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Volumn 37, Issue 3, 2010, Pages 678-679

Methotrexate has no antifibrotic effect in bleomycin-induced experimental scleroderma

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BLEOMYCIN; HYDROXYPROLINE; INTERLEUKIN 2; INTERLEUKIN 4; METHOTREXATE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77949754964     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: 10.3899/jrheum.090961     Document Type: Letter
Times cited : (6)

References (10)
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    • van den Hoogen FH, Boerbooms AM, Swaak AJ, Rasker JJ, van Lier HJ, van de Putte LB. Comparison of methotrexate with placebo in the treatment of systemic sclerosis: a 24 week randomized double-blind trial, followed by a 24 week observational trial. Br J Rheumatol 1996;35:364-72.
    • (1996) Br J Rheumatol , vol.35 , pp. 364-372
    • van den Hoogen, F.H.1    Boerbooms, A.M.2    Swaak, A.J.3    Rasker, J.J.4    van Lier, H.J.5    van de Putte, L.B.6
  • 2
    • 0034970031 scopus 로고    scopus 로고
    • A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma
    • Pope JE, Bellamy N, Seibold JR, Baron M, Ellman M, Carette S, et al. A randomized, controlled trial of methotrexate versus placebo in early diffuse scleroderma. Arthritis Rheum 2001;44:1351-8.
    • (2001) Arthritis Rheum , vol.44 , pp. 1351-1358
    • Pope, J.E.1    Bellamy, N.2    Seibold, J.R.3    Baron, M.4    Ellman, M.5    Carette, S.6
  • 3
    • 0032907817 scopus 로고    scopus 로고
    • Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma
    • Yamamoto T, Takagawa S, Katayama I, Yamazaki K, Hamazaki Y, Shinkai H, et al. Animal model of sclerotic skin. I: Local injections of bleomycin induce sclerotic skin mimicking scleroderma. J Invest Dermatol 1999;112:456-62.
    • (1999) J Invest Dermatol , vol.112 , pp. 456-462
    • Yamamoto, T.1    Takagawa, S.2    Katayama, I.3    Yamazaki, K.4    Hamazaki, Y.5    Shinkai, H.6
  • 4
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    • Anti-sclerotic effect of transforming growth factor-beta antibody in a mouse model of bleomycin-induced scleroderma
    • Yamamoto T, Takagawa S, Katayama I, Nishioka K. Anti-sclerotic effect of transforming growth factor-beta antibody in a mouse model of bleomycin-induced scleroderma. Clin Immunol 1999;92:6-13.
    • (1999) Clin Immunol , vol.92 , pp. 6-13
    • Yamamoto, T.1    Takagawa, S.2    Katayama, I.3    Nishioka, K.4
  • 5
    • 0022637441 scopus 로고
    • Inhibition of 5-aminoimidazole-4- carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide
    • Baggott JE, Vaughn WH, Hudson BB. Inhibition of 5-aminoimidazole-4- carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide. Biochem J 1986;236:193-200.
    • (1986) Biochem J , vol.236 , pp. 193-200
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  • 6
    • 33746968120 scopus 로고    scopus 로고
    • Adenosine A2A receptors in diffuse dermal fibrosis: Pathogenic role in human dermal fibroblasts and in a murine model of scleroderma
    • Chan ES, Fernandez P, Merchant AA, Montesinos MC, Trzaska S, Desai A, et al. Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma. Arthritis Rheum 2006;54:2632-42.
    • (2006) Arthritis Rheum , vol.54 , pp. 2632-2642
    • Chan, E.S.1    Fernandez, P.2    Merchant, A.A.3    Montesinos, M.C.4    Trzaska, S.5    Desai, A.6
  • 8
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    • Fibrotic disease and the T(H)1/T(H)2 paradigm
    • Wynn TA. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol 2004;4:583-94.
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  • 9
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    • Interleukin-1, interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor alpha, and interferon-gamma levels in sera from patients with scleroderma
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  • 10
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    • Methotrexate selectively modulates TH1/TH2 balance in active rheumatoid arthritis patients
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.