Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner

Clinical Immunology

Volumn 134, Issue 3, 2010, Pages 277-288

  Yuan, Xiang Liang ^a   Chen, Lei ^a   Li, Mei Xing ^a   Dong, Ping ^a   Xue, Jian ^a   Wang, Jian ^a   Zhang, Tong tong ^a   Wang, Xing an ^b   Zhang, Feng Min ^c   Ge, Hai Liang ^a   Shen, Li Song ^a   Xu, Dakang ^d  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI PULMONARY HOSPITAL   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d MONASH UNIVERSITY   (Australia)

Author keywords

COX 2; Foxp3; Gastric cancer; Immune suppression; PGE2; Regulatory T cells; TNM stage; Tumor microenvironment

Indexed keywords

CYCLOOXYGENASE 2; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR FOXP3;

ADULT; ARTICLE; CANCER GROWTH; CANCER STAGING; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GROWTH STIMULATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; STOMACH CANCER; TUMOR ASSOCIATED LEUKOCYTE;

CYCLOOXYGENASE 2; DINOPROSTONE; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; NEOPLASM STAGING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; STOMACH NEOPLASMS; T-LYMPHOCYTES, REGULATORY;

EID: 76049117928     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2009.10.005     Document Type: Article

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