Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function

Microvascular Research

Volumn 83, Issue 1, 2012, Pages 45-55

  Usatyuk, Peter V ^a   Natarajan, Viswanathan ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; CYTOSKELETON PROTEIN; FOCAL ADHESION KINASE; GAP JUNCTION PROTEIN; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; GUANOSINE TRIPHOSPHATASE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN; OXIDIZED PHOSPHOLIPID; PHOSPHOLIPASE D; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ARTICLE; ATHEROSCLEROSIS; BIOACCUMULATION; CONFORMATIONAL TRANSITION; CYTOTOXICITY; DIABETES MELLITUS; ENZYME REGULATION; GENE EXPRESSION; HUMAN; ISCHEMIA; LIPID ANALYSIS; LIPID PEROXIDATION; MALIGNANT NEOPLASTIC DISEASE; MEMBRANE PERMEABILITY; MOLECULAR INTERACTION; NONHUMAN; PATHOPHYSIOLOGY; PHOSPHOLIPID MEMBRANE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN TARGETING; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ADHERENS JUNCTIONS; ALDEHYDES; ANIMALS; CAPILLARY PERMEABILITY; CYTOSKELETON; ENDOTHELIAL CELLS; FATTY ACIDS, UNSATURATED; FOCAL ADHESIONS; HUMANS; INFLAMMATION MEDIATORS; LIPID PEROXIDATION; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHOLIPIDS; SIGNAL TRANSDUCTION;

EID: 82955237301     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2011.04.012     Document Type: Article

References (131)

1. Aldini G., Dalle-Donne I., Vistoli G., Maffei Facino R., Carini M. Covalent modification of actin by 4-hydroxy-trans-2-nonenal (HNE): LC-ESI-MS/MS evidence for Cys374 Michael adduction. J. Mass Spectrom. 2005, 40:946-954.
2. Auge N., Garcia V., Maupas-Schwalm F., Levade T., Salvayre R., Negre-Salvayre A. Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. Arterioscler. Thromb. Vasc. Biol. 2002, 22:1990-1995.
3. Awasthi Y.C., Sharma R., Cheng J.Z., Yang Y., Sharma A., Singhal S.S., Awasthi S. Role of 4-hydroxynonenal in stress-mediated apoptosis signaling. Mol. Aspects Med. 2003, 24:219-230.
4. Awasthi Y.C., Yang Y., Tiwari N.K., Patrick B., Sharma A., Li J., Awasthi S. Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases. Free Radic. Biol. Med. 2004, 37:607-619.
5. Bacot S., Bernoud-Hubac N., Baddas N., Chantegrel B., Deshayes C., Doutheau A., Lagarde M., Guichardant M. Covalent binding of hydroxy-alkenals 4-HDDE, 4-HHE, and 4-HNE to ethanolamine phospholipid subclasses. J. Lipid Res. 2003, 44:917-926.
6. Barrera G., Muraca R., Pizzimenti S., Serra A., Rosso C., Saglio G., Farace M.G., Fazio V.M., Dianzani M.U. Inhibition of c-myc expression induced by 4-hydroxynonenal, a product of lipid peroxidation, in the HL-60 human leukemic cell line. Biochem. Biophys. Res. Commun. 1994, 203:553-561.
7. Barrera G., Pizzimenti S., Serra A., Ferretti C., Fazio V.M., Saglio G., Dianzani M.U. 4-hydroxynonenal specifically inhibits c-myb but does not affect c-fos expressions in HL-60 cells. Biochem. Biophys. Res. Commun. 1996, 227:589-593.
8. Barrera G., Pizzimenti S., Laurora S., Briatore F., Toaldo C., Dianzani M.U. 4-hydroxynonenal and cell cycle. Biofactors 2005, 24:151-157.
9. Benedetti A., Comporti M., Esterbauer H. Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids. Biochim. Biophys. Acta 1980, 620:281-296.
10. Benedetti A., Esterbauer H., Ferrali M., Fulceri R., Comporti M. Evidence for aldehydes bound to liver microsomal protein following CCl4 or BrCCl3 poisoning. Biochim. Biophys. Acta 1982, 711:345-356.
11. Berliner J.A., Gharavi N.M. Endothelial cell regulation by phospholipid oxidation products. Free Radic. Biol. Med. 2008, 45:119-123.
12. Birukov K.G., Bochkov V.N., Birukova A.A., Kawkitinarong K., Rios A., Leitner A., Verin A.D., Bokoch G.M., Leitinger N., Garcia J.G. Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. Circ. Res. 2004, 95:892-901.
13. Birukov K.G., Leitinger N., Bochkov V.N., Garcia J.G. Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins. Microvasc. Res. 2004, 67:18-28.
14. Birukova A.A., Chatchavalvanich S., Oskolkova O., Bochkov V.N., Birukov K.G. Signaling pathways involved in OxPAPC-induced pulmonary endothelial barrier protection. Microvasc. Res. 2007, 73:173-181.
15. Birukova A.A., Fu P., Chatchavalvanich S., Burdette D., Oskolkova O., Bochkov V.N., Birukov K.G. Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007, 292:L924-L935.
16. Birukova A.A., Malyukova I., Poroyko V., Birukov K.G. Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007, 293:L199-L211.
17. Bochkov V.N., Kadl A., Huber J., Gruber F., Binder B.R., Leitinger N. Protective role of phospholipid oxidation products in endotoxin-induced tissue damage. Nature 2002, 419:77-81.
18. Bochkov V.N., Mechtcheriakova D., Lucerna M., Huber J., Malli R., Graier W.F., Hofer E., Binder B.R., Leitinger N. Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT. Blood 2002, 99:199-206.
19. Bochkov V.N., Oskolkova O.V., Birukov K.G., Levonen A.L., Binder C.J., Stockl J. Generation and biological activities of oxidized phospholipids. Antioxid. Redox Signal. 2010, 12:1009-1059.
20. Borbiev T., Birukova A., Liu F., Nurmukhambetova S., Gerthoffer W.T., Garcia J.G., Verin A.D. p38 MAP kinase-dependent regulation of endothelial cell permeability. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004, 287:L911-L918.
21. Carbajal J.M., Schaeffer R.C. RhoA inactivation enhances endothelial barrier function. Am. J. Physiol. 1999, 277:C955-C964.
22. Catala A. Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions. Chem. Phys. Lipids 2009, 157:1-11.
23. Chaudhary P., Sharma R., Sharma A., Vatsyayan R., Yadav S., Singhal S.S., Rauniyar N., Prokai L., Awasthi S., Awasthi Y.C. Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling. Biochemistry 2010, 49:6263-6275.
24. Cheng J.Z., Sharma R., Yang Y., Singhal S.S., Sharma A., Saini M.K., Singh S.V., Zimniak P., Awasthi S., Awasthi Y.C. Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress. J. Biol. Chem. 2001, 276:41213-41223.
25. Cheng J.Z., Singhal S.S., Sharma A., Saini M., Yang Y., Awasthi S., Zimniak P., Awasthi Y.C. Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling. Arch. Biochem. Biophys. 2001, 392:197-207.
26. Chiarpotto E., Domenicotti C., Paola D., Vitali A., Nitti M., Pronzato M.A., Biasi F., Cottalasso D., Marinari U.M., Dragonetti A., et al. Regulation of rat hepatocyte protein kinase C beta isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: a signaling pathway to modulate vesicular transport of glycoproteins. Hepatology 1999, 29:1565-1572.
27. Chiarugi P., Pani G., Giannoni E., Taddei L., Colavitti R., Raugei G., Symons M., Borrello S., Galeotti T., Ramponi G. Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J. Cell Biol. 2003, 161:933-944.
28. Cole A.L., Subbanagounder G., Mukhopadhyay S., Berliner J.A., Vora D.K. Oxidized phospholipid-induced endothelial cell/monocyte interaction is mediated by a cAMP-dependent R-Ras/PI3-kinase pathway. Arterioscler. Thromb. Vasc. Biol. 2003, 23:1384-1390.
29. Compton C.N., Franko A.P., Murray M.T., Diebel L.N., Dulchavsky S.A. Signaling of apoptotic lung injury by lipid hydroperoxides. J. Trauma 1998, 44:783-788.
30. Cummings R., Parinandi N., Wang L., Usatyuk P., Natarajan V. Phospholipase D/phosphatidic acid signal transduction: role and physiological significance in lung. Mol. Cell. Biochem. 2002, 234-235:99-109.
31. Dalle-Donne I., Giustarini D., Rossi R., Colombo R., Milzani A. Reversible S-glutathionylation of Cys 374 regulates actin filament formation by inducing structural changes in the actin molecule. Free Radic. Biol. Med. 2003, 34:23-32.
32. Dalle-Donne I., Carini M., Vistoli G., Gamberoni L., Giustarini D., Colombo R., Maffei Facino R., Rossi R., Milzani A., Aldini G. Actin Cys374 as a nucleophilic target of alpha, beta-unsaturated aldehydes. Free Radic. Biol. Med. 2007, 42:583-598.
33. Dickinson D.A., Forman H.J. Glutathione in defense and signaling: lessons from a small thiol. Ann. N.Y. Acad. Sci. 2002, 973:488-504.
34. Donath B., Fischer C., Page S., Prebeck S., Jilg N., Weber M., da Costa C., Neumeier D., Miethke T., Brand K. Chlamydia pneumoniae activates IKK/I kappa B-mediated signaling, which is inhibited by 4-HNE and following primary exposure. Atherosclerosis 2002, 165:79-88.
35. Dubinina E.E., Dadali V.A. Role of 4-hydroxy-trans-2-nonenal in cell functions. Biochemistry (Mosc) 2010, 75:1069-1087.
36. Dudek S.M., Garcia J.G. Cytoskeletal regulation of pulmonary vascular permeability. J. Appl. Physiol. 2001, 91:1487-1500.
37. Eaton P., Li J.M., Hearse D.J., Shattock M.J. Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart. Am. J. Physiol. 1999, 276:H935-H943.
38. Escargueil-Blanc I., Salvayre R., Vacaresse N., Jurgens G., Darblade B., Arnal J.F., Parthasarathy S., Negre-Salvayre A. Mildly oxidized LDL induces activation of platelet-derived growth factor beta-receptor pathway. Circulation 2001, 104:1814-1821.
39. Esterbauer H., Benedetti A., Lang J., Fulceri R., Fauler G., Comporti M. Studies on the mechanism of formation of 4-hydroxynonenal during microsomal lipid peroxidation. Biochim. Biophys. Acta 1986, 876:154-166.
40. Esterbauer H., Schaur R.J., Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 1991, 11:81-128.
41. Forman H.J. Reactive oxygen species and alpha,beta-unsaturated aldehydes as second messengers in signal transduction. Ann. N Y Acad. Sci. 2010, 1203:35-44.
42. Fu P., Birukov K.G. Oxidized phospholipids in control of inflammation and endothelial barrier. Transl. Res. 2009, 153:166-176.
43. Gadoni E., Olivero A., Miglietta A., Bocca C., Gabriel L. Cytoskeletal modifications induced by 4-hydroxynonenal. Cytotechnology 1993, 11(Suppl 1):S62-64.
44. Gayarre J., Sanchez D., Sanchez-Gomez F.J., Terron M.C., Llorca O., Perez-Sala D. Addition of electrophilic lipids to actin alters filament structure. Biochem. Biophys. Res. Commun. 2006, 349:1387-1393.
45. Goyal J., Wang K., Liu M., Subbaiah P.V. Novel function of lecithin-cholesterol acyltransferase. Hydrolysis of oxidized polar phospholipids generated during lipoprotein oxidation. J. Biol. Chem. 1997, 272:16231-16239.
46. Groeneweg M., Vergouwe M.N., Scheffer P.G., Vermue H.P., Sollewijn Gelpke M.D., Sijbers A.M., Leitinger N., Hofker M.H., de Winther M.P. Modification of LDL with oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) results in a novel form of minimally modified LDL that modulates gene expression in macrophages. Biochim. Biophys. Acta 2008, 1781:336-343.
47. Guay J., Lambert H., Gingras-Breton G., Lavoie J.N., Huot J., Landry J. Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J. Cell Sci. 1997, 110(Pt 3):357-368.
48. Guichardant M., Bernoud-Hubac N., Chantegrel B., Deshayes C., Lagarde M. Aldehydes from n-6 fatty acid peroxidation. Effects on aminophospholipids. Prostaglandins Leukot. Essent. Fatty Acids 2002, 67:147-149.
49. Guichardant M., Bacot S., Moliere P., Lagarde M. Hydroxy-alkenals from the peroxidation of n-3 and n-6 fatty acids and urinary metabolites. Prostaglandins Leukot. Essent. Fatty Acids 2006, 75:179-182.
50. Gutierrez J., Ballinger S.W., Darley-Usmar V.M., Landar A. Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circ. Res. 2006, 99:924-932.
51. Hamilton R.F., Li L., Eschenbacher W.L., Szweda L., Holian A. Potential involvement of 4-hydroxynonenal in the response of human lung cells to ozone. Am. J. Physiol. 1998, 274:L8-L16.
52. He N.G., Singhal S.S., Chaubey M., Awasthi S., Zimniak P., Partridge C.A., Awasthi Y.C. Purification and characterization of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme from bovine pulmonary microvessel endothelial cells. Biochim. Biophys. Acta 1996, 1291:182-188.
53. He C.H., Gong P., Hu B., Stewart D., Choi M.E., Choi A.M., Alam J. Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J. Biol. Chem. 2001, 276:20858-20865.
54. Herbst U., Toborek M., Kaiser S., Mattson M.P., Hennig B. 4-Hydroxynonenal induces dysfunction and apoptosis of cultured endothelial cells. J. Cell. Physiol. 1999, 181:295-303.
55. Hernandez-Hernandez A., Sanchez-Yague J., Martin-Valmaseda E.M., Llanillo M. Oxidative inactivation of human and sheep platelet membrane-associated phosphotyrosine phosphatase activity. Free Radic. Biol. Med. 1999, 26:1218-1230.
56. Hernandez-Hernandez A., Garabatos M.N., Rodriguez M.C., Vidal M.L., Lopez-Revuelta A., Sanchez-Gallego J.I., Llanillo M., Sanchez-Yague J. Structural characteristics of a lipid peroxidation product, trans-2-nonenal, that favour inhibition of membrane-associated phosphotyrosine phosphatase activity. Biochim. Biophys. Acta 2005, 1726:317-325.
57. Holinstat M., Knezevic N., Broman M., Samarel A.M., Malik A.B., Mehta D. Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. J. Biol. Chem. 2006, 281:2296-2305.
58. Honjo T., Otsui K., Shiraki R., Kawashima S., Sawamura T., Yokoyama M., Inoue N. Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells. Endothelium 2008, 15:137-141.
59. Hu G., Minshall R.D. Regulation of transendothelial permeability by Src kinase. Microvasc. Res. 2009, 77:21-25.
60. Huot J., Houle F., Marceau F., Landry J. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells. Circ. Res. 1997, 80:383-392.
61. Je J.H., Lee J.Y., Jung K.J., Sung B., Go E.K., Yu B.P., Chung H.Y. NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway. FEBS Lett. 2004, 566:183-189.
62. Ji C., Kozak K.R., Marnett L.J. IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J. Biol. Chem. 2001, 276:18223-18228.
63. Kaminski K., Bonda T., Wojtkowska I., Dobrzycki S., Kralisz P., Nowak K., Prokopczuk P., Skrzydlewska E., Kozuch M., Musial W.J. Oxidative stress and antioxidative defense parameters early after reperfusion therapy for acute myocardial infarction. Acute Card. Care 2008, 10:121-126.
64. Katsumi A., Orr A.W., Tzima E., Schwartz M.A. Integrins in mechanotransduction. J. Biol. Chem. 2004, 279:12001-12004.
65. Kronke G., Bochkov V.N., Huber J., Gruber F., Bluml S., Furnkranz A., Kadl A., Binder B.R., Leitinger N. Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein. J. Biol. Chem. 2003, 278:51006-51014.
66. Kumagai T., Matsukawa N., Kaneko Y., Kusumi Y., Mitsumata M., Uchida K. A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages. J. Biol. Chem. 2004, 279:48389-48396.
67. Landar A., Zmijewski J.W., Dickinson D.A., Le Goffe C., Johnson M.S., Milne G.L., Zanoni G., Vidari G., Morrow J.D., Darley-Usmar V.M. Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species. Am. J. Physiol. Heart Circ. Physiol. 2006, 290:H1777-H1787.
68. Lee H., Shi W., Tontonoz P., Wang S., Subbanagounder G., Hedrick C.C., Hama S., Borromeo C., Evans R.M., Berliner J.A., Nagy L. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ. Res. 2000, 87:516-521.
69. Lee J.Y., Je J.H., Jung K.J., Yu B.P., Chung H.Y. Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation. Free Radic. Biol. Med. 2004, 37:539-548.
70. Lee S., Gharavi N.M., Honda H., Chang I., Kim B., Jen N., Li R., Zimman A., Berliner J.A. A role for NADPH oxidase 4 in the activation of vascular endothelial cells by oxidized phospholipids. Free Radic. Biol. Med. 2009, 47:145-151.
71. Leonarduzzi G., Robbesyn F., Poli G. Signaling kinases modulated by 4-hydroxynonenal. Free Radic. Biol. Med. 2004, 37:1694-1702.
72. Lu C., Chan S.L., Fu W., Mattson M.P. The lipid peroxidation product 4-hydroxynonenal facilitates opening of voltage-dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation. J. Biol. Chem. 2002, 277:24368-24375.
73. Ma Z., Li J., Yang L., Mu Y., Xie W., Pitt B., Li S. Inhibition of LPS- and CpG DNA-induced TNF-alpha response by oxidized phospholipids. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004, 286:L808-L816.
74. Manevich Y., Fisher A.B. Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism. Free Radic. Biol. Med. 2005, 38:1422-1432.
75. Mark R.J., Lovell M.A., Markesbery W.R., Uchida K., Mattson M.P. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide. J. Neurochem. 1997, 68:255-264.
76. Mehta D., Malik A.B. Signaling mechanisms regulating endothelial permeability. Physiol. Rev. 2006, 86:279-367.
77. Mehta D., Tiruppathi C., Sandoval R., Minshall R.D., Holinstat M., Malik A.B. Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function. J. Physiol. 2002, 539:779-789.
78. Mertsch K., Blasig I., Grune T. 4-Hydroxynonenal impairs the permeability of an in vitro rat blood-brain barrier. Neurosci. Lett. 2001, 314:135-138.
79. Miao H., Burnett E., Kinch M., Simon E., Wang B. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. 2000, 2:62-69.
80. Nakamura K., Miura D., Kusano K.F., Fujimoto Y., Sumita-Yoshikawa W., Fuke S., Nishii N., Nagase S., Hata Y., Morita H., et al. 4-Hydroxy-2-nonenal induces calcium overload via the generation of reactive oxygen species in isolated rat cardiac myocytes. J. Card. Fail. 2009, 15:709-716.
81. Natarajan V., Scribner W.M., Taher M.M. 4-Hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells. Free Radic. Biol. Med. 1993, 15:365-375.
82. Natarajan V., Scribner W.M., Vepa S. Phosphatase inhibitors potentiate 4-hydroxynonenal-induced phospholipase D activation in vascular endothelial cells. Am. J. Respir. Cell Mol. Biol. 1997, 17:251-259.
83. Negre-Salvayre A., Vieira O., Escargueil-Blanc I., Salvayre R. Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity. Mol. Aspects Med. 2003, 24:251-261.
84. Negre-Salvayre A., Coatrieux C., Ingueneau C., Salvayre R. Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors. Br. J. Pharmacol. 2008, 153:6-20.
85. Negre-Salvayre A., Auge N., Ayala V., Basaga H., Boada J., Brenke R., Chapple S., Cohen G., Feher J., Grune T., et al. Pathological aspects of lipid peroxidation. Free Radic Res. 2010, 44:1125-1171.
86. Ozeki M., Miyagawa-Hayashino A., Akatsuka S., Shirase T., Lee W.H., Uchida K., Toyokuni S. Susceptibility of actin to modification by 4-hydroxy-2-nonenal. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005, 827:119-126.
87. Page S., Fischer C., Baumgartner B., Haas M., Kreusel U., Loidl G., Hayn M., Ziegler-Heitbrock H.W., Neumeier D., Brand K. 4-Hydroxynonenal prevents NF-kappaB activation and tumor necrosis factor expression by inhibiting IkappaB phosphorylation and subsequent proteolysis. J. Biol. Chem. 1999, 274:11611-11618.
88. Paola D., Domenicotti C., Nitti M., Vitali A., Borghi R., Cottalasso D., Zaccheo D., Odetti P., Strocchi P., Marinari U.M., et al. Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells. Biochem. Biophys. Res. Commun. 2000, 268:642-646.
89. Papadopoulou C., Corrigall V., Taylor P.R., Poston R.N. The role of the chemokines MCP-1, GRO-alpha, IL-8 and their receptors in the adhesion of monocytic cells to human atherosclerotic plaques. Cytokine 2008, 43:181-186.
90. Parola M., Bellomo G., Robino G., Barrera G., Dianzani M.U. 4-Hydroxynonenal as a biological signal: molecular basis and pathophysiological implications. Antioxid. Redox Signal. 1999, 1:255-284.
91. Parsons J.T. Focal adhesion kinase: the first ten years. J. Cell Sci. 2003, 116:1409-1416.
92. Pirone D.M., Liu W.F., Ruiz S.A., Gao L., Raghavan S., Lemmon C.A., Romer L.H., Chen C.S. An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J. Cell Biol. 2006, 174:277-288.
93. Poli G., Schaur R.J., Siems W.G., Leonarduzzi G. 4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest. Med. Res. Rev. 2008, 28:569-631.
94. Rahman I., van Schadewijk A.A., Crowther A.J., Hiemstra P.S., Stolk J., MacNee W., De Boer W.I. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2002, 166:490-495.
95. Raza H., John A. 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells. Toxicol. Appl. Pharmacol. 2006, 216:309-318.
96. Renner A., Sagstetter M.R., Harms H., Lange V., Gotz M.E., Elert O. Formation of 4-hydroxy-2-nonenal protein adducts in the ischemic rat heart after transplantation. J. Heart Lung Transplant. 2005, 24:730-736.
97. Rikitake Y., Kim H.H., Huang Z., Seto M., Yano K., Asano T., Moskowitz M.A., Liao J.K. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke 2005, 36:2251-2257.
98. Robino G., Parola M., Marra F., Caligiuri A., De Franco R.M., Zamara E., Bellomo G., Gentilini P., Pinzani M., Dianzani M.U. Interaction between 4-hydroxy-2,3-alkenals and the platelet-derived growth factor-beta receptor. Reduced tyrosine phosphorylation and downstream signaling in hepatic stellate cells. J. Biol. Chem. 2000, 275:40561-40567.
99. Roede J.R., Jones D.P. Reactive species and mitochondrial dysfunction: mechanistic significance of 4-hydroxynonenal. Environ. Mol. Mutagen. 2008, 51:380-390.
100. Roede J.R., Carbone D.L., Doorn J.A., Kirichenko O.V., Reigan P., Petersen D.R. In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal. Chem. Res. Toxicol. 2008, 21:2289-2299.
101. Romer L.H., Birukov K.G., Garcia J.G. Focal adhesions: paradigm for a signaling nexus. Circ. Res. 2006, 98:606-616.
102. Ron D., Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 2007, 8:519-529.
103. Rouhanizadeh M., Hwang J., Clempus R.E., Marcu L., Lassegue B., Sevanian A., Hsiai T.K. Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase. Free Radic. Biol. Med. 2005, 39:1512-1522.
104. Schneider C., Tallman K.A., Porter N.A., Brash A.R. Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. J. Biol. Chem. 2001, 276:20831-20838.
105. Schwarzer E., Muller O., Arese P., Siems W.G., Grune T. Increased levels of 4-hydroxynonenal in human monocytes fed with malarial pigment hemozoin. A possible clue for hemozoin toxicity. FEBS Lett. 1996, 388:119-122.
106. Sharma R., Yang Y., Sharma A., Dwivedi S., Popov V.L., Boor P.J., Singhal S.S., Awasthi S., Awasthi Y.C. Mechanisms and physiological significance of the transport of the glutathione conjugate of 4-hydroxynonenal in human lens epithelial cells. Invest. Ophthalmol. Vis. Sci. 2003, 44:3438-3449.
107. Sharma R., Yang Y., Sharma A., Awasthi S., Awasthi Y.C. Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid. Redox Signal. 2004, 6:289-300.
108. Sochman J. N-acetylcysteine in acute cardiology: 10years later: what do we know and what would we like to know?!. J Am Coll Cardiol 2002, 39:1422-1428.
109. Song B.J., Soh Y., Bae M., Pie J., Wan J., Jeong K. Apoptosis of PC12 cells by 4-hydroxy-2-nonenal is mediated through selective activation of the c-Jun N-terminal protein kinase pathway. Chem. Biol. Interact. 2001, 130-132:943-954.
110. Spite M., Baba S.P., Ahmed Y., Barski O.A., Nijhawan K., Petrash J.M., Bhatnagar A., Srivastava S. Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes. Biochem. J. 2007, 405:95-105.
111. Srivastava S., Spite M., Trent J.O., West M.B., Ahmed Y., Bhatnagar A. Aldose reductase-catalyzed reduction of aldehyde phospholipids. J. Biol. Chem. 2004, 279:53395-53406.
112. Stokoe D., Campbell D.G., Nakielny S., Hidaka H., Leevers S.J., Marshall C., Cohen P. MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. EMBO J. 1992, 11:3985-3994.
113. Su G., Hodnett M., Wu N., Atakilit A., Kosinski C., Godzich M., Huang X.Z., Kim J.K., Frank J.A., Matthay M.A., et al. Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am. J. Respir. Cell Mol. Biol. 2007, 36:377-386.
114. Sun X., Shikata Y., Wang L., Ohmori K., Watanabe N., Wada J., Shikata K., Birukov K.G., Makino H., Jacobson J.R., et al. Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement. Microvasc. Res. 2009, 77:304-313.
115. Takeshita S., Inoue N., Gao D., Rikitake Y., Kawashima S., Tawa R., Sakurai H., Yokoyama M. Lysophosphatidylcholine enhances superoxide anions production via endothelial NADH/NADPH oxidase. J. Atheroscler. Thromb. 2000, 7:238-246.
116. Tiruppathi C., Ahmmed G.U., Vogel S.M., Malik A.B. Ca2+ signaling, TRP channels, and endothelial permeability. Microcirculation 2006, 13:693-708.
117. Tjalkens R.B., Luckey S.W., Kroll D.J., Petersen D.R. Alpha, beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element. Arch. Biochem. Biophys. 1998, 359:42-50.
118. Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog. Lipid Res. 2003, 42:318-343.
119. Uchida K., Shiraishi M., Naito Y., Torii Y., Nakamura Y., Osawa T. Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J. Biol. Chem. 1999, 274:2234-2242.
120. Ueki K., Mimura T., Nakamoto T., Sasaki T., Aizawa S., Hirai H., Yano S., Naruse T., Nojima Y. Integrin-mediated signal transduction in cells lacking focal adhesion kinase p125FAK. FEBS Lett. 1998, 432:197-201.
121. Usatyuk P.V., Natarajan V. Role of mitogen-activated protein kinases in 4-hydroxy-2-nonenal-induced actin remodeling and barrier function in endothelial cells. J. Biol. Chem. 2004, 279:11789-11797.
122. Usatyuk P.V., Vepa S., Watkins T., He D., Parinandi N.L., Natarajan V. Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells. Antioxid. Redox Signal. 2003, 5:723-730.
123. Usatyuk P.V., Parinandi N.L., Natarajan V. Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins. J. Biol. Chem. 2006, 281:35554-35566.
124. VanWinkle W.B., Snuggs M., Miller J.C., Buja L.M. Cytoskeletal alterations in cultured cardiomyocytes following exposure to the lipid peroxidation product, 4-hydroxynonenal. Cell Motil. Cytoskeleton 1994, 28:119-134.
125. Vigil D., Cherfils J., Rossman K.L., Der C.J. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?. Nat. Rev. Cancer 2010, 10:842-857.
126. Wang Q., Doerschuk C.M. The p38 mitogen-activated protein kinase mediates cytoskeletal remodeling in pulmonary microvascular endothelial cells upon intracellular adhesion molecule-1 ligation. J. Immunol. 2001, 166:6877-6884.
127. Wang Y., Jin G., Miao H., Li J.Y., Usami S., Chien S. Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras. Proc Natl Acad Sci USA 2006, 103:1774-1779.
128. Yang Y., Sharma A., Sharma R., Patrick B., Singhal S.S., Zimniak P., Awasthi S., Awasthi Y.C. Cells preconditioned with mild, transient UVA irradiation acquire resistance to oxidative stress and UVA-induced apoptosis: role of 4-hydroxynonenal in UVA-mediated signaling for apoptosis. J. Biol. Chem. 2003, 278:41380-41388.
129. Yang Y., Sharma R., Sharma A., Awasthi S., Awasthi Y.C. Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. Acta Biochim. Pol. 2003, 50:319-336.
130. Yang Y., Trent M.B., He N., Lick S.D., Zimniak P., Awasthi Y.C., Boor P.J. Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis. Atherosclerosis 2004, 173:211-221.
131. Yeh M., Gharavi N.M., Choi J., Hsieh X., Reed E., Mouillesseaux K.P., Cole A.L., Reddy S.T., Berliner J.A. Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway. J. Biol. Chem. 2004, 279:30175-30181.