The cytotoxicity of cadmium-based quantum dots

Biomaterials

Volumn 33, Issue 5, 2012, Pages 1238-1244

  Chen, Nan ^a   He, Yao ^b   Su, Yuanyuan ^a,b   Li, Xiaoming ^a   Huang, Qing ^a   Wang, Haifeng ^c   Zhang, Xiangzhi ^a   Tai, Renzhong ^a   Fan, Chunhai ^a  

^a SHANGHAI INSTITUTE OF APPLIED PHYSICS   (China)

^b SOOCHOW UNIVERSITY   (China)

^c CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

Author keywords

Cadmium based quantum dots; Cytotoxicity; Metallothioneins; Nanomaterials

Indexed keywords

CADMIUM IONS; CDTE; CDTE/CDS; CORE-SHELL; CYTOTOXICITY ASSESSMENT; GENE EXPRESSION PROFILING; IN-VITRO; INTRACELLULAR DISTRIBUTION; INTRACELLULAR LEVELS; MECHANISTIC STUDIES; METALLOTHIONEINS; NANOSCALE EFFECTS; RECENT PROGRESS; SCANNING TRANSMISSION X RAY MICROSCOPY; SUBCELLULAR LOCALIZATIONS;

CADMIUM; CADMIUM CHLORIDE; CADMIUM COMPOUNDS; CADMIUM TELLURIDE; CELLS; CYTOTOXICITY; GENE EXPRESSION; HEAVY METALS; METAL IONS; OPTICAL PROPERTIES; SHELLS (STRUCTURES); ZINC SULFIDE;

SEMICONDUCTOR QUANTUM DOTS;

CADMIUM; CADMIUM CHLORIDE; CADMIUM SULFIDE; CASPASE 3; CASPASE 9; CYTOCHROME C; METALLOPROTEIN; QUANTUM DOT; ZINC SULFIDE;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HEK293; CELL STRUCTURE; CELL VIABILITY; CELLULAR DISTRIBUTION; CRYSTAL STRUCTURE; CYTOTOXICITY; ENZYME RELEASE; GENE EXPRESSION PROFILING; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; LIGHT SCATTERING; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING TRANSMISSION ELECTRON MICROSCOPY; SYNCHROTRON; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION;

ANIMALS; CADMIUM; CELL DEATH; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMANS; QUANTUM DOTS; SURFACE PROPERTIES;

EID: 83355166777     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.10.070     Document Type: Article

References (59)

1. Rothenfluh D.A., Bermudez H., O'Neil C.P., Hubbell J.A. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nat Mater 2008, 7:248-254.
2. Kostarelos K., Bianco A., Prato M. Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. Nat Nanotechnol 2009, 4:627-633.
3. Michalet X., Pinaud F.F., Bentolila L.A., Tsay J.M., Doose S., Li J.J., et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 2005, 307:538-544.
4. Chen Z., Tabakman S.M., Goodwin A.P., Kattah M.G., Daranciang D., Wang X.R., et al. Protein microarrays with carbon nanotubes as multicolor Raman labels. Nat Biotechnol 2008, 26:1285-1292.
5. Qian X.M., Peng X.H., Ansari D.O., Yin-Goen Q., Chen G.Z., Shin D.M., et al. In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. Nat Biotechnol 2008, 26:83-90.
6. He Y., Fan C.H., Lee S.T. Silicon nanostructures for bioapplications. Nano Today 2010, 5:282-295.
7. Dubertret B., Skourides P., Norris D.J., Noireaux V., Brivanlou A.H., Libchaber A. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 2002, 298:1759-1762.
8. Alivisatos P. The use of nanocrystals in biological detection. Nat Biotechnol 2004, 22:47-52.
9. Alivisatos A.P. Semiconductor nanocrystals as fluorescent biological labels. Abstr Pap Am Chem S 1999, 218. U296-U.
10. Chan W.C.W., Nie S.M. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 1998, 281:2016-2018.
11. Murray C.B., Norris D.J., Bawendi M.G. Synthesis and characterization of nearly monodisperse Cde (e = S, Se, Te) semiconductor nanocrystallites. J Am Chem Soc 1993, 115:8706-8715.
12. Peng X.G., Manna L., Yang W.D., Wickham J., Scher E., Kadavanich A., et al. Shape control of CdSe nanocrystals. Nature 2000, 404:59-61.
13. Qu L.H., Peng X.G. Control of photoluminescence properties of CdSe nanocrystals in growth. J Am Chem Soc 2002, 124:2049-2055.
14. Pellegrino T., Manna L., Kudera S., Liedl T., Koktysh D., Rogach A.L., et al. Hydrophobic nanocrystals coated with an amphiphilic polymer shell: a general route to water soluble nanocrystals. Nano Lett 2004, 4:703-707.
15. Gerion D., Pinaud F., Williams S.C., Parak W.J., Zanchet D., Weiss S., et al. Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots. J Phys Chem B 2001, 105:8861-8871.
16. Wuister S.F., Swart I., van Driel F., Hickey S.G., Donega C.D.M. Highly luminescent water-soluble CdTe quantum dots. Nano Lett 2003, 3:503-507.
17. Bao H.B., Gong Y.J., Li Z., Gao M.Y. Enhancement effect of illumination on the photoluminescence of water-soluble CdTe nanocrystals: toward highly fluorescent CdTe/CdS core-shell structure. Chem Mater 2004, 16:3853-3859.
18. Choi H.S., Liu W.H., Misra P., Tanaka E., Zimmer J.P., Ipe B.I., et al. Renal clearance of quantum dots. Nat Biotechnol 2007, 25:1165-1170.
19. Gaponik N., Talapin D.V., Rogach A.L., Hoppe K., Shevchenko E.V., Kornowski A., et al. Thiol-capping of CdTe nanocrystals: an alternative to organometallic synthetic routes. J Phys Chem B 2002, 106:7177-7185.
20. Guo J., Yang W.L., Wang C.C. Systematic study of the photoluminescence dependence of thiol-capped CdTe nanocrystals on the reaction conditions. J Phys Chem B 2005, 109:17467-17473.
21. He Y., Sai L.M., Lu H.T., Hu M., Lai W.Y., Fan Q.L., et al. Microwave-assisted synthesis of water-dispersed CdTe nanocrystals with high luminescent efficiency and narrow size distribution. Chem Mater 2007, 19:359-365.
22. He Y., Lu H.T., Sai L.M., Lai W.Y., Fan Q.L., Wang L.H., et al. Microwave-assisted growth and characterization of water-dispersed CdTe/CdS core-shell nanocrystals with high photoluminescence. J Phys Chem B 2006, 110:13370-13374.
23. He Y., Lu H.T., Sai L.M., Lai W.Y., Fan Q.L., Wang L.H., et al. Synthesis of CdTe nanocrystals through program process of microwave irradiation. J Phys Chem B 2006, 110:13352-13356.
24. He Y., Lu H.T., Sai L.M., Su Y.Y., Hu M., Fan C.H., et al. Microwave synthesis of water-dispersed CdTe/CdS/ZnS core-shell-shell quantum dots with excellent photostability and biocompatibility. Adv Mater 2008, 20. 3416-+.
25. Yan J., Hu M., Li D., He Y., Zhao R., Jiang X.Y., et al. A nano- and micro- integrated protein chip based on quantum dot probes and a microfluidic network. Nano Res 2008, 1:490-496.
26. Hu M., Yan J., He Y., Lu H.T., Weng L.X., Song S.P., et al. Ultrasensitive, multiplexed detection of cancer biomarkers directly in serum by using a quantum dot-based microfluidic protein chip. Acs Nano 2010, 4:488-494.
27. He Y., Lu H.T., Su Y.Y., Sai L.M., Hu M., Fan C.H., et al. Ultra-photostable, non-cytotoxic, and highly fluorescent quantum nanospheres for long-term, high-specificity cell imaging. Biomaterials 2011, 32:2133-2140.
28. He Y., Zhong Y.L., Su Y.Y., Lu Y.M., Jiang Z.Y., Peng F., et al. Water-dispersed near-infrared-emitting quantum dots of ultrasmall sizes for in vitro and in vivo imaging. Angew Chem Int Edit 2011, 50:5694-5697.
29. Derfus A.M., Chan W.C.W., Bhatia S.N. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 2004, 4:11-18.
30. Kirchner C., Liedl T., Kudera S., Pellegrino T., Javier A.M., Gaub H.E., et al. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett 2005, 5:331-338.
31. Green M., Howman E. Semiconductor quantum dots and free radical induced DNA nicking. Chem Commun 2005, 121-123.
32. Lovric J., Cho S.J., Winnik F.M., Maysinger D. Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death. Chem Biol 2005, 12:1227-1234.
33. Lewinski N., Colvin V., Drezek R. Cytotoxicity of nanoparticles. Small 2008, 4:26-49.
34. Parak W.J., Pellegrino T., Plank C. Labelling of cells with quantum dots. Nanotechnology 2005, 16:R9-R25.
35. Su Y.Y., Peng F., Jiang Z.Y., Zhong Y.L., Lu Y.M., Jiang X., et al. In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots. Biomaterials 2011, 32:5855-5862.
36. Banerjee S.S., Chen D.H. Magnetic nanoparticles grafted with cyclodextrin for hydrophobic drug delivery. Chem Mater 2007, 19:6345-6349.
37. He Y., Kang Z.H., Li Q.S., Tsang C.H.A., Fan C.H., Lee S.T. Ultrastable, highly fluorescent, and water-dispersed silicon-based nanospheres as cellular probes. Angew Chem Int Edit 2009, 48:128-132.
38. Su Y., He Y., Lu H., Sai L., Li Q., Li W., et al. The cytotoxicity of cadmium based, aqueous phase - synthesized, quantum dots and its modulation by surface coating. Biomaterials 2009, 30:19-25.
39. Su Y., Hu M., Fan C., He Y., Li Q., Li W., et al. The cytotoxicity of CdTe quantum dots and the relative contributions from released cadmium ions and nanoparticle properties. Biomaterials 2010, 31:4829-4834.
40. Ipe B.I., Lehnig M., Niemeyer C.M. On the generation of free radical species from quantum dots. Small 2005, 1:706-709.
41. Cho S.J., Maysinger D., Jain M., Roder B., Hackbarth S., Winnik F.M. Long-term exposure to CdTe quantum dots causes functional impairments in live cells. Langmuir 2007, 23:1974-1980.
42. Chan W.H., Shiao N.H., Lu P.Z. CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals. Toxicol Lett 2006, 167:191-200.
43. Gobe G., Crane D. Mitochondria, reactive oxygen species and cadmium toxicity in the kidney. Toxicol Lett 2010, 198:49-55.
44. Klaassen C.D., Liu J., Choudhuri S. Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol 1999, 39:267-294.
45. Andrews G.K. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol 2000, 59:95-104.
46. West A.K., Stallings R., Hildebrand C.E., Chiu R., Karin M., Richards R.I. Human metallothionein genes - structure of the functional locus at 16q13. Genomics 1990, 8:513-518.
47. Stennard F.A., Holloway A.F., Hamilton J., West A.K. Characterisation of six additional human metallothionein genes. Biochim Biophys Acta 1994, 1218:357-365.
48. Lovric J., Bazzi H.S., Cuie Y., Fortin G.R.A., Winnik F.M., Maysinger D. Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J Mol Med-Jmm 2005, 83:377-385.
49. Chao W., Kim J., Rekawa S., Fischer P., Anderson E.H. Demonstration of 12 nm resolution fresnel zone plate lens based Soft X-ray microscopy. Opt Express 2009, 17:17669-17677.
50. Parkinson D.Y., McDermott G., Etkin L.D., Le Gros M.A., Larabell C.A. Quantitative 3-D imaging of eukaryotic cells using soft X-ray tomography. J Struct Biol 2008, 162:380-386.
51. Meyer-Ilse W., Hamamoto D., Nair A., Lelievre S.A., Denbeaux G., Johnson L., et al. High resolution protein localization using soft X-ray microscopy. J Microsc-Oxford 2001, 201:395-403.
52. Zhang X.Z., Xu Z.J., Tai R.Z., Zhen X.J., Wang Y., Guo Z., et al. Ratio-contrast imaging of dual-energy absorption for element mapping with a scanning transmission X-ray microscope. J Synchrotron Radiat 2010, 17:804-809.
53. Bottrill M., Green M. Some aspects of quantum dot toxicity. Chem Commun 2011, 47:7039-7050.
54. Rzigalinski B.A., Strobl J.S. Cadmium-containing nanoparticles: perspectives on pharmacology and toxicology of quantum dots. Toxicol Appl Pharmacol 2009, 238:280-288.
55. Pelley J.L., Daar A.S., Saner M.A. State of academic knowledge on toxicity and biological fate of quantum dots. Toxicol Sci 2009, 112:276-296.
56. Zhang L.W., Baumer W., Monteiro-Riviere N.A. Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells. Nanomedicine-UK 2011, 6:777-791.
57. Hardman R. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ Health Perspect 2006, 114:165-172.
58. Hoshino A., Fujioka K., Oku T., Suga M., Sasaki Y.F., Ohta T., et al. Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 2004, 4:2163-2169.
59. Cuypers A., Plusquin M., Remans T., Jozefczak M., Keunen E., Gielen H., et al. Cadmium stress: an oxidative challenge. Biometals 2010, 23:927-940.