메뉴 건너뛰기




Volumn 23, Issue 6, 2011, Pages 511-518

New insights on chemically induced animal models of systemic sclerosis

Author keywords

Animal models; Bleomycin; Reactive oxygen species; Systemic sclerosis

Indexed keywords

BLEOMYCIN; GAMMA INTERFERON; HYPOCHLOROUS ACID; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 4; L SELECTIN; NOTCH RECEPTOR; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA;

EID: 82955219594     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0b013e32834b1606     Document Type: Review
Times cited : (44)

References (74)
  • 1
    • 28444477739 scopus 로고    scopus 로고
    • Scleroderma: From cell and molecular mechanisms to disease models
    • DOI 10.1016/j.it.2005.09.004, PII S1471490605002395, Autoimmunity Special Issue
    • Abraham DJ, Varga J. Scleroderma: from cell and molecular mechanisms to disease models. Trends Immunol 2005; 26:587-595. (Pubitemid 41726446)
    • (2005) Trends in Immunology , vol.26 , Issue.11 , pp. 587-595
    • Abraham, D.J.1    Varga, J.2
  • 2
    • 77957668307 scopus 로고    scopus 로고
    • Animal models of systemic sclerosis: Prospects and limitations
    • Beyer C, Schett G, Distler O, et al. Animal models of systemic sclerosis: prospects and limitations. Arthritis Rheum 2010; 62:2831-2844.
    • (2010) Arthritis Rheum , vol.62 , pp. 2831-2844
    • Beyer, C.1    Schett, G.2    Distler, O.3
  • 3
    • 79958036406 scopus 로고    scopus 로고
    • Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?
    • Wei J, Melichian D, Komura K, et al. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum 2011; 63:1707-1717.
    • (2011) Arthritis Rheum , vol.63 , pp. 1707-1717
    • Wei, J.1    Melichian, D.2    Komura, K.3
  • 5
    • 0141676369 scopus 로고    scopus 로고
    • In vivo analysis of the apoptosis-inducing effect of anti-endothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay
    • DOI 10.1002/art.11179
    • Worda M, Sgonc R, Dietrich H, et al. In vivo analysis of the apoptosisinducing effect of antiendothelial cell antibodies in systemic sclerosis by the chorionallantoic membrane assay. Arthritis Rheum 2003; 48:2605-2614. (Pubitemid 37129437)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.9 , pp. 2605-2614
    • Worda, M.1    Sgonc, R.2    Dietrich, H.3    Niederegger, H.4    Sundick, R.S.5    Gershwin, M.E.6    Wick, G.7
  • 7
    • 0034536258 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. III: Histopathological comparison of bleomycin-induced scleroderma in various mice strains
    • DOI 10.1007/s004030000183
    • Yamamoto T, Kuroda M, Nishioka K. Animal model of sclerotic skin. III: Histopathological comparison of bleomycin-induced scleroderma in various mice strains. Arch Dermatol Res 2000; 292:535-541. (Pubitemid 32003036)
    • (2000) Archives of Dermatological Research , vol.292 , Issue.11 , pp. 535-541
    • Yamamoto, T.1    Kuroda, M.2    Nishioka, K.3
  • 8
    • 0036150358 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. V: Increased expression of α-smooth muscle actin in fibroblastic cells in bleomycin-induced scleroderma
    • DOI 10.1006/clim.2001.5138
    • Yamamoto T, Nishioka K. Animal model of sclerotic skin. V: Increased expression of a-smooth muscle actin in fibroblastic cells in bleomycin-induced scleroderma. Clin Immunol 2002; 102:77-83. (Pubitemid 34095227)
    • (2002) Clinical Immunology , vol.102 , Issue.1 , pp. 77-83
    • Yamamoto, T.1    Nishioka, K.2
  • 9
    • 0032708703 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. II: Bleomycin induced scleroderma in genetically mast cell deficient WBB6F1- W/W(V) mice
    • Yamamoto T, Takahashi Y, Takagawa S, et al. Animal model of sclerotic skin. II: Bleomycin induced scleroderma in genetically mast cell deficient WBB6F1- W/W(V) mice. J Rheumatol 1999; 26:2628-2634.
    • (1999) J Rheumatol , vol.26 , pp. 2628-2634
    • Yamamoto, T.1    Takahashi, Y.2    Takagawa, S.3
  • 10
    • 0034783450 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. IV: Induction of dermal sclerosis by bleomycin is T cell independent [6]
    • DOI 10.1046/j.0022-202X.2001.01509.x
    • Yamamoto T, Nishioka K. Animal model of sclerotic skin. IV: Induction of dermal sclerosis by bleomycin is T cell independent. J Invest Dermatol 2001; 117:999-1001. (Pubitemid 33001228)
    • (2001) Journal of Investigative Dermatology , vol.117 , Issue.4 , pp. 999-1001
    • Nishioka, K.1    Yamamoto, T.2
  • 11
    • 1842629781 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. VI: Evaluation of bleomycin-induced skin sclerosis in nude mice
    • DOI 10.1007/s00403-003-0439-y
    • Yamamoto T, Nishioka K. Animal model of sclerotic skin. VI: Evaluation of bleomycin-induced skin sclerosis in nude mice. Arch Dermatol Res 2004; 295:453-456. (Pubitemid 38468669)
    • (2004) Archives of Dermatological Research , vol.295 , Issue.10 , pp. 453-456
    • Yamamoto, T.1    Nishioka, K.2
  • 13
    • 67449152710 scopus 로고    scopus 로고
    • Induction of autoimmunity in a bleomycin-induced murine model of experimental systemic sclerosis: An important role for CD4p T cells
    • Ishikawa H, Takeda K, Okamoto A, et al. Induction of autoimmunity in a bleomycin-induced murine model of experimental systemic sclerosis: an important role for CD4 T cells. J Invest Dermatol 2009; 129:1688-1695.
    • (2009) J Invest Dermatol , vol.129 , pp. 1688-1695
    • Ishikawa, H.1    Takeda, K.2    Okamoto, A.3
  • 14
    • 14044268846 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of bleomycin-induced murine scleroderma: Current update and future perspective
    • DOI 10.1111/j.0906-6705.2005.00280.x
    • Yamamoto T, Nishioka K. Cellular and molecular mechanisms of bleomycininduced murine scleroderma: current update and future perspective. Exp Dermatol 2005; 14:81-95. (Pubitemid 40277574)
    • (2005) Experimental Dermatology , vol.14 , Issue.2 , pp. 81-95
    • Yamamoto, T.1    Nishioka, K.2
  • 15
    • 3042822469 scopus 로고    scopus 로고
    • Increased expression of TGF-β1 in the sclerotic skin in bleomycin- 'susceptible' mouse strains
    • Oi M, Yamamoto T, Nishioka K. Increased expression of TGF-beta1 in the sclerotic skin in bleomycin-'susceptible' mouse strains. J Med Dent Sci 2004; 51:7-17. (Pubitemid 41114818)
    • (2004) Journal of Medical and Dental Sciences , vol.51 , Issue.1 , pp. 7-17
    • Oi, M.1    Yamamoto, T.2    Nishioka, K.3
  • 16
    • 0041842736 scopus 로고    scopus 로고
    • Sustained activation of fibroblast transforming growth factor-β/Smad signaling in a murine model of scleroderma
    • DOI 10.1046/j.1523-1747.2003.12308.x
    • Takagawa S, Lakos G, Mori Y, et al. Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma. J Invest Dermatol 2003; 121:41-50. (Pubitemid 36900453)
    • (2003) Journal of Investigative Dermatology , vol.121 , Issue.1 , pp. 41-50
    • Takagawa, S.1    Lakos, G.2    Mori, Y.3    Yamamoto, T.4    Nishioka, K.5    Varga, J.6
  • 18
    • 39549119349 scopus 로고    scopus 로고
    • Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness
    • Mori Y, Hinchcliff M, Wu M, et al. Connective tissue growth factor/CCN2-null mouse embryonic fibroblasts retain intact transforming growth factor-beta responsiveness. Exp Cell Res 2008; 314:1094-1104.
    • (2008) Exp Cell Res , vol.314 , pp. 1094-1104
    • Mori, Y.1    Hinchcliff, M.2    Wu, M.3
  • 20
    • 70350543918 scopus 로고    scopus 로고
    • A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis
    • Hasegawa M, Matsushita Y, Horikawa M, et al. A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis. Arthritis Rheum 2009; 60:3465-3475.
    • (2009) Arthritis Rheum , vol.60 , pp. 3465-3475
    • Hasegawa, M.1    Matsushita, Y.2    Horikawa, M.3
  • 21
    • 33746374436 scopus 로고    scopus 로고
    • The early-immediate gene EGR-1 is induced by transforming growth factor-β and mediates stimulation of collagen gene expression
    • DOI 10.1074/jbc.M603270200
    • Chen SJ, Ning H, Ishida W, et al. The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression. J Biol Chem 2006; 281:21183-21197. (Pubitemid 44115458)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.30 , pp. 21183-21197
    • Chen, S.-J.1    Ning, H.2    Ishida, W.3    Sodin-Semrl, S.4    Takagawa, S.5    Mori, Y.6    Varga, J.7
  • 22
    • 70449575813 scopus 로고    scopus 로고
    • The transcriptional cofactor Nab2 is induced by TGF-Beta and suppresses fibroblast activation: Physiological roles and impaired expression in scleroderma
    • Bhattacharyya S, Wei J, Melichian DS, et al. The transcriptional cofactor Nab2 is induced by TGF-Beta and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma. PLoS One 2009; 4: e7620.
    • (2009) PLoS One , vol.4
    • Bhattacharyya, S.1    Wei, J.2    Melichian, D.S.3
  • 24
    • 0035400078 scopus 로고    scopus 로고
    • Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells
    • Stichtenoth DO, Thoren S, Bian H, et al. Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J Immunol 2001; 167:469-474. (Pubitemid 32567813)
    • (2001) Journal of Immunology , vol.167 , Issue.1 , pp. 469-474
    • Stichtenoth, D.O.1    Thoren, S.2    Bian, H.3    Peters-Golden, M.4    Jakobsson, P.-J.5    Crofford, L.J.6
  • 26
    • 0035144005 scopus 로고    scopus 로고
    • Hypoxia induces expression of the chemokines monocyte chemoattractant protein-1 (MCP-1) and IL-8 in human dermal fibroblasts
    • DOI 10.1046/j.1365-2249.2001.01412.x
    • Galindo M, Santiago B, Alcami J, et al. Hypoxia induces expression of the chemokines monocyte chemoattractant protein-1 (MCP-1) and IL-8 in human dermal fibroblasts. Clin Exp Immunol 2001; 123:36-41. (Pubitemid 32118834)
    • (2001) Clinical and Experimental Immunology , vol.123 , Issue.1 , pp. 36-41
    • Galindo, M.1    Santiago, B.2    Alcami, J.3    Rivero, M.4    Martin-Serrano, J.5    Pablos, J.L.6
  • 27
    • 0041333160 scopus 로고    scopus 로고
    • Role of monocyte chemoattractant protein-1 and its receptor, CCR-2, in the pathogenesis of bleomycin-induced scleroderma
    • DOI 10.1046/j.1523-1747.2003.12408.x
    • Yamamoto T, Nishioka K. Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma. J Invest Dermatol 2003; 121:510-516. (Pubitemid 37072262)
    • (2003) Journal of Investigative Dermatology , vol.121 , Issue.3 , pp. 510-516
    • Yamamoto, T.1    Nishioka, K.2
  • 28
    • 0030014832 scopus 로고    scopus 로고
    • 1 gene expression by monocyte chemoattractant protein-1 via specific receptors
    • DOI 10.1074/jbc.271.30.17779
    • Gharaee-Kermani M, Denholm EM, Phan SH. Costimulation of fibroblast collagen and transforming growth factor b1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 1996; 271:17779-17784. (Pubitemid 26250752)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.30 , pp. 17779-17784
    • Gharaee-Kermani, M.1    Denholm, E.M.2    Phan, S.H.3
  • 30
    • 18244392419 scopus 로고    scopus 로고
    • STAT4: A critical regulator of inflammation in vivo
    • Kaplan MH. STAT4: a critical regulator of inflammation in vivo. Immunol Res 2005; 31:231-242.
    • (2005) Immunol Res , vol.31 , pp. 231-242
    • Kaplan, M.H.1
  • 31
    • 68049112537 scopus 로고    scopus 로고
    • STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis
    • Dieudé P, Guedj M, Wipff J, et al. STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis. Arthritis Rheum 2009; 60:2472-2479.
    • (2009) Arthritis Rheum , vol.60 , pp. 2472-2479
    • Dieudé, P.1    Guedj, M.2    Wipff, J.3
  • 32
    • 79953676584 scopus 로고    scopus 로고
    • Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis
    • Avouac J, Fürnrohr BG, Tomcik M, et al. Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis. Arthritis Rheum 2011; 63:800-809.
    • (2011) Arthritis Rheum , vol.63 , pp. 800-809
    • Avouac, J.1    Fürnrohr, B.G.2    Tomcik, M.3
  • 33
    • 65249092549 scopus 로고    scopus 로고
    • The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis
    • Akhmetshina A, Dees C, Busch N, et al. The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis. Arthritis Rheum 2009; 60:1129-1136.
    • (2009) Arthritis Rheum , vol.60 , pp. 1129-1136
    • Akhmetshina, A.1    Dees, C.2    Busch, N.3
  • 34
    • 77954574870 scopus 로고    scopus 로고
    • Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis
    • Servettaz A, Kavian N, Nicco C, et al. Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis. Am J Pathol 2010; 177:187-196.
    • (2010) Am J Pathol , vol.177 , pp. 187-196
    • Servettaz, A.1    Kavian, N.2    Nicco, C.3
  • 35
    • 79952363189 scopus 로고    scopus 로고
    • The cannabinoid WIN55, 212-2 abrogates dermal fibrosis in scleroderma bleomycin model
    • Balistreri E, Garcia-Gonzalez E, Selvi E, et al. The cannabinoid WIN55, 212-2 abrogates dermal fibrosis in scleroderma bleomycin model. Ann Rheum Dis 2011; 70:695-699.
    • (2011) Ann Rheum Dis , vol.70 , pp. 695-699
    • Balistreri, E.1    Garcia-Gonzalez, E.2    Selvi, E.3
  • 36
    • 78249233276 scopus 로고    scopus 로고
    • Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis
    • Marquart S, Zerr P, Akhmetshina A, et al. Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Arthritis Rheum 2010; 62:3467-3476.
    • (2010) Arthritis Rheum , vol.62 , pp. 3467-3476
    • Marquart, S.1    Zerr, P.2    Akhmetshina, A.3
  • 37
    • 34948844518 scopus 로고    scopus 로고
    • Platelet contributions to the pathogenesis of systemic sclerosis
    • DOI 10.1097/BOR.0b013e3282eeb3a4, PII 0000228120071100000010
    • Postlethwaite AE, Chiang TM. Platelet contributions to the pathogenesis of systemic sclerosis. Curr Opin Rheumatol 2007; 19:574-579. (Pubitemid 47530878)
    • (2007) Current Opinion in Rheumatology , vol.19 , Issue.6 , pp. 574-579
    • Postlethwaite, A.E.1    Chiang, T.M.2
  • 38
    • 79956122627 scopus 로고    scopus 로고
    • Platelet-derived serotonin links vascular disease and tissue fibrosis
    • Dees C, Akhmetshina A, Zerr P, et al. Platelet-derived serotonin links vascular disease and tissue fibrosis. J Exp Med 2011; 208:961-972.
    • (2011) J Exp Med , vol.208 , pp. 961-972
    • Dees, C.1    Akhmetshina, A.2    Zerr, P.3
  • 40
    • 0026446005 scopus 로고
    • Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4
    • Postlethwaite AE, Holness MA, Katai H, et al. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J Clin Invest 1992; 90:1479-1485.
    • (1992) J Clin Invest , vol.90 , pp. 1479-1485
    • Postlethwaite, A.E.1    Holness, M.A.2    Katai, H.3
  • 42
    • 0008635201 scopus 로고
    • Interleukin-1, interleukin-2, interleukin- 4, interleukin-6, tumor necrosis factor a, and interferon-c levels in sera from patients with scleroderma
    • Needlemann BW, Wigley FM, Stair RW. Interleukin-1, interleukin-2, interleukin- 4, interleukin-6, tumor necrosis factor a, and interferon-c levels in sera from patients with scleroderma. Arthritis Rheum 1985; 28:775-780.
    • (1985) Arthritis Rheum , vol.28 , pp. 775-780
    • Needlemann, B.W.1    Wigley, F.M.2    Stair, R.W.3
  • 43
    • 0033017344 scopus 로고    scopus 로고
    • Anti-sclerotic effect of transforming growth factor-β antibody in a mouse model of bleomycin-induced scleroderma
    • DOI 10.1006/clim.1999.4720
    • Yamamoto T, Takagawa S, Katayama I, et al. Antisclerotic effect of antitransforming growth factor b antibody in bleomycin-induced scleroderma. Clin Immunol 1999; 92:6-13. (Pubitemid 29315981)
    • (1999) Clinical Immunology , vol.92 , Issue.1 , pp. 6-13
    • Yamamoto, T.1    Takagawa, S.2    Katayama, I.3    Nishioka, K.4
  • 44
    • 11444270348 scopus 로고    scopus 로고
    • Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma
    • DOI 10.1159/000082331
    • Matsushita M, Yamamoto T, Nishioka K. Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma. Int Arch Allergy Immunol 2004; 135:348-356. (Pubitemid 40082202)
    • (2004) International Archives of Allergy and Immunology , vol.135 , Issue.4 , pp. 348-356
    • Matsushita, M.1    Yamamoto, T.2    Nishioka, K.3
  • 45
    • 33847377509 scopus 로고    scopus 로고
    • Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet
    • DOI 10.1159/000098208
    • Lakos G, Melichian D, Wu M, et al. Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet. Pathobiology 2006; 73:224-237. (Pubitemid 46332830)
    • (2006) Pathobiology , vol.73 , Issue.5 , pp. 224-237
    • Lakos, G.1    Melichian, D.2    Wu, M.3    Varga, J.4
  • 46
    • 33847324516 scopus 로고    scopus 로고
    • Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13
    • Aliprantis AO, Wang J, Fathman JW, et al. Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci U S A 2007; 104:2827-2930.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2827-2930
    • Aliprantis, A.O.1    Wang, J.2    Fathman, J.W.3
  • 48
    • 4744362174 scopus 로고    scopus 로고
    • Interleukin-13 stimulates the transcription of the human α2(I) collagen gene in human dermal fibroblasts
    • DOI 10.1074/jbc.M406951200
    • Jinnin M, Ihn H, Yamane K, et al. Interleukin-13 stimulates the transcription of the human alpha2(I) collagen gene in human dermal fibroblasts. J Biol Chem 2004; 279:41783-41791. (Pubitemid 39313625)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.40 , pp. 41783-41791
    • Jinnin, M.1    Ihn, H.2    Yamane, K.3    Tamaki, K.4
  • 49
    • 0031661468 scopus 로고    scopus 로고
    • IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts
    • DOI 10.1093/intimm/10.10.1421
    • Doucet C, Brouty-Boye D, Pottin-Clemenceau C, et al. IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts. Int Immunol 1998; 10:1421-1433. (Pubitemid 28451436)
    • (1998) International Immunology , vol.10 , Issue.10 , pp. 1421-1433
    • Doucet, C.1    Brouty-Boye, D.2    Pottin-Clemenceau, C.3    Jasmin, C.4    Canonica, G.W.5    Azzarone, B.6
  • 51
    • 75649125362 scopus 로고    scopus 로고
    • Altered blood B lymphocyte homeostasis in systemic sclerosis. Expanded naive B cells and diminished but activated memory B cells
    • Sato S, Fujimoto M, Hasegawa M, et al. Altered blood B lymphocyte homeostasis in systemic sclerosis. Expanded naive B cells and diminished but activated memory B cells. Arthritis Rheum 2001; 50:918-927.
    • (2001) Arthritis Rheum , vol.50 , pp. 918-927
    • Sato, S.1    Fujimoto, M.2    Hasegawa, M.3
  • 52
    • 77952943759 scopus 로고    scopus 로고
    • Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator/inducible costimulator ligand pathway
    • Tanaka C, Fujimoto M, Hamaguchi Y, et al. Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator/inducible costimulator ligand pathway. Arthritis Rheum 2010; 62:1723-1732.
    • (2010) Arthritis Rheum , vol.62 , pp. 1723-1732
    • Tanaka, C.1    Fujimoto, M.2    Hamaguchi, Y.3
  • 53
    • 69449108113 scopus 로고    scopus 로고
    • Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model
    • Liu S, Kapoor M, Denton CP, et al. Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model. Arthritis Rheum 2009; 60:2817-2821.
    • (2009) Arthritis Rheum , vol.60 , pp. 2817-2821
    • Liu, S.1    Kapoor, M.2    Denton, C.P.3
  • 54
    • 77956899738 scopus 로고    scopus 로고
    • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model
    • Yoshizaki A, Yanaba K, Iwata Y, et al. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J Immunol 2010; 185:2502-2515.
    • (2010) J Immunol , vol.185 , pp. 2502-2515
    • Yoshizaki, A.1    Yanaba, K.2    Iwata, Y.3
  • 55
    • 77955349716 scopus 로고    scopus 로고
    • Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis
    • Yoshizaki A, Yanaba K, Yoshizaki A, et al. Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis. Arthritis Rheum 2010; 62:2476-2487.
    • (2010) Arthritis Rheum , vol.62 , pp. 2476-2487
    • Yoshizaki, A.1    Yanaba, K.2    Yoshizaki, A.3
  • 56
    • 77949754964 scopus 로고    scopus 로고
    • Methotrexate has no antifibrotic effect in bleomycin-induced experimental scleroderma
    • Ozgen M, Koca SS, Isik A, et al. Methotrexate has no antifibrotic effect in bleomycin-induced experimental scleroderma. J Rheumatol 2010; 37:678-679.
    • (2010) J Rheumatol , vol.37 , pp. 678-679
    • Ozgen, M.1    Koca, S.S.2    Isik, A.3
  • 57
    • 1842850717 scopus 로고    scopus 로고
    • Acute and sustained effects of dihydropyridine-type calcium channel antagonists on oxidative stress in systemic sclerosis
    • DOI 10.1016/j.amjmed.2003.11.022, PII S0002934303008052
    • Allanore Y, Borderie D, Lemarechal H, et al. Acute and sustained effects of dihydropyridine-type calcium channel antagonists on oxidative stress in systemic sclerosis. Am J Med 2004; 116:595-600. (Pubitemid 38490533)
    • (2004) American Journal of Medicine , vol.116 , Issue.9 , pp. 595-600
    • Allanore, Y.1    Borderie, D.2    Lemarechal, H.3    Ekindjian, O.G.4    Kahan, A.5
  • 59
    • 0035098516 scopus 로고    scopus 로고
    • The emerging problem of oxidative stress and the role of antioxidants in systemic sclerosis
    • Herrick AL, Matucci Cerinic M. The emerging problem of oxidative stress and the role of antioxidants in systemic sclerosis. Clin Exp Rheumatol 2001; 19:4-8. (Pubitemid 32203838)
    • (2001) Clinical and Experimental Rheumatology , vol.19 , Issue.1 , pp. 4-8
    • Herrick, A.L.1    Matucci Cerinic, M.2
  • 61
    • 0035149214 scopus 로고    scopus 로고
    • Oxidative stress in scleroderma: Maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway
    • DOI 10.1002/1529-0131(200111)44:11<2653::AID-ART445>3.0.CO;2-1
    • Sambo P, Baroni SS, Luchetti M, et al. Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive upregulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis Rheum 2001; 44:2653-2664. (Pubitemid 33049343)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.11 , pp. 2653-2664
    • Sambo, P.1    Baroni, S.S.2    Luchetti, M.3    Paroncini, P.4    Dusi, S.5    Orlandini, G.6    Gabrielli, A.7
  • 62
    • 33745620189 scopus 로고    scopus 로고
    • Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis
    • DOI 10.1093/rheumatology/kel012
    • Ogawa F, Shimizu K, Muroi E, et al. Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis. Rheumatology (Oxford) 2006; 45:815-818. (Pubitemid 43985368)
    • (2006) Rheumatology , vol.45 , Issue.7 , pp. 815-818
    • Ogawa, F.1    Shimizu, K.2    Muroi, E.3    Hara, T.4    Hasegawa, M.5    Takehara, K.6    Sato, S.7
  • 65
    • 33745277147 scopus 로고    scopus 로고
    • Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis
    • Svegliati Baroni S, Santillo M, Bevilacqua F, et al. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med 2006; 354:2667-2676.
    • (2006) N Engl J Med , vol.354 , pp. 2667-2676
    • Svegliati Baroni, S.1    Santillo, M.2    Bevilacqua, F.3
  • 66
    • 0031025143 scopus 로고    scopus 로고
    • Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: Implications for pathogenesis
    • DOI 10.1084/jem.185.1.71
    • Casciola-Rosen L, Wigley F, Rosen A. Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis. J Exp Med 1997; 185:71-79. (Pubitemid 27039442)
    • (1997) Journal of Experimental Medicine , vol.185 , Issue.1 , pp. 71-79
    • Casciola-Rosen, L.1    Wigley, F.2    Rosen, A.3
  • 67
    • 66949168883 scopus 로고    scopus 로고
    • Selective oxidation of DNA topoisomerase 1 induced systemic sclerosis in the mouse
    • Servettaz A, Goulvestre C, Kavian N, et al. Selective oxidation of DNA topoisomerase 1 induced systemic sclerosis in the mouse. J Immunol 2009; 182:5855-5864.
    • (2009) J Immunol , vol.182 , pp. 5855-5864
    • Servettaz, A.1    Goulvestre, C.2    Kavian, N.3
  • 68
    • 78249268282 scopus 로고    scopus 로고
    • Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model
    • Kavian N, Servettaz A, Mongaret C, et al. Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model. Arthritis Rheum 2010; 62:3477-3487.
    • (2010) Arthritis Rheum , vol.62 , pp. 3477-3487
    • Kavian, N.1    Servettaz, A.2    Mongaret, C.3
  • 71
    • 79955567838 scopus 로고    scopus 로고
    • Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis
    • Dees C, Zerr P, Tomcik M, et al. Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis. Arthritis Rheum 2011; 63:1396-1404.
    • (2011) Arthritis Rheum , vol.63 , pp. 1396-1404
    • Dees, C.1    Zerr, P.2    Tomcik, M.3
  • 73
    • 34247564964 scopus 로고    scopus 로고
    • Angiogenic and angiostatic factors in systemic sclerosis: Increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers
    • Distler O, Del Rosso A, Giacomelli R, et al. Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis Res 2002; 4:R11.
    • (2002) Arthritis Res , vol.4
    • Distler, O.1    Del Rosso, A.2    Giacomelli, R.3
  • 74
    • 0024539072 scopus 로고
    • Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma
    • Gay S, Jones JRE, Huang GQ, et al. Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma. J Invest Dermatol 1989; 92:301-303. (Pubitemid 19061278)
    • (1989) Journal of Investigative Dermatology , vol.92 , Issue.2 , pp. 301-303
    • Gay, S.1    Jones Jr., R.E.2    Huang, G.-Q.3    Gay, R.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.