-
1
-
-
1942465537
-
High quality ion channel analysis on a chip with the NPC technology
-
Brüggemann A, George M, Klau M, Beckler M, Steindl J, Behrends JC, Fertig N: High quality ion channel analysis on a chip with the NPC technology. Assay Drug Dev Technol 2003;1:665-673.
-
(2003)
Assay Drug Dev Technol
, vol.1
, pp. 665-673
-
-
Brüggemann, A.1
George, M.2
Klau, M.3
Beckler, M.4
Steindl, J.5
Behrends, J.C.6
Fertig, N.7
-
2
-
-
33645300737
-
From molecule to malady
-
Ashcroft FM: From molecule to malady. Nature 2006;440:440-447.
-
(2006)
Nature
, vol.440
, pp. 440-447
-
-
Ashcroft, F.M.1
-
3
-
-
42949108787
-
Ion channels as drug targets: The next GPCRs
-
DOI 10.1085/jgp.200709946
-
Kaczorowski GJ, McManus OB, Priest BT, Garcia ML: Ion channels as drug targets: the next GPCRs. J Gen Physiol 2008;131:399-405. (Pubitemid 351620096)
-
(2008)
Journal of General Physiology
, vol.131
, Issue.5
, pp. 399-405
-
-
Kaczorowski, G.J.1
McManus, O.B.2
Priest, B.T.3
Garcia, M.L.4
-
4
-
-
0038248920
-
+ channel. A model for bad behavior
-
DOI 10.1021/jm0205651
-
Pearlstein R, Vaz R, Rampe D: Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K F channel. A model for bad behavior. J Med Chem 2003;46:2017-2022. (Pubitemid 36583481)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.11
, pp. 2017-2022
-
-
Pearlstein, R.1
Vaz, R.2
Rampe, D.3
-
5
-
-
33645317063
-
HERG potassium channels and cardiac arrhythmia
-
Sanguinetti MC, Tristani-Firouzi M: hERG potassium channels and cardiac arrhythmia. Nature 2006;440:463-469.
-
(2006)
Nature
, vol.440
, pp. 463-469
-
-
Sanguinetti, M.C.1
Tristani-Firouzi, M.2
-
6
-
-
0035936798
-
Molecular and cellular mechanisms of cardiac arrhythmias
-
DOI 10.1016/S0092-8674(01)00243-4
-
Keating MT, Sanguinetti MC: Molecular and cellular mechanisms of cardiac arrhythmias. Cell 2001;104:569-580. (Pubitemid 32201951)
-
(2001)
Cell
, vol.104
, Issue.4
, pp. 569-580
-
-
Keating, M.T.1
Sanguinetti, M.C.2
-
7
-
-
19644375284
-
FLIPR: A new instrument for accurate, high throughput optical screening
-
Schroeder KS, Neagle BD: FLIPR: a new instrument for accurate, high throughput optical screening. J Biomol Screen 1996;1:75-80. (Pubitemid 126677323)
-
(1996)
Journal of Biomolecular Screening
, vol.1
, Issue.2
, pp. 75-80
-
-
Schroeder, K.S.1
Neagle, B.D.2
-
8
-
-
33846876071
-
A nonadherent cell-based HTS assay for N-type calcium channel using calcium 3 dye
-
DOI 10.1089/adt.2006.4.689
-
Lubin ML, Reitz TL, Todd MJ, Flores CM, Qin N, Xin H: A nonadherent cell-based HTS assay for N-type calcium channel using calcium 3 dye. Assay Drug Dev Technol 2006;4:689-694. (Pubitemid 46218166)
-
(2006)
Assay and Drug Development Technologies
, vol.4
, Issue.6
, pp. 689-694
-
-
Lubin, M.L.1
Reitz, T.L.2
Todd, M.J.3
Flores, C.M.4
Qin, N.5
Xin, H.6
-
9
-
-
12144288319
-
R
-
DOI 10.1080/10606820490270410
-
Vickery RG, Amagasu SM, Chang R, Mai N, Kaufman E, Martin J, Hembrador J, O'Keefe MD, Gee C, Marquess D, Smith JA: Comparison of the pharmacological properties of rat Na(V)1.8 with rat Na(V)1.2a and human Na(V)1.5 voltagegated sodium channel subtypes using a membrane potential sensitive dye and FLIPR. Recept Channels 2004;10:11-23. (Pubitemid 38313030)
-
(2004)
Receptors and Channels
, vol.10
, Issue.1
, pp. 11-23
-
-
Vickery, R.G.1
Amagasu, S.M.2
Chang, R.3
Mai, N.4
Kaufman, E.5
Martin, J.6
Hembrador, J.7
O'Keefe, M.D.8
Gee, C.9
Marquess, D.10
Smith, J.A.M.11
-
10
-
-
33645294378
-
A highcapacity membrane potential FRET-based assay for NaV1.8 channels
-
Liu CJ, Priest BT, Bugianesi RM, Dulski PM, Felix JP, Dick IE, Brochu RM, Knaus HG, Middleton RE, Kaczorowski GJ, Slaughter RS, Garcia ML, Köhler MG: A highcapacity membrane potential FRET-based assay for NaV1.8 channels. Assay Drug Dev Technol 2006;4:37-48.
-
(2006)
Assay Drug Dev Technol
, vol.4
, pp. 37-48
-
-
Liu, C.J.1
Priest, B.T.2
Bugianesi, R.M.3
Dulski, P.M.4
Felix, J.P.5
Dick, I.E.6
Brochu, R.M.7
Knaus, H.G.8
Middleton, R.E.9
Kaczorowski, G.J.10
Slaughter, R.S.11
Garcia, M.L.12
Köhler, M.G.13
-
11
-
-
43449106465
-
ir channel inhibitors
-
DOI 10.1089/adt.2008.123
-
Solly K, Cassaday J, Felix JP, Garcia ML, Ferrer M, Strulovici B, Kiss L: Miniaturization and HTS of a FRET-based membrane potential assay for K(ir) channel inhibitors. Assay Drug Dev Technol 2008;6:225-234. (Pubitemid 351670379)
-
(2008)
Assay and Drug Development Technologies
, vol.6
, Issue.2
, pp. 225-234
-
-
Solly, K.1
Cassaday, J.2
Felix, J.P.3
Garcia, M.L.4
Ferrer, M.5
Strulovici, B.6
Kiss, L.7
-
12
-
-
20144376596
-
Identification and biological evaluation of 4-(3-trifluoromethylpyridin- 2- yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist
-
DOI 10.1021/jm0495071
-
Swanson DM, Dubin AE, Shah C, Nasser N, Chang L, Dax SL, Jetter M, Breitenbucher JG, Liu C, Mazur C, Lord B, Gonzales L, Hoey K, Rizzolio M, Bogenstaetter M, Codd EE, Lee DH, Zhang SP, Chaplan SR, Carruthers NI: Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl) piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. J Med Chem 2005;48:1857-1872. (Pubitemid 40396317)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.6
, pp. 1857-1872
-
-
Swanson, D.M.1
Dubin, A.E.2
Shah, C.3
Nasser, N.4
Chang, L.5
Dax, S.L.6
Jetter, M.7
Breitenbucher, J.G.8
Liu, C.9
Mazur, C.10
Lord, B.11
Gonzales, L.12
Hoey, K.13
Rizzolio, M.14
Bogenstaetter, M.15
Codd, E.E.16
Lee, D.H.17
Zhang, S.-P.18
Chaplan, S.R.19
Carruthers, N.I.20
more..
-
13
-
-
31544449199
-
Identification and biological characterization of 6-aryl-7- isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain
-
DOI 10.1021/jm051058x
-
Culshaw AJ, Bevan S, Christiansen M, Copp P, Davis A, Davis C, Dyson A, Dziadulewicz EK, Edwards L, Eggelte H, Fox A, Gentry C, Groarke A, Hallett A, Hart TW, Hughes GA, Knights S, Kotsonis P, Lee W, Lyothier I, McBryde A, McIntyre P, Paloumbis G, Panesar M, Patel S, Seiler MP, Yaqoob M, Zimmermann K: Identification and biological characterization of 6-aryl-7- isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain. J Med Chem 2006;49:471-474. (Pubitemid 43157481)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.2
, pp. 471-474
-
-
Culshaw, A.J.1
Bevan, S.2
Christiansen, M.3
Copp, P.4
Davis, A.5
Davis, C.6
Dyson, A.7
Dziadulewicz, E.K.8
Edwards, L.9
Eggelte, H.10
Fox, A.11
Gentry, C.12
Groarke, A.13
Hallett, A.14
Hart, T.W.15
Hughes, G.A.16
Knights, S.17
Kotsonis, P.18
Lee, W.19
Lyothier, I.20
McBryde, A.21
McIntyre, P.22
Paloumbis, G.23
Panesar, M.24
Patel, S.25
Seiler, M.-P.26
Yaqoob, M.27
Zimmermann, K.28
more..
-
14
-
-
34447498924
-
Recommendations for the reduction of compound artifacts in time-resolved fluorescence resonance energy transfer assays
-
DOI 10.1089/adt.2007.073
-
Imbert PE, Unterreiner V, Siebert D, Gubler H, Parker C, Gabriel D: Recommendations for the reduction of compound artifacts in time-resolved fluorescence resonance energy transfer assays. Assay Drug Dev Technol 2007;5:363-372. (Pubitemid 47067881)
-
(2007)
Assay and Drug Development Technologies
, vol.5
, Issue.3
, pp. 363-372
-
-
Imbert, P.-E.1
Unterreiner, V.2
Siebert, D.3
Gubler, H.4
Parker, C.5
Gabriel, D.6
-
15
-
-
1942433697
-
A benchmark study with sealchip planar patch-clamp technology
-
Xu J, Guia A, Rothwarf D, Huang M, Sithiphong K, Ouang J, Tao G, Wang X, Wu L: A benchmark study with sealchip planar patch-clamp technology. Assay Drug Dev Technol 2003;1:675-684.
-
(2003)
Assay Drug Dev Technol
, vol.1
, pp. 675-684
-
-
Xu, J.1
Guia, A.2
Rothwarf, D.3
Huang, M.4
Sithiphong, K.5
Ouang, J.6
Tao, G.7
Wang, X.8
Wu, L.9
-
16
-
-
0037178198
-
Micromolded PDMS planar electrode allows patch clamp electrical recordings from cells
-
DOI 10.1016/S0956-5663(02)00015-5, PII S0956566302000155
-
Klemic KG, Klemic JF, Reed MA, Sigworth FJ: Micromolded PDMS planar electrode allows patch clamp electrical recordings from cells. Biosens Bioelectron 2002;17:597-604. (Pubitemid 34327414)
-
(2002)
Biosensors and Bioelectronics
, vol.17
, Issue.6-7
, pp. 597-604
-
-
Klemic, K.G.1
Klemic, J.F.2
Reed, M.A.3
Sigworth, F.J.4
-
17
-
-
0042895988
-
High throughput ion-channel pharmacology: Planar-array-based voltage clamp
-
Kiss L, Bennett PB, Uebele VN, Koblan KS, Kane SA, Neagle B, Schroeder K: High throughput ion-channel pharmacology: planar-array-based voltage clamp. Assay Drug Dev Technol 2003;1:127-135.
-
(2003)
Assay Drug Dev Technol
, vol.1
, pp. 127-135
-
-
Kiss, L.1
Bennett, P.B.2
Uebele, V.N.3
Koblan, K.S.4
Kane, S.A.5
Neagle, B.6
Schroeder, K.7
-
18
-
-
1942529810
-
Characterization of potassium channel modulators with QPatch automated patch-clamp technology: System characteristics and performance
-
Kutchinsky J, Friis S, Asmild M, Taboryski R, Pedersen S, Vestergaard RK, Jacobsen RB, Krzywkowski K, Schrøder RL, Ljungstrøm T, Hélix N, Sørensen CB, Bech M, Willumsen NJ: Characterization of potassium channel modulators with QPatch automated patch-clamp technology: system characteristics and performance. Assay Drug Dev Technol 2003;1:685-693.
-
(2003)
Assay Drug Dev Technol
, vol.1
, pp. 685-693
-
-
Kutchinsky, J.1
Friis, S.2
Asmild, M.3
Taboryski, R.4
Pedersen, S.5
Vestergaard, R.K.6
Jacobsen, R.B.7
Krzywkowski, K.8
Schrøder, R.L.9
Ljungstrøm, T.10
Hélix, N.11
Sørensen, C.B.12
Bech, M.13
Willumsen, N.J.14
-
19
-
-
20144389310
-
Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp
-
Dubin AE, Nasser N, Rohrbacher J, Hermans AN, Marrannes R, Grantham C, Van Rossem K, Cik M, Chaplan SR, Gallacher D, Xu J, Guia A, Byrne NG, Mathes C: Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp. J Biomol Screen 2005;10:168-181.
-
(2005)
J Biomol Screen
, vol.10
, pp. 168-181
-
-
Dubin, A.E.1
Nasser, N.2
Rohrbacher, J.3
Hermans, A.N.4
Marrannes, R.5
Grantham, C.6
Van Rossem, K.7
Cik, M.8
Chaplan, S.R.9
Gallacher, D.10
Xu, J.11
Guia, A.12
Byrne, N.G.13
Mathes, C.14
-
20
-
-
17344373426
-
Characterization of a hERG screen using the IonWorks HT: Comparison to a hERG rubidium efflux screen
-
DOI 10.1089/adt.2005.3.47
-
Sorota S, Zhang XS, Margulis M, Tucker K, Priestley T: Characterization of a hERG screen using the ionworks HT: comparison to a hERG rubidium efflux screen, hERG ionworks. Assay Drug Dev Technol 2005;3:47-57. (Pubitemid 40533252)
-
(2005)
Assay and Drug Development Technologies
, vol.3
, Issue.1
, pp. 47-57
-
-
Sorota, S.1
Zhang, X.-S.2
Margulis, M.3
Tucker, K.4
Priestley, T.5
-
21
-
-
29144530265
-
A place for high-throughput electrophysiology in cardiac safety: Screening hERG cell lines and novel compounds with the ion works HT™ system
-
DOI 10.1177/1087057105280566
-
Guthrie H, Livingston FS, Gubler U, Garippa R: A place for high-throughput electrophysiology in cardiac safety: screening hERG cell lines and novel compounds with the ion works HTTM system. J Biomol Screen 2005;10:832-840. (Pubitemid 41818159)
-
(2005)
Journal of Biomolecular Screening
, vol.10
, Issue.8
, pp. 832-840
-
-
Guthrie, H.1
Livingston, F.S.2
Gubler, U.3
Garippa, R.4
-
22
-
-
33748129547
-
Optimisation and validation of a medium-throughput electrophysiology- based hERG assay using IonWorks™ HT
-
DOI 10.1016/j.vascn.2006.02.003, PII S1056871906000207
-
Bridgland-Taylor MH, Hargreaves AC, Easter A, Orme A, Henthorn DC, Ding M, Davis AM, Small BG, Heapy CG, Abi-Gerges N, Persson F, Jacobson I, Sullivan M, Albertson N, Hammond TG, Sullivan E, Valentin JP, Pollard CE: Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks HT. J Pharmacol Toxicol Methods 2006;54:189-199. (Pubitemid 44308866)
-
(2006)
Journal of Pharmacological and Toxicological Methods
, vol.54
, Issue.2
, pp. 189-199
-
-
Bridgland-Taylor, M.H.1
Hargreaves, A.C.2
Easter, A.3
Orme, A.4
Henthorn, D.C.5
Ding, M.6
Davis, A.M.7
Small, B.G.8
Heapy, C.G.9
Abi-Gerges, N.10
Persson, F.11
Jacobson, I.12
Sullivan, M.13
Albertson, N.14
Hammond, T.G.15
Sullivan, E.16
Valentin, J.-P.17
Pollard, C.E.18
-
23
-
-
42149193214
-
High-throughput electrophysiology: An emerging paradigm for ion-channel screening and physiology
-
Dunlop J, Bowlby M, Peri R, Vasilyev D, Arias R: High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology. Nat Rev Drug Discov 2008;7:358-368.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 358-368
-
-
Dunlop, J.1
Bowlby, M.2
Peri, R.3
Vasilyev, D.4
Arias, R.5
-
24
-
-
77954520425
-
Can robots patch-clamp as well as humans? Characterization of a novel sodium channel mutation
-
Estacion M, Choi JS, Eastman EM, Lin Z, Li Y, Tyrrell L, Yang Y, Dib-Hajj SD, Waxman SG: Can robots patch-clamp as well as humans? Characterization of a novel sodium channel mutation. J Physiol 2010;588(Pt 11):1915-1927.
-
(2010)
J Physiol
, vol.588
, Issue.PART 11
, pp. 1915-1927
-
-
Estacion, M.1
Choi, J.S.2
Eastman, E.M.3
Lin, Z.4
Li, Y.5
Tyrrell, L.6
Yang, Y.7
Dib-Hajj, S.D.8
Waxman, S.G.9
-
25
-
-
33747102760
-
Population patch clamp improves data consistency and success rates in the measurement of ionic currents
-
DOI 10.1177/1087057106288050
-
Finkel A, Wittel A, Yang N, Handran S, Hughes J, Costantin J: Population patch clamp improves data consistency and success rates in the measurement of ionic currents. J Biomol Screen 2006;11:488-496. (Pubitemid 44223000)
-
(2006)
Journal of Biomolecular Screening
, vol.11
, Issue.5
, pp. 488-496
-
-
Finkel, A.1
Wittel, A.2
Yang, N.3
Handran, S.4
Hughes, J.5
Costantin, J.6
-
26
-
-
33748325882
-
Drug-target residence time and its implications for lead optimization
-
DOI 10.1038/nrd2082, PII NRD2082
-
Copeland RA, Pompliano DL, Meek TD: Drug-target residence time and its implications for lead optimization. Nat Rev Drug Discov 2006;5:730-739. (Pubitemid 44323700)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 730-739
-
-
Copeland, R.A.1
Pompliano, D.L.2
Meek, T.D.3
-
27
-
-
58449131873
-
The role of binding kinetics in therapeutically useful drug action
-
Swinney DC: The role of binding kinetics in therapeutically useful drug action. Curr Opin Drug Discov Devel 2009;12:31-39.
-
(2009)
Curr Opin Drug Discov Devel
, vol.12
, pp. 31-39
-
-
Swinney, D.C.1
-
28
-
-
22744434981
-
Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37 °C and 42 °C
-
DOI 10.1016/j.hrthm.2005.04.029, PII S1547527105016024
-
Guo J, Zhan S, Lees-Miller JP, Teng G, Duff HJ: Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37 degrees C and 42 degrees C. Heart Rhythm 2005;2:860-866. (Pubitemid 41030733)
-
(2005)
Heart Rhythm
, vol.2
, Issue.8
, pp. 860-866
-
-
Guo, J.1
Zhan, S.2
Lees-Miller, J.P.3
Teng, G.4
Duff, H.J.5
-
29
-
-
33646175501
-
Temperature: An important experimental variable in studying PKC modulation of ligand-gated ion channels
-
Machu TK, Dillon GH, Huang R, Lovinger DM, Leidenheimer NJ: Temperature: an important experimental variable in studying PKC modulation of ligand-gated ion channels. Brain Res 2006;1086:1-8.
-
(2006)
Brain Res
, vol.1086
, pp. 1-8
-
-
MacHu, T.K.1
Dillon, G.H.2
Huang, R.3
Lovinger, D.M.4
Leidenheimer, N.J.5
-
30
-
-
40049101742
-
A receptor
-
DOI 10.1021/ac702148p
-
Millingen M, Bridle H, Jesorka A, Lincoln P, Orwar O: Ligand-specific temperature-dependent shifts in EC50 values for the GABAA receptor. Anal Chem 2008;80:340-343. (Pubitemid 351448441)
-
(2008)
Analytical Chemistry
, vol.80
, Issue.1
, pp. 340-343
-
-
Millingen, M.1
Bridle, H.2
Jesorka, A.3
Lincoln, P.4
Orwar, O.5
-
31
-
-
4644257489
-
Variability in the measurement of hERG potassium channel inhibition: Effects of temperature and stimulus pattern
-
DOI 10.1016/j.vascn.2004.06.003, PII S1056871904000589
-
Kirsch GE, Trepakova ES, Brimecombe JC, Sidach SS, Erickson HD, Kochan MC, Shyjka LM, Lacerda AE, Brown AM: Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern. J Pharmacol Toxicol Methods 2004;50:93-101. (Pubitemid 39286321)
-
(2004)
Journal of Pharmacological and Toxicological Methods
, vol.50
, Issue.2
, pp. 93-101
-
-
Kirsch, G.E.1
Trepakova, E.S.2
Brimecombe, J.C.3
Sidach, S.S.4
Erickson, H.D.5
Kochan, M.C.6
Shyjka, L.M.7
Lacerda, A.E.8
Brown, A.M.9
-
32
-
-
33646581672
-
Mechanism of hERG K F channel blockade by the fluoroquinolone antibiotic moxifloxacin
-
Alexandrou AJ, Duncan RS, Sullivan A, Hancox JC, Leishman DJ, Witchel HJ, Leaney JL: Mechanism of hERG K F channel blockade by the fluoroquinolone antibiotic moxifloxacin. Br J Pharmacol 2006;147:905-916.
-
(2006)
Br J Pharmacol
, vol.147
, pp. 905-916
-
-
Alexandrou, A.J.1
Duncan, R.S.2
Sullivan, A.3
Hancox, J.C.4
Leishman, D.J.5
Witchel, H.J.6
Leaney, J.L.7
-
33
-
-
0038643828
-
Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin
-
DOI 10.1016/S0014-5793(03)00662-8
-
Milnes JT, Dempsey CE, Ridley JM, Crociani O, Arcangeli A, Hancox JC, Witchel HJ: Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin. FEBS Lett 2003;547:20-26. (Pubitemid 36829372)
-
(2003)
FEBS Letters
, vol.547
, Issue.1-3
, pp. 20-26
-
-
Milnes, J.T.1
Dempsey, C.E.2
Ridley, J.M.3
Crociani, O.4
Arcangeli, A.5
Hancox, J.C.6
Witchel, H.J.7
-
34
-
-
21544458021
-
Mammalian electrophysiology on a microfluidic platform
-
DOI 10.1073/pnas.0503418102
-
Ionescu-Zanetti C, Shaw RM, Seo J, Jan YN, Jan LY, Lee LP: Mammalian electrophysiology on a microfluidic platform. Proc Natl Acad Sci USA 2005;102:9112-9117. (Pubitemid 40923525)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.26
, pp. 9112-9117
-
-
Ionescu-Zanetti, C.1
Shaw, R.M.2
Seo, J.3
Jan, Y.-N.4
Jan, L.Y.5
Lee, L.P.6
-
35
-
-
12344326621
-
A single cell electroporation chip
-
DOI 10.1039/b408352k
-
Khine M, Lau A, Ionescu-Zanetti C, Seo J, Lee LP: A single cell electroporation chip. Lab Chip 2005;5:38-43. (Pubitemid 40139338)
-
(2005)
Lab on a Chip - Miniaturisation for Chemistry and Biology
, vol.5
, Issue.1
, pp. 38-43
-
-
Khine, M.1
Lau, A.2
Ionescu-Zanetti, C.3
Seo, J.4
Lee, L.P.5
-
36
-
-
33846264581
-
Open-access microfluidic patch-clamp array with raised lateral cell trapping sites
-
DOI 10.1039/b608439g
-
Lau AY, Hung PJ, Wu AR, Lee LP: Open-access microfluidic patch-clamp array with raised lateral cell trapping sites. Lab Chip 2006;6:1510-1515. (Pubitemid 46100746)
-
(2006)
Lab on a Chip - Miniaturisation for Chemistry and Biology
, vol.6
, Issue.12
, pp. 1510-1515
-
-
Lau, A.Y.1
Hung, P.J.2
Wu, A.R.3
Lee, L.P.4
-
37
-
-
33947672389
-
Automated ion channel screening: Patch clamping made easy
-
DOI 10.1517/14728222.11.4.557
-
Farre C, Stoelzle S, Haarmann C, George M, Brüggemann A, Fertig N: Automated ion channel screening: patch clamping made easy. Expert Opin Ther Targets 2007;11:557-565. (Pubitemid 46487602)
-
(2007)
Expert Opinion on Therapeutic Targets
, vol.11
, Issue.4
, pp. 557-565
-
-
Farre, C.1
Stoelzle, S.2
Haarmann, C.3
George, M.4
Bruggemann, A.5
Fertig, N.6
-
38
-
-
77649174506
-
Development and validation of a secondary screening assay for TRPM8 antagonists using QPatch HT
-
Beck EJ, Hutchinson TL, Qin N, Flores CM, Liu Y: Development and validation of a secondary screening assay for TRPM8 antagonists using QPatch HT. Assay Drug Dev Technol 2010;8:63-72.
-
(2010)
Assay Drug Dev Technol
, vol.8
, pp. 63-72
-
-
Beck, E.J.1
Hutchinson, T.L.2
Qin, N.3
Flores, C.M.4
Liu, Y.5
-
39
-
-
0347784281
-
Conductance measurements part 1: Theory
-
Coury L: Conductance measurements part 1: theory. Curr Separations 1999;18:91-96.
-
(1999)
Curr Separations
, vol.18
, pp. 91-96
-
-
Coury, L.1
-
40
-
-
0028128234
-
Temperature dependence of conductivity in electrolyte solutions and ionic channels of biological membranes
-
DOI 10.1016/0301-4622(94)00034-4
-
Kuyucak S, Chung SH: Temperature dependence of conductivity in electrolyte solutions and ionic channels of biological membranes. Biophys Chem 1994;52:15-24. (Pubitemid 24281165)
-
(1994)
Biophysical Chemistry
, vol.52
, Issue.1
, pp. 15-24
-
-
Kuyucak, S.1
Chung, S.-H.2
-
41
-
-
2442702680
-
Inhibition of human ether-a-go-go-related gene potassium channels by α1-adrenoceptor antagonists prazosin, doxazosin, and terazosin
-
DOI 10.1007/s00210-004-0931-8
-
Thomas D, Wimmer AB, Wu K, Hammerling BC, Ficker EK, Kuryshev YA, Kiehn J, Katus HA, Schoels W, Karle CA: Inhibition of human ether-a-go-gorelated gene potassium channels by a1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. Naunyn Schmiedebergs Arch Pharmacol 2004;369: 462-472. (Pubitemid 38669965)
-
(2004)
Naunyn-Schmiedeberg's Archives of Pharmacology
, vol.369
, Issue.5
, pp. 462-472
-
-
Thomas, D.1
Wimmer, A.-B.2
Wu, K.3
Hammerling, B.C.4
Ficker, E.K.5
Kuryshev, Y.A.6
Kiehn, J.7
Katus, H.A.8
Schoels, W.9
Karle, C.A.10
-
42
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development
-
DOI 10.1016/S0008-6363(02)00846-5
-
Redfern WS, Carlsson L, Davis AS, Lynch WG, MacKenzie I, Palethorpe S, Siegl PK, Strang I, Sullivan AT, Wallis R, Camm AJ, Hammond TG: Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res 2003;58:32-45. (Pubitemid 36351620)
-
(2003)
Cardiovascular Research
, vol.58
, Issue.1
, pp. 32-45
-
-
Redfern, W.S.1
Carlsson, L.2
Davis, A.S.3
Lynch, W.G.4
MacKenzie, I.5
Palethorpe, S.6
Siegl, P.K.S.7
Strang, I.8
Sullivan, A.T.9
Wallis, R.10
Camm, A.J.11
Hammond, T.G.12
-
43
-
-
0031982513
-
Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature
-
Zhou Z, Gong, Q, Ye B, Fan Z, Makielski JC, Robertson GA, January CT: Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys J 1998;74:230-241. (Pubitemid 28041752)
-
(1998)
Biophysical Journal
, vol.74
, Issue.1
, pp. 230-241
-
-
Zhou, Z.1
Gong, Q.2
Ye, B.3
Fan, Z.4
Makielski, J.C.5
Robertson, G.A.6
January, C.T.7
-
44
-
-
33745038225
-
Temperature dependence of human ether-a-go-go-related gene K F currents
-
Vandenberg JI, Varghese A, Lu Y, Bursill JA, Mahaut-Smith MP, Huang CL: Temperature dependence of human ether-a-go-go-related gene K F currents. Am J Physiol Cell Physiol 2006;291:165-175.
-
(2006)
Am J Physiol Cell Physiol
, vol.291
, pp. 165-175
-
-
Vandenberg, J.I.1
Varghese, A.2
Lu, Y.3
Bursill, J.A.4
Mahaut-Smith, M.P.5
Huang, C.L.6
-
45
-
-
43049112043
-
Molecular aspects of the congenital and acquired Long QT Syndrome: Clinical implications
-
Saenen JB, Vrints CJ. Molecular aspects of the congenital and acquired Long QT Syndrome: clinical implications. J Mol Cell Cardiol 2008;44:633-646.
-
(2008)
J Mol Cell Cardiol
, vol.44
, pp. 633-646
-
-
Saenen, J.B.1
Vrints, C.J.2
-
47
-
-
41149120044
-
Glass coating for PDMS microfluidic channels by sol-gel methods
-
DOI 10.1039/b800001h
-
Abate AR, Lee D, Do T, Holtze C, Weitz DA: Glass coating for PDMS microfluidic channels by sol-gel methods. Lab Chip 2008;8:516-518. (Pubitemid 351442777)
-
(2008)
Lab on a Chip - Miniaturisation for Chemistry and Biology
, vol.8
, Issue.4
, pp. 516-518
-
-
Abate, A.R.1
Lee, D.2
Do, T.3
Holtze, C.4
Weitz, D.A.5
-
48
-
-
74549219313
-
Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERGencoded potassium channel
-
MännikköR, Overend G, Perrey C, Gavaghan CL, Valentin JP, Morten J, Armstrong M, Pollard CE: Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERGencoded potassium channel. Br J Pharmacol 2010;159:102-114.
-
(2010)
Br J Pharmacol
, vol.159
, pp. 102-114
-
-
Männikkö, R.1
Overend, G.2
Perrey, C.3
Gavaghan, C.L.4
Valentin, J.P.5
Morten, J.6
Armstrong, M.7
Pollard, C.E.8
-
50
-
-
85120507662
-
Ligand-gated ion channel target screening: New systems enable fast compound additions and continuous electrophysiological recording
-
Ionescu-Zanetti C: Ligand-gated ion channel target screening: new systems enable fast compound additions and continuous electrophysiological recording. Genet Eng News: Assay Tutorials 2010;30. Available at www.genengnews.com/gen- articles/ligand-gated-ion-channel-target-screening/3142/
-
(2010)
Genet Eng News: Assay Tutorials
, pp. 30
-
-
Ionescu-Zanetti, C.1
|