메뉴 건너뛰기




Volumn 7, Issue 3-4, 2010, Pages 57-64

Drugs and supplements that may slow aging of the epigenome

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPENE 1 THIOL; 5 AZA 2' DEOXYCYTIDINE; ACETYL COENZYME A; BUTYRIC ACID; DNA METHYLTRANSFERASE; DOXORUBICIN; ENTINOSTAT; ESTROGEN RECEPTOR ALPHA; GLUTAMATE DECARBOXYLASE; GLUTATHIONE TRANSFERASE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HISTONE METHYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METFORMIN; REELIN; SULFORAPHANE; THIOL DERIVATIVE; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT; ZEBULARINE;

EID: 82955235548     PISSN: None     EISSN: 17406773     Source Type: Journal    
DOI: 10.1016/j.ddstr.2011.03.001     Document Type: Review
Times cited : (12)

References (59)
  • 1
    • 77949522605 scopus 로고    scopus 로고
    • Validated worldwide supercentenarians, living and recently deceased
    • Young, R.D. et al. (2010) Validated worldwide supercentenarians, living and recently deceased. Rejuvenation Res. 13, 127-132.
    • (2010) Rejuvenation Res. , vol.13 , pp. 127-132
    • Young, R.D.1
  • 3
    • 82955231357 scopus 로고    scopus 로고
    • Cancer and aging: The epigenetic connection
    • CRC Press
    • Cooney, C.A. (2008) Cancer and aging: the epigenetic connection. In Cancer Epigenetics (Tollefsbol ed), pp. 303-316, CRC Press.
    • (2008) Cancer Epigenetics (Tollefsbol ed) , pp. 303-316
    • Cooney, C.A.1
  • 4
    • 61849104907 scopus 로고    scopus 로고
    • Epigenetic mechanisms mediating the long-term effects of maternal care on development
    • Champagne, F.A. and Curley, J.P. (2009) Epigenetic mechanisms mediating the long-term effects of maternal care on development. Neurosci. Biobehav. Rev. 33, 593-600.
    • (2009) Neurosci. Biobehav. Rev. , vol.33 , pp. 593-600
    • Champagne, F.A.1    Curley, J.P.2
  • 5
    • 0031873353 scopus 로고    scopus 로고
    • Maternal epigenetics and methyl supplements affect agouti gene expression in A(vy)/a mice
    • Wolff, G.L. et al. (1998) Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. Faseb J. 12, 949-957. (Pubitemid 28359576)
    • (1998) FASEB Journal , vol.12 , Issue.11 , pp. 949-957
    • Wolff, G.L.1    Kodell, R.L.2    Moore, S.R.3    Cooney, C.A.4
  • 7
    • 33847362325 scopus 로고    scopus 로고
    • Epigenetics - DNA-based mirror of our environment?
    • Epigenetic Markers
    • Cooney, C.A. (2007) Epigenetics - DNA-based mirror of our environment? Dis. Markers 23, 121-137. (Pubitemid 46333647)
    • (2007) Disease Markers , vol.23 , Issue.1-2 , pp. 121-137
    • Cooney, C.A.1
  • 8
    • 82955200458 scopus 로고    scopus 로고
    • Nutrients, epigenetics, and embryonic development
    • (Choi, S. and Friso, S., eds) CRC Press
    • Cooney, C. (2009) Nutrients, epigenetics, and embryonic development. In Nutrients and Epigenetics (Choi, S. and Friso, S., eds), pp. 155-174, CRC Press.
    • (2009) Nutrients and Epigenetics , pp. 155-174
    • Cooney, C.1
  • 9
    • 70350028850 scopus 로고    scopus 로고
    • Mammalian cytosine methylation at a glance
    • Ooi, S.K. et al. (2009) Mammalian cytosine methylation at a glance. J. Cell Sci. 122 (Pt 16), 2787-2791.
    • (2009) J. Cell Sci. , vol.122 , Issue.PART 16 , pp. 2787-2791
    • Ooi, S.K.1
  • 10
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin Modifications and Their Function
    • DOI 10.1016/j.cell.2007.02.005, PII S0092867407001845
    • Kouzarides, T. (2007) Chromatin modifications and their function. Cell 128, 693-705. (Pubitemid 46273577)
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 11
    • 77952168294 scopus 로고    scopus 로고
    • Altered histone acetylation is associated with agedependent memory impairment in mice
    • Peleg, S. et al. (2010) Altered histone acetylation is associated with agedependent memory impairment in mice. Science 328, 753-756.
    • (2010) Science , vol.328 , pp. 753-756
    • Peleg, S.1
  • 13
    • 77649240380 scopus 로고    scopus 로고
    • Widespread and tissue specific age-related DNA methylation changes in mice
    • Maegawa, S. et al. (2010) Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res. 20, 332-340.
    • (2010) Genome Res. , Issue.20 , pp. 332-340
    • Maegawa, S.1
  • 14
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry, R.A. et al. (2009) The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat. Genet. 41, 178-186.
    • (2009) Nat. Genet. , vol.41 , pp. 178-186
    • Irizarry, R.A.1
  • 15
    • 13744264091 scopus 로고    scopus 로고
    • Epigenetic changes in prostate cancer: Implication for diagnosis and treatment
    • Li, L.C. et al. (2005) Epigenetic changes in prostate cancer: implication for diagnosis and treatment. J. Natl. Cancer Inst. 97, 103-115.
    • (2005) J. Natl. Cancer Inst. , vol.97 , pp. 103-115
    • Li, L.C.1
  • 16
    • 65949086183 scopus 로고    scopus 로고
    • Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome
    • Elsheikh, S.E. et al. (2009) Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome. Cancer Res. 69, 3802-3809.
    • (2009) Cancer Res. , vol.69 , pp. 3802-3809
    • Elsheikh, S.E.1
  • 19
    • 33847614418 scopus 로고    scopus 로고
    • Covalent Modification of DNA Regulates Memory Formation
    • DOI 10.1016/j.neuron.2007.02.022, PII S0896627307001420
    • Miller, C.A. and Sweatt, J.D. (2007) Covalent modification of DNA regulates memory formation. Neuron 53, 857-869. (Pubitemid 46367557)
    • (2007) Neuron , vol.53 , Issue.6 , pp. 857-869
    • Miller, C.A.1    Sweatt, J.D.2
  • 20
    • 59449101948 scopus 로고    scopus 로고
    • The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes
    • Kundakovic, M. et al. (2009) The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes. Mol. Pharmacol. 75, 342-354.
    • (2009) Mol. Pharmacol. , vol.75 , pp. 342-354
    • Kundakovic, M.1
  • 22
    • 76749091005 scopus 로고    scopus 로고
    • Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease
    • Kilgore, M. et al. (2010) Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 35, 870-880.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 870-880
    • Kilgore, M.1
  • 25
    • 59649118097 scopus 로고    scopus 로고
    • Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization
    • Kattar, S.D. et al. (2009) Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization. Bioorg. Med. Chem. Lett. 19, 1168-1172.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 1168-1172
    • Kattar, S.D.1
  • 26
    • 77950582432 scopus 로고    scopus 로고
    • Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824)
    • Cho, Y.S. et al. (2010) Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824). J. Med. Chem. 53, 2952-2963.
    • (2010) J. Med. Chem. , vol.53 , pp. 2952-2963
    • Cho, Y.S.1
  • 27
    • 63049105405 scopus 로고    scopus 로고
    • Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds
    • Nian, H. et al. (2009) Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. Environ. Mol. Mutagen 50, 213-221.
    • (2009) Environ. Mol. Mutagen , vol.50 , pp. 213-221
    • Nian, H.1
  • 28
    • 77955352742 scopus 로고    scopus 로고
    • Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines
    • Meeran, S.M. et al. (2010) Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One 5, e11457.
    • (2010) PLoS One , vol.5
    • Meeran, S.M.1
  • 29
    • 78650555097 scopus 로고    scopus 로고
    • Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: Effects of a methyl-supplemented diet
    • Downing, C. et al. (2011) Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet. Alcohol 45, 65-71.
    • (2011) Alcohol , vol.45 , pp. 65-71
    • Downing, C.1
  • 31
    • 77953801590 scopus 로고    scopus 로고
    • Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells in vitro
    • Tan, Y. et al. (2010) Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells in vitro. Anticancer Res. 30, 1041-1046.
    • (2010) Anticancer Res. , vol.30 , pp. 1041-1046
    • Tan, Y.1
  • 32
    • 0028886772 scopus 로고
    • Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats
    • Pogribny, I.P. et al. (1995) Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats. Carcinogenesis 16, 2863-2867.
    • (1995) Carcinogenesis , vol.16 , pp. 2863-2867
    • Pogribny, I.P.1
  • 33
    • 55549115068 scopus 로고    scopus 로고
    • Homocysteine level and coronary heart disease incidence: A systematic review and meta-analysis
    • Humphrey, L.L. et al. (2008) Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis. Mayo Clin. Proc. 83, 1203-1212.
    • (2008) Mayo Clin. Proc. , vol.83 , pp. 1203-1212
    • Humphrey, L.L.1
  • 34
    • 62949129136 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and Alzheimer's disease: A systematic review
    • Van Dam, F. and Van Gool, W.A. (2009) Hyperhomocysteinemia and Alzheimer's disease: a systematic review. Arch. Gerontol. Geriatr. 48, 425-430.
    • (2009) Arch. Gerontol. Geriatr. , vol.48 , pp. 425-430
    • Van Dam, F.1    Van Gool, W.A.2
  • 35
    • 66249105703 scopus 로고    scopus 로고
    • ATP-citrate lyase links cellular metabolism to histone acetylation
    • Wellen, K.E. et al. (2009) ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324, 1076-1080.
    • (2009) Science , vol.324 , pp. 1076-1080
    • Wellen, K.E.1
  • 37
    • 77949882290 scopus 로고    scopus 로고
    • Mitochondrial energetics and therapeutics
    • Wallace, D.C. et al. (2010) Mitochondrial energetics and therapeutics. Annu. Rev. Pathol. 5, 297-348.
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 297-348
    • Wallace, D.C.1
  • 38
    • 73449116731 scopus 로고    scopus 로고
    • Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation
    • Madiraju, P. et al. (2009) Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation. Epigenetics 4, 399-403.
    • (2009) Epigenetics , vol.4 , pp. 399-403
    • Madiraju, P.1
  • 39
    • 58149377634 scopus 로고    scopus 로고
    • Aging skin is functionally anaerobic: Importance of coenzyme Q10 for anti aging skin care
    • Prahl, S. et al. (2008) Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care. Biofactors 32, 245-255.
    • (2008) Biofactors , vol.32 , pp. 245-255
    • Prahl, S.1
  • 40
    • 0037069375 scopus 로고    scopus 로고
    • Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts
    • Lee, C.K. et al. (2002) Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc. Natl. Acad. Sci. U.S.A. 99, 14988-14993.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 14988-14993
    • Lee, C.K.1
  • 41
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • DOI 10.1152/physrev.00006.2004
    • Stanley, W.C. et al. (2005) Myocardial substrate metabolism in the normal and failing heart. Physiol. Rev. 85, 1093-1129. (Pubitemid 40894649)
    • (2005) Physiological Reviews , vol.85 , Issue.3 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 42
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg, O. (1956) On respiratory impairment in cancer cells. Science 124, 269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 43
    • 57449115616 scopus 로고    scopus 로고
    • Tumor metabolism: Cancer cells give and take lactate
    • Semenza, G.L. (2008) Tumor metabolism: cancer cells give and take lactate. J. Clin. Invest. 118, 3835-3837.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3835-3837
    • Semenza, G.L.1
  • 44
    • 35648947817 scopus 로고    scopus 로고
    • Mitochondrial regulation of cancer associated nuclear DNA methylation
    • Xie, C.H. et al. (2007) Mitochondrial regulation of cancer associated nuclear DNA methylation. Biochem. Biophys. Res. Commun. 364, 656-661.
    • (2007) Biochem. Biophys. Res. Commun. , vol.364 , pp. 656-661
    • Xie, C.H.1
  • 45
    • 44649104448 scopus 로고    scopus 로고
    • Targeting AMPK: A new therapeutic opportunity in breast cancer
    • Hadad, S.M. et al. (2008) Targeting AMPK: a new therapeutic opportunity in breast cancer. Crit. Rev. Oncol. Hematol. 67, 1-7.
    • (2008) Crit. Rev. Oncol. Hematol. , vol.67 , pp. 1-7
    • Hadad, S.M.1
  • 46
    • 77953589054 scopus 로고    scopus 로고
    • Metformin blocks the stimulative effect of a highenergy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase
    • Algire, C. et al. (2010) Metformin blocks the stimulative effect of a highenergy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. Endocr. Relat. Cancer 17, 351-360.
    • (2010) Endocr. Relat. Cancer , vol.17 , pp. 351-360
    • Algire, C.1
  • 47
    • 77949703788 scopus 로고    scopus 로고
    • Metformin: A therapeutic opportunity in breast cancer
    • Gonzalez-Angulo, A.M. and Meric-Bernstam, F. (2010) Metformin: a therapeutic opportunity in breast cancer. Clin. Cancer Res. 16, 1695-1700.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1695-1700
    • Gonzalez-Angulo, A.M.1    Meric-Bernstam, F.2
  • 49
    • 73349089917 scopus 로고    scopus 로고
    • Novel inhibitors of fatty acid synthase with anticancer activity
    • Puig, T. et al. (2009) Novel inhibitors of fatty acid synthase with anticancer activity. Clin. Cancer Res. 15, 7608-7615.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7608-7615
    • Puig, T.1
  • 50
    • 78149494317 scopus 로고    scopus 로고
    • Fatty acid synthase phosphorylation: A novel therapeutic target in HER2-overexpressing breast cancer cells
    • Jin, Q. et al. (2010) Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res. 12, R96.
    • (2010) Breast Cancer Res. , vol.12
    • Jin, Q.1
  • 51
    • 77950509620 scopus 로고    scopus 로고
    • A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases
    • Hirsch, H.A. et al. (2010) A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell 17, 348-361.
    • (2010) Cancer Cell , vol.17 , pp. 348-361
    • Hirsch, H.A.1
  • 52
    • 78649302320 scopus 로고    scopus 로고
    • Metformin and cancer risk in diabetic patients: A systematic review and meta-analysis
    • Decensi, A. et al. (2010) Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev. Res. (PA) 3, 1451-1461.
    • (2010) Cancer Prev. Res. (PA) , vol.3 , pp. 1451-1461
    • Decensi, A.1
  • 53
    • 77951908829 scopus 로고    scopus 로고
    • Metformin supplementation and life span in Fischer-344 rats
    • Smith, D.L., Jr et al. (2010) Metformin supplementation and life span in Fischer-344 rats. J. Gerontol. A: Biol. Sci. Med. Sci. 65, 468-474.
    • (2010) J. Gerontol. A: Biol. Sci. Med. Sci. , vol.65 , pp. 468-474
    • Smith Jr., D.L.1
  • 54
    • 77958612597 scopus 로고    scopus 로고
    • Epigenetic drugs can stimulate metastasis through enhanced expression of the pro-metastatic Ezrin gene
    • Yu, Y. et al. (2010) Epigenetic drugs can stimulate metastasis through enhanced expression of the pro-metastatic Ezrin gene. PLoS One 5, e12710.
    • (2010) PLoS One , vol.5
    • Yu, Y.1
  • 55
    • 23844464540 scopus 로고    scopus 로고
    • Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
    • DOI 10.1111/j.1474-9726.2005.00152.x
    • Miller, R.A. et al. (2005) Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4, 119-125. (Pubitemid 41602745)
    • (2005) Aging Cell , vol.4 , Issue.3 , pp. 119-125
    • Miller, R.A.1    Buehner, G.2    Chang, Y.3    Harper, J.M.4    Sigler, R.5    Smith-Wheelock, M.6
  • 56
    • 58149192453 scopus 로고    scopus 로고
    • Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes
    • Fauce, S.R. et al. (2008) Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J. Immunol. 181, 7400-7406.
    • (2008) J. Immunol. , vol.181 , pp. 7400-7406
    • Fauce, S.R.1
  • 57
    • 38349093613 scopus 로고    scopus 로고
    • Remarkable longevity and stress resistance of nematode PI3K-null mutants
    • Ayyadevara, S. et al. (2008) Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell 7, 13-22.
    • (2008) Aging Cell , vol.7 , pp. 13-22
    • Ayyadevara, S.1
  • 58
    • 33847258674 scopus 로고    scopus 로고
    • Discovery and development of SAHA as an anticancer agent
    • DOI 10.1038/sj.onc.1210204, PII 1210204
    • Marks, P.A. (2007) Discovery and development of SAHA as an anticancer agent. Oncogene 26, 1351-1356. (Pubitemid 46328465)
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1351-1356
    • Marks, P.A.1
  • 59
    • 77953133352 scopus 로고    scopus 로고
    • Emerging role of epigenetic therapies in cutaneous Tcell lymphomas
    • Zain, J. et al. (2010) Emerging role of epigenetic therapies in cutaneous Tcell lymphomas. Expert Rev. Hematol. 3, 187-203
    • (2010) Expert Rev. Hematol. , vol.3 , pp. 187-203
    • Zain, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.