Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37 °C and 42 °C

Heart Rhythm

Volumn 2, Issue 8, 2005, Pages 860-866

  Guo, Jiqing ^a   Zhan, Shu ^a   Lees Miller, James P ^a   Teng, GuoQi ^a   Duff, Henry J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Action potentials; Erythromycin; Long QT syndrome; Temperature

Indexed keywords

ERYTHROMYCIN; POTASSIUM CHANNEL HERG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG DIFFUSION; DRUG RESPONSE; ENVIRONMENTAL FACTOR; FEVER; GENE MUTATION; GENETIC RISK; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; LONG QT SYNDROME; MAMMAL CELL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR; TEMPERATURE DEPENDENCE;

ACTION POTENTIALS; ANIMALS; BODY TEMPERATURE; CATION TRANSPORT PROTEINS; DISEASE SUSCEPTIBILITY; ELECTROPHYSIOLOGY; ERYTHROMYCIN; ETHER-A-GO-GO POTASSIUM CHANNELS; GENE EXPRESSION REGULATION, NEOPLASTIC; LONG QT SYNDROME; MICE; MYOCYTES, CARDIAC; TIME FACTORS;

EID: 22744434981     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2005.04.029     Document Type: Article

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