Cancer and aging: The epigenetic connection

Cancer Epigenetics

Volumn , Issue , 2008, Pages 303-316

  Cooney, Craig A ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 82955231357     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (114)

1. Goll, M.G. and Bestor, T.H. Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 74, 481, 2005.
2. Berger, J. and Bird, A. Role of MBD2 in gene regulation and tumorigenesis. Biochem. Soc. Trans. 33, (Pt 6), 1537, 2005.
3. Kouzarides, T. Chromatin modifications and their function. Cell 128, 693, 2007.
4. Huang, S. Histone methyltransferases, diet nutrients and tumour suppressors. Nat. Rev. Cancer 2, 469, 2002.
5. Kondo, Y. et al. Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation. Proc. Natl. Acad. Sci. USA 101, 7398, 2004.
6. Taverna, S.D. et al. Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol. Cell 24, 785, 2006.
7. Bulger, M. Hyperacetylated chromatin domains: Lessons from heterochromatin. J. Biol. Chem. 280, 21689, 2005.
8. Roh, T., Cuddapah, S. and Zhao, K. Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes. Dev. 19, 542, 2005.
9. Roh, T. et al. Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns. Genome Res. 17, 74, 2007.
10. Cooney, C.A. Are somatic cells inherently deficient in methylation metabolism? A proposed mechanism for DNA methylation loss, senescence and aging. Growth Dev. Aging 57, 261, 1993.
11. Barbot, W. et al. Epigenetic regulation of an IAP retrotransposon in the aging mouse: Progressive demethylation and de-silencing of the element by its repetitive induction. Nucl. Acids Res. 30, 2365, 2002.
12. Mays-Hoopes, L. et al. Decreased methylation of the major mouse long interspersed repeated DNA during aging and in myeloma cells. Dev. Genet. 7, 65, 1986.
13. Ahuja, N. et al. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res. 58, 5489, 1999.
14. Issa, J.P. et al. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat. Genet. 7, 536, 1994.
15. Issa, J.P. et al. Switch from monoallelic to biallelic human IGF2 promoter methylation during agingáandácarcinogenesis. PNAS 93, 11757, 1996.
16. Nakagawa, H. et al. Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res. 61, 6991, 2001.
17. Yatabe, Y., Tavare, S. and Shibata, D. Investigating stem cells in human colon by using methylation patterns. Proc. Natl. Acad. Sci. U S A 98, 10839, 2001.
18. Post, W.S. et al. Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. Cardiovasc. Res. 43, 985, 1999.
19. Kim, J. et al. Epigenetic changes in estrogen receptor [beta] gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence. Biochim. Biophys. Acta (BBA)-Molecular Basis of Disease 1772, 72, 2007.
20. Kwabi-Addo, B. et al. Age-related DNA methylation changes in normal human prostate tissues. Clin. Cancer Res. 13, 3796, 2007.
21. Reik, W. et al. Age at onset in Huntington's disease and methylation at D4S95. J. Med. Genet. 30, 185, 1993.
22. Zhang, Z. et al. Age-dependent DNA methylation changes in the ITGAL (CD11a) promoter. Mech. Ageing Dev. 123, 1257, 2002.
23. Fraga, M.F. et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. USA 102, 10604, 2005.
24. Mill, J. et al. Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141, 421, 2006.
25. Cooney, C.A. Epigenetics-DNA-based mirror of our environment? Dis. Markers 23, 121, 2007.
26. Poulsen, P. et al. The epigenetic basis of twin discordance in age-related diseases. Pediatr. Res. 61, 38R, 2007.
27. Russanova, V.R. et al. Mapping development-related and age-related chromatin remodeling by a high throughput ChIP-HPLC approach. J. Gerontol. A Biol. Sci. Med. Sci. 59, 1234, 2004.
28. Russanova, V.R. et al. Semirandom sampling to detect differentiation-related and age-related epigenome remodeling. J. Gerontol. A Biol. Sci. Med. Sci. 59, 1221, 2004.
29. Ehrlich, M. DNA methylation in cancer: Too much, but also too little. Oncogene 21, 5400, 2002.
30. Esteller, M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 8, 286, 2007.
31. Gama-Sosa, M.A. et al. The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res. 11, 6883, 1983.
32. Chen, B. et al. Methylation alterations of the MyoD1 upstream region are predictive of subclassification of human rhabdomyosarcomas. Am. J. Pathol. 152, 1071, 1998.
33. Kurmasheva, R.T. et al. Upstream CpG island methylation of the PAX3 gene in human rhabdomyosar-comas. Pediatr. Blood Cancer 44, 328, 2005.
34. Ohm, J.E. et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat. Genet. 39, 237, 2007.
35. Xie, C.H. et al. Mitochondrial regulation of cancer associated nuclear DNA methylation. Biochem. Biophys. Res. Commun. 364, 656, 2007.
36. Liu, H. et al. Loss of epigenetic control of synuclein-gamma gene as a molecular indicator of metastasis in a wide range of human cancers. Cancer Res. 65, 7635, 2005.
37. Goel, A., Mathupala, S.P. and Pedersen, P.L. Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression. J. Biol. Chem. 278, 15333, 2003.
38. Cho, B. et al. Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma. Biochem. Biophys. Res. Commun. 307, 52, 2003.
39. Routh, J.C. and Leibovich, B.C. Adenocarcinoma of the prostate: Epidemiological trends, screening, diagnosis, and surgical management of localized disease. Mayo Clin. Proc. 80, 899, 2005.
40. Seligson, D.B. et al. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 435, 1262, 2005.
41. Fraga, M.F. et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet. 37, 391, 2005.
42. Blasco, M.A. The epigenetic regulation of mammalian telomeres. Nat. Rev. Genet. 8, 299, 2007.
43. Fraga, M.F., Agrelo, R. and Esteller, M. Cross-talk between aging and cancer: The epigenetic language. Ann. N.Y. Acad. Sci. 1100, 60, 2007.
44. Gonzalo, S. et al. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat. Cell Biol. 8, 416, 2006.
45. Garcia-Cao, M. et al. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat. Genet. 36, 94, 2004.
46. Benetti, R., Garcia-Cao, M. and Blasco, M.A. Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat. Genet. 39, 243, 2007.
47. Okino, S.T. et al. Chromatin changes on the GSTP1 promoter associated with its inactivation in prostate cancer. Mol. Carcinog. 46, 839, 2007.
48. Kawamoto, K. et al. Epigenetic modifications of RASSF1A gene through chromatin remodeling in prostate cancer. Clin. Cancer Res. 13, 2541, 2007.
49. Stirzaker, C. et al. Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells. Cancer Res. 64, 3871, 2004.
50. Harden, S.V. et al. Quantitative GSTP1 methylation clearly distinguishes benign prostatic tissue and limited prostate adenocarcinoma. J. Urol. 169, 1138, 2003.
51. Henrique, R. and Jeronimo, C. Molecular detection of prostate cancer: A role for GSTP1 hypermethylation. Eur. Urol. 46, 660, 2004.
52. Li, L.C., Carroll, P.R. and Dahiya, R. Epigenetic changes in prostate cancer: Implication fordiagnosis and treatment. J. Natl. Cancer Inst. 97, 103, 2005.
53. Nakayama, M. et al. GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer. J. Cell Biochem. 91, 540, 2004.
54. Strunnikova, M. et al. Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter. Mol. Cell. Biol. 25, 3923, 2005.
55. Lehmann, U. et al. Quantitative assessment of promoter hypermethylation during breast cancer development. Am. J. Pathol. 160, 605, 2002.
56. Meaney, M.J. and Szyf, M. Maternal care as a model for experience-dependent chromatin plasticity? Trends Neurosci. 28, 456, 2005.
57. Pruitt, K. et al. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS. Genet. 2, e40, 2006.
58. Cooney, C.A., Dave, A.A. and Wolff, G.L. Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J. Nutr. 132 (Suppl 8), 2393S, 2002.
59. Cropley, J.E. et al. Germ-line epigenetic modification of the murine Avy allele by nutritional supplementation. Proc. Natl. Acad. Sci. U S A 103, 17308, 2006.
60. Dolinoy, D.C. et al. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ. Health Perspect. 114, 567, 2006.
61. Waterland, R.A. and Jirtle, R.L. Transposable elements: Targets for early nutritional effects on epigenetic gene regulation. Mol. Cell Biol. 23, 5293, 2003.
62. Wolff, G.L. et al. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J. 12, 949, 1998.
63. Aerts, L. and Van Assche, F.A. Animal evidence for the transgenerational development of diabetes mellitus. Int. J. Biochem. Cell Biol. 38, 894, 2006.
64. Gauguier, D. et al. Inheritance of diabetes mellitus as consequence of gestational hyperglycemia in rats. Diabetes 39, 734, 1990.
65. Dong, E. et al. Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters. Proc. Natl. Acad. Sci. U S A 104, 4676, 2007.
66. Clayton, A.L., Hazzalin, C.A. and Mahadevan, L.C. Enhanced histone acetylation and transcription: A dynamic perspective. Mol. Cell 23, 289, 2006.
67. Lu, Q. et al. Epigenetics, disease, and therapeutic interventions. Ageing Res. Rev. 5, 449, 2006.
68. Ulrey, C.L. et al. The impact of metabolism on DNA methylation. Hum. Mol. Genet. 14 (Suppl 1), R139, 2005.
69. Banerjee, R. and Zou, C. Redox regulation and reaction mechanism of human cystathionine-[beta]-synthase: A PLP-dependent hemesensor protein. Arch. Biochem. Biophy. 433, 144, 2005.
70. Loikkanen, I. et al. Expression of cytosolic acetyl-CoA synthetase gene is developmentally regulated. Mech. Dev. 115, 139, 2002.
71. Starai, V.J. and Escalante-Semerena, J.C. Acetyl-coenzyme A synthetase (AMP forming). Cell Mol. Life Sci. 61, 2020, 2004.
72. Hallows, W.C., Lee, S. and Denu, J.M. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc. Natl. Acad. Sci. USA 103, 10230, 2006.
73. Michan, S. and Sinclair, D. Sirtuins in mammals: Insights into their biological function. Biochem. J. 404, 1, 2007.
74. Takahashi, H. et al. Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol. Cell 23, 207, 2006.
75. Kennedy, A.R. et al. A high-fat, ketogenic diet induces a unique metabolic state in mice. Am. J. Physiol. Endocrinol. Metab. 292, E1724, 2007.
76. Bonnet, S. et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11, 37, 2007.
77. Warburg, O. On respiratory impairment in cancer cells. Science 124, 269, 1956.
78. Brand, K.A. and Hermfisse, U. Aerobic glycolysis by proliferating cells: A protective strategy against reactive oxygen species. FASEB J. 11, 388, 1997.
79. Mobbs, C.V. et al. Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease. Interdiscip. Top. Gerontol. 35, 39, 2007.
80. Roy, S. et al. Overexpression of fibronectin induced by diabetes or high glucose: Phenomenon with a memory. Proc. Natl. Acad. Sci. U S A 87, 404, 1990.
81. Gonzalez, A.A. et al. Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity. Am. J. Physiol. Endocrinol. Metab. 287, E1032, 2004.
82. Hagopian, K., Ramsey, J.J. and Weindruch, R. Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice. Exp. Gerontol. 38, 253, 2003.
83. Hagopian, K., Ramsey, J.J. and Weindruch, R. Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction. Exp. Gerontol. 39, 1145, 2004.
84. Lee, C.K. et al. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc. Natl. Acad. Sci. U S A 99, 14988, 2002.
85. Ma, L., Robinson, L.N. and Towle, H.C. ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver. J. Biol. Chem. 281, 28721, 2006.
86. Weindruch, R. et al. Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice. J. Nutr. 131, 918S, 2001.
87. Mastaitis, J.W. et al. Acute induction of gene expression in brain and liver by insulin-induced hypoglycemia. Diabetes 54, 952, 2005.
88. Mobbs, C.V. et al. Mining microarrays for metabolic meaning: Nutritional regulation of hypothalamic gene expression. Neurochem. Res. 29, 1093, 2004.
89. Roche, E. et al. Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1). J. Biol. Chem. 272, 3091, 1997.
90. Dentin, R. et al. Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J. Biol. Chem. 279, 20314, 2004.
91. Pilkis, S.J. and Granner, D.K. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu. Rev. Physiol. 54, 885, 1992.
92. Abbot, E.L. et al. Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells. FEBS J. 272, 3004, 2005.
93. Aoyama, H., Daitoku, H. and Fukamizu, A. Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice. Int. J. Mol. Med. 18, 433, 2006.
94. Southgate, R.J. et al. PGC-1α gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle. FASEB J. 19, 2072, 2005.
95. Towle, H.C. Glucose as a regulator of eukaryotic gene transcription. Trends Endocrinol. Metabol. 16, 489, 2005.
96. Zhang, W. et al. FoxO1 regulates multiple metabolic pathways in the liver: Effects on gluconeogenic, glycolytic, and lipogenic gene expression. J. Biol. Chem. 281, 10105, 2006.
97. Baranov, V.G. et al. Development of diabetes mellitus in the progeny of 6 generations of female rats with alloxan diabetes. Biull. Eksp. Biol. Med. 105, 13, 1988.
98. Dorner, G. et al. Teratogenetic maternofoetal transmission and prevention of diabetes susceptibility. Exp. Clin. Endocrinol. 91, 247, 1988.
99. Spergel, G., Khan, F. and Goldner, M.G. Emergence of overt diabetes in offspring of rats with induced latent diabetes. Metabolism 24, 1311, 1975
100. Van Assche, F.A. and Aerts, L. Long-term effect of diabetes and pregnancy in the rat. Diabetes 34 (Suppl 2), 116, 1985.
101. Shibata, M. and Yasuda, B. New experimental congenital diabetic mice (N.S.Y. mice). Tohoku J. Exp. Med. 130, 139, 1980.
102. Gauguier, D. et al. Insulin secretion in adult rats after intrauterine exposure to mild hyperglycemia during late gestation. Diabetes 40 (Suppl 2), 109, 1991.
103. Harder, T. et al. Maternal and paternal family history of diabetes in women with gestational diabetes or insulin-dependent diabetes mellitus type I. Gynecol. Obstet. Invest 51, 160, 2001.
104. Masoro, E.J. Overview of caloric restriction and ageing. Mech. Ageing Dev. 126, 913, 2005.
105. Spindler, S.R. Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction. Mech. Ageing Dev. 126, 960, 2005.
106. Koizumi, A. et al. Caloric restriction perturbs the pituitary-ovarian axis and inhibits mouse mammary tumor virus production in a high-spontaneous-mammary-tumor-incidence mouse strain (C3H/SHN). Mech. Ageing Dev. 49, 93, 1989.
107. Masoro, E.J. et al. Dietary restriction alters characteristics of glucose fuel use. J. Gerontol. 47, B202, 1992.
108. Hansson, A. et al. A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts. Proc. Natl. Acad. Sci. USA 101, 3136, 2004.
109. Lehman, J.J. and Kelly, D.P. Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin. Exp. Pharmacol. Physiol. 29, 339, 2002.
110. Stanley, W.C. et al. Myocardial substrate metabolism in the normal and failing heart. Physiol. Rev. 85, 1093, 2005.
111. Greco, M. et al. Marked aging-related decline in efficiency of oxidative phosphorylation in human skin fibroblasts. FASEB J. 17, 1706, 2003.
112. Stockl, P. et al. Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts. Exp. Gerontol. 41, 674, 2006.
113. Trifunovic, A. et al. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc. Natl. Acad. Sci. U S A 102, 17993, 2005.
114. Melov, S. et al. Resistance exercise reverses aging in human skeletal muscle. PLoS. ONE. 2, e465, 2007.