H2 inhibits TNF-α-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor κB activation in endothelial cells

Biotechnology Letters

Volumn 33, Issue 9, 2011, Pages 1715-1722

  Song, Guohua ^a   Tian, Hua ^a   Liu, Jia ^a   Zhang, Hongle ^a   Sun, Xuejun ^b   Qin, Shucun ^a  

^a TAISHAN MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

H2; Human umbilical vein endothelial cells; Lectin like oxidized LDL receptor 1; Nuclear factor B; Tumor necrosis factor

Indexed keywords

ANIMAL MODEL; APOLIPOPROTEIN E; CELL SURFACE RECEPTORS; ENDOTHELIAL DYSFUNCTION; H2; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; KNOCKOUT MICE; LECTIN-LIKE OXIDIZED LDL RECEPTOR-1; LOW DENSITY LIPOPROTEINS; MRNA LEVEL; N-ACETYL L-CYSTEINE; NUCLEAR FACTORS; UP-REGULATION;

AMINO ACIDS; DISEASES; GENE EXPRESSION; MAMMALS; PHOSPHORYLATION;

ENDOTHELIAL CELLS;

ANIMALIA; MUS;

ANTIOXIDANT; HYDROGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; AORTA; ARTICLE; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MOUSE; PATHOLOGY;

ANIMALS; ANTIOXIDANTS; AORTA; ENDOTHELIAL CELLS; GENE EXPRESSION; HUMANS; HYDROGEN; IMMUNOHISTOCHEMISTRY; MALE; MICE; NF-KAPPA B; RECEPTORS, OXIDIZED LDL; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80051470238     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-011-0630-8     Document Type: Article

References (17)

1. Cai J, Kang Z, Liu K, Liu W, Li R, Zhang JH, Luo X, Sun X (2009) Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res 1256: 129-137.
2. Gilmore TD (2006) Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 25(51): 6680-6684.
3. Jersmann HP, Hii CS, Ferrante JV, Ferrante A (2001) Bacterial lipopolysaccharide and tumor necrosis factor alpha synergistically increase expression of human endothelial adhesion molecules through activation of NF-kappaB and p38 mitogen-activated protein kinase signaling pathways. Infect Immun 69(3): 1273-1279.
4. Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H, Yoshikawa T (2008) Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res 28(3): 137-143.
5. Kume N, Murase T, Moriwaki H, Aoyama T, Sawamura T, Masaki T, Kita T (1998) Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res 83(3): 322-327.
6. Li L, Sawamura T, Renier G (2004) Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation. Circ Res 94(7): 892-901.
7. Libby P (2002) Inflammation in atherosclerosis. Nature 420(6917): 868-874.
8. Mihm S, Ennen J, Pessara U, Kurth R, Droge W (1991) Inhibition of HIV-1 replication and NF-kappa B activity by cysteine and cysteine derivatives. AIDS 5(5): 497-503.
9. Minami M, Kume N, Kataoka H, Morimoto M, Hayashida K, Sawamura T, Masaki T, Kita T (2000) Transforming growth factor-beta(1) increases the expression of lectin-like oxidized low-density lipoprotein receptor-1. Biochem Biophys Res Commun 272(2): 357-361.
10. Musa H, Meek S, Gautel M, Peddie D, Smith AJ, Peckham M (2006) Targeted homozygous deletion of M-band titin in cardiomyocytes prevents sarcomere formation. J Cell Sci 119(Pt 20): 4322-4331.
11. Nagase M, Abe J, Takahashi K, Ando J, Hirose S, Fujita T (1998) Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene. J Biol Chem 273(50): 33702-33707.
12. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S (2007) Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13(6): 688-694.
13. Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S (2008) Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun 377(4): 1195-1198.
14. Perkins ND (2007) Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 8(1): 49-62.
15. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T, Masaki T (1997) An endothelial receptor for oxidized low-density lipoprotein. Nature 386(6620): 73-77.
16. Shin S, Kwon J, Lee S, Kong H, Lee CK, Cho K, Ha NJ, Kim K (2010) Immunostimulatory Effects of Cordyceps militaris on macrophages through the enhanced production of cytokines via the activation of NF-kappaB. Immune Netw 10(2): 55-63.
17. Xu X, Gao X, Potter BJ, Cao JM, Zhang C (2007) Anti-LOX-1 rescues endothelial function in coronary arterioles in atherosclerotic ApoE knockout mice. Arterioscler Thromb Vasc Biol 27(4): 871-877.