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Volumn 6, Issue 12, 2011, Pages

Cigarette smoking and p16 ink4α gene promoter hypermethylation in non-small cell lung Carcinoma patients: A meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

ADENOCARCINOMA; ADULT; AGED; ARTICLE; ASIAN; CIGARETTE SMOKING; CONTROLLED STUDY; CORRELATIONAL STUDY; CROSS-SECTIONAL STUDY; DATA ANALYSIS; DNA METHYLATION; GENE EXPRESSION; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MARKER GENE; P16 INK4ALPHA GENE; PROMOTER REGION; QUANTITATIVE STUDY; SMOKING HABIT; SQUAMOUS CELL CARCINOMA; SYSTEMATIC REVIEW; GENETICS; LUNG TUMOR; META ANALYSIS; MIDDLE AGED; PUBLISHING; SAMPLE SIZE; SMOKING;

EID: 83255181725     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028882     Document Type: Article
Times cited : (24)

References (63)
  • 1
    • 83255171853 scopus 로고    scopus 로고
    • Ministry of Health of the People,s Republic of China, Beijing, Peking Union Medical College Press
    • Ministry of Health of the People,s Republic of China (2008) The cause of death in China: the third retrospective sample survey Beijing Peking Union Medical College Press.
    • (2008) The Cause of Death in China: The Third Retrospective Sample Survey
  • 2
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, et al. (2002) Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346: 92-98.
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3    Langer, C.4    Sandler, A.5
  • 4
    • 0028649529 scopus 로고
    • Lifetime probability of developing lung cancer, by smoking status, Canada
    • Villeneuve PJ, Mao Y, (1994) Lifetime probability of developing lung cancer, by smoking status, Canada. Can J Public Health 85: 385-388.
    • (1994) Can J Public Health , vol.85 , pp. 385-388
    • Villeneuve, P.J.1    Mao, Y.2
  • 5
    • 34648815009 scopus 로고    scopus 로고
    • Lung cancer in never smokers-a different disease
    • Sun S, Schiller JH, Gazdar AF, (2007) Lung cancer in never smokers-a different disease. Nat Rev Cancer 7: 778-790.
    • (2007) Nat Rev Cancer , vol.7 , pp. 778-790
    • Sun, S.1    Schiller, J.H.2    Gazdar, A.F.3
  • 6
    • 33947502512 scopus 로고    scopus 로고
    • Lung cancer in never smokers: a review
    • Subramanian J, Govindan R, (2007) Lung cancer in never smokers: a review. J Clin Oncol 25: 561-570.
    • (2007) J Clin Oncol , vol.25 , pp. 561-570
    • Subramanian, J.1    Govindan, R.2
  • 7
    • 34247095520 scopus 로고    scopus 로고
    • Lung cancer in never-smokers
    • Toh CK, Lim WT, (2007) Lung cancer in never-smokers. J Clin Pathol 60: 337-340.
    • (2007) J Clin Pathol , vol.60 , pp. 337-340
    • Toh, C.K.1    Lim, W.T.2
  • 8
    • 4544250024 scopus 로고    scopus 로고
    • Gene-promoter hypermethylation as a biomarker in lung cancer
    • Belinsky SA, (2004) Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer 4: 707-717.
    • (2004) Nat Rev Cancer , vol.4 , pp. 707-717
    • Belinsky, S.A.1
  • 9
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB, (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 10
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB, (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349: 2042-2054.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 12
    • 0037427808 scopus 로고    scopus 로고
    • Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer
    • Toyooka S, Maruyama R, Toyooka KO, McLerran D, Feng Z, et al. (2003) Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer 103: 153-160.
    • (2003) Int J Cancer , vol.103 , pp. 153-160
    • Toyooka, S.1    Maruyama, R.2    Toyooka, K.O.3    McLerran, D.4    Feng, Z.5
  • 15
    • 0032578509 scopus 로고    scopus 로고
    • Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
    • Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, et al. (1998) Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci USA 95: 11891-11896.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11891-11896
    • Belinsky, S.A.1    Nikula, K.J.2    Palmisano, W.A.3    Michels, R.4    Saccomanno, G.5
  • 16
    • 16544386625 scopus 로고    scopus 로고
    • Prognostic factors in resected stage I non-small-cell lung cancer: a multivariate analysis of six molecular markers
    • Lu C, Soria JC, Tang X, Xu XC, Wang L, et al. (2004) Prognostic factors in resected stage I non-small-cell lung cancer: a multivariate analysis of six molecular markers. J Clin Oncol 22: 4575-4583.
    • (2004) J Clin Oncol , vol.22 , pp. 4575-4583
    • Lu, C.1    Soria, J.C.2    Tang, X.3    Xu, X.C.4    Wang, L.5
  • 17
    • 40849124009 scopus 로고    scopus 로고
    • DNA methylation markers and early recurrence in stage I lung cancer
    • Brock MV, Hooker CM, Ota-Machida E, Han Y, Guo M, et al. (2008) DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med 358: 1118-1128.
    • (2008) N Engl J Med , vol.358 , pp. 1118-1128
    • Brock, M.V.1    Hooker, C.M.2    Ota-Machida, E.3    Han, Y.4    Guo, M.5
  • 18
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, Liang G, Aparicio A, Jones PA, (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429: 457-463.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 19
    • 0029011539 scopus 로고
    • 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
    • Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, et al. (1995) 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1: 686-692.
    • (1995) Nat Med , vol.1 , pp. 686-692
    • Merlo, A.1    Herman, J.G.2    Mao, L.3    Lee, D.J.4    Gabrielson, E.5
  • 20
    • 0035266379 scopus 로고    scopus 로고
    • Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers
    • Sanchez-Cespedes M, Decker PA, Doffek KM, Esteller M, Westra WH, et al. (2001) Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers. Cancer Res 61: 2092-2096.
    • (2001) Cancer Res , vol.61 , pp. 2092-2096
    • Sanchez-Cespedes, M.1    Decker, P.A.2    Doffek, K.M.3    Esteller, M.4    Westra, W.H.5
  • 21
    • 0035132145 scopus 로고    scopus 로고
    • Aberrant promoter methylation of multiple genes in non-small cell lung cancers
    • Zochbauer-Muller S, Fong KM, Virmani AK, Geradts J, Gazdar AF, et al. (2001) Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res 61: 249-255.
    • (2001) Cancer Res , vol.61 , pp. 249-255
    • Zochbauer-Muller, S.1    Fong, K.M.2    Virmani, A.K.3    Geradts, J.4    Gazdar, A.F.5
  • 22
    • 0035870282 scopus 로고    scopus 로고
    • p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer
    • Kim DH, Nelson HH, Wiencke JK, Zheng S, Christiani DC, et al. (2001) p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer. Cancer Res 61: 3419-3424.
    • (2001) Cancer Res , vol.61 , pp. 3419-3424
    • Kim, D.H.1    Nelson, H.H.2    Wiencke, J.K.3    Zheng, S.4    Christiani, D.C.5
  • 23
    • 0036808073 scopus 로고    scopus 로고
    • Frequent epigenetic silencing of the p16 gene in non-small cell lung cancers of tobacco smokers
    • Yanagawa N, Tamura G, Oizumi H, Takahashi N, Shimazaki Y, et al. (2002) Frequent epigenetic silencing of the p16 gene in non-small cell lung cancers of tobacco smokers. Jpn J Cancer Res 93: 1107-1113.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 1107-1113
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3    Takahashi, N.4    Shimazaki, Y.5
  • 24
    • 0042563143 scopus 로고    scopus 로고
    • Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers
    • Yanagawa N, Tamura G, Oizumi H, Takahashi N, Shimazaki Y, et al. (2003) Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers. Cancer Sci 94: 589-592.
    • (2003) Cancer Sci , vol.94 , pp. 589-592
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3    Takahashi, N.4    Shimazaki, Y.5
  • 25
    • 2442462112 scopus 로고    scopus 로고
    • Dose effect of smoking on aberrant methylation in non-small cell lung cancers
    • Toyooka S, Suzuki M, Tsuda T, Toyooka KO, Maruyama R, et al. (2004) Dose effect of smoking on aberrant methylation in non-small cell lung cancers. Int J Cancer 110: 462-464.
    • (2004) Int J Cancer , vol.110 , pp. 462-464
    • Toyooka, S.1    Suzuki, M.2    Tsuda, T.3    Toyooka, K.O.4    Maruyama, R.5
  • 26
    • 8444253477 scopus 로고    scopus 로고
    • Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung
    • Kim JS, Kim H, Shim YM, Han J, Park J, et al. (2004) Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung. Carcinogenesis 25: 2165-2171.
    • (2004) Carcinogenesis , vol.25 , pp. 2165-2171
    • Kim, J.S.1    Kim, H.2    Shim, Y.M.3    Han, J.4    Park, J.5
  • 27
    • 20044383744 scopus 로고    scopus 로고
    • Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers
    • Divine KK, Pulling LC, Marron-Terada PG, Liechty KC, Kang T, et al. (2005) Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers. Int J Cancer 114: 400-405.
    • (2005) Int J Cancer , vol.114 , pp. 400-405
    • Divine, K.K.1    Pulling, L.C.2    Marron-Terada, P.G.3    Liechty, K.C.4    Kang, T.5
  • 28
    • 33646427172 scopus 로고    scopus 로고
    • Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients
    • Liu Y, Lan Q, Siegfried JM, Luketich JD, Keohavong P, (2006) Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients. Neoplasia 8: 46-51.
    • (2006) Neoplasia , vol.8 , pp. 46-51
    • Liu, Y.1    Lan, Q.2    Siegfried, J.M.3    Luketich, J.D.4    Keohavong, P.5
  • 29
    • 33646343483 scopus 로고    scopus 로고
    • The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance
    • Nakata S, Sugio K, Uramoto H, Oyama T, Hanagiri T, et al. (2006) The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance. Cancer 106: 2190-2199.
    • (2006) Cancer , vol.106 , pp. 2190-2199
    • Nakata, S.1    Sugio, K.2    Uramoto, H.3    Oyama, T.4    Hanagiri, T.5
  • 30
    • 32944468706 scopus 로고    scopus 로고
    • Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers
    • Toyooka S, Tokumo M, Shigematsu H, Matsuo K, Asano H, et al. (2006) Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers. Cancer Res 66: 1371-1375.
    • (2006) Cancer Res , vol.66 , pp. 1371-1375
    • Toyooka, S.1    Tokumo, M.2    Shigematsu, H.3    Matsuo, K.4    Asano, H.5
  • 31
    • 35148859298 scopus 로고    scopus 로고
    • Aberrant p16 promoter methylation among Greek lung cancer patients and smokers: correlation with smoking
    • Georgiou E, Valeri R, Tzimagiorgis G, Anzel J, Krikelis D, et al. (2007) Aberrant p16 promoter methylation among Greek lung cancer patients and smokers: correlation with smoking. Eur J Cancer Prev 16: 396-402.
    • (2007) Eur J Cancer Prev , vol.16 , pp. 396-402
    • Georgiou, E.1    Valeri, R.2    Tzimagiorgis, G.3    Anzel, J.4    Krikelis, D.5
  • 32
    • 41849107533 scopus 로고    scopus 로고
    • High frequency of p16 promoter methylation in non-small cell lung carcinomas from Chile
    • Guzman LM, Koriyama C, Akiba S, Eizuru Y, Castillo D, et al. (2007) High frequency of p16 promoter methylation in non-small cell lung carcinomas from Chile. Biol Res 40: 365-372.
    • (2007) Biol Res , vol.40 , pp. 365-372
    • Guzman, L.M.1    Koriyama, C.2    Akiba, S.3    Eizuru, Y.4    Castillo, D.5
  • 33
    • 34548510399 scopus 로고    scopus 로고
    • Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population
    • Kim DS, Cha SI, Lee JH, Lee YM, Choi JE, et al. (2007) Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population. Lung Cancer 58: 1-6.
    • (2007) Lung Cancer , vol.58 , pp. 1-6
    • Kim, D.S.1    Cha, S.I.2    Lee, J.H.3    Lee, Y.M.4    Choi, J.E.5
  • 34
    • 67650164499 scopus 로고    scopus 로고
    • Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers
    • Tessema M, Yu YY, Stidley CA, Machida EO, Schuebel KE, et al. (2009) Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers. Carcinogenesis 30: 1132-1138.
    • (2009) Carcinogenesis , vol.30 , pp. 1132-1138
    • Tessema, M.1    Yu, Y.Y.2    Stidley, C.A.3    Machida, E.O.4    Schuebel, K.E.5
  • 35
    • 78650703071 scopus 로고    scopus 로고
    • The influence of anthracosis and p16 ink4a gene aberrant methylation on small-sized pulmonary adenocarcinoma
    • Wang D, Wang J, Li Y, He Z, Zhang Y, (2010) The influence of anthracosis and p16 ink4a gene aberrant methylation on small-sized pulmonary adenocarcinoma. Exp Mol Pathol 90: 131-136.
    • (2010) Exp Mol Pathol , vol.90 , pp. 131-136
    • Wang, D.1    Wang, J.2    Li, Y.3    He, Z.4    Zhang, Y.5
  • 36
    • 79956115427 scopus 로고    scopus 로고
    • Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status
    • Yanagawa N, Tamura G, Oizumi H, Endoh M, Sadahiro M, et al. (2011) Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status. Anticancer Res 31: 1211-1214.
    • (2011) Anticancer Res , vol.31 , pp. 1211-1214
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3    Endoh, M.4    Sadahiro, M.5
  • 37
    • 79952398109 scopus 로고    scopus 로고
    • Relationship between promoter methylation of p16, DAPK and RAR beta genes and the clinical data of non-small cell lung cancer
    • Zhang CY, Jin YT, Xu HY, Zhang H, Zhang WM, et al. (2011) Relationship between promoter methylation of p16, DAPK and RAR beta genes and the clinical data of non-small cell lung cancer. Chin J Med Genet 28: 23-28.
    • (2011) Chin J Med Genet , vol.28 , pp. 23-28
    • Zhang, C.Y.1    Jin, Y.T.2    Xu, H.Y.3    Zhang, H.4    Zhang, W.M.5
  • 38
    • 10244252662 scopus 로고    scopus 로고
    • Anthracotic index and DNA methylation status of sputum contents can be used for identifying the population at risk of lung carcinoma
    • Konno S, Morishita Y, Fukasawa M, Shu Y, Wang D, et al. (2004) Anthracotic index and DNA methylation status of sputum contents can be used for identifying the population at risk of lung carcinoma. Cancer 102: 348-354.
    • (2004) Cancer , vol.102 , pp. 348-354
    • Konno, S.1    Morishita, Y.2    Fukasawa, M.3    Shu, Y.4    Wang, D.5
  • 39
    • 77951489418 scopus 로고    scopus 로고
    • [Value of promoter methylation of RASSF1A, p16, and DAPK genes in induced sputum in diagnosing lung cancers]
    • Peng Z, Shan C, Wang H, (2010) [Value of promoter methylation of RASSF1A, p16, and DAPK genes in induced sputum in diagnosing lung cancers]. J Cent South Univ (Med Sci) 35: 247-253.
    • (2010) J Cent South Univ (Med Sci) , vol.35 , pp. 247-253
    • Peng, Z.1    Shan, C.2    Wang, H.3
  • 40
    • 0142053910 scopus 로고    scopus 로고
    • Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers
    • Zochbauer-Muller S, Lam S, Toyooka S, Virmani AK, Toyooka KO, et al. (2003) Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers. Int J Cancer 107: 612-616.
    • (2003) Int J Cancer , vol.107 , pp. 612-616
    • Zochbauer-Muller, S.1    Lam, S.2    Toyooka, S.3    Virmani, A.K.4    Toyooka, K.O.5
  • 41
    • 2942737264 scopus 로고    scopus 로고
    • Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer
    • Kim H, Kwon YM, Kim JS, Lee H, Park JH, et al. (2004) Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer. J Clin Oncol 22: 2363-2370.
    • (2004) J Clin Oncol , vol.22 , pp. 2363-2370
    • Kim, H.1    Kwon, Y.M.2    Kim, J.S.3    Lee, H.4    Park, J.H.5
  • 42
    • 19944433956 scopus 로고    scopus 로고
    • Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer
    • Fujiwara K, Fujimoto N, Tabata M, Nishii K, Matsuo K, et al. (2005) Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer. Clin Cancer Res 11: 1219-1225.
    • (2005) Clin Cancer Res , vol.11 , pp. 1219-1225
    • Fujiwara, K.1    Fujimoto, N.2    Tabata, M.3    Nishii, K.4    Matsuo, K.5
  • 43
    • 26444431818 scopus 로고    scopus 로고
    • Promoter methylation of genes in bronchial lavages: a marker for early diagnosis of primary and relapsing non-small cell lung cancer?
    • de Fraipont F, Moro-Sibilot D, Michelland S, Brambilla E, Brambilla C, et al. (2005) Promoter methylation of genes in bronchial lavages: a marker for early diagnosis of primary and relapsing non-small cell lung cancer? Lung Cancer 50: 199-209.
    • (2005) Lung Cancer , vol.50 , pp. 199-209
    • de Fraipont, F.1    Moro-Sibilot, D.2    Michelland, S.3    Brambilla, E.4    Brambilla, C.5
  • 44
  • 45
    • 67649858474 scopus 로고    scopus 로고
    • Detection of p16 promotor hypermethylation in "Maras powder" and tobacco users
    • Saatci C, Caglayan AO, Ozkul Y, Tahiri S, Turhan AB, et al. (2009) Detection of p16 promotor hypermethylation in "Maras powder" and tobacco users. Cancer Epidemiol 33: 47-50.
    • (2009) Cancer Epidemiol , vol.33 , pp. 47-50
    • Saatci, C.1    Caglayan, A.O.2    Ozkul, Y.3    Tahiri, S.4    Turhan, A.B.5
  • 46
    • 72749090135 scopus 로고    scopus 로고
    • Association between lifestyle factors and CpG island methylation in a cancer-free population
    • Brait M, Ford JG, Papaiahgari S, Garza MA, Lee JI, et al. (2009) Association between lifestyle factors and CpG island methylation in a cancer-free population. Cancer Epidemiol Biomarkers Prev 18: 2984-2991.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 2984-2991
    • Brait, M.1    Ford, J.G.2    Papaiahgari, S.3    Garza, M.A.4    Lee, J.I.5
  • 47
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, et al. (2005) Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97: 339-346.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3    Nomura, M.4    Suzuki, M.5
  • 48
  • 49
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr CJ, McCormick F, (2002) The RB and p53 pathways in cancer. Cancer Cell 2: 103-112.
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 50
    • 0344301900 scopus 로고    scopus 로고
    • Role of the p16 tumor suppressor gene in cancer
    • Liggett WH Jr, Sidransky D, (1998) Role of the p16 tumor suppressor gene in cancer. J Clin Oncol 16: 1197-1206.
    • (1998) J Clin Oncol , vol.16 , pp. 1197-1206
    • Liggett Jr., W.H.1    Sidransky, D.2
  • 51
    • 0028121279 scopus 로고
    • A cell cycle regulator potentially involved in genesis of many tumor types
    • Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, et al. (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436-440.
    • (1994) Science , vol.264 , pp. 436-440
    • Kamb, A.1    Gruis, N.A.2    Weaver-Feldhaus, J.3    Liu, Q.4    Harshman, K.5
  • 52
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M, Bell DW, Haber DA, Li E, (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 53
    • 0034720284 scopus 로고    scopus 로고
    • CpG methylation is maintained in human cancer cells lacking DNMT1
    • Rhee I, Jair KW, Yen RW, Lengauer C, Herman JG, et al. (2000) CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404: 1003-1007.
    • (2000) Nature , vol.404 , pp. 1003-1007
    • Rhee, I.1    Jair, K.W.2    Yen, R.W.3    Lengauer, C.4    Herman, J.G.5
  • 54
    • 0030006213 scopus 로고    scopus 로고
    • Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer
    • Belinsky SA, Nikula KJ, Baylin SB, Issa JP, (1996) Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc Natl Acad Sci USA 93: 4045-4050.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4045-4050
    • Belinsky, S.A.1    Nikula, K.J.2    Baylin, S.B.3    Issa, J.P.4
  • 55
    • 0033153303 scopus 로고    scopus 로고
    • The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors
    • Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, et al. (1999) The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res 27: 2291-2298.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2291-2298
    • Robertson, K.D.1    Uzvolgyi, E.2    Liang, G.3    Talmadge, C.4    Sumegi, J.5
  • 56
    • 33846111256 scopus 로고    scopus 로고
    • Alteration of DNA methyltransferases contributes to 5′CpG methylation and poor prognosis in lung cancer
    • Lin RK, Hsu HS, Chang JW, Chen CY, Chen JT, et al. (2007) Alteration of DNA methyltransferases contributes to 5′CpG methylation and poor prognosis in lung cancer. Lung Cancer 55: 205-213.
    • (2007) Lung Cancer , vol.55 , pp. 205-213
    • Lin, R.K.1    Hsu, H.S.2    Chang, J.W.3    Chen, C.Y.4    Chen, J.T.5
  • 57
    • 76649112380 scopus 로고    scopus 로고
    • The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients
    • Lin RK, Hsieh YS, Lin P, Hsu HS, Chen CY, et al. (2010) The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J Clin Invest 120: 521-532.
    • (2010) J Clin Invest , vol.120 , pp. 521-532
    • Lin, R.K.1    Hsieh, Y.S.2    Lin, P.3    Hsu, H.S.4    Chen, C.Y.5
  • 58
    • 0037130479 scopus 로고    scopus 로고
    • The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4a) and RASSF1A in human lung cancer cell lines
    • Sato M, Horio Y, Sekido Y, Minna JD, Shimokata K, et al. (2002) The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4a) and RASSF1A in human lung cancer cell lines. Oncogene 21: 4822-4829.
    • (2002) Oncogene , vol.21 , pp. 4822-4829
    • Sato, M.1    Horio, Y.2    Sekido, Y.3    Minna, J.D.4    Shimokata, K.5
  • 59
    • 0033991779 scopus 로고    scopus 로고
    • Exposure to environmental tobacco smoke and the risk of lung cancer: a meta-analysis
    • Zhong L, Goldberg MS, Parent ME, Hanley JA, (2000) Exposure to environmental tobacco smoke and the risk of lung cancer: a meta-analysis. Lung Cancer 27: 3-18.
    • (2000) Lung Cancer , vol.27 , pp. 3-18
    • Zhong, L.1    Goldberg, M.S.2    Parent, M.E.3    Hanley, J.A.4
  • 60
    • 10744221337 scopus 로고    scopus 로고
    • Secondhand smoke exposure in adulthood and risk of lung cancer among never smokers: a pooled analysis of two large studies
    • Brennan P, Buffler PA, Reynolds P, Wu AH, Wichmann HE, et al. (2004) Secondhand smoke exposure in adulthood and risk of lung cancer among never smokers: a pooled analysis of two large studies. Int J Cancer 109: 125-131.
    • (2004) Int J Cancer , vol.109 , pp. 125-131
    • Brennan, P.1    Buffler, P.A.2    Reynolds, P.3    Wu, A.H.4    Wichmann, H.E.5
  • 62
    • 37349113423 scopus 로고    scopus 로고
    • Passive smoking and lung cancer in Japanese non-smoking women: a prospective study
    • Kurahashi N, Inoue M, Liu Y, Iwasaki M, Sasazuki S, et al. (2008) Passive smoking and lung cancer in Japanese non-smoking women: a prospective study. Int J Cancer 122: 653-657.
    • (2008) Int J Cancer , vol.122 , pp. 653-657
    • Kurahashi, N.1    Inoue, M.2    Liu, Y.3    Iwasaki, M.4    Sasazuki, S.5
  • 63


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