Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy

Chemistry - A European Journal

Volumn 10, Issue 21, 2004, Pages 5467-5472

  Sinha, Subhash C ^a   Li, Lian Sheng ^a   Watanabe, Shin Ichi ^a   Kaltgrad, Eiton ^a   Tanaka, Fujie ^a   Rader, Christoph ^a,b   Lerner, Richard A ^a   Barbas III, Carlos F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Aldolase; Antibodies; Chemotherapy; Doxorubicin; Prodrugs

Indexed keywords

ALDEHYDES; BIOASSAY; CELL CULTURE; CHEMICAL ACTIVATION; DRUG PRODUCTS; SYNTHESIS (CHEMICAL);

CANCER CELLS; CYTOTOXICITY; IN VITRO PROLIFERATION ASSAYS;

ANTIBODIES;

93F3 ANTIBODY; ALDEHYDE DERIVATIVE; BUFFER; CYTOTOXIC AGENT; DOXORUBICIN DERIVATIVE; FRUCTOSE BISPHOSPHATE ALDOLASE; MONOCLONAL ANTIBODY; PHOSPHATE; PRODRUG; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ARTICLE; CANCER; CANCER CELL CULTURE; CATALYSIS; CATALYST; CELL POLARITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ALDEHYDES; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, CATALYTIC; CELL LINE, TUMOR; CELL PROLIFERATION; DOXORUBICIN; FRUCTOSE-BISPHOSPHATE ALDOLASE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; NEOPLASMS; PRODRUGS;

EID: 8344238182     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200400419     Document Type: Article

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