Conditioned nausea in rats: Assessment by conditioned disgust reactions, rather than conditioned taste avoidance

Canadian Journal of Experimental Psychology

Volumn 62, Issue 3, 2008, Pages 198-209

  Parker, Linda A ^a   Rana, Shadna A ^b   Limebeer, Cheryl L ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Cannabinoids; Classical conditioning; Disgust; Nausea; Serotonin

Indexed keywords

ANIMAL; ARTICLE; AVOIDANCE BEHAVIOR; CONDITIONING; NAUSEA; RAT; TASTE;

ANIMALS; AVOIDANCE LEARNING; CONDITIONING (PSYCHOLOGY); NAUSEA; RATS; TASTE;

EID: 54549083542     PISSN: 11961961     EISSN: None     Source Type: Journal    
DOI: 10.1037/a0012531     Document Type: Article

References (134)

1. Amit, Z., Baum (1970). Comment on the increased resistance to extinction of an avoidance response induced by certain drugs. Psychological Reports, 27, 310.
2. Andrews, P. L., & Horn, C. C. (2006). Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases. Autonomic Neuroscience: Basic and Clinical, 125, 100-115.
3. Andrews, P. L., Rappaport, W. G., & Sanger, G. J. (1988). Neuropharmacology of emesis induced by anti-cancer therapy. Trends in Pharmacological Science, 9, 334-341.
4. Asin, K. E., Wirtshafter, D., & Kent, E. W. (1980). The effects of electrolytic median raphe lesions on two measures of latent inhibition. Behavioral and Neural Biology, 28, 408-417.
5. Baldessarini, R. J., & Vogt, M. (1988). Release of 3H-dopamine and analogous monoamines from rat striatal tissue. Cellular and Molecular Neurobiology, 8, 205-216.
6. Barann, M., Molderings, G., Bruss, M., Bonisch, H., Urban, B. W., & Gothert, M. (2002). Direct inhibition by cannabinoids of human 5-HT3A receptors: Probably involvement of an allosteric modulatory site. British Journal of Pharmacology, 137, 589-596.
7. Baumgarten, H. G., Klemm, H. P., Lachenmayer, L., Bjorklund, A., Lovenberg, W., & Schlossberger, H. G. (1978). Mode and mechanism of action of neurotoxic indoleamines: A review and a progress report. Annals of the New York Academy of Science, 305, 3-24.
8. Beck, K. D., & Servatius, R. J. (2003). Stress and cytokine effects on learning: What does sex have to do with it? Integrative Physiology and Behavioral Sciences, 38, 179-188.
9. Berger, B. (1972). Conditioning of food aversions by injections of psychoactive drugs. Journal of Comparative and Physiological Psychology, 81, 21-26.
10. Berridge, K. C. (2000). Measuring hedonic impact in animals and infants: Microstructure of affective taste reactivity patterns. Neuroscience and Biobehavioral Reviews, 24, 173-198.
11. Berridge, K. C., Grill, H. J., & Norgen, R. (1981). Relation of consummatory responses and preabsorptive insulin release to palatability and learned taste aversions. Journal of Comparative and Physiological Psychology, 95, 363-382.
12. Bienkowski, P., Iwinska, K., Piasecki, J., & Kostowski, W. (1997). 5,7-Dihydroxytryptamine lesion does not affect ethanol-induced conditioned taste and place aversion in rats. Alcohol, 14, 439-443.
13. Blundell, J. E. (1984). Serotonin manipulations and the structure of feeding behaviour. Appetite, 7, 39-56.
14. Brambilla, P., Cipriani, A., Hotopf, M., & Barbui, C. (2005). Side-effect profile of fluoxetine in comparison with other SSRIs, tricyclic and newer antidepressants: A meta-analysis of clinical trial data. Pharmacopsychiatry, 38, 69-77.
15. Breslin, P. A., Spector, A. C., & Grill, H. J. (1992). A quantitative comparison of taste reactivity behaviors to sucrose before and after lithium chloride pairings: A unidimensional account of palatability. Behavioral Neuroscience, 106, 820-836.
16. Brown, J. S., Kalish, H. I., & Farber, I. E. (1951). Conditioned fear as revealed by magnitude of startle response to an auditory stimulus. Journal of Experimental Psychology, 41, 317-328.
17. Calder, A. J., Beaver, J. D., Davis, M. H., van Ditzhuijzen, J., Keane, J., & Lawrence, A. D. (2007). Disgust sensitivity predicts the insula and pallidal response to pictures of disgusting foods. European Journal of Neuroscience, 25, 3422-3428.
18. Coil, J. D., Hankins, W. G., Jenden, D. J., & Garcia, J. (1978). The attenuation of a specific cue-to-consequence association by antiemetic agents. Psychopharmacologica, 56, 21-25.
19. Cordick, N., Parker. L. A., & Ossenkopp, K. P. (1999). Rotation-induced conditioned rejection in the taste reactivity test. NeuroReport, 10, 1157-1159.
20. Cross-Mellor, S. K., Ossenkopp, K. P., Piomelli, D., & Parker, L. A. (2007). Effects of the FAAH inhibitor, URB597, and anandamice on lithium-induced taste reactivity responses: A measure of nausea in rats. Psychopharmacology, 190, 135-143.
21. Darmani, N. A. (2001). Delta-9-tetrahydrocannabinol and synthetic cannabinoids prevent emesis produced by the cannabinoid CB-1 receptor antagonist/inverse agonist SR141716A. Neuropsychopharmacology, 24, 198-203.
22. Darmani, N. A., McClanahan, B. A., Trinh, C., Petrosino, S., Valent, M., & DiMarzo, V. (2005). Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew. Neuropharmacology, 49, 502-513.
23. Darmani, N. S., & Johnson, C. J. (2004). Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis. European Journal of Pharmacology, 488, 201-212.
24. Davis, M., Falls, W. A., Campeau, S., & Kim, M. (1993). Fear-potentiated startle: A neural and pharmacological analysis. Behavioural Brain Research, 58, 175-198.
25. De Olivera, M. P., Fouquet, N., Oberling, P., Gobaille, S., Graeff, F. G., & Sandner, G. (1999). A neurotoxic lesion of serotonergic neurons using 5,7-dihydroxytryptamine does not disrupt latent inhibition in paradigms sensitive to low doses of amphetamine. Brain Research, 100, 167-175.
26. Deutsch, D. G., & Chin, S. (1993). Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochemical Pharmacology, 46, 791-796.
27. Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988). Determination and characterization of a cannabinoid receptor. Molecular Pharmacology, 34, 605-613.
28. Devane, W. A., Hanus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., et al. (1992). Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science, 258, 1946-1949.
29. Eckel, L. A., & Ossenkopp, K. P. (1996). Area postrema mediates the formation of rapid conditioned palatability shifts to a lithium-paired solution. Behavioral Neuroscience, 110, 200-212.
30. 3 receptors in rat nodose ganglion neurons. Journal of Neurophysiology, 73, 907-910.
31. Flynn, F. W., Grill. H. J., Schulkin, J., & Norgren, R. (1991). Central gustatory lesions: II. Effects on sodium appetite, taste aversion learning, and feeding behaviors. Behavioral Neuroscience, 105, 944-954.
32. Gadusek, F. J., & Kalat, J. W. (1975). Effects of scopolamine on retention of taste-aversion learning in rats. Physiological Psychology, 3, 130-132.
33. Galaverna, O. I. G., Seeley, R. J., Berridge, K. C., Grill, H. J., Epstein, A. N., & Schulkin, J. (1993). Lesions of the central nucleus of the amygdala I: Effects on taste reactivity, taste aversion learning and sodium appetite. Behavioural Brain Research, 59, 11-17.
34. Gamzu, E. (1977). The multifaceted nature of taste aversion inducing agents: Is there a single common factor? In L. Barker, M. Domjan, & M. Best (Eds.), Learning mechanisms of food selection (pp. 447-511). Waco, TX: Baylor University Press.
35. Gaoni, Y., & Mechoulam, R. (1964). Isolation, structure and partial synthesis of an active constituent of hashish. Journal of the American Chemical Society, 86, 1646-1647.
36. Garcia, J. (1989). Food for Tolman: Cognition and cathexis in concert. In T. Archer & L.-G. Nilsson (Eds.), Aversion, avoidance and anxiety (pp. 45-85). Hillsdale, NJ: Erlbaum, Inc.
37. Garcia, J., Ervin, F. R. (1968). Appetites, aversions, and addictions: A model for visceral memory. Recent Advances in Biological Psychiatry, 10, 284-293.
38. Garcia, J., Hankins, W. G., & Rusiniak, K. W. (1974). Behavioral regulation of the milieu interne in man and rat. Science, 185, 824-831.
39. Garcia, J., & Koelling, R. A. (1966). Relation of cue to consequence in avoidance learning. Psychonomic Science, 4, 123-124.
40. Gorzalka, B., Hanson, L., Harrington, J., Killam, S., & Campbell-Meiklejohn, D. (2003). Conditioned taste aversion: Modulation by 5-HT receptor activity and corticosterone. European Journal of Pharmacology, 47, 129-134.
41. Goudie, A. J., Stolerman, I. P., Demellweek, C., & D'Mello, G. D. (1982). Does conditioned nausea mediate drug-induced conditioned taste aversion? Psychopharmacology, 78, 277-282.
42. Grant, V. L. (1987). Do conditioned taste aversions result from activation of emetic mechanisms? Psychopharmacology, 93, 405-415.
43. Grill, H. C. (1985). Introduction: Physiological mechanisms in conditioned taste aversions. In E. Braveman & N. Bronstein (Eds.), Experimental Assessments and Clinical Applications of Conditioned Food Aversion. Annals of the New York Academy of Science, 443, 67-88.
44. Grill, H. C., & Norgren, R. (1978a). The taste reactivity test. I: Mimetic responses to gustatory stimuli in neurologically normal rats. Brain Research, 143, 263-279.
45. Grill, H. C., & Norgren, R. (1978b). Chronically decerebrate rats demonstrate satiation but not bait shyness. Science, 201, 267-269.
46. Hermann, H., Marsicano, G., & Lutz, B. (2002). Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain. Neuroscience, 109, 451-460.
47. 3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret. British Journal of Pharmacology, 97, 247-255.
48. Hillsley, K., & Grundy, D. (1998). Serotonin and cholecystokinin activate different populations of rat mesenteric vagal afferents. Neuroscience Letters, 255, 63-66.
49. Himmi, T., Dallaporta, M., Perrin, J., & Orsini, J. C. (1996). Neuronal responses to delta 9-tetrahydrocannabinol in the solitary tract nucleus. European Journal of Pharmacology, 312, 273-279.
50. Himmi, T., Perrin, J., El Ouazzani, T., & Orsini, J. C. (1998). Neuronal responses to cannabinoid receptor ligands in the solitary tract nucleus. European Journal of Pharmacology, 359, 49-54.
51. Hewlett, A. C., Barth, F., Bonner, T. I., Cabral, P., Casellaa, G., Devane, W. A., et al. (2002). International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors. Pharmacological Reviews, 54, 161-202.
52. Hunt, T., & Amit, Z. (1987). Conditioned taste aversion by self-administered drugs: Paradox revisited. Neuroscience & Biobehavioral Reviews, 11, 107-130.
53. Ionesco, E., & Buresova, O. (1977). Failure to elicit CTA by severe poisoning. Pharmacology, Biochemistry and Behavior, 6, 251-254.
54. Ito, H., & Seki, M. (1998). Ascending projections from the area postrema and nucleus of the solitary tract of Suncus murinus: Anterograde tracing study using Phaseolus vulgaris leucoagglutinin. Okajimas Folia Anatomy Japan, 75, 9-31.
55. Kamin, L. J., Brimer, C. J., & Black, A. H. (1963). Conditioned suppression as a monitor of fear of the CS in the course of avoidance training. Journal of Comparative and Physiological Psychology, 56, 497-501.
56. Kiefer, S. W., & Orr, M. S. (1992). Taste avoidance, but not aversion, learning in rats lacking gustatory cortex. Behavioral Neuroscience, 106, 140-146.
57. Killcross, S., Robbins, T. W., & Everitt, B. J. (1997). Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala. Nature, 388, 377-380.
58. Kimura, T., Ohta, T., Watanabe, K., Yoshimura, H., &Yamamoto, I. (1998). Anandamide, an endogenous cannabinoid receptor ligand, also interacts with 5-hydroxytryptamine (5HT) receptor. Biological Pharmacological Bulletin, 21, 224-226.
59. Konorski, J. (1967). Integrative activity of the brain: An interdisciplinary approach. Chicago, IL: The University of Chicago Press.
60. Kwiatkowska, M., & Parker, L. A. (2005). Ondansetron and Δ-9-Tetrahydrocannabinol interfere with the establishment of lithium-induced conditioned taste avoidance in the house musk shrew (Suncus murinus). Behavioral Neuroscience, 119, 974-982.
61. Kwiatkowska, M., Parker, L. A., Burton, P., & Mechoulam, R. (2004). A comparative analysis of the potential of cannabinoids and ondansetron to suppress cisplatin-induced emesis in the Suncus murinus (house musk shrew). Psychopharmacology, 174, 254-259.
62. Leaf, R. C., & Leaf, S. R. (1966). Recovery time as a measure of degree of conditioned suppression. Psychological Reports, 18, 265-266.
63. Lett, B. T. (1985). The painlike effect of gallamine and naloxone differs from sickness induced by lithium chloride. Behavioral Neuroscience, 99, 145-150.
64. Levy, C. J., Carroll, M. F., Smith, J. C., & Hofer, K. G. (1974). Antihistamines block radiation-induced taste aversions. Science, 186, 1044-1045.
65. Limebeer, C. L., & Parker, L. A. (1999). Delta-9-tetrahydrocannabinol interferes with the establishment and the expression of conditioned rejection reactions produced by cyclophosphamide: A rat model of nausea. Neuroreport, 10, 3769-3772.
66. Limebeer, C. L., & Parker, L. A. (2000). Ondansetron interferes with lithium-induced conditioned rejection reactions, but not lithium-induced taste avoidance. Journal of Experimental Psychology: Animal Behavior Processes, 26, 371-384.
67. 1A agonist 8-OH-DPAT dose-dependently interferes with the establishment and expression of lithium-induced conditioned rejection reactions in rats. Psychopharmacology, 166, 120-126.
68. Limebeer, C. L., Parker, L. A., & Fletcher, P. J. (2004). 5, 7-Dihydroxytryptamine lesions of the dorsal and median raphe nuclei interfere with lithium-induced conditioned gaping, but not conditioned taste avoidance, in rats. Behavioral Neuroscience, 118, 1391-1399.
69. Manji, H. K., Beebchuck, J. M., Moore, G. J., Glitz, D., Hasanat, Chen, G. (1999). Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: Therapeutic implications. Journal of Clinical Psychiatry, 60, 27-39.
70. Mansbach, R. S., Gold, L. H., & Harris, L. S. (1992). The acoustic startle response as a measure of behavioral dependence in rats. Psychopharmacology, 108, 40-46.
71. Matsuki, N., Ueno, S., Kaji, T., Ishihara, A., Wang, C. H., & Saito, H. (1988). Emesis induced by cancer chemotherapeutic agents in the Suncus murinus: A new experimental model. Japan Pharmacology, 48, 303-306.
72. Mayer, L. A., & Parker, L. A. (1993). Rewarding and aversive properties of IP versus SC Cocaine: Assessment by place and taste conditioning. Psychopharmacology, 112, 189-194.
73. McDonald, R. V., Parker, L. A., & Siegel, S. (1997). Conditioned sucrose aversions produced by naloxone-precipitated withdrawal from acutely administered morphine. Pharmacology, Biochemistry & Behavior, 58, 1003-1007.
74. McLaughlin, P. J., Winston, K. M., Limebeer, C. L., Parker, L. A., Makriyannis, A., & Salamone, J. D. (2005). The cannabinoid antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats. Psychopharmacology, 180, 286-293.
75. Mechoulam, R., Parker, L. A., & Gallily, R. (2002). Cannabidiol: An overview of some pharmacological aspects. Journal of Clinical Pharmacology, 42, 11S-19S.
76. Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A., et al. (1995). Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochemical Pharmacology, 50, 83-90.
77. Melia, K. R., Falls, W. A., & Davis, M. (1992). Involvement of pertussis toxin sensitive G-proteins in conditioned fear-potentiated startle: Possible involvement of the amygdala. Brain Research, 584, 141-148.
78. Miller, A. D., Nonaka, S., Jakus, J., & Yates, B. J. (1996). Modulation of vomiting by the medullary midline. Brain Research, 737, 51-58.
79. Nachman, M., & Hartley, P. L. (1975). The role of illness in inducing taste aversions in rats: A comparison of several rodenticides. Journal of Comparative and Physiological Psychology, 81, 1010-1018.
80. Ossenkopp, K. P., Parker, L. A., Limebeer, C. L., Buron, P., Fudge, M. L., & Cross-Mellor, S. K. (2003). Vestibular lesions selectively abolish rotation-induced, but not lithium-induced, conditioned taste aversions (oral rejection responses) in rats. Behavioral Neuroscience, 117, 105-112.
81. Parker, L. A. (1980). Conditioned suppression of drinking: A measure of the CR elicited by a lithium-conditioned flavor. Learning and Motivation, 11, 538-559.
82. Parker, L. A. (1982). Nonconsummatory and consummatory behavioral CRs elicited by lithium- and amphetamine-paired flavors. Learning and Motivation, 13, 281-303.
83. Parker, L. A. (1984). Behavioral conditioned responses across multiple conditioning/testing trials elicited by lithium-and amphetamine-paired flavors. Behavioral and Neural Biology, 41, 190-199.
84. Parker, L. A. (1988). Positively reinforcing drugs may produce a different kind of CTA than drugs which are not positively reinforcing. Learning and Motivation, 19, 207-220.
85. Parker, L. A. (1991). Taste reactivity responses elicited by reinforcing drugs: A dose-response analysis. Behavioral Neuroscience, 105, 955-964.
86. Parker, L. A. (1993). Taste reactivity responses elicited by cocaine-, phencyclidine-, and methamphetamine-paired sucrose solutions. Behavioral Neuroscience, 107, 188-129.
87. Parker, L. A. (1995). Rewarding drugs produce taste avoidance, but not taste aversion. Neuroscience and Biobehavioral Reviews, 19, 143-151.
88. Parker, L. A. (1996). LSD produces a place preference and taste avoidance, but does not produce taste aversion. Behavioral Neuroscience, 109, 503-508.
89. Parker, L. A. (1998). Emetic drugs produce conditioned rejection reactions in the taste reactivity test. Journal of Psychophysiology, 12, 3-13.
90. Parker, L. A. (2003). Taste avoidance and taste aversion: Evidence for two different processes. Learning & Behavior, 31, 165-172.
91. Parker, L. A., & Brosseau, L. (1990). Apomorphine-induced flavor-drug associations: A dose-response analysis by the taste reactivity test and the conditioned taste avoidance test. Pharmacology, Biochemistry & Behavior, 35, 583-587.
92. Parker, L. A., & Carvell, T. (1986). Orofacial and somatic responses elicited by lithium-nicotine- and amphetamine-paired sucrose solution. Pharmacology, Biochemistry & Behavior, 24, 883-887.
93. Parker, L. A., Corrick, M. L., Limebeer, C. L., & Kwiatkowska, M. (2002a). Amphetamine and morphine produce a conditioned taste and place preference in the house musk shrew (Suncus murinus). Journal of Experimental Psychology: Animal Behavior Processes, 28, 75-82.
94. Parker, L. A., & Kemp, S. W. (2001). Tetrahydrocannabinol (THC) interferes with conditioned retching in Suncus murinus: An animal model of anticipatory nausea and vomiting (ANV). Neuroreport, 12, 749-751.
95. Parker, L. A., Kwaitkowska, M., Burton. P., & Mechoulam, R. (2004). Effect of cannabinoids on lithum-induced vomiting in the Suncus murinus (house musk shrew). Psychopharmacology, 171, 156-161.
96. Parker, L. A., Kwiatkowska, M., & Mechoulam, R. (2006). Delta-9-tetrahydrocannabinol and cannabidiol, but not ondansetron, interfere with conditioned retching reactions elicited by a lithium-paired context in Suncus murinus: An animal model of anticipatory nausea and vomiting. Physiology & Behavior, 87, 61-71.
97. Parker, L. A., Limebeer, C. L., & Kwiatkowska, M. (2005). Cannabinoids: Effects on vomiting and nausea in animal models (pp. 183-200). In R. Mechoulam (Ed.), Cannabinoids as therapeutics, Basel, Switzerland: Birkhauser Verlag.
98. Parker, L. A., & Mc Leod, K. B. (1991). Chin rub CRs may reflect conditioned sickness elicited by a lithium-paired sucrose solution. Pharmacology, Biochemistry & Behavior, 40, 983-986.
99. Parker, L. A., & Mechoulam, R. (2003). Cannabinoid agonists and an antagonist modulate lithium-induced conditioned gaping in rats. Integrative Physiology and Behavioral Sciences, 38, 134-146.
100. Parker, L. A., Mechoulam, R., & Schlievert, C. (2002b). Cannabidiol, a non-psychoactive component of cannabis, and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats. Neuro Report, 13, 567-570.
101. Parker, L. A., Mechoulam, R., Schlievert, C., Abbott, L. A., Fudge, M. L., & Burton, P. (2003). Cannabinoid agonists attenuate and a cannabinoid antagonist potentiates lithium-induced conditioned rejection reactions in a rat model of nausea. Psychopharmacology, 166, 156-162.
102. Pelchat, M. L., Grill, H. J., Rozin, P., & Jacobs, J. (1983). Quality of acquired responses to tastes by Rattus norvegicus depends on type of associated discomfort. Journal of Comparative Psychology, 97, 140-153.
103. Pelchat, M. L., & Rozin, P. (1982). The special role of nausea in the acquisition of food dislikes in humans. Appetite, 3, 343-351.
104. Pertwee, R. G. (2001). Cannabinoids and the gastrointestinal tract. Gut, 48, 859-867.
105. Petr, Z., Jiri, K., & Karel, V. (2006). Serotonin and dopamine in the parabrachial nucleus of rats during conditioned taste aversion learning. Behavioural Brain Research, 170, 271-276.
106. Piasecki, J., Bienkowski, P., Dudek, K., Koros, E., & Kostowski, W. (2001). Ethanol-induced conditioned taste aversion in the rat: Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus. Alcohol, 24, 9-14.
107. Pi-Sunyer, F. X., Aronne, L. J., Heshmati, H. M., Devin, J., Rosenstock, J., & RIO-North America Study Group. (2006). Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients. Journal of the American Medical Association, 295, 761-775.
108. Rabin, B. M., & Hunt, W. A. (1983). Effects of anti-emetics on the acquisition and recall of radiation and lithium chloride induced conditioned taste aversions. Pharmacology, Biochemistry and. Behavior, 18, 629-636.
109. Rabin, B. M., & Hunt, W. A. (1992). Relationship between vomiting and taste aversion learning in the ferret: Studies with ionizing radiation. lithium chloride, and amphetamine. Behavioral and Neural Biology, 58, 83-93.
110. Rana, S. A., & Parker, L. A. (2007). Effect of exposure to a lithium-paired or an amphetamine-paired flavor on the acoustic startle response in rats. Journal of Experimental Psychology: Animal Behavior Processes, 33, 172-184.
111. Rana, S. A., & Parker, L. A. (2008). Differential effects of basolateral amygdala and central amygdala lesions on lithium-induced conditioned disgust reactions and taste avoidance. Behavioural Brain Research. In press.
112. Reicher, M. A., & Holman, E. W. (1977). Location preference and flavor aversion reinforced by amphetamine in rats. Animal Learning & Behavior, 5, 343-346.
113. Reilly, S., & Bornovalova, M. A. (2005). Conditioned taste aversions and amygdala lesions in the rat: A critical review. Neuroscience and Biobe havioral Reviews, 29, 1067-1088.
114. 3 receptors are not involved in conditioned taste aversions induced by 5-hydroxytryptamine, ipecacuanha or cisplatin. European Journal of Pharmacology, 352, 143-149.
115. Russo, E. B., Burnnet, A., Hall, B., & Parker, K. K. (2005). Agonist properties of cannabidiol at 5-HT1a receptors. Neurochemical Research, 30, 1037-1043.
116. Rzoska, J. (1953). Bait shyness, a study in rat behaviour. British Journal of Animal Behavior, 1, 128-135.
117. Schafe, G. E., Thiele, T. E., & Bernstein, I. L. (1998). Conditioning method dramatically alters the role of amygdala in taste aversion learning. Learning & Memory, 5, 481-492.
118. Schlicker, E., & Kathman, M. (2001). Modulation of transmitter release via presynaptic cannabinoid receptors. Trends in Pharmacological Sciences, 22, 565-571.
119. Schwarz, M. D., Jacobsen, P. B., & Bjovberg, D. H. (1996). Role of nausea in the development of aversions to a beverage paired with chemotherapy treatment in cancer patients. Physiology and Behavior, 59, 659-663.
120. Selden, N. R. W., Everitt, B. J., Jarrard, L. D., & Robbins, T. W. (1991). Complementary roles for the amygdala and hippocampus in aversive conditioning to explicit and contextual cues. Neuroscience, 42, 335-350.
121. Simoneau, I. I., S., Hamza, M. S., Mata, H. P., Siegel, E. M., Vanderah, T. W., Porreca, F., et al. (2001). The cannabinoid agonist WIN55, 212-2 suppresses opioid-induced emesis in ferrets. Anesthesiology, 94, 882-887.
122. Sink, K. S., McLaughlin, P. J., Brown, C., Fan, P., Vemuri, V., Keran, V., et al. (2008). The novel cannabinoid CB1 receptor neutral antagonist, AM4113, suppresses food intake and food-reinforced behaviour but does not induce signs of nausea in rats. Neuropsychopharmacology, 33, 945-955.
123. Smith, J. E., Friedman, M. I., & Andrews, P. L. R. (2001). Conditioned food aversion in Suncus murinus (house musk shrew) a new model for the study of nausea in a species with an emetic reflex. Physiology and Behavior, 73, 593-598.
124. Tork, I. (1990). Anatomy of the serotonergic system. Annals of the New York Academy of Sciences, 600, 9-34.
125. Travers, J. B., & Norgren, R. (1986). Electromyographic analysis of the ingestion and rejection of sapid stimuli in the rat. Behavioral Neuroscience, 100, 544-555.
126. Treiser, S. L., Cascio, C. S., O'Donohue, T. L., Thao, N. B., Jacobowitz, D. M., & Kellar, K. J. (1981). Lithium increases serotonin release and decreases serotonin receptors in the hippocampus. Science, 213, 1529-1531.
127. Uneo, S., Matsuki, N., & Saito, H. (1988). Suncus murinus as a new experimental model for motion sickness. Life Sciences, 43, 413-420.
128. Van Sickle, M. D., Oland, L. D., Ho, W., Milliard, C. J., Mackie, K., Davison, J. J., et al. (2001). Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret. Gastroenterology, 121, 767-767.
129. 1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets. American Journal of Physiology and Gastrointestinal Liver Physiology, 285, G566-G576.
130. Wang, H. Y., & Friedman, E. (1989). Lithium inhibition of protein kinsase C activation-induced serotonin release. Psychopharmacology, 99, 213-218.
131. Wegener, G., Smith, D. F., & Rosenberg, R. (1997). 5-HT1A receptors in lithium-induced conditioned taste aversion. Psychopharmacology, 133, 51-54.
132. West, H. L., Mark, G. P., & Hoebel, B. G. (1991). Effects of conditioned taste aversion on extracellular serotonin in the lateral hypothalamus and hippocampus of freely moving rats. Brain Research, 556, 95-100.
133. Wise, R., Yokel, P., & DeWit, H. (1976). Both positive reinforcement and conditioned aversion from amphetamine and from apomorphine in rats. Science, 191, 1273-1274.
134. Zalaquett, C., & Parker, L. A. (1989). Further evidence that CTAs produced lithium and amphetamine are qualitatively different. Learning and Motivation, 20, 413-427.