High Quality Ion Channel Analysis on a Chip with the NPC© Technology

Assay and Drug Development Technologies

Volumn 1, Issue 5, 2003, Pages 665-673

  Bruggemann A ^a   George, M ^a,b   Klau, M ^b   Beckler, M ^b   Steindl, J ^a   Behrends, J C ^b,c   Fertig, N ^a,b  

^a NANION TECHNOLOGIES GMBH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL;

ALGORITHM; ANIMAL; ARTICLE; BIOTECHNOLOGY; CELL CULTURE; CELL MEMBRANE POTENTIAL; CHO CELL; COMPARATIVE STUDY; COMPUTER INTERFACE; CRICETULUS; CULTURE TECHNIQUE; DRUG EFFECT; DRUG SCREENING; EQUIPMENT; EQUIPMENT DESIGN; EVALUATION; FEASIBILITY STUDY; HAMSTER; HUMAN; INSTRUMENTATION; KIDNEY; METHODOLOGY; MICROELECTRODE; PATCH CLAMP; PHYSIOLOGY; PILOT STUDY; REPRODUCIBILITY; ROBOTICS; SENSITIVITY AND SPECIFICITY;

ALGORITHMS; ANIMALS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FEASIBILITY STUDIES; HUMANS; ION CHANNELS; KIDNEY; MEMBRANE POTENTIALS; MICROELECTRODES; PATCH-CLAMP TECHNIQUES; PILOT PROJECTS; REPRODUCIBILITY OF RESULTS; ROBOTICS; SENSITIVITY AND SPECIFICITY; USER-COMPUTER INTERFACE;

EID: 1942465537     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/154065803770381020     Document Type: Article

References (20)

1. Sigworth FJ, Klemic KG: Patch clamp on a chip. Biophys J 2002;82:2831–2832.
2. Fertig N, Blick RH, Behrends JC: Whole cell patch clamp recording performed on a planar glass chip. Biophys J 2002;82:3056–3062.
3. Special Issue. Receptors Channels 2003;9.
4. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflüger Arch 1981;391:85–100.
5. Sakmann B, Neher E: Single Channel Recording. Plenum Press, New York, 1995.
6. Fertig N, Klau M, George M, Blick RH, Behrends JC: Activity of single ion channel proteins detected with a planar microstructure. Applied Physics Letters APL 2002;81: 4865-1867.
7. Kostyuk PG, Krishtal OA, Pidoplichko VI: Effect of internal fluoride and phosphate on membrane currents during intracellular dialysis of nerve cells. Nature 1975;257: 691–693.
8. Hille B: Ionic Channels of Excitable Membranes, Sinauer Verlag, Sunderland, MA, 1992.
9. Ashcroft FM: Ion Channels and Disease. Academic Press, New York, 2000.
10. Weinreich F, Jentsch TJ: Neurological diseases caused by ion channels. Curr Opin Neurol 2000;10:409–415.
11. Curran ME: Potassium ion channels and human disease: phenotypes to drug targets? Curr Opin Biotechnol 1998;9:565–572.
12. Clare JL, Tate SN, Nobbs M, Romanos MA: Voltage-gated sodium channels as therapeutic targets. Drug Discov Today 2000;5:506–520.
13. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, et al.: The sequence of the human genome. Science 2001; 291:1304–1351.
14. Mattheakis LC, Savchenko A: Assay technologies for ion channel targets. Curr Opin Drug Discov Devel 2001;4:124–134.
15. Denyer J, Worley X, Cox B, Allenby G, Banks M: HTS approaches to voltage-gated ion channel drug discovery. Drug Discov Today 1998;3:323.
16. Xu J, Wang X, Ensign B, Li M, Wu L, Guia A, Xu J: Ionchannel assay technologies: quo vadis? Drug Discov Today 2001;6:1278–1287.
17. Kiss L, Bennett PB, Uebele VN, Koblan KS, Kane SA, Neagle B, Schroeder K: High throughput ion-channel pharmacology: Planar-array-based voltage clamp. Assay Drug Dev Technol 2003 1: 27–135.
18. Willumsen NJ, Bech M, Olesen SP, Jensen BS, Korsgaard MPG, Christophersen P: High throughput electrophysiology: new perspectives for ion channel drug discovery. Receptors Channels 2003;9:3–12.
19. Comley J: Patchers vs. Screeeners: Divergent opinion on high throughput electrophysiology. Drug Discov World (in press).
20. Catterall WA, Chandy KG, Gutman GA: The IUPHAR Compendium of Voltage-Gated Ion Channels. IUPHAR Media, University of Leeds, U.K., 2002.