcinoma: A pilot study
    • [abstract 2362]
    • Fernadez-Morales L.A., Pujadas J., Garcia Y.et al. Combination of oral tegafur (TF) and levofolinic acid (LA) with gemcitabine (gem) in locally advanced or metastatic pancreatic carcinoma: a pilot study. Proc. Am. Soc. Clin. Oncol. 21:2002;137b. [abstract 2362].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Fernadez-Morales, L.A.1    Pujadas, J.2    Garcia, Y.3
  • 102
    • 0029556670 scopus 로고    scopus 로고
    • Phase II trial of ZD1694 (Tomudex) on patients with advanced pancreatic cancer
    • Pazdur R., Meropol N.J., Casper E.S.et al. Phase II trial of ZD1694 (Tomudex) on patients with advanced pancreatic cancer. Invest New Drugs. 13:1996;355-358.
    • (1996) Invest New Drugs , vol.13 , pp. 355-358
    • Pazdur, R.1    Meropol, N.J.2    Casper, E.S.3
  • 103
    • 0033981350 scopus 로고    scopus 로고
    • Phase II study of the multitargeted antifolate LY231514 (ALIMTA, MTA, pemetrexed disodium) in patients with advanced pancreatic cancer
    • Miller K.D., Picus J., Blanke C.et al. Phase II study of the multitargeted antifolate LY231514 (ALIMTA, MTA, pemetrexed disodium) in patients with advanced pancreatic cancer. Ann. Oncol. 11(1):2000;101-103.
    • (2000) Ann. Oncol. , vol.11 , Issue.1 , pp. 101-103
    • Miller, K.D.1    Picus, J.2    Blanke, C.3
  • 104
    • 0037481752 scopus 로고    scopus 로고
    • Activity of raltitrexed and gemcitabine in advanced pancreatic cancer
    • Kralidis E., Aebi S., Friess H., Buchler M.W., Borner M.M. Activity of raltitrexed and gemcitabine in advanced pancreatic cancer. Ann. Oncol. 14(4):2003;574-579.
    • (2003) Ann. Oncol. , vol.14 , Issue.4 , pp. 574-579
    • Kralidis, E.1    Aebi, S.2    Friess, H.3    Buchler, M.W.4    Borner, M.M.5
  • 105
    • 0000539776 scopus 로고    scopus 로고
    • Clinical outcomes in patients with advanced pancreatic cancer treated with pemetrexed/gemcitabine
    • [abstract 499]
    • Kindler H.L., Dugan W., Hochster H.et al. Clinical outcomes in patients with advanced pancreatic cancer treated with pemetrexed/gemcitabine. Proc. Am. Soc. Clin. Oncol. 21:2002;125a. [abstract 499].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Kindler, H.L.1    Dugan, W.2    Hochster, H.3
  • 106
    • 0003368088 scopus 로고    scopus 로고
    • Phase 2 study of troxacitabine in chemotherapy naive patients with advanced cancer of the pancreas
    • [abstract 565]
    • Lapointe R., Letourneau R., Steward W.et al. Phase 2 study of troxacitabine in chemotherapy naive patients with advanced cancer of the pancreas. Proc. Am. Soc. Clin. Oncol. 21:2002;142a. [abstract 565].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Lapointe, R.1    Letourneau, R.2    Steward, W.3
  • 107
    • 0029556666 scopus 로고    scopus 로고
    • Phase III trial of topotecan in advanced or metastatic adenocarcinoma of the pancreas
    • Scher R., Kosierowski R., Lush C.et al. Phase III trial of topotecan in advanced or metastatic adenocarcinoma of the pancreas. Invest New Drugs. 13:1996;347-354.
    • (1996) Invest New Drugs , vol.13 , pp. 347-354
    • Scher, R.1    Kosierowski, R.2    Lush, C.3
  • 108
    • 0028839053 scopus 로고
    • Phase II trial of CPT11 in patients with advanced pancreatic cancer, an EORTC early clinical trials group study
    • Wagener D.J., Verdonk H.E., Dirix L.Y.et al. Phase II trial of CPT11 in patients with advanced pancreatic cancer, an EORTC early clinical trials group study. Ann. Oncol. 6:1995;129-132.
    • (1995) Ann. Oncol. , vol.6 , pp. 129-132
    • Wagener, D.J.1    Verdonk, H.E.2    Dirix, L.Y.3
  • 109
    • 0033105413 scopus 로고    scopus 로고
    • CPT11 in gastrointestinal cancer
    • Bleiberg H. CPT11 in gastrointestinal cancer. Eur. J. Cancer. 35:1999;371-379.
    • (1999) Eur. J. Cancer , vol.35 , pp. 371-379
    • Bleiberg, H.1
  • 110
    • 0031872387 scopus 로고    scopus 로고
    • A phase II study of temozolomide in advanced untreated pancreatic cancer
    • Moore M.J., Feld R., Hedley D., Oza A., Siu L.L. A phase II study of temozolomide in advanced untreated pancreatic cancer. Invest New Drugs. 16:1998;77-79.
    • (1998) Invest New Drugs , vol.16 , pp. 77-79
    • Moore, M.J.1    Feld, R.2    Hedley, D.3    Oza, A.4    Siu, L.L.5
  • 111
    • 4243966683 scopus 로고    scopus 로고
    • A phase II study evaluating the tolerability and efficacy of Caelix (Liposomal ADM, Doxil) in the treatment of unresectable pancreatic carcinoma
    • [abstract 1182]
    • Yip D., Halford S., Karapetis C.S.et al. A phase II study evaluating the tolerability and efficacy of Caelix (Liposomal ADM, Doxil) in the treatment of unresectable pancreatic carcinoma. Proc. Am. Soc. Clin. Oncol. 19:2000;301a. [abstract 1182].
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Yip, D.1    Halford, S.2    Karapetis, C.S.3
  • 112
    • 0030900150 scopus 로고    scopus 로고
    • Phase II trial of paclitaxel and granulocyte colony-stimulating factor in patients with pancreatic cancer: A Southwest Oncology Group Study
    • Whitehead R.P., Jacobson J., Brown T.D., Taylor S.A., Weiss G.R., Macdonald J.S. Phase II trial of paclitaxel and granulocyte colony-stimulating factor in patients with pancreatic cancer: a Southwest Oncology Group Study. J. Clin. Oncol. 15:1997;2414-2419.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2414-2419
    • Whitehead, R.P.1    Jacobson, J.2    Brown, T.D.3    Taylor, S.A.4    Weiss, G.R.5    Macdonald, J.S.6
  • 113
    • 0029588498 scopus 로고
    • Docetaxel delivers new management opportunities for gastrointestinal carcinomas
    • Rougier P. Docetaxel delivers new management opportunities for gastrointestinal carcinomas. Invest New Drugs. suppl 6(4):1995;25-29.
    • (1995) Invest New Drugs , vol.6 , Issue.4 , pp. 25-29
    • Rougier, P.1
  • 114
    • 0034122470 scopus 로고    scopus 로고
    • A phase II study: Docetaxel as first line chemotherapy for advanced pancreatic adenocarcinoma
    • Rougier P., Adenis A., Ducreux M.et al. A phase II study: docetaxel as first line chemotherapy for advanced pancreatic adenocarcinoma. Eur. J. Cancer. 36:2000;1016-1025.
    • (2000) Eur. J. Cancer , vol.36 , pp. 1016-1025
    • Rougier, P.1    Adenis, A.2    Ducreux, M.3
  • 115
    • 0033002404 scopus 로고    scopus 로고
    • Treatment of pancreatic cancer with docetaxel and granulocyte colony-stimulating factor: A multicenter phase II study
    • Androulakis N., Koukourakis C., Dimopoulos M.et al. Treatment of pancreatic cancer with docetaxel and granulocyte colony-stimulating factor: a multicenter phase II study. J. Clin. Oncol. 17(6):1999;1779-1785.
    • (1999) J. Clin. Oncol. , vol.17 , Issue.6 , pp. 1779-1785
    • Androulakis, N.1    Koukourakis, C.2    Dimopoulos, M.3
  • 116
    • 0031044606 scopus 로고    scopus 로고
    • Paclitaxel and concurrent radiation for locally advanced pancreatic cancer and gastric cancer: A phase I study
    • Safran H., King T.P., Choy H.et al. Paclitaxel and concurrent radiation for locally advanced pancreatic cancer and gastric cancer: a phase I study. J. Clin. Oncol. 15:1997;901-907.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 901-907
    • Safran, H.1    King, T.P.2    Choy, H.3
  • 117
    • 0000904016 scopus 로고    scopus 로고
    • Weekly chemotherapy with irinotecan plus taxanes in advanced pancreatic cancer
    • [abstract 1081]
    • Burtness B., Argiris A., Rich R.S.et al. Weekly chemotherapy with irinotecan plus taxanes in advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 19:2000;277a. [abstract 1081].
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Burtness, B.1    Argiris, A.2    Rich, R.S.3
  • 118
    • 85030906773 scopus 로고    scopus 로고
    • Kurtz J, Husseini F, Negrier S, et al. Docetaxel and irinotecan combination chemotherapy in advanced pancreatic cancer. A phase II study. Proc Am Soc Clin Oncol 2001;141b [abstract 2313].
    • Kurtz J, Husseini F, Negrier S, et al. Docetaxel and irinotecan combination chemotherapy in advanced pancreatic cancer. A phase II study. Proc Am Soc Clin Oncol 2001;141b [abstract 2313].
  • 119
    • 0011777615 scopus 로고    scopus 로고
    • Irinotecan (CPT11), oxaliplatin (L-OHP) plus 5FU/leucovorin (5FU/LV) as first line chemotherapy in patients with advanced pancreatic adenocarcinoma (APA)
    • [abstract 585]
    • Conroy T., Paillot B., Francois E.et al. Irinotecan (CPT11), oxaliplatin (L-OHP) plus 5FU/leucovorin (5FU/LV) as first line chemotherapy in patients with advanced pancreatic adenocarcinoma (APA). Proc. Am. Soc. Clin. Oncol. 21:2002;147a. [abstract 585].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Conroy, T.1    Paillot, B.2    Francois, E.3
  • 120
    • 0001776802 scopus 로고    scopus 로고
    • Irinotecan and oxaliplatin combination therapy in patients with advanced pretreated pancreatic cancer
    • [abstract 2197]
    • Cantore M., Rabbi C., Cavazzini G.et al. Irinotecan and oxaliplatin combination therapy in patients with advanced pretreated pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 21:2002;96b. [abstract 2197].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Cantore, M.1    Rabbi, C.2    Cavazzini, G.3
  • 121
    • 0032837731 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition selectively decreases type II MMP activity in a murine model of pancreatic cancer
    • Zervos E.E., Shafii A.E., Rosemurgy A.S. Matrix metalloproteinase inhibition selectively decreases type II MMP activity in a murine model of pancreatic cancer. J. Surg. Res. 81:1999;65-68.
    • (1999) J. Surg. Res. , vol.81 , pp. 65-68
    • Zervos, E.E.1    Shafii, A.E.2    Rosemurgy, A.S.3
  • 122
    • 0033563795 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition suppresses MMP-2 activity and activation of PANC-1 cells in vitro
    • Zervos E.E., Shafii A.E., Haq M., Rosemurgy A.S. Matrix metalloproteinase inhibition suppresses MMP-2 activity and activation of PANC-1 cells in vitro. J. Surg. Res. 84(2):1999;162-167.
    • (1999) J. Surg. Res. , vol.84 , Issue.2 , pp. 162-167
    • Zervos, E.E.1    Shafii, A.E.2    Haq, M.3    Rosemurgy, A.S.4
  • 123
    • 0033804934 scopus 로고    scopus 로고
    • New directions in systemic therapy of pancreatic cancer
    • Rosemurgy A.S., Serafini F.M. New directions in systemic therapy of pancreatic cancer. Cancer Control. 7(5):2000;437-444.
    • (2000) Cancer Control , vol.7 , Issue.5 , pp. 437-444
    • Rosemurgy, A.S.1    Serafini, F.M.2
  • 125
    • 0031148314 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition attenuates human pancreatic cancer growth in vitro and decreases mortality and tumorigenesis in vivo
    • Zervos E.E., Norman J.G., Gower W.R., Franz M.G., Rosemurgy A.S. Matrix metalloproteinase inhibition attenuates human pancreatic cancer growth in vitro and decreases mortality and tumorigenesis in vivo. J. Surg. Res. 69(2):1997;367-371.
    • (1997) J. Surg. Res. , vol.69 , Issue.2 , pp. 367-371
    • Zervos, E.E.1    Norman, J.G.2    Gower, W.R.3    Franz, M.G.4    Rosemurgy, A.S.5
  • 126
    • 0034044162 scopus 로고    scopus 로고
    • Addition of matrix metalloproteinase inhibition to conventional cytotoxic therapy reduces tumor implantation and prolongs survival in a murine model of human pancreatic cancer
    • Haq M., Shafii A., Zervos E.E., Rosemurgy A.S. Addition of matrix metalloproteinase inhibition to conventional cytotoxic therapy reduces tumor implantation and prolongs survival in a murine model of human pancreatic cancer. Cancer Res. 60(12):2000;3207-3211.
    • (2000) Cancer Res. , vol.60 , Issue.12 , pp. 3207-3211
    • Haq, M.1    Shafii, A.2    Zervos, E.E.3    Rosemurgy, A.S.4
  • 127
    • 0001391575 scopus 로고    scopus 로고
    • Phase II study of anti-epidermal growth factor receptor (EGFR) antibody Cetuximab (IMC-C225) in combination with gemcitabine in patients with advanced pancreatic cancer
    • [abstract 518]
    • Abbruzzese J.L., Rosenberg A., Xiong Q.et al. Phase II study of anti-epidermal growth factor receptor (EGFR) antibody Cetuximab (IMC-C225) in combination with gemcitabine in patients with advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 20:2001;130a. [abstract 518].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Abbruzzese, J.L.1    Rosenberg, A.2    Xiong, Q.3
  • 128
    • 0000616471 scopus 로고    scopus 로고
    • Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress Her-2/neu
    • [abstract 517]
    • Safran H., Ramanathan R., Schwartz J.et al. Herceptin and gemcitabine for metastatic pancreatic cancers that overexpress Her-2/neu. Proc. Am. Soc. Clin. Oncol. 20:2001;130a. [abstract 517].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Safran, H.1    Ramanathan, R.2    Schwartz, J.3
  • 129
    • 0035170259 scopus 로고    scopus 로고
    • Anticancer therapy targeting the erbB family of receptor tyrosine kinases
    • Slichenmyer W.J., Fry D.W. Anticancer therapy targeting the erbB family of receptor tyrosine kinases. Semin. Oncol. 28(Suppl 16):2001;67-79.
    • (2001) Semin. Oncol. , vol.28 , Issue.SUPPL. 16 , pp. 67-79
    • Slichenmyer, W.J.1    Fry, D.W.2
  • 130
    • 0032704708 scopus 로고    scopus 로고
    • Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
    • Rowinsky E., Winde J., Von Hoff D. Ras protein farnesyltransferase: a strategic target for anticancer therapeutic development. J. Clin. Oncol. 17:1999;3631-3652.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 3631-3652
    • Rowinsky, E.1    Winde, J.2    Von Hoff, D.3
  • 131
    • 0002989445 scopus 로고    scopus 로고
    • Randomized phase II trial of SCH 66336 and gemcitabine in the treatment of metastatic adenocarcinoma of the pancreas
    • [abstract 609]
    • Lersch C., Van Cutsem E., Amado R.et al. Randomized phase II trial of SCH 66336 and gemcitabine in the treatment of metastatic adenocarcinoma of the pancreas. Proc. Am. Soc. Clin. Oncol. 20:2001;153a. [abstract 609].
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Lersch, C.1    Van Cutsem, E.2    Amado, R.3
  • 132
    • 0000324578 scopus 로고    scopus 로고
    • Phase III trial comparing gemcitabine R115777 (Zarnestra) versus gemcitabine placebo in advanced pancreatic cancer (PC)
    • [abstract 517]
    • Van Cutsem E., Karasek H., Oettle H.et al. Phase III trial comparing gemcitabine R115777 (Zarnestra) versus gemcitabine placebo in advanced pancreatic cancer (PC). Proc. Am. Soc. Clin. Oncol. 21:2002;130a. [abstract 517].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Van Cutsem, E.1    Karasek, H.2    Oettle, H.3
  • 133
    • 0001100607 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic phase I study of PS-341 and gemcitabine in patients with advanced solid tumors
    • [abstract 379]
    • Ryan D.P., Eder J.P., Winkelmann J.et al. Pharmacokinetic and pharmacodynamic phase I study of PS-341 and gemcitabine in patients with advanced solid tumors. Proc. Am. Soc. Clin. Oncol. 21:2002;95a. [abstract 379].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Ryan, D.P.1    Eder, J.P.2    Winkelmann, J.3
  • 134
    • 0038561540 scopus 로고    scopus 로고
    • Pharmacology study of celecoxib in combination with gemcitabine for advanced pancreatic cancer
    • [abstract 448]
    • Xiong H.Q., Du M., Wolff R.A.et al. Pharmacology study of celecoxib in combination with gemcitabine for advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 21:2002;113a. [abstract 448].
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Xiong, H.Q.1    Du, M.2    Wolff, R.A.3
  • 135
    • 0033788030 scopus 로고    scopus 로고
    • A phase II study of 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: Correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints
    • Ferry D.R., Deakin M., Baddeley J.et al. A phase II study of 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. Ann. Oncol. 11:2000;1165-1170.
    • (2000) Ann. Oncol. , vol.11 , pp. 1165-1170
    • Ferry, D.R.1    Deakin, M.2    Baddeley, J.3
  • 137
    • 0029816590 scopus 로고    scopus 로고
    • Chemotherapy improves quality of life in advanced pancreatic and biliary cancer
    • Lara Maria Pasetto was born on 5 January 1969 at Alicante (Spain). Since 11 February 2000
    • Glimelius B., Hoffman K., Sjoden P.O.et al. Chemotherapy improves quality of life in advanced pancreatic and biliary cancer. Ann. Oncol. 7:1996;593-600.
    • (1996) Ann. Oncol. , vol.7 , pp. 593-600
    • Glimelius, B.1    Hoffman, K.2    Sjoden, P.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.