The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent

Chemistry and Biology

Volumn 8, Issue 11, 2001, Pages 1033-1049

  Zewail Foote, Maha ^a   Li, Ven Shun ^b   Kohn, Harold ^b   Bearss, David ^c   Guzman, Mary ^c   Hurley, Laurence H ^a,c  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b University of Houston   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Alkylating agent; Anticancer drug; DNA repair; Ecteinascidin

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; ALKYLATING AGENT; DEOXYRIBONUCLEASE; DNA; ENDODEOXYRIBONUCLEASE UVRABC; ESCHERICHIA COLI PROTEIN; ISOQUINOLINE DERIVATIVE; TRABECTEDIN;

ANIMAL; ARTICLE; BINDING SITE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; DNA ADDUCT; DNA REPAIR; DRUG DELIVERY SYSTEM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; HAMSTER; HUMAN; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

ANIMAL; ANTINEOPLASTIC AGENTS, ALKYLATING; BASE SEQUENCE; BINDING SITES; CELL SURVIVAL; CHO CELLS; DIOXOLES; DNA; DNA ADDUCTS; DNA REPAIR; DRUG DELIVERY SYSTEMS; ENDODEOXYRIBONUCLEASES; ESCHERICHIA COLI PROTEINS; GENE TARGETING; HAMSTERS; HUMAN; ISOQUINOLINES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035199322     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00071-0     Document Type: Article

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