Essential factors for incompatible DNA end joining at chromosomal DNA double strand breaks in vivo

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Ogiwara, Hideaki ^a   Kohno, Takashi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME PAIRING; CONTROLLED STUDY; DNA DETERMINATION; DNA REPAIR; DNA STRAND BREAKAGE; DNA STRUCTURE; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC INCOMPATIBILITY; HUMAN; HUMAN CELL; NONHOMOLOGOUS END JOINING; PROTEIN DEPLETION; PROTEIN FUNCTION; CHROMOSOME BREAKAGE; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; HUMAN CHROMOSOME; METABOLISM; TUMOR CELL LINE;

PROTEIN;

CELL LINE, TUMOR; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; HUMANS; PROTEINS;

EID: 83355168615     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028756     Document Type: Article

References (35)

1. Lieber MR, Ma Y, Pannicke U, Schwarz K, (2003) Mechanism and regulation of human non-homologous DNA end-joining. Nat Rev Mol Cell Biol 4: 712-720.
2. Valerie K, Povirk LF, (2003) Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22: 5792-5812.
3. Lieber MR, (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79: 181-211.
4. van Gent DC, van der Burg M, (2007) Non-homologous end-joining, a sticky affair. Oncogene 26: 7731-7740.
5. Lieber MR, (2008) The mechanism of human nonhomologous DNA end joining. J Biol Chem 283: 1-5.
6. Kabotyanski EB, Gomelsky L, Han JO, Stamato TD, Roth DB, (1998) Double-strand break repair in Ku86- and XRCC4-deficient cells. Nucleic Acids Res 26: 5333-5342.
7. Verkaik NS, Esveldt-van Lange RE, van Heemst D, Bruggenwirth HT, Hoeijmakers JH, et al. (2002) Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol 32: 701-709.
8. Smith J, Riballo E, Kysela B, Baldeyron C, Manolis K, et al. (2003) Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res 31: 2157-2167.
9. Katsura Y, Sasaki S, Sato M, Yamaoka K, Suzukawa K, et al. (2007) Involvement of Ku80 in microhomology-mediated end joining for DNA double-strand breaks in vivo. DNA Repair (Amst) 6: 639-648.
10. Burma S, Chen BP, Chen DJ, (2006) Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst) 5: 1042-1048.
11. Ma Y, Pannicke U, Schwarz K, Lieber MR, (2002) Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108: 781-794.
12. Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, et al. (2004) A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell 16: 701-713.
13. Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA, (2002) Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Mol Cell Biol 22: 5194-5202.
14. Ogiwara H, Ui A, Otsuka A, Satoh H, Yokomi I, et al. (2011) Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors. Oncogene 30: 2135-2146.
15. Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, et al. (2004) Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 64: 9152-9159.
16. Veuger SJ, Curtin NJ, Richardson CJ, Smith GC, Durkacz BW, (2003) Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res 63: 6008-6015.
17. Ma Y, Pannicke U, Lu H, Niewolik D, Schwarz K, et al. (2005) The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis. J Biol Chem 280: 33839-33846.
18. Guirouilh-Barbat J, Huck S, Bertrand P, Pirzio L, Desmaze C, et al. (2004) Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. Mol Cell 14: 611-623.
19. Vandersickel V, Mancini M, Marras E, Willems P, Slabbert J, et al. (2010) Lentivirus-mediated RNA interference of Ku70 to enhance radiosensitivity of human mammary epithelial cells. Int J Radiat Biol 86: 114-124.
20. Weterings E, van Gent DC, (2004) The mechanism of non-homologous end-joining: a synopsis of synapsis. DNA Repair (Amst) 3: 1425-1435.
21. Smith GC, Jackson SP, (1999) The DNA-dependent protein kinase. Genes Dev 13: 916-934.
22. Covo S, Blanco L, Livneh Z, (2004) Lesion bypass by human DNA polymerase mu reveals a template-dependent, sequence-independent nucleotidyl transferase activity. J Biol Chem 279: 859-865.
23. Davis BJ, Havener JM, Ramsden DA, (2008) End-bridging is required for pol mu to efficiently promote repair of noncomplementary ends by nonhomologous end joining. Nucleic Acids Res 36: 3085-3094.
24. Daley JM, Laan RL, Suresh A, Wilson TE, (2005) DNA joint dependence of pol X family polymerase action in nonhomologous end joining. J Biol Chem 280: 29030-29037.
25. Miller KM, Tjeertes JV, Coates J, Legube G, Polo SE, et al. (2010) Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol 17: 1144-1151.
26. Lan L, Ui A, Nakajima S, Hatakeyama K, Hoshi M, et al. (2010) The ACF1 complex is required for DNA double-strand break repair in human cells. Mol Cell 40: 976-987.
27. Peng G, Yim EK, Dai H, Jackson AP, Burgt I, et al. (2009) BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol 11: 865-872.
28. Murr R, Loizou JI, Yang YG, Cuenin C, Li H, et al. (2006) Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat Cell Biol 8: 91-99.
29. Bertocci B, De Smet A, Weill JC, Reynaud CA, (2006) Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. Immunity 25: 31-41.
30. Kohno T, Yokota J, (2006) Molecular processes of chromosome 9p21 deletions causing inactivation of the p16 tumor suppressor gene in human cancer: deduction from structural analysis of breakpoints for deletions. DNA Repair (Amst) 5: 1273-1281.
31. Weinstock DM, Elliott B, Jasin M, (2006) A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair. Blood 107: 777-780.
32. Mani RS, Chinnaiyan AM, (2010) Triggers for genomic rearrangements: insights into genomic, cellular and environmental influences. Nat Rev Genet 11: 819-829.
33. Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, et al. (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434: 907-913.
34. Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, et al. (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434: 864-870.
35. Helleday T, Petermann E, Lundin C, Hodgson B, Sharma RA, (2008) DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 8: 193-204.