Suppression of choroidal neovascularization in lectin-like oxidized low-density lipoprotein receptor type 1-deficient mice

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 8, 2009, Pages 3970-3976

  Inomata, Yasuya ^a   Fukushima, Mikiko ^a   Hara, Ryuhei ^a   Takahashi, Eri ^a   Honjo, Megumi ^b   Koga, Takahisa ^a   Kawaji, Takahiro ^a   Satoh, Hiroo ^a   Takeya, Motohiro ^a   Sawamura, Tatsuya ^c   Tanihara, Hidenobu ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME PRECURSOR; GELATINASE A; GELATINASE B; LECTIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; SCAVENGER RECEPTOR; VASCULOTROPIN; CCL2 PROTEIN, MOUSE; OLR1 PROTEIN, MOUSE; PRO MATRIX METALLOPROTEINASE 9; PRO-MATRIX METALLOPROTEINASE 9; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; EYE FUNDUS; FLUORESCENCE ANGIOGRAPHY; GENE EXPRESSION; LASER COAGULATION; MALE; MORPHOMETRICS; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBRETINAL NEOVASCULARIZATION; WESTERN BLOTTING; ZYMOGRAPHY; ANIMAL; C57BL MOUSE; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CHEMOKINE CCL2; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; ENZYME PRECURSORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCEIN ANGIOGRAPHY; GENE EXPRESSION REGULATION; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCAVENGER RECEPTORS, CLASS E; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 68349113750     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-1177     Document Type: Article

References (45)

1. Fine SL, Berger JW, Maguire MG, Ho AC. Age-related macular degeneration. N Engl J Med. 2000;342(7):483-492.
2. Haines JL, Hauser MA, Schmidt S, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005;308(5720):419-421.
3. Vingerling JR, Hofman A, Grobbee DE, de Jong PT. Age-related macular degeneration and smoking: the Rotterdam Study. Arch Ophthalmol. 1996;114(10):1193-1196.
4. McGwin G Jr, Xie A, Owsley C. The use of cholesterol-lowering medications and age-related macular degeneration. Ophthalmology. 2005;112(3):488-494.
5. Friedman E. The role of the atherosclerotic process in the patho-genesis of age-related macular degeneration. Am J Ophthalmol. 2000;130(5):658-663.
6. Mullins RF, Russell SR, Anderson DH, Hageman GS. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 2000;14(7):835-846.
7. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340(2):115-126.
8. Ikeda T, Obayashi H, Hasegawa G, et al. Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration. Am J Ophthalmol. 2001;132(2):191-195.
9. Kamei M, Yoneda K, Kume N, et al. Scavenger receptors for oxidized lipoprotein in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2007;48(4):1801-1807.
10. Lambert V, Wielockx B, Munaut C, et al. MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB J. 2003;17(15):2290-2292.
11. Sluijter JP, de Kleijn DP, Pasterkamp G. Vascular remodeling and protease inhibition: bench to bedside. Cardiovasc Res. 2006; 69(3):595-603.
12. Cheng C, Tempel D, van Haperen R, et al. Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines. J Clin Invest. 2007;117(3):616-626.
13. Nagai N, Oike Y, Izumi-Nagai K, et al. Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: minimalrole ofbradykinin. Invest Ophthalmol VisSci. 2007;48(5): 2321-2326.
14. Sawamura T, Kume N, Aoyama T, et al. An endothelial receptor for oxidized low-density lipoprotein. Nature. 1997;386(6620):73-77.
15. Mehta JL, Sanada N, Hu CP, et al. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res. 2007;100(11):1634-1642.
16. Honjo M, Sawamura T, Hinagata J, et al. Expression of LOX-1, an oxidized low-density lipoprotein receptor, in choroidal neovascu-larization. Arch Ophthalmol. 2004;122(12):1873-1876.
17. Li D, Liu L, Chen H, et al. LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells. Circulation. 2003;107(4): 612-617.
18. Li D, Mehta JL. Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and mono-cyte adhesion to human coronary artery endothelial cells. Circulation. 2000;101(25):2889-2895.
19. Tobe T, Ortega S, Luna JD, et al. Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model. Am J Pathol. 1998;153(5):1641-1646.
20. Awai M, Koga T, Inomata Y, et al. NMDA-induced retinal injury is mediated by an endoplasmic reticulum stress-related protein, CHOP/GADD153. J Neurochem. 2006;96(1):43-52.
21. Takano A, Hirata A, Inomata Y, et al. Intravitreal plasmin injection activates endogenous matrix metalloproteinase-2 in rabbit and human vitreous. Am J Ophthalmol. 2005;140(3):654-660.
22. Sakurai E, Anand A, Ambati BK, van Rooijen N, Ambati J. Macro-phage depletion inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003;44:3578-3585.
23. Itaya M, Sakurai E, Nozaki M, et al. Upregulation of VEGF in murine retina via monocyte recruitment after retinal scatter laser photocoagulation. Invest Ophthalmol Vis Sci. 2007;48:5677-5683.
24. Sagara N, Kawaji T, Takano A, et al. Effect of pitavastatin on experimental choroidal neovascularization in rats. Exp Eye Res. 2007;84(6):1074-1080.
25. Bora PS, Sohn JH, Cruz JM, et al. Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization. J Immunol. 2005;174(1):491-497.
26. Schlingemann RO. Role of growth factors and the wound healing response in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2004;242(1):91-101.
27. Campochiaro PA, Soloway P, Ryan SJ, Miller JW. The pathogenesis of choroidal neovascularization in patients with age-related macular degeneration. Mol Vis. 1999;5:34.
28. Lopez PF, Sippy BD, Lambert HM, Thach AB, Hinton DR. Trans-differentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest Ophthalmol Vis Sci. 1996;37(5):855-868.
29. Lopez PF, Grossniklaus HE, Lambert HM, et al. Pathologic features of surgically excised subretinal neovascular membranes in age related macular degeneration. Am J Ophthalmol. 1991;112(6): 647-656.
30. Kume N, Moriwaki H, Kataoka H, et al. Inducible expression of LOX-1, a novel receptor for oxidized LDL, in macrophages and vascular smooth muscle cells. Ann N Y Acad Sci. 2000;902:323-327.
31. Nagase M, Ando K, Nagase T, et al. Redox-sensitive regulation of LOX-1 gene expression in vascular endothelium. Biochem Biophys Res Commun. 2001;281(3):720-725.
32. Li D, Mehta JL. Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors. Arterioscler Thromb Vasc Biol. 2000;20(4):1116-1122.
33. Kume N, Murase T, Moriwaki H, et al. Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res. 1998;83(3):322-327.
34. Murase T, Kume N, Korenaga R, et al. Fluid shear stress transcrip-tionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res. 1998;83(3):328-333.
35. Cominacini L, Pasini AF, Garbin U, et al. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kB through an increased production of intracellular reactive oxygen species. J Biol Chem. 2000; 275(17):12633-12638.
36. Cominacini L, Rigoni A, Pasini AF, et al. The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide. J Biol Chem. 2001;276(17):13750-13755.
37. Honjo M, Nakamura K, Yamashiro K, et al. Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-in-duced inflammation. Proc Natl Acad Sci USA. 2003;100(3):1274-1279.
38. Berglin L, Sarman S, van der Ploeg I, et al. Reduced choroidal neovascular membrane formation in matrix metalloproteinase-2-deficient mice. Invest Ophthalmol Vis Sci. 2003;44(1):403-408.
39. Fiotti N, Pedio M, Battaglia Parodi M, et al. MMP-9 microsatellite polymorphism and susceptibility to exudative form of age-related macular degeneration. Genet Med. 2005;7(4):272-277.
40. Chau KY, Sivaprasad S, Patel N, et al. Plasma levels of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) in age-related mac-ular degeneration. Eye. 2008;22(6):855-859.
41. Hamakawa Y, Omori N, Ouchida M, et al. Severity dependent upregulations of LOX-1 and MCP-1 in early sclerotic changes of common carotid arteries in spontaneously hypertensive rats. Neurol Res. 2004;26(7):767-773.
42. Yamada K, Sakurai E, Itaya M, Yamasaki S, Ogura Y. Inhibition of laser-induced choroidal neovascularization by atorvastatin by downregulation of monocyte chemotactic protein-1 synthesis in mice. Invest Ophthalmol Vis Sci. 2007;48(4):1839-1843.
43. Grossniklaus HE, Ling JX, Wallace TM, et al. Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol Vis. 2002;8:119-126.
44. Tsutsumi C, Sonoda KH, Egashira K, et al. The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization. J Leukoc Biol. 2003;74(1):25-32.
45. Hu C, Dandapat A. Mehta JL. Angiotensin II induces capillary formation from endothelial cells via the lox-1- dependent redox-sensitive pathway. Hypertension. 2007;50:952-957.