SV40 DNA replication inhibition by the monofunctional DNA alkylator Et743

Biochemistry

Volumn 43, Issue 44, 2004, Pages 14228-14237

  Dziegielewska, Barbara ^a   Kowalski, David ^a   Beerman, Terry A ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CARCINOGENS; CONCENTRATION (PROCESS); DRUG PRODUCTS; ELECTROPHORESIS; EXTRACTION; MATHEMATICAL MODELS; SYNTHESIS (CHEMICAL);

ANTICANCER AGENT; CYTOTOXICITY; DNA ALKYLATORS;

DNA;

ALKYLATING AGENT; BENZODIAZEPINE DERIVATIVE; CELL EXTRACT; DNA; SAFRAMYCIN A; TRABECTEDIN;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; CELL GROWTH; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; DNA ADDUCT; DNA ALKYLATION; DNA HELIX; DNA ISOLATION; DNA REPLICATION; DNA SEQUENCE; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; DNA TEMPLATE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SIMIAN VIRUS 40; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTIVIRAL AGENTS; ASPERGILLUS NUCLEASE S1; BENZODIAZEPINES; CELL LINE; CELL-FREE SYSTEM; CERCOPITHECUS AETHIOPS; DIOXOLES; DNA ADDUCTS; DNA REPLICATION; DNA, VIRAL; EXODEOXYRIBONUCLEASES; HCT116 CELLS; HUMANS; INTRACELLULAR FLUID; ISOQUINOLINES; PYRROLES; SIMIAN VIRUS 40; TEMPLATES, GENETIC; TETRAHYDROISOQUINOLINES; UROCHORDATA; VIRUS REPLICATION;

ANIMALIA; ECTEINASCIDIA; ECTEINASCIDIA TURBINATA; MAMMALIA; SIMIAE; SIMIAN VIRUS 40;

EID: 8344224571     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049407x     Document Type: Article

References (43)

1. Vogt, V. M. (1973) Purification and further properties of single-strand-specific nuclease from Aspergillus oryzae, Eur. J. Biochem. 33, 192-200.
2. Valoti, G., Nicoletti, M. I., Pellegrino, A., Jimeno, J., Hendriks, H., D'Incalci, M., Faircloth, G., and Giavazzi, R. (1998) Ectein-ascidin-743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts, Clin. Cancer Res. 4, 1977-1983.
3. Hendriks, H. R., Fiebig, H. H., Giavazzi, R., Langdon, S. P., Jimeno, J. M., and Faircloth, G. T. (1999) High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer, Ann. Oncol. 10, 1233-1240.
4. Izbicka, E., Lawrence, R., Raymond, E., Eckhardt, G., Faircloth, G., Jimeno, J., Clark, G., and Von Hoff, D. D. (1998) In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients, Ann. Oncol. 9, 981-987.
5. Demetri, G. D. (2002) ET-743: The US experience in sarcomas of soft tissues, Anticancer Drugs 13 (Suppl 1), S7-S9.
6. Pommier, Y., Kohlhagen, G., Bailly, C., Waring, M., Mazumder, A., and Kohn, K. W. (1996) DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata, Biochemistry 35, 13303-13309.
7. Petrusek, R. L., Anderson, G. L., Garner, T. F., Fannin, Q. L., Kaplan, D. J., Zimmer, S. G., and Hurley, L. H. (1981) Pyrrol-[1,4]benzodiazepine antibiotics. Proposed structures and characteristics of the in vitro deoxyribonucleic acid adducts of anthramycin, tomaymycin, sibiromycin, and neothramycins A and B, Biochemistry 20, 1111-1119.
8. Zewail-Foote, M., and Hurley, L. H. (1999) Ecteinascidin 743: A minor groove alkylator that bends DNA toward the major groove, J. Med. Chem. 42, 2493-2497.
9. Bonfanti, M., La Valle, E., Fernandez Sousa Faro, J. M., Faircloth, G., Caretti, G., Mantovani, R., and D'Incalci, M. (1999) Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA, Anti-Cancer Drug Des. 14, 179-186.
10. Minuzzo, M., Marchini, S., Broggini, M., Faircloth, G., D'Incalci, M., and Mantovani, R. (2000) Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743, Proc. Natl. Acad. Sci. U.S.A. 97, 6780-6784.
11. Zewail-Foote, M., Li, V. S., Kohn, H., Bearss, D., Guzman, M., and Hurley, L. H. (2001) The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent, Chem. Biol. 8, 1033-1049.
12. Takebayashi, Y., Pourquier, P., Zimonjic, D. B., Nakayama, K., Emmert, S., Ueda, T., Urasaki, Y., Kanzaki, A., Akiyama, S. I., Popescu, N., Kraemer, K. H., and Pommier, Y. (2001) Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair, Nat. Med. 7, 961-966.
13. Takebayashi, Y., Goldwasser, F., Urasaki, Y., Kohlhagen, G., and Pommier, Y. (2001) Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression, Clin. Cancer Res. 7, 185-191.
14. Gajate, C., An, F., and Mollinedo, F. (2002) Differential Cytostatic and Apoptotic Effects of Ecteinascidin-743 in Cancer Cells. Transcription-dependent cell cycle arrest and transcription-independent jnk and mitochondrial mediated apoptosis, J. Biol. Chem. 277, 41580-41589.
15. Erba, E., Bergamaschi, D., Bassano, L., Damia, G., Ronzoni, S., Faircloth, G. T., and D'Incalci, M. (2001) Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action, Eur. J. Cancer 37, 97-105.
16. Basu, A. K., Hanrahan, C. J., Malia, S. A., Kumar, S., Bizanek, R., and Tomasz, M. (1993) Effect of site-specifically located mitomycin C-DNA monoadducts on in vitro DNA synthesis by DNA polymerases, Biochemistry 32, 4708-4718.
17. Heiger-Bernays, W. J., Essigmann, J. M., and Lippard, S. J. (1990) Effect of the antitumor drug cis-diamminedichloroplatinum(II) and related platinum complexes on eukaryotic DNA replication, Biochemistry 29, 8461-8466.
18. Marchetti, M. A., Kumar, S., Hartsuiker, E., Maftahi, M., Carr, A. M., Freyer, G. A., Burhans, W. C., and Huberman, J. A. (2002) A single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway, Proc. Natl. Acad. Sci. U.S.A. 99, 7472-7477.
19. Canman, C. E., and Lim, D. S. (1998) The role of ATM in DNA damage responses and cancer, Oncogene 17, 3301-3308.
20. Zhou, B. B., and Elledge, S. J. (2000) The DNA damage response: Putting checkpoints in perspective, Nature 408, 433-439.
21. Shao, R. G., Cao, C. X., Zhang, R, Kohn, K. W., Wold, M. S., and Pommier, Y. (1999) Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes, EMBO J. 18, 1397-1406.
22. Wang, J. L., Wang, X., Wang, H., Iliakis, G., and Wang, Y. (2002) CHK1-regulated S-phase checkpoint response reduces camptothecin cytotoxicity, Cell Cycle 1, 267-272.
23. Damia, G., Silvestri, S., Carrassa, L., Filiberti, L., Faircloth, G. T., Liberi, G., Foiani, M., and D'Incalci, M. (2001) Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways, Int. J. Cancer 92, 583-588.
24. Cobuzzi, R. J., Burhans, W. C., and Beerman, T. A. (1996) Inhibition of initiation of simian virus 40 DNA replication in infected BSC-1 cells by the DNA alkylating drug adozelesin, J. Biol. Chem. 271, 19852-19859.
25. McHugh, M. M., Kuo, S. R., Walsh-O'Beirne, M. H., Liu, J. S., Melendy, T., and Beerman, T. A. (1999) Bizelesin, a bifunctional cyclopropylpyrroloindole alkylating agent, inhibits simian virus 40 replication in trans by induction of an inhibitor, Biochemistry 38, 11508-11515.
26. Li, J. J., and Kelly, T. J. (1984) Simian virus 40 DNA replication in vitro, Proc. Natl. Acad. Sci. U.S.A. 81, 6973-6977.
27. McHugh, M. M., Beerman, T. A., and Burhans, W. C. (1997) DNA-damaging enediyne C-1027 inhibits initiation of intracellular SV40 DNA replication in trans, Biochemistry 36, 1003-1009.
28. Liu, J. S., Kuo, S. R., McHugh, M. M., Beerman, T. A., and Melendy, T. (2000) Adozelesin triggers DNA damage response pathways and arrests SV40 DNA replication through replication protein A inactivation, J. Biol. Chem. 275, 1391-1397.
29. Kizu, R., Draves, P. H., and Hurley, L. H. (1993) Correlation of DNA sequence specificity of anthramycin and tomaymycin with reaction kinetics and bending of DNA, Biochemistry 32, 8712-8722.
30. Stillman, B. W. and Gluzman, Y. (1985) Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells, Mol. Cell. Biol. 5, 2051-2060.
31. Stillman, B., Gerard, R. D., Guggenheimer, R. A., and Gluzman, Y. (1985) T antigen and template requirements for SV40 DNA replication in vitro, EMBO J. 4, 2933-2939.
32. Arad, U. (1998) Modified Hirt procedure for rapid purification of extrachromosomal DNA from mammalian cells, BioTechniques 24, 760-762.
33. Brewer, B. J., and Fangman, W. L. (1987) The localization of replication origins on ARS plasmids in S. cerevisiae, Cell 51, 463-471.
34. Rao, K. E., and Lown, J. W. (1990) Mode of action of saframycin antitumor antibiotics: Sequence selectivities in the covalent binding of saframycins A and S to deoxyribonucleic acid, Chem. Res. Toxicol. 3, 262-267.
35. Lopes, M., Cotta-Ramusino, C., Pellicioli, A., Liberi, G., Plevani, P., Muzi-Falconi, M., Newlon, C. S., and Foiani, M. (2001) The DNA replication checkpoint response stabilizes stalled replication forks, Nature 412, 557-561.
36. Sogo, J. M., Lopes, M., and Foiani, M. (2002) Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects, Science 297, 599-602.
37. Zsido, T. J., Woynarowski, J. M., Baker, R. M., Gawron, L. S., and Beerman, T. A. (1991) Induction of heat-labile sites in DNA of mammalian cells by the antitumor alkylating drug CC-1065, Biochemistry 30, 3733-3738.
38. Miao, H., Seiler, J. A., and Burhans, W. C. (2003) Regulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpoints, J. Biol. Chem. 278, 4295-4304.
39. Lin, S., and Kowalski, D. (1994) DNA helical instability facilitates initiation at the SV40 replication origin, J. Mol. Biol. 235, 496-507.
40. Weinberger, M., Trabold, P. A., Lu, M., Sharma, K., Huberman, J. A., and Burhans, W. C. (1999) Induction by adozelesin and hydroxyurea of origin recognition complex-dependent DNA damage and DNA replication checkpoints in Saccharomyces cerevisiae, J. Biol. Chem. 274, 35975-35984.
41. Woynarowski, J. M., Napier, C., Trevino, A. V., and Arnett, B. (2000) Region-specific DNA damage by AT-specific DNA-reactive drugs is predicted by drug binding specificity, Biochemistry 39, 9917-9927.
42. Wang, Y., Beerman, T. A., and Kowalski, D. (2001) Antitumor drug adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase mutants, Cancer Res. 61, 3787-3794.
43. Goodman, M. F. (2002) Error-prone repair DNA polymerases in prokaryotes and eukaryotes, Annu. Rev. Biochem. 71, 17-50.