Angiogenesis is a link between atherosclerosis and tumorigenesis: Role of LOX-1

Cardiovascular Drugs and Therapy

Volumn 25, Issue 5, 2011, Pages 461-468

  Jiang, Junlin ^a   Yan, Meiling ^a   Mehta, Jawahar L ^b   Hu, Changping ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Angiogenesis; Atherosclerosis; LOX 1; Tumorigenesis

Indexed keywords

OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1;

ANGIOGENESIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CANCER CELL CULTURE; CARCINOGENESIS; DIABETES MELLITUS; DYSLIPIDEMIA; ENDOTHELIUM CELL; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RISK FACTOR; TUMOR GROWTH;

ANIMALS; ATHEROSCLEROSIS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; LIPOPROTEINS, LDL; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; SCAVENGER RECEPTORS, CLASS E;

EID: 83055172735     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-011-6343-3     Document Type: Article

References (91)

1. W Risau 1997 Mechanisms of angiogenesis Nature 386 671 674 9109485 10.1038/386671a0 1:STN:280:DyaK2s3mtlGksg%3D%3D (Pubitemid 27193480)
2. B Doyle N Caplice 2007 Plaque neovascularization and antiangiogenic therapy for atherosclerosis J Am Coll Cardiol. 49 2073 2080 17531655 10.1016/j.jacc.2007.01.089 (Pubitemid 46771052)
3. FT Wu MO Stefanini F Mac Gabhann CD Kontos BH Annex AS Popel 2010 A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use J Cell Mol Med 14 528 552 19840194 1:CAS:528: DC%2BC3cXns1yktr4%3D
4. M Slevin P Kumar Q Wang S Kumar J Gaffney M Grau-Olivares, et al. 2008 New VEGF antagonists as possible therapeutic agents in vascular disease Expert Opin Investig Drugs. 17 1301 1314 18694364 10.1517/13543784.17.9.1301 1:CAS:528:DC%2BD1cXpslaksr0%3D
5. M Shibuya 2008 Vascular endothelial growth factor-dependent and -independent regulation of angiogenesis BMB Rep. 41 278 286 18452647 10.5483/BMBRep.2008.41.4.278 1:CAS:528:DC%2BD1cXlvFelsL0%3D (Pubitemid 351656921)
6. GD Yancopoulos S Davis NW Gale JS Rudge SJ Wiegand J Holash 2000 Vascular-specific growth factors and blood vessel formation Nature. 407 242 248 11001067 10.1038/35025215 1:CAS:528:DC%2BD3cXmvVSlsrY%3D
7. D Hanahan J Folkman 1996 Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis Cell. 86 353 364 8756718 10.1016/S0092-8674(00)80108-7 1:CAS:528:DyaK28XltVSks7s%3D (Pubitemid 26272076)
8. D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell. 100 57 70 10647931 10.1016/S0092-8674(00)81683-9 1:CAS:528:DC%2BD3cXks1CktA%3D%3D (Pubitemid 30046295)
9. A Mantovani P Allavena A Sica F Balkwill 2008 Cancer-related inflammation Nature 454 436 444 18650914 10.1038/nature07205 1:CAS:528:DC%2BD1cXovV2mtbg%3D
10. SC Larsson CS Mantzoros A Wolk 2007 Diabetes mellitus and risk of breast cancer: a meta-analysis Int J Cancer. 121 856 862 17397032 10.1002/ijc.22717 1:CAS:528:DC%2BD2sXotlequ7w%3D (Pubitemid 47106217)
11. IR Hsu SP Kim M Kabir RN Bergman 2007 Metabolic syndrome, hyperinsulinemia, and cancer Am J Clin Nutr. 86 867 871
12. Y Kuge N Kume S Ishino N Takai Y Ogawa T Mukai, et al. 2008 Prominent lectin-like oxidized low density lipoprotein (LDL) receptor-1 (LOX-1) expression in atherosclerotic lesions is associated with tissue factor expression and apoptosis in hypercholesterolemic rabbits Biol Pharm Bull. 31 1475 1482 18670075 10.1248/bpb.31.1475 1:CAS:528:DC%2BD1cXht1Sgur3O
13. JL Mehta N Sanada CP Hu J Chen A Dandapat F Sugawara, et al. 2007 Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet Circ Res. 100 1634 1642 17478727 10.1161/CIRCRESAHA.107.149724 1:CAS:528:DC%2BD2sXmtVGjtb4%3D (Pubitemid 46897266)
14. HA Hirsch D Iliopoulos A Joshi Y Zhang SA Jaeger M Bulyk, et al. 2010 A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases Cancer Cell. 17 348 361 20385360 10.1016/j.ccr.2010.01.022 1:CAS:528:DC%2BC3cXmsF2msLk%3D
15. C Hu A Dandapat JL Mehta 2007 Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway Hypertension. 50 952 957 17893372 10.1161/HYPERTENSIONAHA.107.096446 1:CAS:528:DC%2BD2sXhtFGjur7I (Pubitemid 350287540)
16. P Carmeliet 2000 Mechanisms of angiogenesis and arteriogenesis Nature Med. 6 389 395 10742145 10.1038/74651 1:CAS:528:DC%2BD3cXisVOrur4%3D (Pubitemid 30208155)
17. RE Friesel T Maciag 1995 Molecular mechanism of angiogenesis: Fibroblast growth factor signal transducing FASEB J. 9 919 925 7542215 1:CAS:528: DyaK2MXntFyrsbw%3D
18. J Folkman M Klagsbrun 1987 Angiogenic factors Science 235 442 447 2432664 10.1126/science.2432664 1:CAS:528:DyaL2sXps1amsQ%3D%3D (Pubitemid 17009577)
19. N Ferrara K Houk L Jackman DW Leung 1992 Molecular and biological properties of vascular endothelial growth factor family of proteins Endocr Rev. 13 18 32 1372863 1:CAS:528:DyaK38Xit1ygsr8%3D
20. P Carmeliet D Collen 1997 Molecular analysis of blood vessel formation and disease Am J Physiol. 273 H2091 H2104 9374741 1:CAS:528:DyaK2sXnsVClu7s%3D
21. G Neufeld T Cohen S Gengrinovitch Z Poltorak 1999 Vascular endothelial growth factor (VEGF) and its receptors FASEB J. 13 9 22 9872925 1:CAS:528:DyaK1MXlt1ygsQ%3D%3D (Pubitemid 29038270)
22. I Appelmann R Liersch T Kessler RM Mesters WE Berdel 2010 Angiogenesis inhibition in cancer therapy: platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) and their receptors: biological functions and role in malignancy Recent Results Cancer Res. 180 51 81 20033378 10.1007/978-3-540-78281-0-5 1:CAS:528:DC%2BC3cXovVCru7Y%3D
23. C Hellberg A Ostman CH Heldin 2010 PDGF and vessel maturation Recent Results Cancer Res. 180 103 114 20033380 10.1007/978-3-540-78281-0-7 1:CAS:528:DC%2BC3cXovVCqsr4%3D
24. S Davis TH Aldrich PF Jones A Acheson DL Compton V Jain, et al. 1996 Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning Cell. 87 1161 1169 8980223 10.1016/S0092-8674(00)81812-7 1:CAS:528:DyaK2sXit1Cqsw%3D%3D (Pubitemid 27010100)
25. PC Maisonpierre C Suri PF Jones S Bartunkova SJ Wiegand C Radziejewski, et al. 1997 Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis Science. 277 55 60 9204896 10.1126/science.277.5322.55 1:CAS:528:DyaK2sXksVyhu78%3D (Pubitemid 27450643)
26. TI Koblizek C Weiss GD Yancopoulos U Deutsch W Risau 1998 Angiopoietin-1 induces sprouting angiogenesis in vitro Curr Biol. 8 529 532 9560344 10.1016/S0960-9822(98)70205-2 1:CAS:528:DyaK1cXislaksbk%3D (Pubitemid 28203073)
27. D Fulton JP Gratton TJ McCabe J Fontana Y Fujio K Walsh, et al. 1999 Regulation of endothelium-derived nitric oxide production by the protein kinase Akt Nature. 399 597 601 10376602 10.1038/21218 1:CAS:528:DyaK1MXjvFegu78%3D (Pubitemid 29279181)
28. K Kawasaki RS Smith Jr CM Hsieh J Sun J Chao JK Liao 2003 Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis Mol Cell Biol. 23 5726 5737 12897144 10.1128/MCB.23.16.5726-5737.2003 1:CAS:528:DC%2BD3sXmt1SrtL4%3D (Pubitemid 36951336)
29. BH Fryer J Field 2005 Rho, Rac, Pak and angiogenesis: old roles and newly identified responsibilities in endothelial cells Cancer Lett. 229 13 23 16157214 10.1016/j.canlet.2004.12.009 1:CAS:528:DC%2BD2MXhtVSmtL%2FF (Pubitemid 41263406)
30. EM Yu M Jain JB Aragon-Ching 2010 Angiogenesis inhibitors in prostate cancer therapy Discov Med. 10 521 530 21189223
31. R Kerbel J Folkman 2002 Clinical translation of angiogenesis inhibitors Nat Rev Cancer. 2 727 739 12360276 10.1038/nrc905 1:CAS:528:DC%2BD38XnsVGrtb0%3D (Pubitemid 37328908)
32. DP Sieveking RW Chow MK Ng 2010 Androgens, angiogenesis and cardiovascular regeneration Curr Opin Endocrinol Diabetes Obes. 17 277 283 20389240 10.1097/MED.0b013e3283394e20 1:CAS:528:DC%2BC3cXltFKgtb4%3D
33. J Kastrup 2010 Gene therapy and angiogenesis in patients with coronary artery disease Expert Rev Cardiovasc Ther. 8 1127 1138 20670190 10.1586/erc.10.95 1:CAS:528:DC%2BC3cXpsVChu78%3D
34. PR Seevinck LH Deddens RM Dijkhuizen 2010 Magnetic resonance imaging of brain angiogenesis after stroke Angiogenesis. 13 101 111 20552268 10.1007/s10456-010-9174-0
35. N Thairu S Kiriakidis P Dawson E Paleolog 2011 Angiogenesis as a therapeutic target in arthritis in 2011: learning the lessons of the colorectal cancer experience Angiogenesis. 14 223 234 21431303 10.1007/s10456-011-9208-2 1:CAS:528:DC%2BC3MXhtVagtrvJ
36. K Grote H Schütt B Schieffer 2011 Toll-like receptors in angiogenesis Sci World J. 11 981 991 1:CAS:528:DC%2BC3MXmsVSks74%3D
37. Z Szekanecz AE Koch 2008 Vascular involvement in rheumatic diseases: 'vascular rheumatology' Arthritis Res Ther. 10 224 18947376 10.1186/ar2515
38. AP Hall 2006 Review of the pericyte during angiogenesis and its role in cancer and diabetic retinopathy Toxicol Pathol. 34 763 775 17162534 10.1080/01926230600936290 1:CAS:528:DC%2BD2sXns1Ghuw%3D%3D
39. H Al Sabti 2007 Therapeutic angiogenesis in cardiovascular disease J Cardiothorac Surg 2 49 18021404 10.1186/1749-8090-2-49
40. W Yang DY Lee Y Ben-David 2011 The roles of microRNAs in tumorigenesis and angiogenesis Int J Physiol Pathophysiol Pharmacol. 3 140 155 21760972 1:CAS:528:DC%2BC3MXpvVGhs7k%3D
41. S Goel DG Duda L Xu LL Munn Y Boucher D Fukumura, et al. 2011 Normalization of the vasculature for treatment of cancer and other diseases Physiol Rev. 91 1071 1121 21742796 10.1152/physrev.00038.2010 1:CAS:528:DC%2BC3MXhtFyjurzO
42. MC Fishbein 2010 The vulnerable and unstable atherosclerotic plaque Cardiovasc Pathol. 19 6 11 18835793 10.1016/j.carpath.2008.08.004
43. KS Moulton 2006 Angiogenesis in atherosclerosis: gathering evidence beyond speculation Curr Opin Lipidol. 17 548 555 16960504 10.1097/01.mol. 0000245261.71129.f0 1:CAS:528:DC%2BD28XptF2rtLY%3D (Pubitemid 44372686)
44. J Herrmann LO Lerman D Mukhopadhyay C Napoli A Lerman 2006 Angiogenesis in atherogenesis Arterioscler Thromb Vasc Biol. 26 1948 1957 16794218 10.1161/01.ATV.0000233387.90257.9b 1:CAS:528:DC%2BD28XotVWlsL0%3D (Pubitemid 44253775)
45. KS Moulton K Vakili D Zurakowski M Soliman C Butterfield E Sylvin, et al. 2003 Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis Proc Natl Acad Sci. 100 4736 4741 12682294 10.1073/pnas.0730843100 1:CAS:528:DC%2BD3sXjt12nsLo%3D (Pubitemid 36457799)
46. JC Sluimer MJ Daemen 2009 Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis J Pathol. 218 7 29 19309025 10.1002/path.2518
47. JC Sluimer JM Gasc JL van Wanroij N Kisters M Groeneweg MD Sollewijn Gelpke, et al. 2008 Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis J Am Coll Cardiol 51 1258 1265 18371555 10.1016/j.jacc.2007.12.025 1:CAS:528:DC%2BD1cXktV2lt7g%3D (Pubitemid 351400903)
48. Q Zhao K Egashira K Hiasa M Ishibashi S Inoue K Ohtani, et al. 2004 Essential role of vascular endothelial growth factor and Flt-1 signals in neointimal formation after peri-adventitial injury Arterioscler Thromb Vasc Biol. 24 2284 2289 15472126 10.1161/01.ATV.0000147161.42956.80 1:CAS:528:DC%2BD2cXhtVaisrvM (Pubitemid 39658030)
49. AC Langheinrich DG Sedding M Kampschulte R Moritz J Wilhelm WG Haberbosch, et al. 2008 3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE (-/-)/LDL(-/-) double knockout mice Atherosclerosis. 202 103 110 18495128 10.1016/j.atherosclerosis.2008.04.008
50. K Pilarczyk KJ Sattler O Galili D Versari ML Olson FB Meyer, et al. 2008 Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization Atherosclerosis. 196 333 340 17157858 10.1016/j.atherosclerosis.2006.10.038 1:CAS:528:DC%2BD1cXpt12isw%3D%3D
51. U Garbin A Fratta Pasini C Stranieri S Manfro C Mozzini V Boccioletti, et al. 2008 Effects of nebivolol on endothelial gene expression during oxidative stress in human umbilical vein endothelial cells Mediators Inflamm 2008 367590 18437228 10.1155/2008/367590 (Pubitemid 352000405)
52. J Folkman 1996 Fighting cancer by attacking its blood supply Sci Am. 275 150 154 8701285 10.1038/scientificamerican0996-150 1:CAS:528:DyaK28Xls1Omurk%3D
53. V Baeriswyl G Christofori 2009 The angiogenic switch in carcinogenesis Semin Cancer Biol. 19 329 337 19482086 10.1016/j.semcancer.2009.05.003 1:CAS:528:DC%2BD1MXhsV2msbnL
54. D Ribatti B Nico E Crivellato AM Roccaro A Vacca 2007 The history of the angiogenic switch concept Leukemia. 21 44 52 16990761 10.1038/sj.leu.2404402 1:CAS:528:DC%2BD28XhtlSqurzI (Pubitemid 44921833)
55. C Liss MJ Fekete R Hasina MW Lingen 2002 Retinoic acid modulates the ability of macrophages to participate in the induction of the angiogenic phenotype in head and neck squamous cell carcinoma Int J Cancer 100 283 289 12115542 10.1002/ijc.10507 1:CAS:528:DC%2BD38Xlt1Shsbo%3D (Pubitemid 34728985)
56. R Avni B Cohen M Neeman 2011 Hypoxic stress and cancer: imaging the axis of evil in tumor metastasis NMR Biomed. 24 569 581 21793071 1:CAS:528: DC%2BC3MXpt1ygsbk%3D
57. HR Rezvani N Ali LJ Nissen G Harfouche H de Verneuil A Taïeb, et al. 2011 HIF-1α in epidermis: oxygen sensing, cutaneous angiogenesis, cancer, and non-cancer disorders J Invest Dermatol 131 1793 1805 21633368 10.1038/jid.2011.141 1:CAS:528:DC%2BC3MXhtVWrs77K
58. OV Glinskii TW Abraha JR Turk VV Glinsky VH Huxley 2008 PDGF/VEGF system activation and angiogenesis following initial post ovariectomy meningeal microvessel loss Cell Cycle. 7 1385 1390 18418080 10.4161/cc.7.10.5819 1:CAS:528:DC%2BD1cXptF2jt78%3D (Pubitemid 351872577)
59. JA Diaz-Gonzalez J Russell A Rouzaut I Gil-Bazo L Montuenga 2005 Targeting hypoxia and angiogenesis through HIF-1alpha inhibition Cancer Biol Ther. 4 1055 1062 16294030 10.4161/cbt.4.10.2195 1:CAS:528:DC%2BD28XkvFGhtbY%3D (Pubitemid 41598557)
60. P Carmeliet 2005 VEGF as a key mediator of angiogenesis in cancer Oncology. 69 Suppl 3 4 10 16301830 10.1159/000088478 1:CAS:528: DC%2BD2MXht1aqsrnE (Pubitemid 41680947)
61. JE Klaunig LM Kamendulis BA Hocevar 2010 Oxidative stress and oxidative damage in carcinogenesis Toxicol Pathol. 38 96 109 20019356 10.1177/ 0192623309356453 1:CAS:528:DC%2BC3cXjt1ajtb4%3D
62. S Rajput A Wilber 2010 Roles of inflammation in cancer initiation, progression, and metastasis Front Biosci (Schol Ed). 2 176 183 10.2741/s55
63. A Rojas R Silva H Figueroa MA Morales 2008 Oxidative stress in tumor microenvironment-Its role in angiogenesis Zhongguo Fei Ai Za Zhi. 11 297 305 20731924 1:CAS:528:DC%2BD1cXpt1Oqs78%3D (Pubitemid 351976658)
64. H Ashino M Shimamura H Nakajima M Dombou S Kawanaka T Oikawa, et al. 2003 Novel function of ascorbic acid as an angiostatic factor Angiogenesis. 6 259 269 15166494 10.1023/B:AGEN.0000029390.09354.f8 1:CAS:528:DC%2BD2cXktlyktL0%3D (Pubitemid 38987535)
65. FY Tang M Meydani 2001 Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production Nutr Cancer. 41 119 125 12094614 1:CAS:528:DC%2BD38XlsVehsr0%3D (Pubitemid 34666231)
66. FY Tang NM Nguyen M Meydani 2003 Green tea catechins inhibit VEGF-induced angiogenesis in vitro through suppression of VE-cadherin phosphorylation and inactivation of akt molecule Int J Cancer 106 871 878 12918064 10.1002/ijc.11325 1:CAS:528:DC%2BD3sXnsVGrsLk%3D (Pubitemid 37071665)
67. K Sappayatosok Y Maneerat S Swasdison P Viriyavejakul K Dhanuthai J Zwang, et al. 2009 Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in oral squamous cell carcinoma (OSCC), relationship with angiogenesis and their clinico-pathological correlation Med Oral Patol Oral Cir Bucal. 14 E319 E324 19300368
68. M Chen M Nagase T Fujita S Narumiya T Masaki T Sawamura 2001 Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE Biochem Biophys Res Commun. 287 962 968 11573959 10.1006/bbrc.2001.5674 1:CAS:528:DC%2BD3MXntV2ns74%3D (Pubitemid 32953570)
69. D Li V Williams L Liu H Chen T Sawamura T Antakli, et al. 2002 LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation Am J Physiol Heart Circ Physiol. 283 H1795 H1801 12384456 1:CAS:528:DC%2BD38XovVOmtrc%3D (Pubitemid 35217012)
70. T Aoyama H Fujiwara T Masaki T Sawamura 1999 Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells J Mol Cell Cardiol. 31 2101 2114 10640439 10.1006/jmcc.1999. 1041 1:CAS:528:DC%2BD3cXkvVSjsA%3D%3D (Pubitemid 30029022)
71. DY Li YC Zhang MI Philips T Sawamura JL Mehta 1999 Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation Circ Res. 84 1043 1049 10325241 1:CAS:528:DyaK1MXjtFCjtrY%3D (Pubitemid 29227683)
72. L Cominacini AF Pasini U Garbin A Davoli ML Tosetti M Campagnola, et al. 2000 Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-κB through an increased production of intracellular reactive oxygen species J Biol Chem. 275 12633 12638 10777555 10.1074/jbc.275.17.12633 1:CAS:528:DC%2BD3cXjtVartL4%3D (Pubitemid 30241412)
73. G Song H Tian J Liu H Zhang X Sun S Qin 2011 H(2) inhibits TNF-α-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor κB activation in endothelial cells Biotechnol Lett. 33 1715 1722 21544615 10.1007/s10529-011-0630-8 1:CAS:528:DC%2BC3MXhtVSiu7jK
74. O Hofnagel B Luechtenborg K Stolle S Lorkowski H Eschert G Plenz, et al. 2004 Proinflammatory cytokines regulate LOX-1 expression in vascular smooth muscle cells Arterioscler Thromb Vasc Biol. 24 1789 1795 15271788 10.1161/01.ATV.0000140061.89096.2b 1:CAS:528:DC%2BD2cXotVOns7Y%3D (Pubitemid 39350293)
75. XQ Zhao MW Zhang F Wang YX Zhao JJ Li XP Wang, et al. 2011 CRP enhances soluble LOX-1 release from macrophages by activating TNF-α converting enzyme J Lipid Res. 52 923 933 21364202 10.1194/jlr.M015156 1:CAS:528: DC%2BC3MXltFGhtLk%3D
76. T Murase N Kume R Korenaga J Ando T Sawamura T Masaki, et al. 1998 Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells Circ Res. 83 328 333 9710126 1:CAS:528: DyaK1cXltlegtbo%3D (Pubitemid 28371323)
77. D Li JL Mehta 2000 Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors Arterioscler Thromb Vasc Biol. 20 1116 1122 10764682 10.1161/01.ATV.20.4.1116 1:CAS:528:DC%2BD3cXjtV2hsLc%3D (Pubitemid 30207591)
78. DY Li HJ Chen ED Staples K Ozaki B Annex BK Singh, et al. 2002 Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions J Cardiovasc Pharmacol Ther. 7 147 153 12232563 10.1177/ 107424840200700304 1:CAS:528:DC%2BD38XotlGksLY%3D (Pubitemid 36055995)
79. Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL. Oxidative Stress and Lectin-Like Ox-LDL-Receptor LOX-1 in Atherogenesis and Tumorigenesis. Antioxid Redox Signal. 2011 May 25.
80. M Liang P Zhang J Fu 2007 Up-regulation of LOX-1 expression by TNF-alpha promotes trans-endothelial migration of MDA-MB-231 breast cancer cells Cancer Lett. 258 31 37 17868983 10.1016/j.canlet.2007.08.003 1:CAS:528: DC%2BD2sXht1anu7zI (Pubitemid 47600486)
81. A Dandapat C Hu L Sun JL Mehta 2007 Small concentrations of oxLDL induce capillary tube formation from endothelial cells via LOX-1-dependent redox-sensitive pathway Arterioscler Thromb Vasc Biol. 27 2435 2442 17717293 10.1161/ATVBAHA.107.152272 1:CAS:528:DC%2BD2sXhtFKitbjE (Pubitemid 350203961)
82. M Khaidakov J Szwedo S Mitra S Ayyadevara M Dobretsov J Lu, et al. 2010 Antiangiogenic and antimitotic effects of aspirin in hypoxia-reoxygenation modulation of the LOX-1-NADPH oxidase axis as a potential mechanism J Cardiovasc Pharmacol. 56 635 641 20881612 10.1097/FJC.0b013e3181f801e4 1:CAS:528:DC%2BC3MXjs1WmsQ%3D%3D
83. Y Inomata M Fukushima R Hara E Takahashi M Honjo T Koga, et al. 2009 Suppression of choroidal neovascularization in lectin-like oxidized low-density lipoprotein receptor type 1-deficient mice Invest Ophthalmol Vis Sci. 50 3970 3976 19182261 10.1167/iovs.07-1177
84. S Kanata M Akagi S Nishimura S Hayakawa K Yoshida T Sawamura, et al. 2006 Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma Biochem Biophys Res Commun. 348 1003 1010 16904074 10.1016/j.bbrc.2006.07.133 1:CAS:528:DC%2BD28XosVOisrw%3D (Pubitemid 44233514)
85. M Khaidakov X Wang JL Mehta 2011 Potential involvement of LOX-1 in functional consequences of endothelial senescence PLoS One. 6 e20964 21698300 10.1371/journal.pone.0020964 1:CAS:528:DC%2BC3MXotVSqu78%3D
86. R Koretz 2011 Meta-analysis: aspirin reduces risk for colon cancer and related mortality at 20 years, particularly when taken for ≥ 5 years Ann Intern Med 154 JC3-3 21403066
87. M Khaidakov W Wang JA Khan BY Kang PL Hermonat JL Mehta 2009 Statins and angiogenesis: is it about connections? Biochem Biophys Res Commun. 387 543 547 19615978 10.1016/j.bbrc.2009.07.057 1:CAS:528:DC%2BD1MXps1Clsb0%3D
88. S Shimoyama 2011 Statins and gastric cancer risk Hepatogastroenterology. 58 1057 1061 21830442
89. Ahern TP, Pedersen L, Tarp M, Cronin-Fenton DP, Garne JP, Silliman RA, et al. Statin Prescriptions and Breast Cancer Recurrence Risk: A Danish Nationwide Prospective Cohort Study. J Natl Cancer Inst. 2011 Aug 2.
90. C Marelli C Gunnarsson S Ross S Haas DF Stroup P Cload, et al. 2011 Statins and risk of cancer a retrospective cohort analysis of 45,857 matched pairs from an electronic medical records database of 11 million adult americans J Am Coll Cardiol. 58 530 537 21777752 10.1016/j.jacc.2011.04.015 1:CAS:528:DC%2BC3MXhtFCnsbfL
91. D Li H Chen F Romeo T Sawamura T Saldeen JL Mehta 2002 Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1 J Pharmacol Exp Ther. 302 601 605 12130721 10.1124/jpet.102.034959 1:CAS:528:DC%2BD38Xls1OgtrY%3D (Pubitemid 34787225)