High-throughput screening identifies two classes of antibiotics as radioprotectors: Tetracyclines and fluoroquinolones

Clinical Cancer Research

Volumn 15, Issue 23, 2009, Pages 7238-7245

  Kim, Kwanghee ^a   Pollard, Julianne M ^a   Norris, Andrew J ^a   McDonald, J Tyson ^a   Sun, Yingli ^b   Micewicz, Ewa ^a   Pettijohn, Kelly ^a   Damoiseaux, Robert ^a   Iwamoto, Keisuke S ^a   Sayre, James W ^a   Price, Brendan D ^b   Gatti, Richard A ^a   McBride, William H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIVICIN; CHLORTETRACYCLINE; CIPROFLOXACIN; CYCLOPIAZONIC ACID; DEOXYADENOSINE; DOXYCYCLINE; ENOXACIN; FLUMEQUINE; GATIFLOXACIN; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE TIP 60; LEVOFLOXACIN; LINOLEIC ACID; LOMEFLOXACIN; MECLOCYCLINE; METACYCLINE; MINOCYCLINE; MOXIFLOXACIN; NORFLOXACIN; OXYTETRACYCLINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RADIOPROTECTIVE AGENT; RIFABUTIN; ROLITETRACYCLINE; SCOPOLAMINE; TETRACYCLINE; TETRACYCLINE DERIVATIVE; TILORONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIDARABINE;

ACUTE RADIATION SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL PROTECTION; CELL VIABILITY; CHROMATIN STRUCTURE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ASSAY; HEMATOPOIETIC STEM CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LETHALITY; LYMPHOBLASTOID CELL; LYMPHOCYTE; MALE; MOLECULAR LIBRARY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RADIATION PROTECTION; RADIOSENSITIVITY; STRUCTURE ACTIVITY RELATION; SURVIVAL TIME; WHOLE BODY RADIATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BONE MARROW CELLS; CARCINOMA, LEWIS LUNG; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; FLUOROQUINOLONES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTES; MALE; MICE; MICE, INBRED C3H; RADIATION-PROTECTIVE AGENTS; TETRACYCLINES; TIME FACTORS; WHOLE-BODY IRRADIATION;

EID: 73149094244     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-09-1964     Document Type: Article

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