-
1
-
-
70350734809
-
The microenvironment in mature B-cell malignancies: a target for new treatment strategies
-
Burger JA, Ghia P, Rosenwald A, Caligaris-Cappio F, (2009) The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood 114: 3367-3375.
-
(2009)
Blood
, vol.114
, pp. 3367-3375
-
-
Burger, J.A.1
Ghia, P.2
Rosenwald, A.3
Caligaris-Cappio, F.4
-
2
-
-
33645286546
-
Regulatory T cells, tumour immunity and immunotherapy
-
Zou W, (2006) Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6: 295-307.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 295-307
-
-
Zou, W.1
-
3
-
-
0035554676
-
Regulatory T cells in the control of immune pathology
-
Maloy KJ, Powrie F, (2001) Regulatory T cells in the control of immune pathology. Nat Immunol 2: 816-822.
-
(2001)
Nat Immunol
, vol.2
, pp. 816-822
-
-
Maloy, K.J.1
Powrie, F.2
-
4
-
-
1242295282
-
Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance
-
Piccirillo CA, Shevach EM, (2004) Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance. Semin Immunol 16: 81-88.
-
(2004)
Semin Immunol
, vol.16
, pp. 81-88
-
-
Piccirillo, C.A.1
Shevach, E.M.2
-
5
-
-
77951638740
-
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
-
Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, et al. (2010) Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol 184: 3433-3441.
-
(2010)
J Immunol
, vol.184
, pp. 3433-3441
-
-
Thornton, A.M.1
Korty, P.E.2
Tran, D.Q.3
Wohlfert, E.A.4
Murray, P.E.5
-
7
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S, (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
8
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot JD, Gavin MA, Rudensky AY, (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4: 330-336.
-
(2003)
Nat Immunol
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
9
-
-
33745813929
-
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
-
Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, et al. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 203: 1693-1700.
-
(2006)
J Exp Med
, vol.203
, pp. 1693-1700
-
-
Seddiki, N.1
Santner-Nanan, B.2
Martinson, J.3
Zaunders, J.4
Sasson, S.5
-
10
-
-
33745817085
-
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
-
Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203: 1701-1711.
-
(2006)
J Exp Med
, vol.203
, pp. 1701-1711
-
-
Liu, W.1
Putnam, A.L.2
Xu-Yu, Z.3
Szot, G.L.4
Lee, M.R.5
-
11
-
-
79960898228
-
Elevated frequencies of CD4(+) CD25(+) CD127(lo) regulatory T cells is associated to poor prognosis in patients with acute myeloid leukemia
-
Shenghui Z, Yixiang H, Jianbo W, Kang Y, Laixi B, et al. (2011) Elevated frequencies of CD4(+) CD25(+) CD127(lo) regulatory T cells is associated to poor prognosis in patients with acute myeloid leukemia. Int J Cancer 129: 1373-1381.
-
(2011)
Int J Cancer
, vol.129
, pp. 1373-1381
-
-
Shenghui, Z.1
Yixiang, H.2
Jianbo, W.3
Kang, Y.4
Laixi, B.5
-
12
-
-
38949128315
-
FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection
-
Ndhlovu LC, Loo CP, Spotts G, Nixon DF, Hecht FM, (2008) FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection. J Leukoc Biol 83: 254-262.
-
(2008)
J Leukoc Biol
, vol.83
, pp. 254-262
-
-
Ndhlovu, L.C.1
Loo, C.P.2
Spotts, G.3
Nixon, D.F.4
Hecht, F.M.5
-
13
-
-
74249118677
-
Phenotypic analysis of human peripheral blood regulatory T cells (CD4+FOXP3+CD127lo/-) ex vivo and after in vitro restimulation with malaria antigens
-
Finney OC, Riley EM, Walther M, (2010) Phenotypic analysis of human peripheral blood regulatory T cells (CD4+FOXP3+CD127lo/-) ex vivo and after in vitro restimulation with malaria antigens. Eur J Immunol 40: 47-60.
-
(2010)
Eur J Immunol
, vol.40
, pp. 47-60
-
-
Finney, O.C.1
Riley, E.M.2
Walther, M.3
-
14
-
-
58149399352
-
FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions
-
Ahmadzadeh M, Felipe-Silva A, Heemskerk B, Powell DJ Jr, Wunderlich JR, et al. (2008) FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions. Blood 112: 4953-4960.
-
(2008)
Blood
, vol.112
, pp. 4953-4960
-
-
Ahmadzadeh, M.1
Felipe-Silva, A.2
Heemskerk, B.3
Powell Jr., D.J.4
Wunderlich, J.R.5
-
15
-
-
76049117928
-
Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner
-
Yuan XL, Chen L, Li MX, Dong P, Xue J, et al. (2010) Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner. Clin Immunol 134: 277-288.
-
(2010)
Clin Immunol
, vol.134
, pp. 277-288
-
-
Yuan, X.L.1
Chen, L.2
Li, M.X.3
Dong, P.4
Xue, J.5
-
16
-
-
68449093742
-
Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia
-
Jak M, Mous R, Remmerswaal EB, Spijker R, Jaspers A, et al. (2009) Enhanced formation and survival of CD4+ CD25hi Foxp3+ T-cells in chronic lymphocytic leukemia. Leuk Lymphoma 50: 788-801.
-
(2009)
Leuk Lymphoma
, vol.50
, pp. 788-801
-
-
Jak, M.1
Mous, R.2
Remmerswaal, E.B.3
Spijker, R.4
Jaspers, A.5
-
17
-
-
69249229779
-
CD13+CD4+CD25hi regulatory T cells exhibit higher suppressive function and increase with tumor stage in non-small cell lung cancer patients
-
Ju S, Qiu H, Zhou X, Zhu B, Lv X, et al. (2009) CD13+CD4+CD25hi regulatory T cells exhibit higher suppressive function and increase with tumor stage in non-small cell lung cancer patients. Cell Cycle 8: 2578-2585.
-
(2009)
Cell Cycle
, vol.8
, pp. 2578-2585
-
-
Ju, S.1
Qiu, H.2
Zhou, X.3
Zhu, B.4
Lv, X.5
-
18
-
-
44749086828
-
Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma
-
Mittal S, Marshall NA, Duncan L, Culligan DJ, Barker RN, et al. (2008) Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma. Blood 111: 5359-5370.
-
(2008)
Blood
, vol.111
, pp. 5359-5370
-
-
Mittal, S.1
Marshall, N.A.2
Duncan, L.3
Culligan, D.J.4
Barker, R.N.5
-
19
-
-
33646422454
-
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma
-
Yang ZZ, Novak AJ, Stenson MJ, Witzig TE, Ansell SM, (2006) Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma. Blood 107: 3639-3646.
-
(2006)
Blood
, vol.107
, pp. 3639-3646
-
-
Yang, Z.Z.1
Novak, A.J.2
Stenson, M.J.3
Witzig, T.E.4
Ansell, S.M.5
-
20
-
-
4043089285
-
CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-to-cell interaction
-
Trzonkowski P, Szmit E, Mysliwska J, Dobyszuk A, Mysliwski A, (2004) CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-to-cell interaction. Clin Immunol 112: 258-267.
-
(2004)
Clin Immunol
, vol.112
, pp. 258-267
-
-
Trzonkowski, P.1
Szmit, E.2
Mysliwska, J.3
Dobyszuk, A.4
Mysliwski, A.5
-
21
-
-
63949086950
-
The immunosuppressive tumor microenvironment in hepatocellular carcinoma
-
Pang YL, Zhang HG, Peng JR, Pang XW, Yu S, et al. (2009) The immunosuppressive tumor microenvironment in hepatocellular carcinoma. Cancer Immunol Immunother 58: 877-886.
-
(2009)
Cancer Immunol Immunother
, vol.58
, pp. 877-886
-
-
Pang, Y.L.1
Zhang, H.G.2
Peng, J.R.3
Pang, X.W.4
Yu, S.5
-
22
-
-
79955774902
-
Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice
-
Liu J, Zhang N, Li Q, Zhang W, Ke F, et al. (2011) Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice. PLoS One 6: e19495.
-
(2011)
PLoS One
, vol.6
-
-
Liu, J.1
Zhang, N.2
Li, Q.3
Zhang, W.4
Ke, F.5
-
23
-
-
79960658382
-
Requirement of Cognate CD4 T-Cell Recognition for the Regulation of Allospecific CTL by Human CD4CD127CD25FOXP3 Cells Generated in MLR
-
Yu Y, Miller J, Leventhal JR, Tambur AR, Chandrasekaran D, et al. (2011) Requirement of Cognate CD4 T-Cell Recognition for the Regulation of Allospecific CTL by Human CD4CD127CD25FOXP3 Cells Generated in MLR. PLoS One 6: e22450.
-
(2011)
PLoS One
, vol.6
-
-
Yu, Y.1
Miller, J.2
Leventhal, J.R.3
Tambur, A.R.4
Chandrasekaran, D.5
-
24
-
-
77957909177
-
Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8+ T cell immune response by the cytokine TGFbeta
-
Frimpong-Boateng K, van Rooijen N, Geiben-Lynn R, (2010) Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8+ T cell immune response by the cytokine TGFbeta. PLoS One 5: e12281.
-
(2010)
PLoS One
, vol.5
-
-
Frimpong-Boateng, K.1
van Rooijen, N.2
Geiben-Lynn, R.3
-
25
-
-
77951881004
-
Enrichment of CCR6+Foxp3+ regulatory T cells in the tumor mass correlates with impaired CD8+ T cell function and poor prognosis of breast cancer
-
Xu L, Xu W, Qiu S, Xiong S, (2010) Enrichment of CCR6+Foxp3+ regulatory T cells in the tumor mass correlates with impaired CD8+ T cell function and poor prognosis of breast cancer. Clin Immunol 135: 466-475.
-
(2010)
Clin Immunol
, vol.135
, pp. 466-475
-
-
Xu, L.1
Xu, W.2
Qiu, S.3
Xiong, S.4
-
26
-
-
79961102493
-
Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo
-
Suarez N, Alfaro C, Dubrot J, Palazon A, Bolanos E, et al. (2011) Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo. Int J Cancer 129: 374-386.
-
(2011)
Int J Cancer
, vol.129
, pp. 374-386
-
-
Suarez, N.1
Alfaro, C.2
Dubrot, J.3
Palazon, A.4
Bolanos, E.5
-
27
-
-
79957660239
-
Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma
-
Takata Y, Nakamoto Y, Nakada A, Terashima T, Arihara F, et al. (2011) Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma. Cancer Lett 307: 165-173.
-
(2011)
Cancer Lett
, vol.307
, pp. 165-173
-
-
Takata, Y.1
Nakamoto, Y.2
Nakada, A.3
Terashima, T.4
Arihara, F.5
-
28
-
-
58149376998
-
Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells
-
Ai WZ, Hou JZ, Zeiser R, Czerwinski D, Negrin RS, et al. (2009) Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells. Int J Cancer 124: 239-244.
-
(2009)
Int J Cancer
, vol.124
, pp. 239-244
-
-
Ai, W.Z.1
Hou, J.Z.2
Zeiser, R.3
Czerwinski, D.4
Negrin, R.S.5
-
29
-
-
38049022492
-
The ratio of FOXP3+ regulatory T cells to granzyme B+ cytotoxic T/NK cells predicts prognosis in classical Hodgkin lymphoma and is independent of bcl-2 and MAL expression
-
Kelley TW, Pohlman B, Elson P, Hsi ED, (2007) The ratio of FOXP3+ regulatory T cells to granzyme B+ cytotoxic T/NK cells predicts prognosis in classical Hodgkin lymphoma and is independent of bcl-2 and MAL expression. Am J Clin Pathol 128: 958-965.
-
(2007)
Am J Clin Pathol
, vol.128
, pp. 958-965
-
-
Kelley, T.W.1
Pohlman, B.2
Elson, P.3
Hsi, E.D.4
-
30
-
-
40849126992
-
Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma
-
Tzankov A, Meier C, Hirschmann P, Went P, Pileri SA, et al. (2008) Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma. Haematologica 93: 193-200.
-
(2008)
Haematologica
, vol.93
, pp. 193-200
-
-
Tzankov, A.1
Meier, C.2
Hirschmann, P.3
Went, P.4
Pileri, S.A.5
-
31
-
-
33751194652
-
High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma
-
Carreras J, Lopez-Guillermo A, Fox BC, Colomo L, Martinez A, et al. (2006) High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma. Blood 108: 2957-2964.
-
(2006)
Blood
, vol.108
, pp. 2957-2964
-
-
Carreras, J.1
Lopez-Guillermo, A.2
Fox, B.C.3
Colomo, L.4
Martinez, A.5
-
33
-
-
34948875291
-
CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25 T cells
-
Yang ZZ, Novak AJ, Ziesmer SC, Witzig TE, Ansell SM, (2007) CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25 T cells. Blood 110: 2537-2544.
-
(2007)
Blood
, vol.110
, pp. 2537-2544
-
-
Yang, Z.Z.1
Novak, A.J.2
Ziesmer, S.C.3
Witzig, T.E.4
Ansell, S.M.5
-
34
-
-
79955928676
-
Gastric cancer cells induce human CD4+Foxp3+ regulatory T cells through the production of TGF-beta1
-
Yuan XL, Chen L, Zhang TT, Ma YH, Zhou YL, et al. (2011) Gastric cancer cells induce human CD4+Foxp3+ regulatory T cells through the production of TGF-beta1. World J Gastroenterol 17: 2019-2027.
-
(2011)
World J Gastroenterol
, vol.17
, pp. 2019-2027
-
-
Yuan, X.L.1
Chen, L.2
Zhang, T.T.3
Ma, Y.H.4
Zhou, Y.L.5
-
35
-
-
34249872196
-
Human ovarian carcinoma cells generate CD4(+)CD25(+) regulatory T cells from peripheral CD4(+)CD25(-) T cells through secreting TGF-beta
-
Li X, Ye F, Chen H, Lu W, Wan X, et al. (2007) Human ovarian carcinoma cells generate CD4(+)CD25(+) regulatory T cells from peripheral CD4(+)CD25(-) T cells through secreting TGF-beta. Cancer Lett 253: 144-153.
-
(2007)
Cancer Lett
, vol.253
, pp. 144-153
-
-
Li, X.1
Ye, F.2
Chen, H.3
Lu, W.4
Wan, X.5
-
36
-
-
65549136983
-
Mechanisms of foxp3+ T regulatory cell-mediated suppression
-
Shevach EM, (2009) Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 30: 636-645.
-
(2009)
Immunity
, vol.30
, pp. 636-645
-
-
Shevach, E.M.1
-
37
-
-
79955785050
-
Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production
-
Curran MA, Kim M, Montalvo W, Al-Shamkhani A, Allison JP, (2011) Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production. PLoS One 6: e19499.
-
(2011)
PLoS One
, vol.6
-
-
Curran, M.A.1
Kim, M.2
Montalvo, W.3
Al-Shamkhani, A.4
Allison, J.P.5
-
38
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, et al. (2008) CTLA-4 control over Foxp3+ regulatory T cell function. Science 322: 271-275.
-
(2008)
Science
, vol.322
, pp. 271-275
-
-
Wing, K.1
Onishi, Y.2
Prieto-Martin, P.3
Yamaguchi, T.4
Miyara, M.5
-
39
-
-
77955515915
-
Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy
-
Coe D, Begom S, Addey C, White M, Dyson J, et al. (2010) Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy. Cancer Immunol Immunother 59: 1367-1377.
-
(2010)
Cancer Immunol Immunother
, vol.59
, pp. 1367-1377
-
-
Coe, D.1
Begom, S.2
Addey, C.3
White, M.4
Dyson, J.5
-
40
-
-
13444270323
-
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
-
Hirano F, Kaneko K, Tamura H, Dong H, Wang S, et al. (2005) Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res 65: 1089-1096.
-
(2005)
Cancer Res
, vol.65
, pp. 1089-1096
-
-
Hirano, F.1
Kaneko, K.2
Tamura, H.3
Dong, H.4
Wang, S.5
-
41
-
-
65649139622
-
PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV
-
Franceschini D, Paroli M, Francavilla V, Videtta M, Morrone S, et al. (2009) PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV. J Clin Invest 119: 551-564.
-
(2009)
J Clin Invest
, vol.119
, pp. 551-564
-
-
Franceschini, D.1
Paroli, M.2
Francavilla, V.3
Videtta, M.4
Morrone, S.5
|