Preclinical evaluation of anti-inflammatory activities of the novel pyrrolopyrimidine PNU-142731A, a potential treatment for asthma

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 1, 1999, Pages 188-195

  Chin, Jia En ^a   Hatfield, Cheryl A ^a   Winterrowd, Greg E ^a   Krzesicki, Raymond F ^a   Shull, Kathy L ^a   Fidler, Stephen F ^a   Kolbasa, Karen P ^a   Brashler, John R ^a   Griffin, Robert L ^a   Fleming, William E ^a   Justen, James M ^a   Banitt, Lee S ^a   Bundy, Gordon L ^a   Richards, Ivan M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2,4 DI 1 PYRROLIDINYL 9H PYRIMIDO[4,5 B]INDOL 9 YL)ACETYL]PYRROLIDINE; ANTIASTHMATIC AGENT; ANTIINFLAMMATORY AGENT; DEXAMETHASONE; PYRROLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; DRUG MECHANISM; DRUG SCREENING; HISTOPATHOLOGY; LEUKOCYTE ACTIVATION; LUNG LAVAGE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROVOCATION TEST; RESPIRATORY TRACT INFLAMMATION;

ANIMALS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; EPITHELIAL CELLS; FEMALE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULINS; INDOLES; LEUKOCYTES; LUNG; MICE; MICE, INBRED C57BL; MUCUS; OVALBUMIN; PYRROLIDINES; RESPIRATORY SYSTEM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE PROTEINASE INHIBITORS; SPLEEN;

EID: 0007415636     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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