Inverse agonism of cannabinoid CB 1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats

British Journal of Pharmacology

Volumn 161, Issue 2, 2010, Pages 336-349

  Limebeer, C L ^a   Vemuri, V K ^b   Bedard, H ^a   Lang, S T ^a   Ossenkopp, K P ^c   Makriyannis, A ^b   Parker, L A ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b NORTHEASTERN UNIVERSITY   (United States)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

AM251; AM6527; AM6545; CB 1 receptor; conditioned gaping; intracerebroventricular; inverse agonist; nausea; neutral antagonist; palatability; rat

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; AM 6527; AM 6545; CANNABINOID 1 RECEPTOR ANTAGONIST; LITHIUM CHLORIDE; SACCHARIN; SUCROSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN FOURTH VENTRICLE; CONDITIONING; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; LATERAL BRAIN VENTRICLE; NAUSEA; NONHUMAN; PALATABILITY; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BRAIN; CONDITIONING, CLASSICAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; LITHIUM CHLORIDE; MALE; MORPHOLINES; NAUSEA; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; SACCHARIN;

EID: 77956031482     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00885.x     Document Type: Article

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