Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: A double-blind randomized trial

International Journal of Radiation Oncology Biology Physics

Volumn 58, Issue 1, 2004, Pages 213-219

  Ozturk, Berrin ^a,b   Egehan, Ibrahim ^a   Atavci, Sevil ^a   Kitapci, Mehmet ^a  

^a GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

^b AMERICAN HOSPITAL   (Turkey)

Author keywords

LENT score; Lung; Pentoxifylline; Radiotherapy; Toxicity

Indexed keywords

BIOLOGICAL ORGANS; CARBON MONOXIDE; RADIOTHERAPY; STATISTICAL METHODS; TISSUE; TOXICITY; TUMORS;

RADIOTOXICITY;

ONCOLOGY;

CARBON MONOXIDE; PENTOXIFYLLINE; PLACEBO; TUMOR NECROSIS FACTOR;

ARTICLE; BREAST CARCINOMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; LUNG CARCINOMA; LUNG FUNCTION TEST; LUNG INJURY; LUNG PARENCHYMA; LUNG TOXICITY; MALE; MEDICAL ASSESSMENT; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; REDUCTION; SCINTIGRAPHY; STATISTICAL ANALYSIS; THROMBOCYTE AGGREGATION;

EID: 0346993594     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(03)01444-5     Document Type: Article

References (38)

1. Overgaard J., Bartelink H. About tolerance and quality An important notice to all radiation oncologists . Radiother Oncol. 35:1995;1-3.
2. Rubin P., Constine L.S., Fajardo L.S., et al. Overview of late effects normal tissues (LENT) scoring system. Radiother Oncol. 35:1995;9-10.
3. McDonald S., Rubin P., Maasilta P. Response of normal lung to irradiation Tolerance doses/tolerance volumes in pulmonary radiation syndromes . Front Radiat Ther Oncol. 23:1989;255-276.
4. McDonald S., Rubin P., Phillips T.L., et al. Injury to the lung from cancer therapy Clinical syndromes, measurable endpoints, and potential scoring systems . Int J Radiat Oncol Biol Phys. 31:1995;1187-1203.
5. Libshitz H.I. Radiation changes in the lung. Semin Roentgenol. 28:1993;303-320.
6. Ward A., Clissold S.P. Pentoxifylline A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy . Drugs. 34:1987;50-97.
7. Strieter R.M., Remick D.G., Ward P.A., et al. Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun. 155:1988;1230-1236.
8. Stephens K.E., Ishizaka A., Larrick J.W., et al. Tumor necrosis factor causes increased pulmonary permeability and edema Comparison to septic acute lung injury . Am Rev Respir Dis. 137:1988;1364-1370.
9. Dion M.W., Hussey D.H., Osborne J.W. The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice. Int J Radiat Oncol Biol Phys. 17:1989;101-107.
10. Dion M.W., Hussey D.H., Doornbos J.F., et al. Preliminary results of a pilot study of pentoxifylline in the treatment of late radiation soft tissue necrosis. Int J Radiat Oncol Biol Phys. 19:1990;401-407.
11. Koh W.J., Stelzer K.J., Peterson L.M., et al. Effect of pentoxifylline on radiation-induced lung and skin toxicity in rats. Int J Radiat Oncol Biol Phys. 31:19951;71-77.
12. Wasik M.W., Jones H.M. Pentoxifylline relieves pain from postradiation fibrosis (letter). Int J Radiat Oncol Biol Phys. 25:1993;757-758.
13. LENT-SOMA scales for all anatomic sides. Int J Radiat Oncol Biol Phys 1995;31:1049-1091.
14. CTC. Cancer therapy evaluation program. Common toxicity criteria version 2.0. Bethesda: National Cancer Institute, DCTD, DHHS; 1998.
15. Libshitz H.I., Shuman L.S. Radiation-induced pulmonary change CT findings . J Comput Assist Tomogr. 8:1984;15-19.
16. Robnett T.J., Machtay M., Vines E.F., et al. Factors predicting severe radiation pneumonitis in patients receiving definitive chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys. 48:2000;89-94.
17. Oetzel D., Schraube P., Hensley F. Estimation of pneumonitis risk in three-dimensional treatment planning using dose-volume histogram analysis. Int J Radiat Oncol Biol Phys. 33:1995;455-460.
18. Kwa S.L., Lebesque J.V., Theuws J.C., et al. Radiation pneumonitis as a function of mean lung dose An analysis of pooled data of 540 patients . Int J Radiat Oncol Biol Phys. 42:1998;1-9.
19. Martel M.K., Ten Haken R.K., Hazuka M.B., et al. Dose-volume histogram and 3-D treatment planning evaluation of patients with pneumonitis. Int J Radiat Oncol Biol Phys. 28:1994;575-581.
20. Graham M.V., Purdy J.A., Emami B., et al. Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys. 45:1999;323-329.
21. Lind P.A., Gagliardi G., Wennberg B., et al. A descriptive study of pulmonary complications after postoperative radiation therapy in node-positive stage II breast cancer. Acta Oncol. 36:1997;509-515.
22. Rubin P., Finkelstein J., McDonald S., et al. The identification of new early molecular mechanisms in the pathogenesis of radiation induced pulmonary fibrosis. Int J Radiat Oncol Biol Phys. 21:(Suppl. 1):1991;163.
23. Rodemann H.P., Bamberg M. Cellular basis of radiation-induced fibrosis. Radiother Oncol. 35:1995;83-90.
24. Lilly C.M., Sandhu J.S., Ishizaka A., et al. Pentoxifylline prevents tumor necrosis factor-induced lung injury. Am Rev Respir Dis. 139:1989;1361-1368.
25. Bianco A., Appelbaum F.R., Nemunaitis J., et al. Phase I-II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation. Blood. 78:1991;1205-1211.
26. Lipsztein R., Dalton J.F., Bloomer W.D. Sequelae of breast irradiation. JAMA. 253:1985;3582-3584.
27. Kaufman J., Gunn W., Hartz A.J., et al. The pathophysiologic and roentgenologic effects of chest irradiation in breast carcinoma. Int J Radiat Oncol Biol Phys. 12:1986;887-893.
28. Choi N.C., Kanarek D.J., Grillo H.C. Effect of postoperative radiotherapy on changes in pulmonary function in patients with stage II and IIIA lung carcinoma. Int J Radiat Oncol Biol Phys. 18:1990;95-99.
29. Choi N.C., Kanarek D.J., Kazemi H. Prospective study of pulmonary tolerance to radiotherapy or radiotherapy plus multidrug chemotherapy for loco-regional lung carcinoma. Antibiot Chemother. 41:1988;213-219.
30. Shapiro S.J., Shapiro S.D., Mill W.B., et al. Prospective study of long-term pulmonary manifestations of mantle irradiation. Int J Radiat Oncol Biol Phys. 19:1990;707-714.
31. Abratt R.P., Willcox P.A. The effect of irradiation on lung function and perfusion in patients with lung cancer. Int J Radiat Oncol Biol Phys. 31:1995;915-919.
32. Bell J., McGivern D., Bullimore J., et al. Diagnostic imaging of post-irradiation changes in the chest. Clin Radiol. 39:1988;109-119.
33. Stelzer K.J., Koh W.J., Peterson L.M., et al. Effect of high-dose pentoxifylline on acute radiation-induced lung toxicity in a rat lung perfusion model. Int J Radiat Oncol Biol Phys. 34:1996;111-115.
34. Marks L.B., Spencer D.P., Bentel G.C., et al. The utility of SPECT lung perfusion scans in minimizing and assessing the physiologic consequences of thoracic irradiation. Int J Radiat Oncol Biol Phys. 26:1993;659-668.
35. Monson J.M., Stark P., Reilly J.J., et al. Clinical radiation pneumonitis and radiographic changes after thoracic radiation therapy for lung carcinoma. Cancer. 82:1998;842-850.
36. Lind P.A., Marks L.B., Hardenbergh P.H., et al. Technical factors associated with radiation pneumonitis after local +/- regional radiation therapy for breast cancer. Int J Radiat Oncol Biol Phys. 52:2002;137-143.
37. Lingos T.I., Recht A., Vicini F., et al. Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys. 21:1991;355-360.
38. Rothwell R.I., Kelly S.A., Joslin C.A. Radiation pneumonitis in patients treated for breast cancer. Radiother Oncol. 4:1985;9-14.